The use of mineral fertilizers is an important agronomic technique in the system of intensive agriculture. In 2021-2022, field experiments were conducted in the Maktaaral district of Turkestan province to assess the response of mid-season melon to different doses and ratios of nitrogen, phosphorus and potassium fertilizers. To model the effect of fertilizers and soil salinity on the indicators of yield and nutrient use by melon plants, the data by years were subjected to mathematical processing separately in order to build the most adequate regression models describing the dependence of the resulting factors on the studied factors against the background of the real state of soil fertility. In the first year of research, the early melon yield was 96% dependent on the combined effect of all factors studied. At the same time, nitrogen fertilizer had a separate positive effect, but the effect of its interaction with phosphorus and salt was negative. Potassium combined with phosphorus accelerated melon's early maturity, but in interaction with salt it slowed it down. The gross yield of melon was 92 % dependent on the combined effect of the studied factors, with nitrogen separately and in combination with phosphorus and phosphorus combined with potassium showing a positive effect. The dependence of nitrogen removal per unit of melon yield on the studied factors was 99 %, phosphorus – 88 % and potassium – 78 %. In the second year of research, the early harvest of melons was 97 % dependent on the total effect of all the studied factors. Nitrogen fertilizers had a positive effect, while phosphorus and soil salinity had a negative effect. Nitrogen interaction with phosphorus and soil salinity had a negative effect. Potassium in interaction with phosphorus had a positive effect on early melon yield, but in interaction with soil salt it was negative. The gross yield of melon was 90% dependent on the combined effect of all 4 studied factors. The combination of nitrogen nutrition with potassium and soil salinity had a negative effect, while phosphorus combined with potassium had a positive effect on melon gross yield. Nutrient removal by a unit of melon yield responded adequately to changes in the studied factors (R2=0.84-0.90) in the second year of the study. Application of nitrogen fertilizer increased normative removal of nitrogen, phosphorus and potassium.