HIV Prevention Research Articles

Knowledge and Attitude Towards Pre-Exposure Prophylaxis for HIV/AIDS and its Associated Factors Among Health Care Workers in Debretabor Compressive Specialized Hospital 2023

Back ground: Human immunodeficiency virus infection is a severe public health issue that claims the lives of numerous people, including medical professionals. The effectiveness of daily oral pre-exposure prophylaxis for HIV prevention among at-risk individuals has thus been repeatedly shown in clinical trials. An important public health opportunity to reduce HIV incidence is presented by pre-exposure prophylaxis. Objective: The purpose of this study is to evaluate health care workers' knowledge, attitudes, and factors related to pre-exposure prophylaxis against HIV/AIDS at Debretabor comprehensive specialized hospital in Debretabor, Ethiopia. Method: A cross-sectional study was conducted among 322 health care workers in Debretabor comprehensive specialized hospital from June to July, 2023. The data were collected by trained data collectors using a structured questionnaire with self-administered questioners. The collected data were entered, and the data were checked, coded, data cleaning and analysis using SPSS version 23. Result: The level of attitudes of pre-exposure prophylaxis was analyzed among all 322 respondents. Overall attitudes of health care workers were 68% [95% CL: 62.7-72.7].Off 322 study participants were participated with a response rate of 100%. About 134(41.6%) health care workers had six to ten year clinical experience in their profession, and almost half, 63(51.6%) health care workers in this study were Nurses followed by 62(19.3%) doctors. Majority of 203(63%), and 127(39.4%) were male, and educational status were BSc degree, Prior to conduct this survey, 273 (84.8%) the respondents were aware of the concept of HIV pre-exposure prophylaxis. but only half of, 171 (53.1%) Previously took training on pre-exposure prophylaxis. And 37 (11.5%) of participants had self-rating poor knowledge about HIV- pre-exposure prophylaxis. Variables which had P value less than 0.25 in bivariable analysis would be adequate for multivariable logistic regression analysis, and then in the final stage of multivariable analysis two variables such as marital status [AOR:.211(0.048-0.932],educational status[AOR:.032(.003- .365],[AOR:.181(0.054-0.600)],[AOR:.112(0.027-0.469)],[AOR: .084(0.025-0.286)], and [AOR: .204(0.058-0.720)] of health care workers had significantly associated with the attitudes of pre-exposure prophylaxis.. Conclusion and Recommendation: Our study shows that, inadequate knowledge, and attitude towards pre-exposure prophylaxis, and its management comparing to previously conducted researches, but the current study shows low levels of attitudes, there is suboptimal knowledge about PrEP. So concerned bodies expected to give training to health care workers to increase knowledge, and attitude of health care workers, and researchers expected to conduct research in the area of pre-exposure prophylaxis.

HIV Pre-exposure Prophylaxis Awareness, Eligibility and Intention in Men Who Have Sex with Men and Transgender Women: a cross-sectional study in Colombia 2020 - 2021

Background: Despite overwhelming evidence supporting the efficacy and effectiveness of Pre-Exposure Prophylaxis (PrEP) in HIV prevention, its adoption has been marginal. In Colombia, more information about eligibility, awareness, and intentions to use PrEP in target populations and how these relate to social determinants is needed. Aim: to assess PrEP awareness, the motivational cascade, and the social conditions related to the cascade. Methods: A cross-sectional study in a non-probabilistic sample was conducted between April 2020 and February 2021 among 552 Men with Sex with Men (MSM) and 158 Transgender Women (TGW). We used the Poisson regression to explore the associations between PrEP eligibility, awareness, and elements of the motivational PrEP cascade (willingness, intention, and self-perceived need to take) and their sociodemographic characteristics. Results: 51.2 % of the participants were aware of PrEP, 58.7 % were willing to use it, 45 % were self-perceived as PrEP candidates, and 56.2 % intended to take it.TGW were less likely to be aware but more willing to use PrEP than the sample of MSM interviewed face-to-face. Low education was related to low PrEP awareness and low income to low willingness to start PrEP. Conclusions: These results support the pertinence of the cascade concept to describe the stage of the target population regarding eligibility and motivation to take it. To accelerate PrEP implementation, efforts are needed to increase awareness among MSM and TGW with focalized strategies for those with low socioeconomic status.

School Dropout, Absenteeism and Coverage of Sexual and Reproductive Health Services in South Africa: Are Those Most at Risk Reached?

School attendance or completion is important for adolescents’ development. Adolescents who drop out or are regularly absent from school are at higher risk of adverse sexual and reproductive health (SRH) outcomes. However, there is little evidence evaluating SRH service coverage among adolescents in and out of school. In the context of a large-scale combination HIV and pregnancy prevention intervention funded by the Global Fund, we compared the SRH intervention coverage and SRH risks among adolescent girls who dropped out of school with those who were still in school or who had completed grade 12 in South Africa. Among those still in school, we compared the SRH intervention coverage and SRH risk profiles of those with high versus low or no absenteeism. In 2017 to 2018, we conducted a household survey of adolescent girls aged 15 to 19 years in six of the ten combination intervention districts. Of 2515 participants, 7.6% had dropped out of school. Among the 1864 participants still in school, 10.8% had high absenteeism. Ever having had sex, and condomless sex were more prevalent among dropouts compared with non-dropouts. Dropouts were more likely to access SRH services such as condoms and contraceptives, except the combination prevention intervention services which were more likely to reach those who had not dropped out and were equally likely to reach those in school with high versus low/no absenteeism. Combination SRH prevention programmes can improve the accessibility of SRH services for adolescents in school/who complete school.

Elevated stress-responsive biomarkers are associated with HIV acquisition in young women in rural South Africa: A HPTN 068 case cohort study.

Biological markers of stress have been associated with HIV progression and pathogenesis but not with HIV incidence. We sought to determine if elevated stress-responsive biomarkers would be associated with incident HIV among adolescent girls and young women (AGYW). We conducted a case-cohort study within the HIV Prevention Trials Network (HPTN) 068 study among 949 AGYW in South Africa. Cases were AGYW who tested HIV-positive during the eight-year follow-up. Unmatched controls were randomly selected from the HIV-negative population at enrollment. Dried blood spots from cases and controls were tested from enrollment (2011-2012) for C-reactive protein (CRP), herpes simplex virus type-1 (HSV-1) antibody titers, and cytomegalovirus (CMV) antibody titers. Cox proportional hazards models estimated the association between each biomarker and time to incident HIV. Compared to AGYW with the lowest CRP levels, those with medium and high CRP levels had a higher hazard ratio (HR) of incident HIV (HR: 1.45, 95% CI: 0.95, 2.21; HR: 1.50, 95% CI: 0.98,2.30, respectively), although not statistically significant. The relative hazard of incident HIV was also higher among AGYW who were CMV seropositive vs. seronegative (low antibodies HR: 2.18, 95% CI: 1.2,3.87; medium HR: 2.25, 95% CI: 1.28,3.95; high HR: 1.78, 95% CI: 0.99,3.21). Those with the highest HSV-1 antibody levels experienced an increased hazard of HIV compared to those who were HSV-1 seronegative (HR: 1.58, 95% CI: 1.03,2.44). Biological stress may increase AGYW's susceptibility to HIV acquisition through changes in immune function, viral infection, and increased biological vulnerability to disease.

Interest in and Willingness to Use PrEP: A Cross-Sectional Study of Individuals with Problematic Substance Use Residing in a High HIV Prevalence Jurisdiction

Although it is an effective HIV prevention method, pre-exposure prophylaxis (PrEP) is underutilized in the Southern US. Many people who use drugs (PWUD) have increased susceptibility to HIV which could be lessened by using PrEP. Potential barriers to PrEP use include lack of awareness of PrEP, low knowledge about HIV prevention, low self-efficacy for HIV prevention, inaccurate risk perceptions, and anticipated stigma. The current study examined predisposing, enabling, and reinforcing factors that may predict interest in PrEP. The purpose of the current study was to explore factors associated with interest in and willingness to use daily oral and long acting injectable PrEP among sexually active adult PWUD. The data were collected from adult participants (n = 270) residing in Harris County, TX, who self-reported problematic substance use and who reported oral, anal, or vaginal sex in the six months prior to completing the survey. The survey was distributed and completed online via Qualtrics Panels in March of 2022 and included measures of PrEP and HIV knowledge, PrEP stigma, sexual health self-efficacy, experiences of discrimination, health literacy, and medical mistrust. The majority of participants reported circumstances or behaviors that increased their susceptibility to HIV. Findings indicated that PrEP user stereotypes and PrEP anticipated disapproval by others were associated with interest in using daily oral PrEP and willingness to use long acting injectable PrEP. These results provide insight into reasons for low PrEP uptake among PWUD who live in a high HIV prevalence jurisdiction. Implications for HIV prevention intervention are discussed.

Adaptation and Reach of a Pre-Exposure Prophylaxis Social Marketing Campaign for Latino, Latina, and Latinx Populations: Development Study.

Latino, Latina, and Latinx (Latino/a/x) individuals remain disproportionately impacted by HIV, particularly sexual minority men and transgender women. Pre-exposure prophylaxis (PrEP) is an effective means of biomedical HIV prevention, but awareness and uptake remain low among marginalized Latino/a/x populations. Social marketing campaigns have demonstrated promise in promoting PrEP in other populations but are poorly studied in Latino/a/x sexual minority men and transgender women. This study aims to (1) adapt and pilot a PrEP social marketing campaign tailored to Latino/a/x populations with a focus on sexual minority men and transgender women through community-based participatory research (CBPR) and (2) evaluate the reach and ad performance of the adapted PrEP social marketing campaign. We used the ADAPT-ITT (assessment, decision, adaptation, production, topical experts-integration, training, and testing) framework for adapting evidence-based interventions for new settings or populations. This paper presents how each phase of the ADAPT-ITT framework was applied via CBPR to create the PrEPárate ("Be PrEPared") campaign. Key community engagement strategies included shared ownership with community partners, focus groups to guide content, crowdsourcing to name the campaign, design by local Latino/a/x artists, and featuring local influencers as the faces of PrEPárate. We evaluated campaign reach and advertisement performance using social media platform metrics (paid and organic reach, impressions, unique clicks, and click-through rates [CTR]) and website use statistics from Google Analytics. The PrEPárate campaign ran in Cook County, Illinois, from April to September 2022. The campaign reached over 118,750 people on social media (55,750 on Facebook and Instagram [Meta Platforms Inc] and 63,000 on TikTok [ByteDance Ltd]). The Meta ads performed over the industry benchmark with ads featuring local transgender women (2% CTR) and cisgender sexual minority men (1.4% CTR). Of the different Grindr (Grindr Inc) ad formats piloted, the interstitial Grindr ads were the highest performing (1183/55,479, 2.13% CTR). YouTube (Google) ads were low performing at 0.11% (153/138,337) CTR and were stopped prematurely, given limits on sexual education-related content. In the first year, there were 5006 visitors to the website. Adaptation of an existing evidence-based intervention served as an effective method for developing a PrEP social marketing campaign for Latino/a/x audiences. CBPR and strong community partnerships were essential to tailor materials and provide avenues to systematically address barriers to PrEP access. Social marketing is a promising strategy to promote PrEP among underserved Latino/a/x populations.

The impact of COVID-19 on sexual risk behaviour for HIV acquisition in east Zimbabwe: An observational study.

The Covid-19 pandemic and associated restrictions have the potential to alter sexual risk behaviours for HIV acquisition with important implications for HIV prevention programmes in sub-Saharan Africa. To date, no large-scale data have been published to substantiate hypothesised changes in sexual risk behaviours. We used longitudinal survey data to assess the impact of Covid-19 on sexual risk behaviours in east Zimbabwe. Data on sexual behaviours in HIV-negative adults aged 15-54 years were collected in two rounds of a general population open-cohort survey conducted in Manicaland, Zimbabwe shortly before (July 2018 to December 2019; N = 7316) and several months into the Covid-19 epidemic (February to July 2021; N = 6356). Descriptive statistics and logistic regression models of serial cross-sectional and prospective cohort data were used to assess changes in sexual risk behaviours. The proportion of females aged 15-19 years reporting sexual debut declined from 29.7% before Covid-19 to 20.3% during Covid-19 (adjusted odds ratio (AOR) = 0.49, 95% confidence interval (95% CI), 0.38-0.63). Fewer sexually-active females reported multiple sexual partners during Covid-19 (3.35% versus 6.07%; AOR = 0.55, 95% CI, 0.43-0.72). No population-level changes in male behaviour between survey rounds were recorded but the cohort analysis revealed a complex pattern of behaviour change with HIV risk behaviours increasing for some individuals and decreasing for others. Overall HIV risk behaviours remained high in a sub-Saharan African population with a generalised HIV epidemic over a period of Covid-19 lockdowns when movements and social contacts were restricted.

HIV incidence among women engaging in sex work in sub-Saharan Africa: a systematic review and meta-analysis

Women who engage in sex work in sub-Saharan Africa have a high risk of acquiring HIV infection. HIV incidence has declined among all women in sub-Saharan Africa, but trends among women who engage in sex work are poorly characterised. We synthesised data on HIV incidence among women who engage in sex work in sub-Saharan Africa and compared these with the total female population to understand relative incidence and trends over time. We searched MEDLINE, Embase, Global Health, and Google Scholar from Jan 1, 1990, to Feb 28, 2024, and grey literature for studies that reported empirical estimates of HIV incidence among women who engage in sex work in any sub-Saharan Africa country. We calculated incidence rate ratios (IRRs) compared with total female population incidence estimates matched for age, district, and year, did a meta-analysis of IRRs, and used a continuous mixed-effects model to estimate changes in IRR over time. From 32 studies done between 1985 and 2020, 2194 new HIV infections were observed among women who engage in sex work over 51 490 person-years. Median HIV incidence was 4·3 per 100 person years (IQR 2·8-7·0 per 100 person-years). Incidence among women who engage in sex work was eight times higher than matched total population women (IRR 7·8 [95% CI 5·1-11·8]), with larger relative difference in western and central Africa (19·9 [9·6-41·0]) than in eastern and southern Africa (4·9 [3·4-7·1]). There was no evidence that IRRs changed over time (IRR per 5 years: 0·9 [0·7-1·2]). Across sub-Saharan Africa, HIV incidence among women who engage in sex work remains disproportionately high compared with the total female population. However, constant relative incidence over time indicates HIV incidence among women who engage in sex work has declined at a similar rate. Location-specific data for women who engage in sex work incidence are sparse, but improved surveillance and standardisation of incidence measurement approaches could fill these gaps. Sustained and enhanced HIV prevention for women who engage in sex work is crucial to address continuing inequalities and ensure declines in new HIV infections. Bill & Melinda Gates Foundation, UK Research and Innovation, National Institutes of Health. For the French translation of the abstract see Supplementary Materials section.

Faith Leaders’ Perspectives on Involvement in HIV Prevention for Urban Black Youth in New Jersey, USA

Faith Leaders’ Perspectives on Involvement in HIV Prevention for Urban Black Youth in New Jersey, USA

Challenges towards an AIDS-free generation in Africa and Asia.

To review the latest data on prevention of HIV vertical transmission in Asia and Africa and discuss strategic directions to achieve an AIDS free generation by 2030. Progress in vertical transmission elimination efforts in Africa and Asia have stalled in the last decade, with 130 000 new infections in 2022. Main causes of vertical transmissions vary; in Asia-Pacific due to its low-burden, thus low testing coverage, but high overall vertical transmission rates, in South and East Africa due to new HIV infections during pregnancy and breast/chestfeeding, whereas in Western and Central Africa due to low antiretroviral therapy (ART) coverage. Long-acting injectable ART and neutralizing antibodies for treatment and prevention show promise in supporting efforts to further reduce vertical transmissions. Integrated and more accessible pre- and postnatal care is needed to achieve an AIDS-free generation. Much can be implemented to address existing HIV service gaps; including strengthening of HIV prevention services for youth and women of childbearing age and pregnant people, early detection and treatment, and the delivery of integrated services that can reach and retain pregnant and postpartum people living with HIV in care.

HIV-1 Molecular Networks and Pretreatment Drug Resistance at the Frontier of Yunnan Province, China.

The border areas of Yunnan Province in China are severely affected by human immunodeficiency virus (HIV). To investigate the risk of HIV transmission and assess the prevalence of pretreatment drug resistance (PDR) in the border area, blood samples were collected from individuals with newly reported HIV in 2021 in three border counties (Cangyuan, Gengma, and Zhenkang) in Yunnan Province. Among the 174 samples successfully genotyped, eight circulating recombinant forms (CRFs), two subtypes, and several unique recombinant forms (URFs) were identified. CRF08_BC (56.9%, 99/174), URFs (14.4%, 25/174), CRF01_AE (10.9%, 19/174), and CRF07_BC (8.0%, 14/174) were the main genotypes. CRF08_BC and URFs were detected more frequently in Chinese and Burmese individuals, respectively. CRF07_BC was found more frequently in men who have sex with men. The proportion of individuals detected in HIV-1 networks was only associated with case-reporting counties. When stratified by county, individuals aged ≤40 years in Cangyuan and ≥41 years in Gengma were more likely to be found in these networks. Furthermore, 93.8% (15/16) of the links in Cangyuan and 79.4% (50/63) of those in Gengma were located within their own counties. The prevalence of PDR to any antiretroviral drug, nucleoside reverse transcriptase inhibitors (NRTIs), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) were 10% (17/170), 0.6% (1/170), and 9.4% (16/170), respectively. The most frequent resistance-associated mutations (RAMs) were V179D/VD/E/T (22.9%, 39/170) and E138A/G/K/R (13.5%, 23/170). In the molecular networks, six clusters shared common RAMs. HIV-1 genetics has become more diverse in border areas. HIV-1 molecular network analysis revealed the different characteristics of the HIV-1 epidemic in the border counties. The prevalence of PDR showed an upward trend, and the PDR to NNRTIs was close to the public response threshold. These findings provide information for the development of AIDS prevention and treatment strategies.

Perception of couples’ on multipurpose prevention technology attribute choice: the case of MTN 045

BackgroundMultipurpose prevention technologies (MPTs) are products capable of simultaneously addressing multiple sexual and reproductive health needs such as unwanted pregnancy, STIs including HIV-1, and other reproductive tract infections. MPTs are urgently needed to address the double burden of unplanned pregnancy and HIV. While condoms are currently the only accessible MPTs, they are not solely under a woman’s control, and female condoms face limitations due to poor acceptability and high cost.MethodsWe conducted a sub-analysis of qualitative data from 39 couples participating in the MTN 045 study to examine the perception of couples on choice and acceptability of a “2 in 1” MPT that combines HIV and pregnancy prevention.ResultsCouples recognized the benefits of MPTs for HIV and pregnancy prevention but perceptions tied to each indication and a novel prevention technology tool raised important concerns relevant to use of future MPTs. In the study, participants’ perceptions of MPT use were influenced by pregnancy planning. When the timing was less critical, they prioritized HIV prevention. Misinformation about family planning methods, including MPTs, affected decision-making with potential to hinder uptake of future MPTs. Concerns about side effects, such as weight gain and hormonal imbalances, influenced willingness to use MPTs.ConclusionAddressing the myths and misconceptions surrounding the use of contraceptives is crucial in promoting their acceptance and ultimate use. Strategies for addressing the drawbacks women might experience while using a particular product should be in place as new MPTs progress through the development pipeline and approach roll-out.

Capturing the HIV-related social exclusion practices experienced by key populations through photovoice: an interpretative phenomenological study

BackgroundKey populations are defined as groups that are susceptible to HIV, including Men Sex with Men (MSM), Transgender (TG), Persons who Inject Drug (PID), and Female Sex Worker (FSW). These key populations groups are among the fastest-growing populations in Indonesia. These vulnerable groups are ostracized by society and health services, which makes it difficult to get treatment. This project was carried out to investigate the different experiences and perspectives of these key populations in facing and addressing social and spiritual exclusion.MethodsA qualitative phenomenological study using photovoice was carried out from July to December 2022. Key populations comprising MSM, TG, PID, and FSW were recruited from community-based peer groups in West Bandung Regency using snowball sampling. This was followed by the Photovoice stages, from workshops to focus group discussions and interviews with audio recordings. Furthermore, thematic data analysis was carried out by interpretative participant narratives and photographs supported by Atlas.ti software.ResultEighteen participants comprising four MSM, five TG, four PIDs, and five FSWs participated in this research. Among these eighteen participants, six were HIV-negative, including 3 PIDs and 3 FSWs, while the remaining were positive. The analysis of the collected data identified four main themes: 1) limited access like unequal treatment, disadvantage, and harassment, 2) social and spiritual impact, 3) coping mechanisms, and 4) self-reflection through photovoice. These results showed that social exclusion occurred in an environment where community values, beliefs, and norms dehumanised these key populations, and where removal of support and care was prominent. Despite these challenges, participant resilience was evidenced by using internal resources and peer support as coping mechanisms. The participants considered photovoice as a tool to foster self-confidence and self-awareness through a reflective process.ConclusionsThe findings of this study highlight the emphasis on participants' openness in sharing their experiences, which can build empathy and promote a more inclusive community in HIV prevention efforts. This research findings can be used to inform HIV policy and practice and inclusion of these key populations in the community. We advocate making the photovoice efforts accessible to a wider audience through exhibitions and various media.

HIV related knowledge and practices among undergraduate students in Africa: A cross-sectional multinational study

BackgroundAfrica has the highest burden of HIV/AIDS globally, with young people being the most affected. This study aimed to assess HIV knowledge and practices among undergraduate students in Africa. MethodsAn analytical cross-sectional study was conducted in ten African countries using an online, self-administered, pre-validated questionnaire. The study was conducted in 10 African countries, located in 5 different regions across Africa including Kenya, Algeria, Botswana, Burkina Faso, Ethiopia, Nigeria, Rwanda, Sudan, Tanzania, and Uganda, during the academic year 2022–2023. A convenience sampling approach was utilized to collect the data. African undergraduates who were 18 years and older, enrolled in universities across ten African countries and were willing to participate and gave an e-informed consent were included.Shapiro-Wilk test was utilized to check the data normality. Student’s t-test and Chi-square test were used for continuous and categorical variables in independent samples. Mann-Whitney U and Kruskal-Wallis tests were used for nonparametric comparisons. Logistic regression was used for identifying the predictors for the knowledge regarding HIV. Significance level was set at p < 0.05. ResultsA total of 3727 undergraduate students responded to the questionnaire. Most students were medical students (68.1 %), single (94.9 %), and living in urban areas (78.7 %). The overall median HIV knowledge score was 14, and medical students had significantly higher knowledge than non-medical students (p < 0.001). While the students had a strong understanding of HIV transmission, some aspects of their knowledge were inadequate. Most students relied on academic curricula for HIV information (72.3 %) and their institutions provided formal HIV prevention strategies (57.8 %). A low percentage engaged in risky sexual behaviors. The results indicated that being male (AOR (95 % CI) = 4 (1.2–13.2)), pursuing medical education (AOR (95 % CI) = 2.4 (2–2.8)), being in the final years of study (i.e. fourth, fifth, and sixth years) (AOR (95 % CI) = 1.3 (1.02–1.6), 1.6 (1.2–2.1), 2.4 (1.6–3.8), ever testing for HIV (AOR (95 % CI) = 2.3 (1.9–2.8), and ever engaging in sexual activity (AOR (95 % CI) = 2.6 (2.3–3) were independent predictors of good knowledge of HIV. ConclusionThe findings of this study reveal a notable proficiency in HIV knowledge among African undergraduate students, particularly those enrolled in medical programs. However, there remains scope for enhancing their HIV-related practices, particularly in the areas of routine HIV testing and the establishment of Voluntary Counseling and Testing (VCT) services.

Incentivizing adherence to pre-exposure prophylaxis for HIV prevention: a randomized pilot trial among male sex workers in Mexico.

Low adherence to preventative medications against life-long health conditions is a major contributor to global morbidity and mortality. We implemented a pilot randomized controlled trial in Mexico to measure the extent to which conditional economic incentives help male sex workers increase their adherence to pre-exposure prophylaxis (PrEP) for HIV prevention. We followed n = 110 male sex workers over 6 months. At each quarterly visit (at months 0, 3, and 6), all workers received a $10 transport reimbursement, a free 3-month PrEP supply, and completed socio-behavioral surveys. The primary outcome was an objective biomarker of medication adherence based on tenofovir (TFV) drug concentration levels in hair collected at each visit. Individuals randomized to the intervention received incentives based on a grading system as a function of PrEP adherence: those with high (> 0.043 ng/mg TFV concentration), medium (0.011 to 0.042 ng/mg), or low (< 0.011 ng/mg) adherence received $20, $10, or $0, respectively. Six-month pooled effects of incentives on PrEP adherence were analyzed using population-averaged gamma generalized estimating equation models. We estimated heterogeneous treatment effects by sex worker characteristics. The incentive intervention led to a 28.7% increase in hair antiretroviral concentration levels over 6 months consistent with increased PrEP adherence (p = 0.05). The effect of incentives on PrEP adherence was greater for male sex workers who were street-based (vs. internet) workers (p < 0.10). These pilot findings suggest that modest conditional economic incentives could be effective, at scale, for improving PrEP adherence among male sex workers, and should be tested in larger implementation trials. ClinicalTrials.gov Identifier: NCT03674983.

W48 - The Development of a Conceptual Model to Assess Intersectional Stigma’s Role in Shaping Rural Primary Care Providers’ Decisions to Implement Harm Reduction, Buprenorphine, and HIV Prevention

W48 - The Development of a Conceptual Model to Assess Intersectional Stigma’s Role in Shaping Rural Primary Care Providers’ Decisions to Implement Harm Reduction, Buprenorphine, and HIV Prevention

W57 - Characterizing Empirically-Derived Sub-Groups of Latinx PWID Living Along the U.S.-Mexico Border for HIV and HCV Prevention

W57 - Characterizing Empirically-Derived Sub-Groups of Latinx PWID Living Along the U.S.-Mexico Border for HIV and HCV Prevention

M145 - Assessing Provider Readiness to Implement Pre-Exposure Prophylaxis for HIV Prevention and Medications for Opioid Use Disorder Among People who Inject Drugs

M145 - Assessing Provider Readiness to Implement Pre-Exposure Prophylaxis for HIV Prevention and Medications for Opioid Use Disorder Among People who Inject Drugs

T73 - Application of the Multiphase Optimization Strategy (MOST) to Optimize HIV Prevention Targeting People on Medication for Opioid Use Disorder (MOUD) who Have Cognitive Dysfunction: A Study Protocol

T73 - Application of the Multiphase Optimization Strategy (MOST) to Optimize HIV Prevention Targeting People on Medication for Opioid Use Disorder (MOUD) who Have Cognitive Dysfunction: A Study Protocol

Implications of HIV status disclosure

Disclosure of HIV status is critical for HIV prevention and control. However, although the benefits of HIV disclosure have received extensive documentation, the same cannot be said for its drawbacks. In the current study, we used a descriptive qualitative study design to highlight the implications of disclosure among 30 pregnant and postpartum women living with HIV in Uganda. We conducted a qualitative content analysis and found that healthcare professionals responded positively and supportively when HIV-positive pregnant and postpartum women disclosed their status, and that individuals who disclosed their status to their husbands but not to wider circles also experienced no mistreatment or discrimination. Contrarily, however, some husbands reacted unfavourably to their wife’s HIV-positive status when a larger audience was involved in the disclosure. In particular, we discovered that co-wives and in-laws promoted stigmatization, including violence, by husbands. The interaction between these HIV-positive women and their mothers also demonstrated both positive and negative implications. This counterintuitive attitude has the consequence of reducing the uptake of antiretroviral drugs. There is therefore a need for policies and initiatives that not only encourage disclosure to health professionals, spouses and a few close relatives or friends but prevent stigmatization, violence and other forms of abuse against HIV-positive women.