Rosmarinus offi cialis L., Lamiaceae, has been used to treat a range of illnesses in Iraq for decades and is regarded as a desirable species due to its medicinal properties and antioxidant properties. Aim of study: The main aim of this study was to study more about how the R. offi cialis L plant may help to reduce the negative eff ects of epilepsy. Materials and methods: To estimate the alteration of antioxidant enzymes and lipid peroxidation. Fifty male rats were split into fi ve groups: control (no additions), FeCl3 group, and the rest of the groups were fed R. offi cialis L. components (fl avonoid, glycoside, and alkaloids). Results: β-asecretase, Na and K levels raised in FeCl3 and other R. offi cialis compounds groups while. In contrast to the FeCl3 group and FeCl3 groups containing R. offi cialis L. plant components reduced fucose, vit-C, and Zn levels. In compared to the control group, the activity of oxidant enzymes and lipid peroxidation resulted in a signifi cant amount of glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) in the FeCl3 group; however, R. offi cialis components increased the levels of MDA and SOD, whilst reducing GSH, and CAT. Conclusion: R. offi cinalis extraction components have an eff ects on -asecretase, fucose, and vit-C in male rats, in addition to antioxidant activity and may increase or decrease lipid peroxidation while also improving antioxidative enzymes significantly. The active components of the R. offi cinalis L. plant might be used as one of the next generation of anti-epileptic medications.