You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder II1 Apr 2018MP23-13 ANTIMICROBIAL RESISTANCE AND EXTENDED SPECTRUM BETA-LACTAMASE AGENTS IN URINARY TRACT INFECTIONS: A SERIOUS PROBLEM IN THE NORTH OF MEXICO José Iván Robles-Torres, Lauro Gómez-Guerra, Elvira Garza-González, Soraya Mendoza-Olazarán, Samantha Flores-Treviño, Rolando Delgado-Balderas, and Adrián Gutiérrez-González José Iván Robles-TorresJosé Iván Robles-Torres More articles by this author , Lauro Gómez-GuerraLauro Gómez-Guerra More articles by this author , Elvira Garza-GonzálezElvira Garza-González More articles by this author , Soraya Mendoza-OlazaránSoraya Mendoza-Olazarán More articles by this author , Samantha Flores-TreviñoSamantha Flores-Treviño More articles by this author , Rolando Delgado-BalderasRolando Delgado-Balderas More articles by this author , and Adrián Gutiérrez-GonzálezAdrián Gutiérrez-González More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.745AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Inappropiate use of antibiotics has developed an increase incidence of resistant strains in urinary tract infections (UTI) in the past decades. The incidence of Extended Spectrum Beta-Lactamase (ESBL) agents has increase in community aquired-UTI, reaching up to 11% in some studies. The aim of this study is to describe causal agents, prevalence of drug resistance and to determine the risk factors for ESBL-producing agents in UTI. METHODS The study was done in a tertiary-care teaching hospital in Monterrey, Mexico. All positive urine cultures from outpatients and hospitalized patients with UTI from March to October 2015 were included. Drug resistance profile was determined using microdilution plate. The antibiotics tested included amikacin, gentamicin, amoxicillin-clavulanate, aztreonam, ceftriaxone, ertapenem, ciprofloxacin, levofloxacin, nitrofurantoin, fosfomycin, trimethoprim-sulfamethoxazole, and colistin. Statistical analysis was performed with the SPSS software version 20.0. Clinical and demographic characteristics were analyzed using ?2 test for categorical variables, and T-test for continuous variables. Statistical significance was set at p <0.05. RESULTS A total of 353 positive urine cultures were confirmed. Hospitalized UTI were 34.5% (n=122) and 65.5% (n=231) were community acquired UTI. The production of ESBL was found in 21.5% of strains. High resistance to amoxicillin-clavulanate (over 75%) and moderate resistance rates to gentamicin, aztreonam, ceftriaxone, ciprofloxacin, levofloxacin, fosfomycin, and trimethoprim-sulfamethoxazole were detected. ESBL-producing agents were associated with complicated UTI (p=<0.0001). Comorbilities associated with ESBL-producing UTI were diabetes mellitus (p=0.02), immunodeficiency (p=0.008), radiotherapy (p=0.025), and previous use of antibiotics (p=<0.001). CONCLUSIONS One every five UTI are caused by ESBL agents. The emergence of ESBL-producing strains is a serious health problem both in our community and hospital setting. An alarmingly high resistance to antibiotics recommended as first-line empirical therapy in UTIs (fosfomycin, fluoroquinolones and trimethoprim-sulfamethoxazole) was observed in both outpatient and inpatient strains. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e286 Advertisement Copyright & Permissions© 2018MetricsAuthor Information José Iván Robles-Torres More articles by this author Lauro Gómez-Guerra More articles by this author Elvira Garza-González More articles by this author Soraya Mendoza-Olazarán More articles by this author Samantha Flores-Treviño More articles by this author Rolando Delgado-Balderas More articles by this author Adrián Gutiérrez-González More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...