Hard turning with ceramic tools provides an alternative to grinding operation in machining high precision and hardened components. But, the main concerns are the cost of expensive tool materials and the effect of the process on machinability. The poor selection of cutting conditions may lead to excessive tool wear and increased surface roughness of workpiece. Hence, there is a need to investigate the effects of process parameters on machinability characteristics in hard turning. In this work, the influence of cutting speed, feed rate, and machining time on machinability aspects such as specific cutting force, surface roughness, and tool wear in AISI D2 cold work tool steel hard turning with three different ceramic inserts, namely, CC650, CC650WG, and GC6050WH has been studied. A multilayer feed-forward artificial neural network (ANN), trained using error back-propagation training algorithm has been employed for predicting the machinability. The input–output patterns required for ANN training and testing are obtained from the turning experiments planned through full factorial design. The simulation results demonstrate the effectiveness of ANN models to analyze the effects of cutting conditions as well as to study the performance of conventional and wiper ceramic inserts on machinability.