Aggressive Components Research Articles

Nanoscale Functional Additives Application in the Low Temperature Greases.

Due to the fact that the application of AW and EP additives in low-temperature greases may lead to worse high-temperature and anti-corrosion characteristics as well as additional burden on the environment due to the content of aggressive components, in this paper, the possibility of replacing these additives with NFA, which do not have these disadvantages, was investigated. The analysis of nanosized particles being used as functional additives in greases was carried out. The morphology of the following nanoparticles was studied: montmorillonite K 10, silica, calcium car-bonate and borate, halloysite, and molybdenum disulfide incorporated in halloysite tubes. The effect of nanostructured components on the physicochemical characteristics and anti-wear and anti-scuffing properties of complex lithium, polyurea, and polymer greases were studied. Maximal improvement of anti-wear and anti-scuffing characteristics of cLi-greases was reached when using silica and calcium borate. Maximal improvement of anti-scuffing properties of PU-lubricant was reached when using calcium carbonate and the two-component NFA based on halloysite, for anti-wear properties when adding silicon dioxide and halloysite. When the concentrations of silicon dioxide and calcium carbonate was increased from 1 to 3 wt.%, there was a decrease in yield stress of the structural frame of the PU-lubricant and its colloidal stability was worse. The increase of the concentration of calcium carbonate and borate nanoparticles in the studied range led to a significant improvement of the anti-wear and anti-scuffing characteristics of the PU grease, respectively. The greases properties’ dependence from the nanostructured functional additives’ introduction method and their concentration were investigated. Nanoparticles were added into the test lubricants before and after the thermo-mechanical dispersion stage. The addition of silicon dioxide and calcium carbonate NFA after the heat treatment stage led to worsening of the characteristics of the plastic material, and the increase of their concentration from 1 to 3 wt.% formed a harder structure of Li-grease. On the contrary, the addition of calcium borate NFA is recommended after the thermomechanical dispersion. The choice of nanoparticles and the method of their addition to the lubricants of various types was carried out according to the results of the previous stage of the research. Along with the analysis of the physicochemical characteristics and anti-wear and anti-scuffing properties of the lubricants, the structure of the dispersion phase of nanomodified lubricants were studied.

FP06.01 Unexpected Aggressive Histological Component in Subsolid Lung Adenocarcinoma: Priority for Resection Without Delay

Ground glass opacity (GGO)-containing small-sized adenocarcinoma of the lung can generally be expected to have a fair prognosis after resection. However, some of such tumors might contain a histological aggressive component that is related to poor prognosis. This study aimed to identify the predictors for the aggressive histological component in GGO-containing small-sized lung adenocarcinoma to screen the patients who should undergo resection without delay in the era of COVID-19.

The Effectiveness of Teaching Strategies Based on Emotion-Focused Therapy on the Components of Verbal Intelligence and Aggression in Preschool Students

The Effectiveness of Teaching Strategies Based on Emotion-Focused Therapy on the Components of Verbal Intelligence and Aggression in Preschool Students

34.5 THE EMOTIONAL OUTBURST INVENTORY (EMO-I): RATING WHAT KIDS DO WHEN THEY ARE IRRITABLE

Inadequate attention has been given to irritability’s tonic (persistently angry mood) vs phasic (outbursts of excessive temper with verbal or physical aggression) components or how one feels vs what one does. Most interviews do not make those distinctions; general rating scales address broadband aggression, although a few have a specific irritability factor. A good measure of outbursts (phasic irritability) and the impairment they cause is needed. The Emotional Outburst Inventory (EMO-I) is a brief screening tool developed for youth in clinical settings. It has 3 domains: outburst behaviors (up to 8, including swears, threatens, punches walls, throws things, hits/kicks), frequency (< monthly, weekly, daily), and duration (<15 minutes to more than 2 hours).

Steel protection by superhydrophobic coating in atmosphere with high content of aggressive components

Новые технологии, Химическая промышленность, Химическая технология, Научные журналы, Защита от коррозии, Технология металлов, Свойства материалов, Технические журналы, Наука и технологии, Справочная литература, Научные разработки

Biological monitoring — as a method of hygienic assessment of the effects of pesticides on workers

Introduction. When conducting registration tests of the active substances of pesticides, it is essential to assess the risk for workers using these pesticide preparations in field experiments, where there is a direct human interaction with a potentially hazardous substance. The use of personal protective equipment and strict adherence to the regulations for the use of pesticide preparations cannot guarantee complete protection against contact with aggressive components. Biomonitoring occupies a special place in studies on the assessment of exposure of workers with pesticides, which makes it possible to assess the actual, rather than potential, absorption of a biologically active substance. Purpose of the work. Study of biomaterial (urine) of employees participating in field experiments when working with drugs based on active substances of the neonicotinoid group to determine their trace amounts by high performance liquid chromatography with a mass detector and risk assessment for those working with these pesticides. Materials and methods. Preparation of urine samples and their subsequent analysis for the content of residual amounts of acetamiprid, imidacloprid, thiamethoxam and its metabolite clothianidin were performed in accordance with the certified method “Measurement of the concentration of active substances of pesticides of the neonicotinoid class in urine”. The measurements were carried out using a method based on a tandem high performance liquid chromatography with a triple quadrupole mass detector, which makes it possible to estimate the minimum levels of active substances by two transitions of the parent ions (for quantitative calculation and confirmation by the ionic ratio). Electrostatic sputtering was used as a source of ionization; measurements were carried out in the multiple reaction monitoring mode. Results. The detected levels of imidacloprid in the urine of the researchers correspond to the data on the exposure assessment obtained from the results of measuring the concentration of this active substance in the air of the working area, as well as in washes from the skin of workers in agriculture. The maximum content of imidacloprid was revealed during the sowing of the etched seed material. Conclusion. Based on the data obtained, it was concluded that biomonitoring is the preferred method in a production environment due to its simplicity and sufficient information content.

Safety of fertility sparing management in invasive mucinous ovarian carcinoma

Objectives: Mucinous ovarian carcinoma (MOC) is the most common histology in young women eligible for fertility-sparing surgery. The aim of the study was to evaluate the safety and reproductive outcomes after fertility-sparing surgery in invasive mucinous ovarian carcinomas. Methods: A retrospective review was performed of all MOCs diagnosed between 1999 and 2019 at two tertiary care cancer centers. Pathology was reviewed to rule out cases with metastasis from gastrointestinal tract primary. The demographics and survival outcomes were compared between women who underwent fertility-sparing surgery and those who underwent radical surgery (at least hysterectomy, bilateral salpingo-oophorectomy±staging). Five-year overall survival (OS) and recurrence free survival (RFS) were calculated from Kaplan-Meier curves and comparisons made using log-rank test. Cox proportional hazard models were constructed to evaluate the effect of fertility sparing surgery on survival. Results: Of 149 women with apparent stage I disease upon presentation, 43 (29%) underwent fertility-sparing surgery in the form of unilateral salpingo-oophorectomy±omentectomy and lymphadenectomy. Compared to women who underwent radical surgery, these women were younger (30 years vs 55 years; p Conclusions: Fertility-sparing surgery in apparent stage I MOC is not associated with worse survival outcomes; however, it is important that candidates are carefully selected based on pathologic factors. In those with aggressive histologic components, radical surgery should be considered.

Advanced Non-Metallic Coatings and Composite Materials for O & G Industry

Materials used in the oil and gas industry are required to possess resilient properties to sustain operational challenges. These include high pressures and temperatures of the working fluids created by both reservoir depths and compressors combined with the inherent aggressive and corrosive components. Multiple solutions have been introduced to the industry to minimize corrosion probability in recent years. Utilizing external and internal tubular non-metallic coating as well as switching to the products entirely made of the non-metallic composites are the most commonly used and best performing solutions. This paper presents a comprehensive overview of the advances of the most promising research and development activities in the area of protective coatings as well as non-metallic composite material products with real case studies in downhole applications. Special emphases are put on the most promising technological breakthroughs such as 3D printing with non-metallic composites containing nano-sized short fibers and continuous nanofibers, which could be potentially used in the fabrication of future downhole composite products. The breakthrough solutions in composite technologies such as self-healing systems, including capsule-based, fiber-based and vascular healing network, which are perfectly aligned with the 4th Industrial Revolution are also described.

Components of Aggressiveness in Phytophthora nicotianae During Adaptation to Multiple Sources of Partial Resistance in Tobacco.

Black shank is a devastating disease of tobacco caused by Phytophthora nicotianae. Host resistance has been an integral part of black shank management but after the loss of Php single-gene resistance following its widespread deployment in the 1990s, growers have relied on varieties with varying levels of partial resistance. Partial resistance is effective in suppressing disease, but continued exposure can result in an increase in pathogen aggressiveness that threatens durability of the resistance to P. nicotianae. Aggressiveness components in P. nicotianae were characterized following adaptation on two sources of partial resistance, Fla 301 and the Wz genomic region from Nicotiana rustica. An aggressive isolate of the two major races of P. nicotianae, race 0 and race 1, was adapted for either one/two or five/six generations on the two resistance sources, giving four sets of isolates based on race, number of generations of adaptation, and source of resistance. Across the four sets of isolates, adapted isolates infected higher proportions of tobacco root tips, produced more sporangia per infected root tip, and caused larger lesions than their respective nonadapted isolates of the same race and from the same resistance source. Adapted isolates also produced more aggressive zoospore progeny than the nonadapted isolates. Adaptation to partial resistance involves multiple aggressiveness components and results in the increased aggressiveness observed for P. nicotianae. These results improve our knowledge on the nature of P. nicotianae adaptation to partial resistance in tobacco and indicate that different resistance sources are likely to select for similar aggressiveness components in the pathogen.

Symptomatic endometriosis in women of fertile age through the prism of autoimmunization to food allergens

The article provides a systematic review of the scientific publications, manuals and recommendations over the past 10 years devoted to the problem of endometriosis. The systematization of information about the etiopathogenetic mechanisms of the development of pathology and the data of multidisciplinary analysis of the carbohydrate metabolism disorders and food intolerance in the course of symptomatic endometriosis was carried out.Endometriosis is one of the most common benign gynecological proliferative pathologies in women around the world. Studying the structure of the rate of symptomatic endometriosis, a higher incidence of carbohydrate metabolism disorders and food intolerance was found in this group of patients. The incidence of endometriosis, the prevalence of carbohydrate metabolism disorders and autoimmunization demonstrate a significant tendency towards growth and «rejuvenation», which is undoubtedly a consequence of poor nutrition and lifestyle, excessive consumption of carbohydrate products, as well as social characteristics of the life of a modern woman.According to the current scientific evidence, carbohydrate metabolism disorders are associated with autoimmunization and immune dysfunction. Based on the analysis of literature data and the results of our own retrospective observations, the role of carbohydrate metabolism disorders and autoimmunization with food allergens (gluten, fructose, lactose) in the manifestation and progression of symptomatic endometriosis was revealed. Due to the violation of the interaction between the endocrine and immune axes of regulation of the female reproductive system as a result of systematic autoimmunization with certain aggressive food components, which can act as endocrine disruptors and secondary neuroendocrine messengers, women with food intolerance and carbohydrate metabolism disorders have a worse course of endometriosis and a higher course of endometriosis risks.Normalization of carbohydrate metabolism by using an elimination diet with the exclusion of disinfectant products is the topic of this article and the direction of the search for an effective and acceptable algorithm for the treatment of endometriosis.

Performance Pressure as an Antecedent and Authentic Leadership as a Moderator of the Relationship Between Co-worker Undermining and Psychological Capital.

As a component of organizational aggression, co-worker undermining erodes the well-being of the victims and the sustainability of the organization. Drawing on conservation of resources theory, this study identified the negative impact of co-worker undermining on the victim’s psychological capital, and empirically examined the influence of performance pressure as an antecedent and of authentic leadership as a moderator to suggest approaches to minimize this negative impact. A total of 485 subordinate employees from 10 organizations in South Korea completed a questionnaire survey. To prevent common method bias, the survey was designed to recruit participants from multiple organizations and was conducted in two waves. First, the results revealed that performance pressure had a positive relationship with the perception of co-worker’s undermining. Second, this perception of co-worker undermining had a negative influence on the victim’s psychological capital. Third, authentic leadership had the moderating effect of decreasing the negative relationship between co-worker undermining and psychological capital. Furthermore, authentic leadership moderated the mediating relationship between the performance pressure and psychological capital through co-worker’s undermining. These findings suggest that the level of performance pressure should be managed in advance so as not to reach excessive levels and the psychological capital of victims should be preserved through authentic leadership to minimize the negative impact of co-worker undermining.

Comparative Genomics of Eight Fusarium graminearum Strains with Contrasting Aggressiveness Reveals an Expanded Open Pangenome and Extended Effector Content Signatures

Fusarium graminearum, the primary cause of Fusarium head blight (FHB) in small-grain cereals, demonstrates remarkably variable levels of aggressiveness in its host, producing different infection dynamics and contrasted symptom severity. While the secreted proteins, including effectors, are thought to be one of the essential components of aggressiveness, our knowledge of the intra-species genomic diversity of F. graminearum is still limited. In this work, we sequenced eight European F. graminearum strains of contrasting aggressiveness to characterize their respective genome structure, their gene content and to delineate their specificities. By combining the available sequences of 12 other F. graminearum strains, we outlined a reference pangenome that expands the repertoire of the known genes in the reference PH-1 genome by 32%, including nearly 21,000 non-redundant sequences and gathering a common base of 9250 conserved core-genes. More than 1000 genes with high non-synonymous mutation rates may be under diverse selection, especially regarding the trichothecene biosynthesis gene cluster. About 900 secreted protein clusters (SPCs) have been described. Mostly localized in the fast sub-genome of F. graminearum supposed to evolve rapidly to promote adaptation and rapid responses to the host’s infection, these SPCs gather a range of putative proteinaceous effectors systematically found in the core secretome, with the chloroplast and the plant nucleus as the main predicted targets in the host cell. This work describes new knowledge on the intra-species diversity in F. graminearum and emphasizes putative determinants of aggressiveness, providing a wealth of new candidate genes potentially involved in the Fusarium head blight disease.

OPTIMAL DESIGN OF HEAT EXCHANGER NETWORK IN OIL REFINERIES

Today, the main methods of protection against corrosion of contact devices of rectification equipment for oil refining, in particular, stainless steel mesh packing, under conditions of relatively high temperatures (150–250°C) and in the presence of aggressive components in oil feedstock (hydrogen sulfide, sulfides, mercaptans, other sulfur compounds, chloride ions, organochlorine compounds, water) are the use of special alloys as protective coatings, as well as corrosion inhibitors that reduce the corrosive effect of an aggressive environment. At the same time, most of these methods have disadvantages associated with high operating costs, insufficient efficiency, or the ability to protect only from a certain factor, and not from their combination. In this regard, studies of the corrosion resistance of mesh contact devices made of stainless steel grade 12Х18Н10Т, on three types of samples: alloy wire, welded mesh, thin sheet. Titanium nitride (TiN) and metal coatings of nickel (Ni), titanium (Ti) and chromium (Cr) were used as anticorrosive coatings for these samples. These coatings were applied to the samples by two methods: electrolytic method and vacuum ion-plasma spraying. It was found that the optimum thickness of the coating is 10–15 µm, at which the resulting films have sufficient ductility and do not peel off from the surface of the corresponding stainless alloy. The study of corrosion of samples of stainless steel 12Cr18N10T with applied coatings and without coatings was carried out by immersion in compositions containing oil, as well as in simulating aggressive oil-containing media. As a result of the studies, it was found that protective coatings of chromium and titanium nitride, applied by vacuum ion-plasma spraying, are the most effective from the point of view of corrosion protection of stainless steel mesh contact devices used in rectification columns. Keywords: rectification column, mesh contact devices, stainless steel, aggressive media, corrosion inhibitors, anti-corrosion protective coatings.

An Ovine Model of Hemorrhagic Shock and Resuscitation, to Assess Recovery of Tissue Oxygen Delivery and Oxygen Debt, and Inform Patient Blood Management.

Aggressive fluid or blood component transfusion for severe hemorrhagic shock may restore macrocirculatory parameters, but not always improve microcirculatory perfusion and tissue oxygen delivery. We established an ovine model of hemorrhagic shock to systematically assess tissue oxygen delivery and repayment of oxygen debt; appropriate outcomes to guide Patient Blood Management. Female Dorset-cross sheep were anesthetized, intubated, and subjected to comprehensive macrohemodynamic, regional tissue oxygen saturation (StO2), sublingual capillary imaging, and arterial lactate monitoring confirmed by invasive organ-specific microvascular perfusion, oxygen pressure, and lactate/pyruvate levels in brain, kidney, liver, and skeletal muscle. Shock was induced by stepwise withdrawal of venous blood until MAP was 30 mm Hg, mixed venous oxygen saturation (SvO2) < 60%, and arterial lactate >4 mM. Resuscitation with PlasmaLyte® was dosed to achieve MAP > 65 mm Hg. Hemorrhage impacted primary outcomes between baseline and development of shock: MAP 89 ± 5 to 31 ± 5 mm Hg (P < 0.01), SvO2 70 ± 7 to 23 ± 8% (P < 0.05), cerebral regional tissue StO2 77 ± 11 to 65 ± 9% (P < 0.01), peripheral muscle StO2 66 ± 8 to 16 ± 9% (P < 0.01), arterial lactate 1.5 ± 1.0 to 5.1 ± 0.8 mM (P < 0.01), and base excess 1.1 ± 2.2 to -3.6 ± 1.7 mM (P < 0.05). Invasive organ-specific monitoring confirmed reduced tissue oxygen delivery; oxygen tension decreased and lactate increased in all tissues, but moderately in brain. Blood volume replacement with PlasmaLyte® improved primary outcome measures toward baseline, confirmed by organ-specific measures, despite hemoglobin reduced from baseline 10.8 ± 1.2 to 5.9 ± 1.1 g/dL post-resuscitation (P < 0.01). Non-invasive measures of tissue oxygen delivery and oxygen debt repayment are suitable outcomes to inform Patient Blood Management of hemorrhagic shock, translatable for pre-clinical assessment of novel resuscitation strategies.

Automated detection of aggressive and indolent prostate cancer on magnetic resonance imaging.

PurposeWhile multi‐parametric magnetic resonance imaging (MRI) shows great promise in assisting with prostate cancer diagnosis and localization, subtle differences in appearance between cancer and normal tissue lead to many false positive and false negative interpretations by radiologists. We sought to automatically detect aggressive cancer (Gleason pattern ≥ 4) and indolent cancer (Gleason pattern 3) on a per‐pixel basis on MRI to facilitate the targeting of aggressive cancer during biopsy.MethodsWe created the Stanford Prostate Cancer Network (SPCNet), a convolutional neural network model, trained to distinguish between aggressive cancer, indolent cancer, and normal tissue on MRI. Ground truth cancer labels were obtained by registering MRI with whole‐mount digital histopathology images from patients who underwent radical prostatectomy. Before registration, these histopathology images were automatically annotated to show Gleason patterns on a per‐pixel basis. The model was trained on data from 78 patients who underwent radical prostatectomy and 24 patients without prostate cancer. The model was evaluated on a pixel and lesion level in 322 patients, including six patients with normal MRI and no cancer, 23 patients who underwent radical prostatectomy, and 293 patients who underwent biopsy. Moreover, we assessed the ability of our model to detect clinically significant cancer (lesions with an aggressive component) and compared it to the performance of radiologists.ResultsOur model detected clinically significant lesions with an area under the receiver operator characteristics curve of 0.75 for radical prostatectomy patients and 0.80 for biopsy patients. Moreover, the model detected up to 18% of lesions missed by radiologists, and overall had a sensitivity and specificity that approached that of radiologists in detecting clinically significant cancer.ConclusionsOur SPCNet model accurately detected aggressive prostate cancer. Its performance approached that of radiologists, and it helped identify lesions otherwise missed by radiologists. Our model has the potential to assist physicians in specifically targeting the aggressive component of prostate cancers during biopsy or focal treatment.

Developing a Metabolic Therapy for Osteosarcoma

Developing a Metabolic Therapy for Osteosarcoma

Резистентность слизистой оболочки пищевода у больных ГЭРБ: диалог клинициста и морфолога

Gastroesophageal reflux disease (GERD) is the most common of all acid-related diseases, it is recognized as the leading cause of esophageal adenocarcinoma. The natural factor of protection against aggressive refluxate components is the integrity of the esophageal mucosa, which performs a barrier function with the participation of a number of mechanical, chemical and immunological mechanisms. Their damage under the regular influence of acidic or mixed reflux causes the development of the pathological process. The review was prepared to systematize knowledge of the main components of mucosal barrier of the esophagus providing resistance of mucosa under conditions of GERD. The literature was searched in Embase, PubMed, and Google Scholar using the keywords: gastroesophageal reflux disease, mucosal protection, esophageal mucosa epithelium, dense contact proteins, epithelial protection, esophagoprotection. The main structural and functional components of esophageal mucosal protection were emphasized

Impulsivity in depressed clients

This study aims to explore impulsivity as a component of aggression in depressed clients. This study used a qualitative method with a phenomenological study approach. There were 11 study participants in this investigation. A thematic analysis was used in analyzing the data. The study produced four themes: (1) uncontrolled anger as the initial expression of impulsivity, (2) anger manifestations through reckless actions, (3) homicidal versus suicidal thoughts during the impulsive phase, and (4) self-efficacy at the end of impulsivity. Impulsivity is the main form of aggression in depressed clients. Nurses need to pay attention to impulsive behaviors in depressed clients, especially by helping clients to build good coping strategies and improve the quality of their social relations so that they can break the chain of the characteristics of impulsivity.

ИССЛЕДОВАНИЕ ХИМИЧЕСКИХ РЕАГЕНТОВ ДЛЯ БОРЬБЫ С КОРРОЗИЕЙ В УСЛОВИЯХ МЕСТОРОЖДЕНИЯУЗЕНЬ

One of the biggest challenges in oil and gas production projects is dealing with the various types of corrosion to which certain parts of field equipment are exposed. Selecting the right corrosion inhibitor for the specific environment is extremely important. Choosing inhibitors for a particular location can be a difficult task because there are many factors to be considered. Understanding the corrosion problems that can arise is important in the oil and gas industry, and knowledge of which inhibitors to use to deal with general and localized corrosion will save time and money in the long run. This article presents the results of studies of various brands of domestic and foreign corrosion inhibitors for use in the Uzen field: physical and chemical characteristics (density, viscosity, freezing temperature, mass fraction of active substance, compatibility with field waters, amine number), efficiency of corrosion inhibitors in laboratory conditions and on a bench simulating field reservoir conditions, taking into account pressure, temperature, fluid flow rate, as well as aggressive components - hydrogen sulfide and carbon dioxide. In addition, studies of corrosion inhibitors' effect on the process of preparation of production are also given. The works were carried out in the center of scientific and laboratory research of KMG Engineering branch " KazNIPImunaygas" LLP.

In Vitro and In Planta Studies on Temperature Adaptation of Exserohilum turcicum Isolates from Maize in Europe and South America.

Northern Corn Leaf Blight (NCLB) is a fungal leaf disease in maize caused by Exserohilum turcicum. NCLB occurs worldwide, from tropical to temperate zones raising the question about plasticity of temperature adaptation of local isolates of the pathogen. Seven isolates of E. turcicum originating from South America and seven from Europe were compared for their response to temperature variations in vitro and in vivo between 15 and 30 °C. In vitro, isolates originating from Europe and South America significantly differed in mycelial growth rate at 30 °C and in sporulation at 25 °C and 30 °C. Aggressiveness of E. turcicum isolates was evaluated on three susceptible maize cultivars (maize lines B37, Sus1 and the German hybrid Niklas) under different day/night temperature regimes (15/10 °C, 20/15 °C, 25/20 °C, or 30/25 °C) with a photoperiod of 14 h. Aggressiveness, recorded as area under the disease progress curve (AUDPC), of South American isolates was higher than for European isolates at 15 °C, 20 °C and 25 °C, and for sporulation in vivo in all temperatures. In general, aggressiveness components were most influenced by temperature. Therefore, multivariate analysis was performed with aggressiveness component data at 30 °C, which expressed the highest number of variables with significant differences between isolate origins. According to their aggressiveness, European and South American isolates can be grouped separately, demonstrating that South American isolates are better adapted to higher temperatures and display a higher level of aggressiveness under similar conditions than European isolates from a cool climate. It is concluded that plasticity of temperature adaptation in E. turcicum populations is relatively large and allowed E. turcicum to follow the recent expansion of maize cultivation into cool climate zones in Europe. However, our data suggest that adaptation to higher temperature is likely to increase aggressiveness of NCLB on maize in cooler climate zones when experiencing further climate warming. This plasticity in adaptation to environmental conditions of E. turcicum may also hamper the success of breeding programs as it may decrease the durability of resistance.