Due to the vast amount of patient health data, automated healthcare systems still struggle to classify and diagnose various ailments. Learning redundant data also reduces categorization accuracy. A Deep Belief Network (DBN) has been used to precisely extract the most important aspects from clinical data by ignoring irrelevant/redundant features. Due of many learning variables, training is complicated. Similarly, the hybrid model has been employed by ensemble Convolutional Neural Network (CNN), Long Short-Term Memory (LSTM) and Support Vector Machine (SVM) to categorize diseases. But, its efficiency depends on the proper choice of kernels and hyper-parameters. Therefore, this paper develops an efficient feature extraction and classification model for healthcare systems. First, several medical data related to the patient’s health are collected. Then, an Optimized DBN (ODBN) model is presented for maximizing the accurateness of DBN by optimizing the learning variables depends on the Ant Lion Optimization (ALO) algorithm. With learning ODBN, the most relevant features are extracted with reduced computational complexity. After that, the CNN-LSTM with Unsupervised Fine-tuned Deep Self-Organizing Map (UFDSOM)-based classifier model is designed to categorize the extracted features into categories of illnesses. In this novel classifier, dropout normalization and parameter tuning processes are applied to avoid overfitting and optimize the hyper-parameters, which results in a less training period. In the end, studies utilizing publically accessible datasets show that the ODBN with CNN-LSTM-UFDSOM system outperforms classical models by 98.23%.