Agent For Ablation Research Articles

Single Center Experience of Percutaneous Septal Ablation in Patients With Hypertrophic Cardiomyopathy With A Novel Agent: Polidocanol

Septal reduction therapy is recommended in patients with obstructive hypertrophic cardiomyopathy (HCM) who remain symptomatic under maximally tolerated optimal medical treatment. Alcohol septal ablation is a favorable option, especially in patients with high surgical risk or who refuse surgery. Alcohol; causes scar-related ventricular arrhythmias and advanced heart blocks more frequently than surgical myectomy. Therefore, novel, safer agents are required for percutaneous septal ablation therapy. All the patients who underwent percutaneous septal ablation between January 2017 and June 2021 with polidocanol because of ongoing symptoms related to HCM despite maximally tolerated medical treatment were enrolled. Data were obtained retrospectively from the hospital electronic database. A total of 28 patients were included. Median age was 61 years (43.5-67), and 19 (67.8%) patients were male. Most of the patients underwent index procedures; however, only 2 cases had history of previous septal ablation. Median follow-up was 3.5 months (0.25 to 12.25). Median left ventricular outflow tract (LVOT) gradient at rest was 68.5 (37-80) mmHg, and after Valsalva maneuver median LVOT gradient was 95.5 (75-125) mmHg. Median volume of polidocanol used in procedures was 2 (2-3.37) ml, and mean procedure time was 28.1±2.5minutes. LVOT gradient invasively measured was significantly reduced (mean 76.5mm Hg vs mean 30mm Hg; p<0.001) immediately after the septal ablation. Conduction defects developed in 18 patients (64.2%); however, de novo permanent cardiac implantable electronic device implantation was required in only 4 (14.3%) cases. Leakage of polidocanol and mortality did not occur in any cases. Pericardial effusion developed in only 1 case, and it resolved with medical treatment. After mean 3.5months follow-up, both LVOT gradient and New York Heart Association functional class parameters were better than baseline values. In conclusion, polidocanol is a safe and effective agent for septal ablation in patients with HCM. Outcomes and complication rates are similar with alcohol septal ablation.

Modulated plasmonic nanofibrous scaffold reinforced breast cancer photo-ablation and breast neurotization with resensation

Herein, we report the bioactivity of the hybrid plasmonic aligned nanofibrous scaffolds composed of reduced graphene oxide (rGO, 209 nm) nanosheets enfolded gold nanorods (AuNR) with polycaprolactone (PCL) for breast cancer photo-therapy and subsequent nerve regeneration. The strategic inclusion of 0.00068 wt% (OD = 4.0) of monodispersed AuNR-rGO in PCL (AuNR-rGO@PCL (4.0)) leads to significant higher physicochemical and optical properties such as higher mechanical strength (7-fold increase), electrical conductivity (∼6-times enhancement), larger surface area (6.4 times), and more NIR light absorbance. Hence, the AuNR-rGO@PCL (4.0) was found to be an excellent photo agent for breast tumor ablation with more than 90% cancer cell (MCF-7) death under 808 nm NIR irradiation at low laser power density (0.72 W/cm2). Also, the nanofibrous scaffold was observed to have a substantial effect on adhesion, proliferation, growth, and differentiation of PC12 and high affinity to S42 cell proliferation and migration which led to an exceptional nerve growth with a 2.5-fold (with NIR light after 3 days) and 2-fold (without NIR light after 7 days) increase in neurite length in comparison to PCL. The present study provides a new bioactive, biocompatible, non-toxic, and bifunctional aligned plasmonic scaffolds as an excellent single platform for breast cancer treatment and potential bioimplant to regain sensation loss after breast surgery and reconstruction.

Phase-Dependent 1T/2H-MoS2 Nanosheets for Effective Photothermal Killing of Bacteria

The crystal phase of a nanomaterial can affect its biochemical properties and, as a result, greatly influence its application performance. Transition metal dichalcogenides (TMDs), a group of nanomaterials with the ability to crystallize into distinct crystal phases, show distinct electronic structures which are believed to be material-dependent. Molybdenum disulfide (MoS2) can crystallize into distinct crystal phases of 1T and 2H, and in each of these phases, MoS2 shows completely different and distinct biochemical properties. Although several biochemical properties of MoS2 have been extensively reported, particularly its role as a potent antibacterial agent, exactly how the different crystal phases of MoS2 nanosheets (NSs) influence the nanomaterial’s biochemical performance in the near-infrared (NIR)-I window still remains unknown. Herein, we show through detailed experiments and density functional theory (DFT) simulation of the NIR-based electronic structure–activity relationship of 1T- and 2H-MoS2 NSs exactly how these two distinct phases influence the antibacterial performance at each crystal phase and the different factors involved in this process. We also show how the coordination modes, atomic arrangements, and water adsorption energies of these two crystal phases greatly impact the nanomaterial’s distinct phase properties. 1T-MoS2 NSs are metallic phases with a lower band gap and surface water adsorption energy, while 2H-MoS2 NSs are semiconducting phases; as a result, 1T-MoS2 NSs show superior absorbance in the NIR-I window and hence display a higher photothermal performance and excellent antibacterial effects compared to the semiconducting 2H-MoS2 NSs. Our work shows the factors responsible for the distinct antibacterial behaviors of MoS2 NSs in the two crystal phases. We believe that these findings can be employed in the tunable, effective, and stable nanofabrication of MoS2 NSs as either photothermal agents for cancer cell ablation or as antimicrobial agents.

Abstract No. 355 Percutaneous needle-based liquid ablation agent for tumor treatment and drug delivery

The purpose of the study was to determine whether a single percutaneous needle based injection of an ionic liquid with various therapeutics could be used to ablate normal and tumor tissue, incite inflammation, retain chemotherapy drugs within the ablation zone and achieve uniform delivery of drugs within tissue.

Experimental research on rapid removing characteristics of carbon monoxide generated during gas explosions.

A large amount of gas, such as CO, accumulates in a coal mine after an explosion, leading to CO poisoning. In this study, a self-developed platform was used to eliminate CO from coal mines and determine the mass of the rapidly eliminated CO and its concentration in the eliminated gases. Equations were derived to calculate the amount of CO eliminated and the removing rate. The results showed that a rapid removing reagent in the form of nonprecious metal catalysts is useful for removing CO. Removing agents with larger masses facilitated the activation, irrespective of the CO concentration. For removing reagent amounts of 10, 15, 20, 25, and 30 g, the amount of CO eliminated, the removing rate, and the time required to complete catalytic oxidation increased sequentially. The CO removing process could be divided into three stages (I, II, and III) based on the variations in the CO, CO2, and O2 concentrations during CO removing. The removing reagent first chemically adsorbs CO and O2, and then desorbs CO2. The final CO concentration tends to 0, the O2 concentration remains stable, and the CO2 concentration decreases. This shows that the ablation agent has an impact on the changes in the CO and CO2 concentrations.

Bright, Magnetic NIR-II Quantum Dot Probe for Sensitive Dual-Modality Imaging and Intensive Combination Therapy of Cancer.

Improving the effectiveness of cancer therapy will require tools that enable more specific cancer targeting and improved tumor visualization. Theranostics have the potential for improving cancer care because of their ability to serve as both diagnostics and therapeutics; however, their diagnostic potential is often limited by tissue-associated light absorption and scattering. Herein, we develop CuInSe2@ZnS:Mn quantum dots (QDs) with intrinsic multifunctionality that both enable the accurate localization of small metastases and act as potent tumor ablation agents. By leveraging the growth kinetics of a ZnS shell on a biocompatible CuInSe2 core, Mn doping, and folic acid functionalization, we produce biocompatible QDs with high near-infrared (NIR)-II fluorescence efficiency up to 31.2%, high contrast on magnetic resonance imaging (MRI), and preferential distribution in 4T1 breast cancer tumors. MRI-enabled contrast of these nanoprobes is sufficient to timely identify small metastases in the lungs, which is critically important for preventing cancer spreading and recurrence. Further, exciting tumor-resident QDs with NIR light produces both fluorescence for tumor visualization through radiative recombination pathways as well as heat and radicals through nonradiative recombination pathways that kill cancer cells and initiate an anticancer immune response, which eliminates tumor and prevents tumor regrowth in 80% of mice.

Comparison of Aminoglycoside Antibiotics and Cobalt Chloride for Ablation of the Lateral Line System in Giant Danios.

SynopsisThe mechanoreceptive lateral line system in fish is composed of neuromasts containing hair cells, which can be temporarily ablated by aminoglycoside antibiotics and heavy metal ions. These chemicals have been used for some time in studies exploring the functional role of the lateral line system in many fish species. However, little information on the relative effectiveness and rate of action of these chemicals for ablation is available. In particular, aminoglycoside antibiotics are thought to affect canal neuromasts, which sit in bony or trunk canals, differently from superficial neuromasts, which sit directly on the skin. This assumed ablation pattern has not been fully quantified for commonly used lateral line ablation agents. This study provides a detailed characterization of the effects of two aminoglycoside antibiotics, streptomycin sulfate and neomycin sulfate, and a heavy metal salt, cobalt (II) chloride hexahydrate (CoCl2), on the ablation of hair cells in canal and superficial neuromasts in the giant danio (Devario aequipinnatus) lateral line system, as a model for adult teleost fishes. We also quantified the regeneration of hair cells after ablation using CoCl2 and gentamycin sulfate to verify the time course to full recovery, and whether the ablation method affects the recovery time. Using a fluorescence stain, 4-Di-2-ASP, we verified the effectiveness of each chemical by counting the number of fluorescing canal and superficial neuromasts present throughout the time course of ablation and regeneration of hair cells. We found that streptomycin and neomycin were comparably effective at ablating all neuromasts in less than 12 h using a 250 μM dosage and in less than 8 h using a 500 μM dosage. The 500 μM dosage of either streptomycin or neomycin can ablate hair cells in superficial neuromasts within 2–4 h, while leaving those in canal neuromasts mostly intact. CoCl2 (0.1 mM) worked the fastest, ablating all of the hair cells in less than 6 h. Complete regeneration of the neuromasts in the lateral line system took 7 days regardless of chemicals used to ablate the hair cells. This study adds to the growing knowledge in hearing research about how effective specific chemicals are at ablating hair cells in the acoustic system of vertebrates.

Recent Development of MOF-Based Photothermal Agent for Tumor Ablation.

Metal-organic frameworks (MOFs) are 3D-architecture compounds of metal ions and organic molecules with sufficient and permanent porosity, showing great potential as a versatile platform to load various functional moieties to endow the hybrid materials with specific applications. Currently, a variety of photothermal nanometals have been embedded into organic ligands for integrating the unique photothermal effects with the merits of MOFs to improve their performances for cancer therapy. In this review, we have summarized a series of novel MOF-based photothermal materials for this unique therapeutic modality against tumors from three main aspects according to their chemical compositions and structures, i) metal-doped MOF, ii) organic-doped MOF, and iii) polymer-coated MOF. In addition, we have summarized the latest developments and characteristics of MOF-based photothermal agents, such as good biocompatibility, low toxicity, and responsive photothermal conversion without destroying the structure of hybrid photothermal agent. At last, we addressed the future perspectives of MOF-based photothermal agent in the field of phototherapy.

In Situ Nanozyme‐Amplified NIR‐II Phototheranostics for Tumor‐Specific Imaging and Therapy

AbstractThe discovery of near‐IR‐II (NIR‐II) tumor phototheranostics holds a great promise for use in nanomedicine on account of its enhanced penetration depth, high spatial resolution, and noninvasiveness. However, contemporary “always on” phototherapeutic agents often have many undesirable side effects that hinder their clinical trial progress. To overcome this dilemma, an in situ nanozyme‐amplified chromogenic nanoreactor by loading 3,3′,5,5′‐tetramethylbenzidine (TMB) and ultrasmall PtAu nanoparticles into a metal–organic framework is developed for specific tumor theranostics, leaving normal tissues unharmed. As an intelligent photoacoustic diagnostic agent, the as‐constructed nanoreactor remains silent until they enter the tumor site (H2O2‐activated and acid‐enhanced conditions) and turns on the photoacoustic signal to render a preoperative tumor diagnosis. As a nanozyme, the special microenvironment of the tumor tissue is used to initiate its catalytic damage by reactive oxygen species for chemodynamic therapy (CDT). More importantly, the TMB is oxidized, and the subsequent photothermal therapy (PTT) can be realized, leading to an optimal combination of CDT and PTT to concurrently fight obstinate cancers. The present “all‐in‐one” phototheranostics utilize nanozyme‐augmented NIR‐II agents for specific tumor ablation, which are promising for further development of intelligent nanozymes in tumor therapy.

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

Molybdenum oxide nanoparticles (NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to the crystalline and defective structures such as oxygen deficiencies. However, fundamental understanding on the structure-function relationship between crystalline/defective structures and photothermal properties is still unclear. To address this, herein, we have developed an “in-situ confined oxidation-reduction” strategy to regulate the defect features of molybdenum oxide NPs in the dual-mesoporous silica nanoreactor. Especially, the effects of crystalline structure/oxygen defects of molybdenum oxides on the photothermal performances were investigated by facilely tuning the amount of molybdenum resource and the reduction temperature. As a photothermal nanoagent, the optimal defective molybdenum oxide NPs encapsulated in PEGylated porous silica nanoreactor (designated as MoO3−x@PPSNs) exhibit excellent biological stability and strong localized surface plasmon resonance effect in near-infrared absorption range with the highest photothermal conversion efficiency up to 78.7% under 808 nm laser irradiation. More importantly, the remarkable photothermal effects of MoO3−xPPSNs were comprehensively demonstrated both in vitro and in vivo. Consequently, we envision that the plasmonic MoO3−x NPs in a biocompatible porous silica nano-reactor could be used as an efficient photothermal therapy agent for photothermal ablation of tumors.

A Protein-Binding Molecular Photothermal Agent for Tumor Ablation.

Photothermal therapy usually requires a high power density to activate photothermal agent for effective treatment, which inevitably leads to damage to normal tissues and inflammation in tumor tissues. Herein, we rationally design a protein-binding strategy to build a molecular photothermal agent for photothermal ablation of tumor. The synthesized photothermal agent can covalently bind to the thiol groups on the intracellular proteins. The heat generated by the photothermal agent directly destroyed the bioactive proteins in the cells, effectively reducing the heat loss and the molecular leakage. Under a low power density of 0.2 W cm-2 , the temperature produced by the photothermal agent was sufficient to induce apoptosis. In vitro and in vivo experiments showed that the therapeutic effect of photothermal therapy can be efficiently improved with the protein-binding strategy.

A Protein‐Binding Molecular Photothermal Agent for Tumor Ablation

A protein-binding molecular photothermal agent was developed for photothermal therapy. In vitro and in vivo experiments demonstrated that the heat generated by the photothermal agent directly destroyed the intracellular bioactive proteins and induced apoptosis under low power density laser irradiation. The therapeutic effect can be efficiently improved with the protein-binding strategy.

Chemical Ablation for Treating Anal Fistulas without Surgical Intervention: Long-Term Results

Purposes. This study aimed to evaluate long-term outcomes after the application of a corrosive chemical agent for ablation of epithelial tissue as a non-surgical treatment of anal fistulas. Methods. Adult patients with symptomatic perianal fistula were prospectively included in the study. The fistula tract was irrigated with a 5% silver nitrate solution. The primary outcome measured in this study was the rate of clinical healing after long-term follow-up. Factors that may affect healing were also analysed. Results. A total of 186 patients with anal fistula were analysed. After irrigation with silver nitrate, 82 (44%) patients had complete clinical healing during a median follow-up time of 50 (7-64) months. Patients with intermittent discharge had a significantly higher rate of complete clinical healing than those with continuous discharge (P < .04). Fistulas without abscesses or secondary tracts had a significantly higher rate of complete clinical healing than the other types (P = .007). Conclusion. Chemical ablation of the epithelium of the anal fistula yields promising long-term outcomes in the management of anal fistulas without surgical intervention.

Percutaneous liquid ablation agent for tumor treatment and drug delivery.

Percutaneous locoregional therapies (LRTs), such as thermal ablation, are performed to limit the progression of hepatocellular carcinoma (HCC) and offer a bridge for patients waiting for liver transplantation. However, physiological challenges related to tumor location, size, and existence of multiple lesions as well as safety concerns related to potential thermal injury to adjacent tissues may preclude the use of thermal ablation or lead to its failure. Here, we showed a successful injection of an ionic liquid into tissue under image guidance, ablation of tumors in response to the injected ionic liquid, and persistence (28 days) of coinjected chemotherapy with the ionic liquid in the ablation zone. In a rat HCC model, the rabbit VX2 liver tumor model, and 12 human resected tumors, injection of the ionic liquid led to consistent tumor ablation. Combining the ionic liquid with the chemotherapy agent, doxorubicin, resulted in synergistic cytotoxicity when tested with cultured HCC cells and uniform drug distribution throughout the ablation zone when percutaneously injected into liver tumors in the rabbit liver tumor model. Because this ionic liquid preparation is simple to use, is efficacious, and has a low cost, we propose that this new LRT may bridge more patients to liver transplantation.

A novel purification method of activated carbon-supported carbon nanotubes using a mixture of Ca(OH)2 and KOH as the ablation agent.

Transition metals (Fe, Co, Ni) supported on activated carbons with different pore diameters (<2 nm, 10 nm, 50 nm) to synthesize carbon nanotubes (CNTS) are first investigated in this study. Through several characteristic analyses, Ni supported on 50 nm activated carbon is verified to be the most efficient catalyst among the samples for CNT growth. The optimum conditions for CNT growth are at a growth temperature of 750 °C with a reaction time of 45 min. Furthermore, a novel purification method for CNTs is proposed, in which KOH and Ca(OH)2 powder are pre-mixed with the crude CNTs and CO2 and N2 gas are introduced into this mixture. When KOH and Ca(OH)2 powder are used at a ratio of 2 : 1 under the atmosphere of CO2 and N2 at the temperature of 750 °C for 1 h, almost all of the amorphous carbon is ablated. Compared with KOH powder, the addition of Ca(OH)2 not only advances the ablation effect, but reduces the damage to CNTs.

Application of phototherapeutic-based nanoparticles in colorectal cancer.

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer death, which accounts for approximately 10% of all new cancer cases worldwide. Surgery is the main method for treatment of early-stage CRC. However, it is not effective for most metastatic tumors, and new treatment and diagnosis strategies need to be developed. Photosensitizers (PSs) play an important role in the treatment of CRC. Phototherapy also has a broad prospect in the treatment of CRC because of its low invasiveness and low toxicity. However, most PSs are associated with limitations including poor solubility, poor selectivity and high toxicity. The application of nanomaterials in PSs has added many advantages, including increased solubility, bioavailability, targeting, stability and low toxicity. In this review, based on phototherapy, we discuss the characteristics and development progress of PSs, the targeting of PSs at organ, cell and molecular levels, and the current methods of optimizing PSs, especially the application of nanoparticles as carriers in CRC. We introduce the photosensitizer (PS) targeting process in photodynamic therapy (PDT), the damage mechanism of PDT, and the application of classic PS in CRC. The action process and damage mechanism of photothermal therapy (PTT) and the types of ablation agents. In addition, we present the imaging examination and the application of PDT / PTT in tumor, including (fluorescence imaging, photoacoustic imaging, nuclear magnetic resonance imaging, nuclear imaging) to provide the basis for the early diagnosis of CRC. Notably, single phototherapy has several limitations in vivo, especially for deep tumors. Here, we discuss the advantages of the combination therapy of PDT and PTT compared with the single therapy. At the same time, this review summarizes the clinical application of PS in CRC. Although a variety of nanomaterials are in the research and development stage, few of them are actually on the market, they will show great advantages in the treatment of CRC in the near future.

Engineering Test of Gas Ablation Agent in Mine Gas Control

Gas is a major threat to the safety of coal mine production, Gas Ablation Agent is a major component of methane oxidation bacteria, added a special catalyst, used to eliminate the high concentration of gas biological solvents, gas reduction speed, low cost, non-toxic harmless characteristics. Gas Ablation Agent can quickly decompose or convert gas into other harmless substances, eliminate or reduce gas in coal seams, reduce gas pressure and gas content, so as to eliminate the prominent risk of coal and gas, is a new biochemical technology to control coal mine gas. After 24 hours, the gas content decreased by an average of 3.64m³/t and 2.24m³/t respectively. Gas ablation microorganisms, while breaking down methane, can promote the rapid decomposition of methane adsorbed in coal bodies. Compared with the conventional excavation method, the number of construction drilling holes decreased by about 92%, the total number of digging days decreased by 59 days, and the efficiency of coal extraction increased by 3.2 times. Gas Ablation Agent is an effective and environmentally friendly technical method to control gas, which is of great practical significance for the prevention and control of coal and gas, and the promotion of efficient and safe production.

Biodegradable Multifunctional Nanotheranostic Based on Ag2S-Doped Hollow BSA-SiO2 for Enhancing ROS-Feedback Synergistic Antitumor Therapy.

Stimuli-responsive silica nanoparticles are an attractive therapeutic agent for effective tumor ablation, but the responsiveness of silica nanoagents is limited by intrastimulation level and silica framework structure. Herein, a biodegradable hollow SiO2-based nanosystem (Ag2S-GOx@BHS NYs) is developed by a novel one-step dual-template (bovine serum albumin (BSA) and cetyltrimethylammonium bromide (CTAB)) synthetic strategy for image-guided therapy. The Ag2S-GOx@BHS NYs can be specifically activated in the tumor microenvironment via a self-feedback mechanism to achieve reactive oxygen species (ROS)-induced multistep therapy. In response to the inherent acidity and H2O2 at the tumor sites, Ag2S-GOx@BHS would accelerate the structural degradation while releasing glucose oxidase (GOx), which could efficiently deplete intratumoral glucose to copious amounts of gluconic acid and H2O2. More importantly, the sufficient H2O2 not only acts as a reactant to generate Ag+ from Ag2S for metal-ion therapy and improves the oxidative stress but also combines with gluconic acid results in the self-accelerating degradation process. Moreover, the released Ag2S nanoparticles can help the Ag2S-GOx@BHS NYs realize the second near-infrared window fluorescence (NIR-II FL) and photoacoustic (PA) imaging-guided precise photothermal therapy (PTT). Taken together, the development of a self-feedback nanosystem may open up a new dimension for a highly effective multistep tumor therapy.

Gold nanoclusters decorated amine-functionalized graphene oxide nanosheets for capture, oxidative stress, and photothermal destruction of bacteria

Gold nanoclusters decorated amine-functionalized graphene oxide (Au-GO-NH2) nanosheets were designed as a highly efficient visible light active antibacterial agent. This assembled nanosheet is positively charged and of high specific surface area that captures bacteria through physical adsorption and electrostatic interaction. Under visible light irradiation, this photoactive nanosheet concurrently generates massive heat and produces substantial reactive oxygen species to inactivate bacteria. In comparison with bare gold nanoclusters and amine-functionalized graphene oxides, this nanosheet appears an enhanced antibacterial activity >5-fold towards Gram-postive and Gram-negative bacteria. Moreover, a nanosheet modified silicone surface was employed as a model of implant devices, which showed superior antibacterial efficacy against bacterial colonization in vitro. This work demonstrates that the assembled nanosheet is a promising novel strategy in the construction of next generation antimicrobial agent for synergistic bacterial capture, oxidative stress, and photothermal ablation in the biomedical and environmental fields.

One‐Step Preparation of Biocompatible Gold Nanoplates with Controlled Thickness and Adjustable Optical Properties for Plasmon‐Based Applications

AbstractThe ability to synthesize plasmonic nanomaterials with well‐defined structures and tailorable size is crucial for exploring their potential applications. Gold nanoplates (AuNPLs) exhibit appealing structural and optical properties, yet their applications are limited by difficulties in thickness control. Other challenges include a narrow range of tunability in size and surface plasmon resonance, combined with a synthesis conventionally involving cytotoxic cetyltrimethylammonium (CTA) halide surfactant. Here, a one‐step, high‐yield synthesis of single‐crystalline AuNPLs is developed, based on the combined use of two structure‐directing agents, methyl orange and FeBr3, which undergo preferential adsorption onto different crystalline facets of gold. The obtained AuNPLs feature high shape homogeneity that enables mesoscopic self‐assembly, broad‐range tunability of dimensions (controlled thickness from ≈7 to ≈20 nm, accompanied by modulation of the edge length from ≈150 nm to ≈2 µm) and plasmonic properties. These merits, coupled with a preparation free of CTA‐halide surfactants, have facilitated the exploration of various uses, especially in bio‐related areas. For example, they are demonstrated as biocompatible photothermal agents for cell ablation in NIR I and NIR II windows. This work paves the way to the innovative fabrication of anisotropic plasmonic nanomaterials with desired attributes for wide‐ranging practical applications.