Age-related Problems Research Articles

BIOACTIVE COMPOUNDS AND PHARMACOGNOSTIC POTENTIAL OF Tetragonia tetragonioides

In the recent years, due to the increasing resistance of pathogens to synthetic antimicrobial drugs, the use of highly active compounds from plants, which have proven their effectiveness in traditional medicine practices, is increased. Extracts of medicinal plants often contain a unique species ‒ specific combination of active ingredients that have a synergistic therapeutic effect. Therefore, the analysis of the biochemical composition of cultivated plants and the range of their potential biotechnological application is an urgent task. Aim. To summarize the information on the potential of the xerophytic plant Tetragonia tetragonioides as a source of functional food ingredients and biologically active substances that increase nonspecific organism resistance and contribute to the prevention and treatment of various diseases. Results. T. tetragonioides is a salt-tolerant and heat-resistant plant containing valuable nutrients and biologically active substances, a significant amount of vitamins, minerals, and dietary fibers. The high level of antioxidant compounds, especially flavonoids and carotenoids, helps to reduce the risk of degenerative pathologies developing associated with excessive oxidative stress. The unique complex of biologically active substances in T. tetragonioides, which includes 6-methoxyflavonols, predominantly derivatives of 6-methoxykaempferol, as well as megastigmanes and their glucosides, lignanamide, provides significant antioxidant, anti-inflammatory, antitumor, and antimicrobial activity and may be beneficial for the prevention of chronic diseases and age-related health problems. The effectiveness of T. tetragonioides has been demonstrated in animal models in the treatment of metabolic disorders such as obesity, hyperlipidemia, and hyperuricemia. Conclusions. T. tetragonioides, containing a specific complex of biologically active compounds, primarily 6-methoxyflavonols, may be a promising raw material for obtaining effective medications for the treatment and prevention of various chronic diseases and metabolic disorders.

”It´s like walking in a bubble”, nursing students´ perspectives on age suit simulation in a home environment – group interviews from reflection seminars

BackgroundOlder persons with age-related and complex health problems will increasingly depend on care provision from nurses in their own homes. However, a barrier to quality care is ageism and nursing students´ disinterest in geriatrics. In addition, nurse education often falls short in preparing students for the complexity of geriatric care. Welfare technology (WT) is progressively implemented in home care to help older persons live at home despite their health problems. However, this process is intricate and requires acceptance and digital literacy among caregivers and older persons. Despite these challenges, nurse education can address and change negative attitudes through innovative teaching methods such as age suit simulation. Therefore, the study aims to describe nursing students´ experiences of age suit simulation in a home-like environment with WT and technical aids, and will reveal their perspective on ageing and providing care to older adults.MethodsA qualitative explorative design using semi-structured group interviews (n=39) among nursing students. Data was analysed through reflexive thematic analysis.ResultsThe analysis generated three main themes; “It’s like walking in a bubble”, “An eye opener” and “Concerns about ageing and the current structure of geriatric care”. The main themes included eight subthemes. Adapting to the sensory and physical limitations of the age suit was an immersive experience and caused feelings of frustration, loneliness and disconnection. A prominent result was a raised awareness of cognitive loss, especially impaired vision, and students felt the simulations had made them aware of the everyday challenges older persons faced. Students highlighted the importance of patience and giving enough time in care situations by being present and having a critical perspective of WT. The students were mostly negative towards their own ageing and could better relate to older persons´ vulnerability.ConclusionsAge suit simulation was described as an embodied and eye-opening experience, raising nursing students´ awareness of older persons´ functional limitations and the consequences for dignity and independence. Coping with cognitive loss was especially difficult. Students were motivated to apply their new knowledge to clinical practice. Age suit simulation can complement geriatric education, preparing students for the complex care needs of older persons.

How Old Are You in Chimpanzee Years?

It is fascinating to think about biology and behavior in humans and other animals. Chimpanzees are particularly interesting because they are humans’ closest living relatives. In this article, we will tell you about how humans grow up and age compared to chimpanzees, and how to calculate your age in chimpanzee years. Humans and chimpanzees are roughly similar in age after birth, but humans take a bit longer to mature and age. Also, some humans live much longer than chimpanzees do. This means many of us live long enough to interact with our grandchildren and also struggle with aging-related problems, but this is less the case for chimpanzees.

Degenerative disc disease: analysis of treatments, tissue, and market

The prevalence of intervertebral thinning discs and the degradation of spinal discs as a whole has created a new market and area of research to find a solution to this age-related problem. The loss of the cartilage cushioning two vertebrae is called degenerative disc disease, or DDD. DDD can impact a patient’s quality of life greatly – putting them in severe pain, limiting mobility, and decreasing their ability to perform daily activities. The market for DDD treatment shows promising growth, both globally and in the US. Most of the drugs and devices that are currently on the market aim to alleviate pain or reduce inflammation, addressing the symptoms of DDD rather than regenerating the lost disc tissue. However, there are many new treatments that are in development or are being tested in clinical trials that could satisfy this need. In the context of tissue engineering, regeneration of the intervertebral disc is a prime target. A scaffold could fulfill the need for mechanical support in between the vertebrae and growth factors and cells could stimulate the regrowth of the injured tissue.

Eight-year trends in cardio-vascular risk factors in people living with HIV: A plea for more person-centered care in an ageing population with high medical, nursing and social demands.

Background: The prognosis for people living with HIV (PLWHIV) has improved tremendously in the past years, and life expectancy in PLWHIV is almost the same as in the general population. HIV now is regarded as chronic condition, and as PLWHIV age, additional age-related problems emerge. These seem to occur more often and earlier compared to the general population, due to the virus itself, due to antiretroviral therapy, or due to lifestyle factors. Among these problems are biological factors such as chronic non-communicable diseases, other communicable diseases, and frailty, mental factors like common mental disorders and substance use, as well as social factors like stigma, discrimination, prejudices, work disability and unemployment, and having no partner. It was the aim of this study to monitor medical health burdens in a cohort of PLWHIW over time with an emphasis on cardio-vascular risk factors in order to design a comprehensive, integrated, person-centred care model around the antiretroviral therapy. The study was carried out by researchers and caregivers together with PLWHIV, and supported by a pharmaceutical company.
 Methods: PLWHIV participated in a baseline study (2013) in an HIV treatment centre and in a follow-up study (2021). At baseline the study population comprised of consecutive patients with HIV, who visited their treating physicians for routine checks. Inclusion criteria were age >= 18 years, documented HIV-Infection and written informed consent. Risk factors were recorded as either having a corresponding diagnosis in the patient´s charts OR being treated with specific drugs, OR having laboratory values outside the normal range. 
 Results: From the initially included 450 participants, 360 (80%) patients participated in the follow-up. The mean age at baseline was 41.4 years, 5.3% were female. 10.8% were affected by hypertension at baseline, and 19.6% at follow-up (P<0.001). Prevalence of type 2 diabetes mellitus was 3.1% at baseline and 5.3% at follow-up (P=0.039), and of dyslipidaemia 76.9% at baseline and 71.4% at follow-up (P=0.042). The proportion of smokers decreased from 42.6% a baseline to 37.1% a follow-up (P=0.007). Prevalence of overweight was 36.6% and of obesity 8.9% at follow-up (no baseline data available). 
 Learnings and next steps: PLWHIV have a high prevalence of cardio-vascular risk factors in an early age, which will increase health problems as this population is ageing. Most cardio-vascular risk factors increased rapidly in PLWHIV and therefore they are a major challenge for comprehensive and integrated care. As an important next step not only medical, but also psycho-social, sexual, spiritual and lifestyle-related health burdens as well as health resources need to be assessed and monitored to ensure care for PLWHIV is truly person-centered. Furthermore, PLWHIV want to be perceived as a partner in their treatment and this needs to become an integral part of routine care. 

Mitophagy Decreases in the Peripheral Vestibular System of Aged C57BL/6J Mice.

Mitophagy is a cardinal process for maintaining healthy and functional mitochondria. A decline in mitophagy has been associated with age-related pathologies. We aimed to investigate mitophagy changes in age-related balance problems using an animal model. C57BL/6J mice were divided into young (1 month old) and aged (12 months old) groups. Balance performance, mitochondrial DNA integrity, ATP content, mitophagic process, and mitophagy-related genes and proteins were investigated in both groups. Balance and motor performance were reduced in the aged group. Mitochondrial DNA integrity and ATP content, and mRNA levels of PINK1, Parkin, BNIP3, AMBRA1, MUL1, NIX, Bcl2-L-13, Atg3, Atg5, Atg12, and Atg13 in the vestibule were significantly lower in aged mice compared with those in young mice. The protein levels of PINK1, Parkin, BNIP3, LC3B, and OXPHOS subunits were significantly decreased in the aged vestibule. Mitophagosome and mitophagolysosome counts and the immunohistochemical expression of Parkin and BNIP3 were also decreased in the saccule, utricle, and crista ampullaris in the aged group. A general decrease in mitophagy with aging might be attributed to a decrease in cellular function in the aged vestibule during the development of age-related balance problems.

SIMULATION IN AGE SUIT: AN INNOVATIVE NURSING EDUCATION INTERVENTION TO INCREASE THE UNDERSTANDING OF OLDER ADULTS

Abstract Background Negative attitudes towards older adults are often recognized in society, especially among health care providers. Lack of education in gerontology and geriatrics and limited practical training in nursing education have been identified as influencing aspects. Simulation in education through age suit has been recognized to increase empathy and reduce negative attitudes towards older adults. An innovative education intervention with simulation in age suit with a follow up reflection seminar was developed to counteract ageism and increase the understanding of aging, age related health problems, older adults and to influence the willingness to provide care to older adults. Methods The intervention with simulation in age suit, grounded in the pedagogy experiential learning, was implemented in the fourth semester in the three-year nursing education program. The simulation was conducted in a highly accessible home environment equipped with welfare technology and other technical aids. The nursing students were assigned a persona, a person with different health problems, and performed scenarios consisting of daily chores. Research on nurses’ experiences of the intervention and its sustainability through the education program and on perceptions of providing care for older adults, is conducted qualitatively and quantitatively in a doctoral project. Conclusion The learning acquainted through simulation in age suit became embodied both physically and psychologically. The simulation in age suit conveyed new insights as need of time and patience. The technology in the environment both hindered and facilitated activities in daily life. Implications suggested the need for all health and social care providers to carry out this simulation.

Hexahydrocurcumin Attenuates Neuronal Injury and Modulates Synaptic Plasticity in Chronic Cerebral Hypoperfusion in Rats.

Dementia is the most common age-related problem due predominantly to Alzheimer's disease (AD) and vascular dementia (VaD). It has been shown that these contributors are associated with a high amount of oxidative stress that leads to changes in neurological function and cognitive impairment. The aim of study was to explore the mechanism by which hexahydrocurcumin (HHC) attenuates oxidative stress, amyloidogenesis, phosphorylated Tau (pTau) expression, neuron synaptic function, and cognitive impairment and also the potential mechanisms involved in induced permanent occlusion of bilateral common carotid arteries occlusion (BCCAO) or 2-vessel occlusion (2VO) in rats. After surgery, rats were treated with HHC (40mg/kg) or piracetam (600mg/kg) by oral gavage daily for 4weeks. The results showed that HHC or piracetam attenuated oxidative stress by promoting nuclear factor erythroid 2-related factor 2 (Nrf2) activity, and alleviated expression of synaptic proteins (pre- and post-synaptic proteins) mediated by the Wingless/Integrated (Wnt)/β-catenin signaling pathway. Moreover, HHC or piracetam also improved synaptic plasticity via the brain-derived neurotrophic factor (BDNF)/Tyrosine receptor kinase B (TrkB)/cAMP responsive element binding protein (CREB) signaling pathway. In addition, HHC reduced amyloid beta (Aβ) production and pTau expression and improved memory impairment as evidenced by the Morris water maze. In conclusion, HHC exerted remarkable improvement in cognitive function in the 2VO rats possibly via the attenuation of oxidative stress, improvement in synaptic function, attenuation of amyloidogenesis, pTau, and neuronal injury, thereby improving cognitive performance.

Age Related Dental Problems

AIM: The aim is to make a survey on age related dental problems. OBJECTIVE : The purpose of this study is know how the aging develops different dental abnormalities. Mastication, tongue mobility, and lip closure and skills of the oral phase of ingestion and have been shown to deteriorate with age MATERIALS AND METHODS: The sample size for this study includes about 100 participants. Questionnaire were created by using survey planet software and all the were compiled for statistical analysis. RESULTS: The purpose of this study is to know how aging develops different dental abnormalities

Coenzyme q10 in cardiovascular disease: an insight for a potential therapeutic benefit

The human body synthesizes the provitamin coenzyme Q10 (CoQ10), which plays a crucial role in the electron transport chain by ensuring a consistent and sufficient energy supply. CoQ10 exhibits multiple cellular roles, including its involvement in mitochondrial function, numerous cellular compartments, and plasma lipoproteins. Furthermore, CoQ10 plays a crucial role as an important antioxidant. The chemical composition of CoQ10 exhibits a strong correlation with vitamin K. It consists of a benzoquinone ring serving as the head group, accompanied by a tail made of ten isoprene units. A lack of CoQ10 has been identified as a fundamental factor contributing to numerous age-related and chronic illness problems. The efficacy of CoQ10 in various medical conditions has been proved by empirical evidence. Numerous research trials are now investigating the therapeutic and nutritional potential of CoQ10. CoQ10 continues to be predominantly utilized in the realm of cardiac research and reproductive treatments. However, there has been a notable surge of interest in exploring novel applications, notably in the context of topical administration.

Frailty phenotype and cognitive functioning in middle-aged and older adults with congenital heart disease: results of an international multicentric study

Abstract Background The life expectancy of patients with congenital heart disease (CHD) has increased rapidly, resulting in a growing and aging population. Recent studies showed that older CHD patients have a higher morbidity, healthcare utilization, and mortality. Furthermore, many will encounter a state of frailty. To maintain longevity and quality of life, understanding the evolving medical and psychosocial challenges of older patients is important to enable the mapping of specific healthcare needs. There are indications that, independent of age and comorbidity, the frailty phenotype can guide risk prediction in chronically ill patients. However, current knowledge on frailty phenotype and cognitive function of older CHD patients is limited. Purpose This study aimed (i) to describe the frailty and cognitive profile of older adults with mild to complex CHD, and (ii) to investigate the relationship with patient-related factors (e.g., age, complexity of CHD and physiological stage). Methods Using a cross-sectional, multicentric design, we included 814 patients aged ≥ 40 years (median age: 52y [45.0-61.0]; 52% women; 13% mild, 70% moderate, 17% complex CHD) from 17 centers in 11 countries. The frailty phenotype was determined using the Fried method, which classifies patients as robust, prefrail and frail based on five criteria: weakness; slow walking speed; unintentional weight loss; exhaustion; and low physical activity. Cognitive function was evaluated using the Montréal Cognitive Assessment (MoCA). Comorbidities were assessed using the Charlson Comorbidity Index (CCI). Results In this sample, 52% of patients were assessed as robust, 42% prefrail, and 6% frail. Based on the MoCA, 39% had cognitive dysfunction. A weak negative correlation was found between frailty and cognitive functioning (rho=-0.210, p<0.001). Multinomial regression showed that prefrail and frail status was associated with older age, female sex, higher physiological class, and comorbidities (Table 1). Logistic regression demonstrated that cognitive dysfunction was related to older age and comorbidities. Conclusion Approximately half of the sample of CHD patients were (pre)frail and almost two out of five experienced cognitive impairment. These age-related problems were not related to the anatomical complexity of the heart condition, indicating that these issues are not limited to severe CHD. Future research is needed to determine the impact of these findings on healthcare use.

THE IMPACT OF AGE ON OUTCOMES OF CORONARY ARTERY BYPASS GRAFTING

As people live longer, the number of individuals aged 75 and above is increasing. This makes it crucial to provide careful medical care for elderly cardiac patients. Our study was conducted at the Punjab Institute of Cardiology and involved 300 patients divided into three age groups: those under 60, those between 60-75, and those over 75. Participants had no history of cardiac surgery. We documented preoperative demographics and other relevant variables and then analyzed post-operative data concerning complications and other variables separately for each age group. Our research revealed a significant association between age and 30-day mortality (p < 0.001), with a 2.5% incidence of 30-day mortality observed among those over 75 years old. We also found that re-intubation, dialysis, extended ICU stays, and atrial fibrillation occurred more frequently in the over-75 age group compared to other age groups (P < 0.001). Our findings highlight the significant impact of age on mortality after cardiac surgery, as well as the heightened likelihood of complications in elderly individuals. Therefore, it is essential to carefully consider age-related organ abnormalities and the increasing burden of age-related health problems when managing elderly patients who undergo cardiac surgery. These insights suggest a need for personalized strategies to address the unique challenges posed by advanced age in the context of cardiac surgical procedures.

Deep Learning Techniques for Radar-Based Continuous Human Activity Recognition

Human capability to perform routine tasks declines with age and age-related problems. Remote human activity recognition (HAR) is beneficial for regular monitoring of the elderly population. This paper addresses the problem of the continuous detection of daily human activities using a mm-wave Doppler radar. In this study, two strategies have been employed: the first method uses un-equalized series of activities, whereas the second method utilizes a gradient-based strategy for equalization of the series of activities. The dynamic time warping (DTW) algorithm and Long Short-term Memory (LSTM) techniques have been implemented for the classification of un-equalized and equalized series of activities, respectively. The input for DTW was provided using three strategies. The first approach uses the pixel-level data of frames (UnSup-PLevel). In the other two strategies, a convolutional variational autoencoder (CVAE) is used to extract Un-Supervised Encoded features (UnSup-EnLevel) and Supervised Encoded features (Sup-EnLevel) from the series of Doppler frames. The second approach for equalized data series involves the application of four distinct feature extraction methods: i.e., convolutional neural networks (CNN), supervised and unsupervised CVAE, and principal component Analysis (PCA). The extracted features were considered as an input to the LSTM. This paper presents a comparative analysis of a novel supervised feature extraction pipeline, employing Sup-ENLevel-DTW and Sup-EnLevel-LSTM, against several state-of-the-art unsupervised methods, including UnSUp-EnLevel-DTW, UnSup-EnLevel-LSTM, CNN-LSTM, and PCA-LSTM. The results demonstrate the superiority of the Sup-EnLevel-LSTM strategy. However, the UnSup-PLevel strategy worked surprisingly well without using annotations and frame equalization.

The Ageing Foot.

Feet suffer significant stress throughout a lifetime and undergo ageing-associated problems due to gradual tissue degeneration affecting the skin, connective tissue, and nerves. Oxygen supply to the tissues may be diminished. The skin gets dry and calluses, ulcers and fungal infections of the skin and nails are not uncommon. Ligaments and tendons degenerate and, without proper prevention, deformities including claw toes, hammer toes, tendonitis, and bursitis may occur. Skeletal toe deformities such as bunions, bony spurs, and hallux valgus may increase discomfort, while stress fractures may have an adverse impact on the patients' quality of life. The ageing foot pathology may add up to common age-related problems, such as crystal deposition arthropathies, diabetes mellitus, peripheral circulatory disorders, and peripheral edema, increasing morbidity. This review summarizes ageing-related feet problems, focusing on prevention and treatment. Foot health has a paramount role in overall wellbeing, therefore prevention, proper foot care, and prompt diagnosis and management of ageing-related changes are vital for maintaining a healthy, active status.

Serum Trimethylamine N-Oxide Level Is Positively Associated with Aortic Stiffness Measured by Carotid-Femoral Pulse Wave Velocity in Patients Undergoing Maintenance Hemodialysis.

Trimethylamine N-oxide (TMAO) is a biomarker that is effective in predicting major adverse cardiovascular (CV) events. Age-related vascular problems are significantly affected by aortic stiffness (AS), which is independently linked to CV morbidity and mortality. This study aimed to determine the association between serum TMAO levels and carotid-femoral pulse wave velocity (cfPWV) in patients receiving hemodialysis (HD) therapy. In total, 115 patients with HD were enrolled in this study. The AS group included patients whose cfPWV was >10 m/s. Using high-performance liquid chromatography and mass spectrometry, the levels of serum TMAO were measured. The AS group included 42 (36.5%) patients, and compared with the non-AS group, the rates of diabetes, hypertension, older age, systolic blood pressure, serum glucose, and TMAO levels were high. In the multivariate logistic regression analysis, serum TMAO and age were independently linked with AS after correcting for the factors significantly associated with AS. Following multivariate stepwise linear regression analysis, serum TMAO in these individuals was found to be strongly correlated with cfPWV values (p < 0.001). In patients on chronic HD, serum TMAO level is an independent measure of AS and strongly correlated with cfPWV.

Diagnostic Sensitivity and Specificity of Cognitive Tests for Mild Cognitive Impairment and Alzheimer's Disease in Patients with Down Syndrome: A Systematic Review and Meta-Analysis.

Improved health care for people with Down syndrome (DS) has resulted in an increase in their life expectancy therefore increasing comorbidities associated with age-related problems in this population, the most frequent being Alzheimer's disease (AD). To date, several cognitive tests have been developed to evaluate cognitive changes related to the development of mild cognitive impairment (MCI) and AD in people with DS. Identify and evaluate available cognitive tests for the diagnosis of MCI and AD in people with DS. A systematic search of the Pubmed and PsycInfo databases was performed to identify articles published from January 1, 2000 and July 1, 2022. Keysearch terms were DS, AD or MCI, cognition, and assessment. Relevant studies assessing the diagnostic accuracy of cognitive tests for AD or MCI with standard clinical evaluation were extracted. Risk of bias was assessed using the QUADAS 2. We identified 15 batteries, 2 intelligence scales, 14 memory tests, 11 executive, functioning tests, 11 motor and visuospatial functioning tests, 5 language tests, 3 attention tests, and 2 orientation tests. Analysis showed that the CAMCOG-DS present a fair to excellent diagnostic accuracy for detecting AD in patients with DS. However, for the diagnosis of MCI, this battery showed poor to good diagnostic accuracy. The findings highlight important limitations of the current assessment available for the screening of mild cognitive impairment and AD in patients with DS and support the need for more clinical trials to ensure better screening for this highly at-risk population.

Exploring the Future Design Approach to Ageing Based on the Double Diamond Model

As the global trend of aging continues to intensify, there will inevitably be more complex and diverse aging-related problems. Designers have a responsibility to explore the possible outcomes of the future and solve the ageing-related problems that will be faced in the future. Based on the Future Cone, the Double Diamond Model and the IDEO Method Cards, this study proposes a new model to guide the design practice of future aging issues in the context of aging. With the aim of validating and refining the framework, an ageing designer workshop was held, in which participants were asked to imagine, explore and express ideas about future ageing-related issues. The workshop was used to refine the proposed model. Specifically, the model includes a future concept, a design guidance process based on the Double Diamond Model, and tools that can be applied at all stages of design, which can help designers to generate ideas and solutions for future aging problems, as well as collectively lead society toward a more desirable future. Moreover, this study explores broader directions for the development of the model and provides a reference for continued research into this topic in the future.

THE AGE PROBLEM OF IDENTIFICATION AT THE “PERSONALITY - SOCIETY” LEVEL AMONG 19-21-YEAR-OLD WOMEN

The authors of the paper consider the age-related problems of personality identification among 19-21-year-old women at the level of “personality - society”. The paper describes the application of the author’s questionnaire, which was formulated a few years before within the Bachelor degree programme. The authors investigated the phenomenon of spirituality and considered it as a synonym of psychological maturity. The investigation revealed 19 criteria of spirituality, which 44 Научное мнение № 1-2 (2023) were formalised as a questionnaire. The current research describes the difficulties in the application of the questionnaire. The respondents expressed a lack of understanding of individual questions and suggested their wishes for new wording and clarification of questions in the questionnaire. The questionnaire was modified based on the feedback from the sample and was re-applied to the new sample. The results were recorded and analysed. Among those interviewed, a group of female students aged 19 to 21 was identified. The answers of this group were summarised in the form of diagrams, which revealed some features that seemed interesting to the authors as research material within age psychology. The conclusions of this analysis are presented in the paper.

Understanding skin aging: Exploring anti-aging modalities

With ever-improving life expectancy, skin aging has become the first casualty of exuberant health. People are progressively seeking remedies for their age-related skin problems. Understanding the aging process is unfolding newer realms in the molecular biology of the skin, giving us new insights to combat senescence more effectively. Epidermal dysfunction, compromised permeability homeostasis, elevated skin pH, diminished stratum corneum hydration, and dermal extracellular matrix aberrations with changes in its cellular composition are now well understood. Thus, a more scientific approach can be utilized while evolving various specific anti-aging therapies. The present communication attempts to address both the process of skin aging and various therapies to combat it in a concise yet succinct way.

Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants

ABSTRACT Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders and mortality. Further, maternal PTSD is associated with gestational epigenetic age acceleration in newborns, implicating the prenatal period as a developmental time period for the transmission of effects across generations. Here, we evaluated the associations between PTSD symptoms, maternal epigenetic age acceleration, and infant gestational epigenetic age acceleration in 89 maternal-neonatal dyads. Trauma-related experiences and PTSD symptoms in mothers were assessed during the third trimester of pregnancy. The MethylationEPIC array was used to generate DNA methylation data from maternal and neonatal saliva samples collected within 24 h of infant birth. Maternal epigenetic age acceleration was calculated using Horvath’s multi-tissue clock, PhenoAge and GrimAge. Gestational epigenetic age was estimated using the Haftorn clock. Maternal cumulative past-year stress (GrimAge: p = 3.23e-04, PhenoAge: p = 9.92e-03), PTSD symptoms (GrimAge: p = 0.019), and difficulties in emotion regulation (GrimAge: p = 0.028) were associated with accelerated epigenetic age in mothers. Maternal PTSD symptoms were associated with lower gestational epigenetic age acceleration in neonates (p = 0.032). Overall, our results suggest that maternal cumulative past-year stress exposure and trauma-related symptoms may increase the risk for age-related problems in mothers and developmental problems in their newborns.