Sesame (Sesamum indicum L., 2n=26) grouped under the family Pedaliaceae; is probably the most ancient oil seed known and used by man. It is called ‘Queen of oil seeds’ due to its high quality polyunsaturated stable fatty acid. The availability of large amount of wild forms of sesame in Ethiopia show that it is indigenous and considered as the center of origin for sesame and the genetic diversity is high, serving as resources for further improvement of the crop. Sesame improving research was started in Ethiopia at Werer Agricultural Research Center with the target to develop high yielding and adaptable varieties which meet the demands of the sesame farmers, processor and user. A lot of varieties released by different research centers and most of the varieties are under production in different agro ecologies of Ethiopia. It is foreign currency generating crop next to coffee in Ethiopia and the leading crop from all oil crops growing in the country. Therefore, the main objective of this paper is to access the current sesame research and its production status in Ethiopia so that the information can be used as a good reference resource for researchers, students, agricultural extension workers and NGOs working in Ethiopia in the area of oil crops in general and sesame in particular.