Age-sex Groups Research Articles

CLINICAL AND EPIDEMIOLOGICAL FEATURES OF ENT PATHOLOGY IN CHILDREN

Relevance. The insufficiency of studies on the field study of the structure and level of ENT morbidity, which affects the quality and life expectancy of a person in all social and age-sex groups of the population, indicates the relevance of this work.
 Purpose of the study A retrospective analysis of the indicators of the appealability of pediatric patients with ENT pathology.
 Material and research methods. In accordance with the set goal and objectives, the study was conducted in the period 2015-2019. An assessment was made of the condition of the ENT organs in children.
 Results of researches. The obtained data of statistical analysis confirm the high incidence of patients with allergic and catarrhal rhinitis, chronic pharyngitis, sinusitis, inflammatory diseases of the tonsils and adenoid vegetations, etc. Along with the high prevalence of adenoid vegetations, an increase in chronic rhinosinusitis was also observed. On average for 5 years, such diseases of the paranasal sinuses as acute rhinosinusitis 20.7±1.40% and chronic rhinosinusitis 7.8±0.93% prevail. At the same time, the prevalence of injuries to the bones of the nose and nosebleeds decreased during the study period. The data obtained determine the need for timely detection of diseases of the upper respiratory tract in children at the early stages of their development and the organization of measures for systematic dispensary observation.
 Conclusions.
 
 The pathological incidence of ENT diseases in children, being high, nevertheless does not exceed the similar indicators recorded at the final stage of the research.
 In the structure of ENT pathology of preschool age, the leading place belongs to diseases of the ear.
 Considering that the lowest prevalence rates of ENT diseases fall on the last year of observation, further reorganization of ENT care for the children's population and periodic preventive medical examinations with the involvement of certain individuals in medical examinations are necessary.

Associations among the anterior maxillary dental arch form, alveolar bone thickness, and the sagittal root position of the maxillary central incisors in relation to immediate implant placement: A cone-beam computed tomography analysis.

PurposeThis study evaluated the associations of the dental arch form, age-sex groups, and sagittal root position (SRP) with alveolar bone thickness of the maxillary central incisors using cone-beam computed tomography (CBCT) images.Materials and MethodsCBCT images of 280 patients were categorized based on the dental arch form and age-sex groups. From these patients, 560 sagittal CBCT images of the maxillary central incisors were examined to measure the labial and palatal bone thickness at the apex level and the palatal bone at the mid-root level, according to the SRP classification. The chi-square test, Kruskal-Wallis test, and multiple linear regression were used for statistical analyses.ResultsSignificant differences were found in alveolar bone thickness depending on the arch form and SRP at the apex level. The square dental arch form and class I SRP showed the highest bone thickness at both levels of the palatal aspect. The taper dental arch form and class II SRP presented the highest bone thickness at the apex level of the labial aspect. No association was found between the dental arch form and SRP. Elderly women showed a significant association with thinner alveolar bone. Age-sex group, the dental arch form, and SRP had significant associations with alveolar bone thickness at the apex level.ConclusionThe patient’s age-sex group, dental arch form, and SRP were associated with alveolar bone thickness around the maxillary central incisors with varying magnitudes. Therefore, clinicians should take these factors into account when planning immediate implant placement.

Prevalence of overweight and obesity in children

The growing prevalence of overweight and obesity is an urgent problem not only in adults but also in children in both developed and developing countries. The purpose of this study was to analyze the prevalence of overweight and obesity and other forms of nutritional disorders in Russian children. Material and methods. The nutritional status of 17 329 children aged 2-18 years was assessed on the basis of anthropometric data, obtained by the Federal State Statistics Service during the "Sample Survey of the Population's Diet" in 2018. The prevalence of various forms of malnutrition was assessed by the Z-score categories: underweight, stunted growth (short stature), thinness, overweight, obesity. Results. Population mean and median values of Z-scores in all sex-age groups do not exceed ±0.5 in relation to WHO standards, which indicates the applicability of the standards to assessing the nutritional status of Russian children population. High body weight (WAZ>2) occurs in 7.6% of children, underweight in 2.6%. The incidence of short stature in boys and girls is 7.0 and 6.8%, respectively. The prevalence of overweight and obesity in boys is 20.4 and 10.4%, respectively, while in girls, 15.4 and 7.6%. In general, in the population of children 2-18 years old, the prevalence of overweight is 18%, and obesity is 9.1%. The index of malnutrition, including the sum of the frequency of various combinations of low Z-scores (<-2), characterizing underweight, short stature, thinness, and their combinations was 8.0%. The multilevel logistic regression showed that overweight and obesity inversely depend on age; the risk of developing these conditions is lower in the city, but higher in male children compared to female children. Conclusion. The population of children 2-18 years old in the Russian Federation is characterized by a low incidence of forms of malnutrition, such as underweight and thinness. However, the prevalence of overweight and obesity is higher than in European countries.

ԽՈԶԵՐԻ ՎԱՐԱԿԻՉ ԱՏՐՈՖԻԿ ՌԻՆԻՏ ՀԻՎԱՆԴՈՒԹՅԱՆ ՏԱՐԱԾՎԱԾՈՒԹՅՈՒՆԸ ՀՀ ՈՐՈՇ ՄԱՐԶԵՐՈՒՄ ԵՎ ԴՐԱ ԴԵՄ ԻՐԱԿԱՆԱՑՎՈՂ ՊԱՅՔԱՐԻ ՄԻՋՈՑԱՌՈՒՄՆԵՐԸ

Currently, the atrophic rhinitis of pigs is registered in some pig breeding farms of the Armavir and Kotayk regions. According to investigations swines of all breed and sex-age groups are susceptible to the disease but the inherent symptoms are manifested in the 3-5-month-old fattened gilts. In Armenia the spread of the mentioned disease is promoted by the disposing factors and economic relationships between pig breeding farms. Rehabilitation of insecure pig breeding farms, as well as measures to prevent the further spread of the pathogen, were carried out in accordance with the directive on measures for the prevention and control of diseases. Sulfaprim 48-BT preparation was used for treatment.

The influence of camera-trap flash type on the behavioural response, detection rate and individual recognition of Eld’s deer

Context Camera traps are available with infrared or white flash, with the former being more commonly used. However, white flash produces colour night-time photographs that can be critically useful for both species and individual identification. White flash was thought to cause more disturbance to wildlife than was infrared and this may lead to camera avoidance. Evaluating the extent of this response, and differences between the flash types, is useful to develop improved survey designs. Aims This research aimed to quantify the behavioural responses of Eld’s deer to white and infrared flash, to determine whether white-flash cameras were suitable for use in population surveys of this species. Methods A behavioural ethogram was used to quantify the responses of the deer to the two flash types, as well as the responses of different sex-age classes and group sizes when encountering a camera trap. Additionally, the detection rate for white flash and infrared flash cameras was compared through time, to determine any pattern of avoidance. Key results While deer were more likely to observe and be startled by white flash than infrared, this did not adversely affect the detection of the deer, with no significant change in the detection rate between the two different flash types over time. Group size was found not to influence behavioural response when encountering camera traps, whereas different age–sex classes of deer showed very few differences in response to camera traps. Conclusions White flash cameras were found to be suitable for Eld’s deer population surveys and were beneficial in providing colour night-time photos that allow for spotted female deer to be individually identified. Implications Practitioners should not be concerned about the influence of white flash when using camera traps to monitor populations of Eld’s deer, and using white flash is recommended when individual identification is required.

Assessing contribution of bottled water in nutrient absorption using the bottled water nutritional quality index (BWNQI) in Iran

In this study, the contribution of bottled water in the absorption of nutritional minerals in Iran has been investigated. To calculate the nutritional quality index of bottled water (BWNQI) and evaluate the contribution of bottled water in nutrient absorption; the concentration of nutrient minerals, the standard level of these elements in bottled water, the recommended amount of nutrient mineral and the total consumption of drinking water in different age-sex groups were analyzed. The results showed that the average contribution of bottled water in absorbing the recommended amount of the nutrients of fluoride (F), magnesium (Mg), calcium (Ca), sodium (Na), copper (Cu), zinc (Zn) and manganese (Mn) was 12.16, 4.98, 4.85, 2.12, 0.49, 0.33 and 0.02%, respectively. According to the BWNQI index, the bottled water quality was as follows: 53.5% poor, 36.6% marginal, 7% fair, 2.81% good. Although most of the bottled water studied in this research were mineral water, a significant portion of them had poor nutritional quality, so the addition of minerals needed by the body through bottled water should be given more attention by the bottled water manufacturers and suppliers.

Are we really all in this together? The social patterning of mortality during the first wave of the COVID-19 pandemic in Belgium

BackgroundBelgium was one of the countries that was struck hard by COVID-19. Initially, the belief was that we were ‘all in it together’. Emerging evidence showed however that deprived socioeconomic groups suffered disproportionally. Yet, few studies are available for Belgium. The main question addressed in this paper is whether excess mortality during the first COVID-19 wave followed a social gradient and whether the classic mortality gradient was reproduced.MethodsWe used nationwide individually linked data from the Belgian National Register and the Census 2011. Age-standardized all-cause mortality rates were calculated during the first COVID-19 wave in weeks 11-20 in 2020 and compared with the rates during weeks 11-20 in 2015-2019 to calculate absolute and relative excess mortality by socioeconomic and -demographic characteristics. For both periods, relative inequalities in total mortality between socioeconomic and -demographic groups were calculated using Poisson regression. Analyses were stratified by age, gender and care home residence.ResultsExcess mortality during the first COVID-19 wave was high in collective households, with care homes hit extremely hard by the pandemic. The social patterning of excess mortality was rather inconsistent and deviated from the usual gradient, mainly through higher mortality excesses among higher socioeconomic groups classes in specific age-sex groups. Overall, the first COVID-19 wave did not change the social patterning of mortality, however. Differences in relative inequalities between both periods were generally small and insignificant, except by household living arrangement.ConclusionThe social patterning during the first COVID-19 wave was exceptional as excess mortality did not follow the classic lines of higher mortality in lower classes and patterns were not always consistent. Relative mortality inequalities did not change substantially during the first COVID-19 wave compared to the reference period.

Associations between Toxoplasma gondii infection and steroid hormone levels in spotted hyenas.

Toxoplasma gondii is a common parasite that infects warm-blooded animals and influences host physiology. T. gondii is known to target the host's central nervous system, affecting circulating levels of steroid hormones, fear-related behaviors, and health, although these effects appear to vary among host taxa. Here, we investigated the relationship between T. gondii infection and levels of plasma testosterone and cortisol within a wild population of spotted hyenas (Crocutacrocuta, n = 109). In our analyses, we accounted for age and sex via stratified regression analyses. We detected a negative association between circulating plasma testosterone and T. gondii infection among female cubs and subadults as well as adult male hyenas. We found no associations between T. gondii infection and cortisol in any age class or sex group of hyenas. Our work adds to a growing body of literature by characterizing the relationship between T. gondii infection and physiology in a novel host in its natural habitat. In a broader context, our findings indicate that responses to infection vary with characteristics of the host and point to a clear need for additional studies and priorities for future work that include diverse taxa and ecological settings.

Abstract 11389: Prevalence and Trends of Ideal Cardiovascular Health in 18 Countries: A Pooled Analysis of 68 Nationally Representative Surveys

Introduction: Increasing the prevalence of the ideal cardiovascular health (CVH) phenotype over the coming decades would likely result in dramatic improvements in healthy longevity and reductions in healthcare costs. Therefore, it is of paramount importance to understand the global prevalence and trends of the ideal CVH behaviors and factors for monitoring progress and providing evidence to support policy efforts. Hypothesis: We aim to describe the prevalence of CVH for the AHA defined metrics of tobacco use, body mass index, total cholesterol, blood pressure and glucose levels, and estimate its trends worldwide. Methods: We used data from people aged &gt; 20 years who participated in 68 national health examination surveys from 1983 to 2017 in 18 countries: Australia, Czech Republic, Denmark, Germany, Greece, Ireland, Italy, Malaysia, Mexico, Poland, Seychelles, Slovakia, South Korea, Spain, Sweden, Turkey, the UK, and the USA. We calculated age-standardized prevalence of ideal CVH (no current smoking, BMI &lt; 25 kg/m2, untreated TC &lt; 200 mg/dL, untreated BP &lt; 120 / &lt; 80 mmHg, and absence of diabetes mellitus). Additionally, we examined the trends of the ideal CVH for countries that had at least two individual-level national surveys in two different decades (2000-2009 vs 2010-2019). Results: With the exception of Australia and South Korea, age-standardized prevalence of idea CVH was lower than 10% in women and lower than 5% in men across all countries. Older individuals had a lower prevalence of Ideal CVH than younger ones. Those over 65 years of age had a prevalence almost equal to zero. In ages 35-64 years, ideal CVH prevalence ranged from 3.6% to 25.4% among women, and from 0.6% to 7.1% among men. For the 10 countries where trends were estimated by age-sex groups, ideal CVH prevalence did not change or declined in the selected middle-income countries and increased in the selected high-income countries except for South Korea, where it plateaued for men and declined for women. Conclusions: Prevalence of ideal CVH worldwide is low and is declining for adults in middle-income countries in recent decades.

Prevalence of inadequate intake of folate in the post-fortification era: data from the Brazilian National Dietary Surveys 2008-2009 and 2017-2018.

The objectives were to compare the evolution of dietary folate intake, to estimate the prevalence of folate inadequacy (POFI) and the contribution of food groups to folate intake (dietary folate plus folic acid from fortified foods) in two post-fortification periods in the Brazilian population, according to life stages, geographic regions and per capita income. Population-based study including representative data from the National Dietary Survey - Brazilian Household Budget Surveys (NDS-HBS) 2008-2009 and 2017-2018, with a total of 32749 (2008-2009) and 44744 (2017-2018) individuals aged ≥ 10 years old, excluding pregnant and lactating women. The National Cancer Institute method was used to estimate the distributions of usual dietary folate intake. POFI was estimated according to estimated average requirement cut-off point method. After 10 years of the first NDS-HBS, POFI has increased in all sex-age groups, except for 10-13 years. POFI among women of reproductive age was around 30 and 40 % in 2008-2009 and 2017-2018. Higher POFI was observed in the North region. The top five food groups contributors to folate intake in Brazil were beans, breads, pasta and pizza, cakes and cookies and non-alcoholic beverages groups in both periods, differing in the rank order of the last two groups. Although being a country that has adopted mandatory folic acid flour fortification for almost two decades, increased POFI was observed in 2017-2018. This study brings significant scientific information, which can help understand folate dietary data in different contexts and consequently guide the approach for public health fortification strategies.

Фактори ризику та особливості надання медичної допомоги зростаючій кількості хворих на рак в Україні

Актуальність. В публікації проведено науковий аналіз описаних у вітчизняній та закордонній літературі результатів щодо сучасних факторів ризику розвитку онкологічної патології серед різних статево-вікових груп населення, регіональних особливостей поширеності раку та організації надання медичної допомоги онкологічним хворим, їх змін у світі та в Україні, зокрема. Метою написання роботи стало оприлюднення отриманих результатів дослідження динаміки основних статистичних показників, факторів ризику розвитку онкологічної патології, особливостей організації надання медичної допомоги пацієнтам із злоякісними новоутвореннями в світі та Україні, зокрема. Матеріали та методи. Матеріалами для дослідження слугували результати наукових досліджень, опубліковані у вітчизняному та світовому науковому контенті за останні 5 років. В дослідженні використано бібліосемантичний, аналітико-синтетичний методи наукового аналізу. Результати. За результатами роботи виокремлені основні фактори ризику розвитку раку, вплив яких виявився доведеним, досліджено тенденції захворюваності на злоякісні новоутворення та їх регіональні особливості у світі, в тому числі загальноукраїнські. Обґрунтовано актуальність подальшого вивчення динаміки виявлених регіональних особливостей в розрізі областей України, що в перспективі могло би стати суттєвим інформаційним підґрунтям для формування регіональних програм удосконалення організації надання медичної допомоги цьому контингенту хворих з акцентом на посилення профілактичного її напряму. Висновки. Вивчення регіональних особливостей організації надання медичної допомоги хворим з онкологічною патологією з роками не втрачають своєї актуальності, з’являються сучасні фактори ризику раку, що потребує ефективного формування груп ризику для підвищення якості надання профілактичної складової медичної допомоги населенню України.

CHANGING PATTERN OF INTER-STATES IN-MIGRATION TO WEST BENGAL: CENSUS 2001-2011

This paper attempts to understand the pattern of the change of in-migration to West Bengal from different states of India. Inter-state migration flow to West Bengal is an old and essential phenomenon from the times of pre-independence periods. The total population of West Bengal in 2001 was about 80 million, and in 2011 the population increased to 91million persons. During the same period, it is observed that total in-migrants declined slightly from 2.45 million persons in 2001 to 2.38 million persons. The Study's objective is to examine the pattern of inter-state in-migration to West Bengal during 2001-2011 censuses and analyze the reasons and duration of stay of in-migration by the age-sex groups. The primary source of the Study is the census of India 2001 and 2011 (D2 &amp; D5 Tables) based on place of last residence (POLR). The analysis includes computation of rate, ratio, and the result are shown by graphs and maps using ArchMap10.3.1 software. Significant findings include changing the pattern of inter-state in-migration by POLR between North 24 Parganas and Kolkata, indicating a flow decline pattern. The top ten major states in India send enormous numbers of migrants (94.33% in 2001 and 94.30% in 2011), the working-age groups have quite diminished as in-migrants in the past ten years. Bihar and Jharkhand sent the most prominent migrants to West Bengal. The Study feels that to attract the migrants again back, West Bengal would require a new regional developmental strategy to regain its old status as one important destination for in-migrants.

Directional dummies in gravity models: application to Japanese inter-municipal migration by age-sex group

Directional dummies in gravity models: application to Japanese inter-municipal migration by age-sex group

Prevalencia e incidencia de sobrepeso y obesidad en 2,5 millones de niños y adolescentes en España

Introduction and objectivesChildhood obesity trends are plateauing in Spain, but limited information is available about how they differ by region. This study assessed childhood and adolescent the prevalence and incidence of overweight and obesity from 2005 to 2017 across 8 Spanish regions. MethodsThis longitudinal study used height and weight measurements from 2.5 million children aged 2 to 17 years to calculate overweight and obesity, according to the World Health Organization (WHO) guidelines. Data were obtained from The Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria, and the Information System for Research in Primary Care. Prevalence and incidence rates and trends from 2005 to 2017 were calculated and stratified by age, sex, and region. ResultsThe overall obesity prevalence increased in boys and girls from age 2 (0.8%; 95%CI, 0.8-0.9 in both sexes) until peaking at age 7 in girls (17.3%; 95%CI, 17.1-17.5) and age 9 in boys (24.1%; 95%CI 23.9-24.3). The highest and lowest obesity prevalences were observed in Murcia and Navarre. Overall obesity prevalence trends decreased from 2005 to 2017 in all age-sex groups and in most regions. Highest obesity incidence rates were found in children aged 6 to 7 years, (4.5 [4.5-4.5] and 3.5 [3.5-3.5] new obesity cases per 100 person-years in boys and girls, respectively). Boys had higher prevalence and incidence rates than girls across all regions. Overweight/obesity prevalence and incidence rates and their trends were consistently higher than the obesity results, although a similar pattern was observed across sex and age. ConclusionsOverweight and obesity prevalence slightly decreased in Spain from 2005 to 2017, but regional, sex, and age differences persisted. Because incidence peaked around the age of 6 years, it may be important to begin health promotion programs at an early age.

Nutrient intakes of Canadian adults: results from the Canadian Community Health Survey (CCHS)–2015 Public Use Microdata File

Accurate estimates of the usual intake of nutrients are important for monitoring nutritional adequacy and diet quality of populations. In Canada, comprehensive, nationally representative nutrient estimates have not been available since the Canadian Community Health Survey (CCHS)-Nutrition 2004 survey. The objective of this research was to assess nutrient intakes, distributions, and adequacy of the intakes of Canadian adults. Participants' first 24-h dietary recall, and the second-day recall from a subset of participants from the recently released CCHS 2015 Public Use Microdata File (PUMF) were used to estimate usual intakes of macronutrients, vitamins, and minerals in adults [≥19 y, excluding lactating females and those with invalid energy intake (EI)]. Usual intakes by DRI age-sex groups were estimated using the National Cancer Institute method, adjusted for age, sex, misreporting status, weekend/weekday, and sequence of recall analyzed (first/second) with outliers removed (final sample, n=11,992). Usual intakes from food were assessed for prevalence of inadequacy in relation to DRI recommendations. Canadian macronutrient intakes were within the recommended acceptable macronutrient distribution ranges. EI was 2154 kcal/d for males (19+) and 1626 kcal/d for females (19+). A high prevalence of inadequate intakes was seen for vitamin A (>47%), vitamin D (>94%), vitamin C (>29% for nonsmokers and>59% for smokers), magnesium (>45%), and calcium (>44%), whereas<25% and<40% of adults (19+) had intakes above the adequate intake for fiber and potassium, respectively. Canadians continue to consume sodium in excess of recommendations (74.8% of males and 47.6% of females). A significant number of Canadian adults may not be meeting recommendations for several essential nutrients, contributing to nutrient inadequacies. These results highlight the nutrients of concern by specific age-sex groups that may be important for public health interventions aimed at improving diet quality and nutrient adequacy for Canadian adults.

The prevalence and incidence rate of overweight and obesity among 2.5 million children and adolescents in Spain

Introduction and objectivesChildhood obesity trends are plateauing in Spain, but limited information is available about how they differ by region. This study assessed childhood and adolescent the prevalence and incidence of overweight and obesity from 2005 to 2017 across 8 Spanish regions. MethodsThis longitudinal study used height and weight measurements from 2.5 million children aged 2 to 17 years to calculate overweight and obesity, according to the World Health Organization (WHO) guidelines. Data were obtained from The Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria, and the Information System for Research in Primary Care. Prevalence and incidence rates and trends from 2005 to 2017 were calculated and stratified by age, sex, and region. ResultsThe overall obesity prevalence increased in boys and girls from age 2 (0.8%; 95%CI, 0.8-0.9 in both sexes) until peaking at age 7 in girls (17.3%; 95%CI, 17.1-17.5) and age 9 in boys (24.1%; 95%CI 23.9-24.3). The highest and lowest obesity prevalences were observed in Murcia and Navarre. Overall obesity prevalence trends decreased from 2005 to 2017 in all age-sex groups and in most regions. Highest obesity incidence rates were found in children aged 6 to 7 years, (4.5 [4.5-4.5] and 3.5 [3.5-3.5] new obesity cases per 100 person-years in boys and girls, respectively). Boys had higher prevalence and incidence rates than girls across all regions. Overweight/obesity prevalence and incidence rates and their trends were consistently higher than the obesity results, although a similar pattern was observed across sex and age. ConclusionsOverweight and obesity prevalence slightly decreased in Spain from 2005 to 2017, but regional, sex, and age differences persisted. Because incidence peaked around the age of 6 years, it may be important to begin health promotion programs at an early age.

Thinness, overweight and obesity among 6- to 17-year-old Malaysians: secular trends and sociodemographic determinants from 2006 to 2015.

To examine secular trends and sociodemographic determinants of thinness, overweight and obesity among Malaysian children and adolescents from 2006 to 2015. We used cross-sectional data from the National Health and Morbidity Surveys 2006, 2011 and 2015. Individuals were classified into pre- (6-9 years), early (10-13 years) and mid- (14-17 years) adolescence. BMI status was determined according to the International Obesity Task Force (IOTF) and WHO criteria, using measured height and weight. We analysed trends using log-binomial regression, by sex-age groups, stratified by sociodemographic factors (ethnicity, residential area, household size and household income), and accounting for the complex survey design. Associations between sociodemographic factors and prevalence of thinness and overweight (obesity included) in 2015 were assessed using log-Poisson regression. Nationwide population-based surveys, Malaysia. Eligible 6-17-year-olds from urban and rural residential areas (n 28094). The prevalence of thinness decreased from 2006 to 2015 (IOTF: boys from 22 % to 18 %, girls from 23 % to 19 %; WHO: boys from 9 % to 7 %, girls from 8 % to 6 %), while the prevalence of overweight increased (IOTF: boys from 20 % to 26 %, girls from 19 % to 24 %; WHO: boys from 25 % to 31 %, girls from 22 % to 27 %). These changes were statistically significant in most sex-age groups. Thinness and overweight co-existed in all sociodemographic subgroups, with variation in the prevalence estimates, but similar secular changes in most subgroups. Malaysia is facing a double burden of malnutrition at population level with a secular increase in overweight and obesity and a gradual decrease in thinness among 6-17-year-olds from varying sociodemographic backgrounds.

Specific Features of the Spread of New Coronavirus Infection (COVID 19) in Orenburg Region

Relevance. They did not learn completely the information of the distribution of morbidity by territory and population sex-age groups in the context of a pandemic of a new coronavirus infection (COVID-19).Aims. It is necessary to study COVID-19 distribution features among the population of the central Orenburg region administrative districts in June–December 2020.Materials &amp; Methods. We analyzed the results of the study of the polymerase chain reaction (PCR) COVID-19 of the population of the Central Orenburg region for June-December 2020 (72 484 nasopharyngeal smears from 13 districts of the region). The presence of SARS-CoV2 RNA was detected by real-time reverse transcription PCR. The significance of differences in indicators was assessed using the paired Pearson test (p≤0.05; EPI-INFO, version 7.2.4; CDC).Results. The share of positive findings was 15,5% of the studied material from 12,5% of the population. Registration of COVID 19 cases in the Central Orenburg region began in June 2020. They revealed a significant correlation between the dynamics of the districts population morbidity and the dynamics of examined persons number. The study of morbidity dynamics showed a significant growth with the registration of maximum values in October with a decrease in disease cases in December by 2 times. They identified the highest morbidity rates territories (Aleksandrovsky, Akbulaksky, Sharlyksky, Tyulgansky, Perevolotsky, Sol-Iletsky, Saraktashsky, Belyaevsky dist at the average regional level 2204,9 0 /0000 ). The distribution of cases by sex revealed the predominance of women disease cases (56,8%) over the men proportion (43,2%). Women dominated among adults under 65 years of age, while men dominated in the children's and over 65 years of age groups. However, the prevalence analysis for the given period showed the women dominance in all age groups in all the studied territories. They can conclude that there is a great women commitment to medical care. It was not possible to identify significant correlations between the morbidity level and the districts remoteness from Orenburg. It is likely that at modern communication speeds distances of 250–300 km are not a significant barrier to a new infection with a dominant airborne transmission pathway spread.Conclusions. The study showed a mobidity significant growth for 2020. 8 of 13 territories under study became those of increased risk of morbidity. Cases of the disease ratio among men and women responds to the men and women ratio among the population. The age group of 0-18 was least affected. The analysis showed a morbidity reliable growth with increasing age of patients of both sexes and revealed a large inferiority of the female population.

A pilot project to study troponin I in a representative sample of the region from the ESSE-RF study: distribution among population and associations with risk factors

Aim. To assess the distribution of cardiac troponin I (cTnI) in a sample of the region from the ESSE-RF study and to study its associations with risk factors (RFs) and the Systematic Coronary Risk Evaluation (SCORE) system.Material and methods. This observational cross-sectional study includes a representative sample of the population aged 25-64 years of the Vologda region (n=1591). The analysis included sex, age, behavioral and cardiometabolic RFs, biomarkers, prior cardiovascular diseases (CVDs), and SCORE. The differences between age-sex groups were considered significant at p&lt;0,05.Results. According to study results, asymmetry in cTnI distribution among population was revealed. The median cTnI level in the sample was 1,5 pg/ml (95% confidence interval, 0,80-2,50). Noteworthy is the high level of the 99th percentile of cTnI in men aged 45-54 years (55,3 pg/ml). At the same time, the 99th percentile for the entire sample in men was 47,7 pg/ml, while in women — 13,3 pg/ml. The cTnI level log increases significantly with age in both men (p&lt;0,0001) and women (p&lt;0,0001), but faster in men. There was a higher level of cTnI in young men compared to same-age women. In multivariate analysis, significant associations of cTnI levels with sex, age, blood low-density lipoprotein cholesterol, abdominal obesity, hypertension, and brain natriuretic peptide level were obtained. Insufficient accuracy of classification of study participants by SCORE risk was revealed.Conclusion. The distribution of cTnI in the sample of the Russian region from the ESSE-RF study is sharply shifted to the left (median, 1,5 pg/ml). Higher cTnI levels were revealed in young men compared to their female peers. Significant associations of cTnI with obesity (body mass index, hypertension, elevated low-density lipoprotein cholesterol, and brain natriuretic peptide concentration) were found. It was demonstrated that SCORE does not accurately classify individuals with high and moderate cТnI levels.

STATODYNAMIC DISTURBANCES OF FUNCTIONS AS ONE OF THE REASONS FOR THE ACCUMULATED DISABILITY OF THE POPULATION IN THE ROSTOV REGION

In the course of the study, it was possible to identify the weighted average values of the burden of static-dynamic diseases among the female and male population of young age. A continuous study was carried out in 2020 on the basis of the Main Bureau of Medical and Social Expertise in the Rostov Region. In the course of the work, a database was compiled on the accumulated disability in the Rostov region for people aged 18–45 years (23,248 cases). In the course of the study, five age-sex groups were identified: 1) 18–25 years old, 2) 26–30 years old, 3) 31–35 years old, 4) 36–40 years old, 5) 41–45 years old. The study of indicators of a separate age group included the calculation of the frequency of accumulated disability, assessment of the structure of the contingent, taking into account the causes and severity of disability. Statistical processing of the data obtained was carried out by comparing the average values in the Statistica 10 application program. In the first studied age group, the incidence of accumulated disability is 87.9 cases per 10 thousand of the population, among them 17.7 cases per 10 thousand of the population are people with disabilities. statodynamic disturbances (20.1%). In the second group, the frequency of general disability is 70.9 cases per 10 thousand of the population, among them 17.0 cases per 10 thousand of the population are people with disabilities with staticdynamic disorders (24.0%). In the third group, the incidence of accumulated disability is 119.1 cases per 10 thousand of the population, among them 31.4 cases per 10 thousand of the population are disabled persons with static-dynamic disorders (26.4%). In the fourth group, the incidence of accumulated disability is 182.0 cases per 10 thousand of the population, among them 54.7 cases per 10 thousand of the population are people with disabilities with static-dynamic disorders (30.0 %). In the fifth group, the frequency of general disability is 276.2 cases per 10 thousand of the population, among them 82.9 cases per 10 thousand of the population are people with disabilities with static-dynamic disorders (30.0 %). Thus, the indicator of accumulated disability with statodynamic disorders is higher in the fifth age-sex group of the study (82.9 cases per 10 thousand population); in the structure of the severity of disability, the third group prevails.