Objective: Emissions from the agri-food system (AFS) account for between 21% and 37% of total global greenhouse gas emissions. Concurrently, climate change has the potential to significantly impact the AFS production processes. The objective is to clarify the context that justifies the need for transformation and transition of the agri-food system, considering climate change as a prioritized challenge. Method: This study adopts a descriptive, bibliographical approach with a qualitative analysis. Content analysis of the literature review enabled examination of: a) the AFS's contribution to global emissions, and b) its susceptibility to climate change impacts. Results and Discussion: The agri-food chain has been notably responsible for emitting a substantial amount of greenhouse gases, particularly during land-use change and in pre- and post-production processes including manufacturing, transportation, refrigeration, food processing, packaging, and waste disposal. Additionally, the agri-food sector is among the most affected by climate change effects, notably due to increased occurrences of extreme events affecting agricultural production, harvesting, and other chain processes, thereby leading to rising prices and food scarcity. Research Implications: This paper highlights the importance of developing and expanding sustainable agri-food systems in response to the intensifying impacts of climate change and food insecurity. Originality/Value: The study aims to contribute to the discourse on the imperative for transformation and transition from the dominant agri-food system paradigm towards alternative production approaches that are more sustainable and resilient to environmental changes.