The aim of the research is to determine whether there was synergism between mobile phone exposure and higher release and accumulation of mercury in tissues of the individuals with amalgam fillings. For this purpose, the computer electro-magnetic simulation and the Bi-Digital O-Ring Test (BDORT) method were used. For the electro-magnetic simulation, the FIT method (Finite Integration technique - numerical simulation method for calculation elelctromagnentic fields in space, expecialy in body) was used and the results of the electric field and Specific absorption rate (SAR) in the tooth model with and without amalgam fillings were obtained. Specific absorption rate is a measure of the rate at which energy is absorbed by the human body when exposed to a radio frequency (RF) electromagnetic field. It is dose for absorbed electromagnetic radiation which is dependent on frequency and can be associated with the adverse effect of tissue heating. Standards indicate SAR values that should not be exceeded. The numerical result of absorption electro-magnetic energy shows increased value of the electric field, magnetic field, induced currents and SAR in teeth with fillings. These results indicated the possible explanation of the increased release mechanism of the mercury (Hg) when using mobile phones. The Bi-Digital O-Ring Test method tested the levels of mercury in the body, liver, and urine in a group of examinees who had amalgam fillings and used cell phones. By using indirect BDORT we examined groups of examinees 10 with and 10 examinees without amalgam fillings. By using BDORT we measaured level ofHg in the body and urin samples in all examinees before exposure to electromagnetic fields (EMFs) of mobile phone and after 15 minutes of exposure of mobile phone EMF. The results showed significantly higher level of Hg in urin after exposure of EMF of mobile phone, only in a group of examinees with amalgam fillings. The results showed significant matches with some published papers by other researchers. These effects might cause potential organism disorders and represent secondary harmful effects of electro-magnetic radiation on the health of individuals. This approach throws a new light in clarifying the interplay of cellular electro-magnetic radiation and increased the release of mercury from the amalgam fillings. Increased toxic effects are imposed by themselves as possible.