Wrist mobility is vital for post-stroke patients to carry out their daily activities. The use of robotic devices in hand rehabilitation has increased significantly in recent years, allowing patients to get training at home and effectively compensating for the therapist-to-patient ratio. Nevertheless, rehabilitation devices are expensive, cumbersome, immobile, and difficult to wear and operate. This work proposes a new method for designing a wrist rehabilitation device that uses airbag technology to minimize device weight and size. A triangular prism-shaped Neoprene (synthetic rubber) airbag is utilized in the experiment; which is inflated and deflated using a DC motorized air pump. An accelerometer sensor serves as the control input for the wrist rehabilitation exercise device. The proposed device trains the impaired hand of ten hemiplegic post-stroke patients. A goniometer and Fugl-Meyer Assessment (FMA) are used to measure wrist motion before and after the training regimen to evaluate the results. The mean angle (in degree) of wrist flexion increases from 8.6 ± 2.59 to 18.4 ± 5.19 (p = 0.005). Likewise, an increase in the wrist extension angle from 12.3 ± 3.62 to 17.7 ± 6.2 (p = 0.008) is noted. The wrist rehabilitation device is lightweight, portable, and simple to use, producing good results for hemiplegic individuals with hand disability. The suggested invention enables the user to extend their wrist’s range of motion.