Elderly Individuals Research Articles

Self-assessment of health in the elderly population

The objective of the study was to evaluate the Self-Assessment of Health (SAH) in elderly individuals before and after participating in a physical exercise program. It was a quasi-experimental study conducted with 96 elderly participants ( = 67 ± 6.07 years) enrolled in a 16-week physical exercise program. Before and after the program, participants filled out a medical history form and the Short Form 36 Health Survey Questionnaire (SF-36). The study found a prevalence of obesity (75.6%), with the predominant health conditions being hypertension (27.08% of the sample) and diabetes (5.21%), while 7.29% reported having both conditions. A notable enhancement in SAH was observed following the completion of the exercise program, both in terms of physical health (∆%= 3.75%, p = 0.0002), mental health (∆%= 17.95%, p = 0.004), and the overall SAH index (∆%= 6.75%, p = 0.001). This suggests the importance of physical exercise programs for the self-assessment of health in elderly individuals.

Exploring the nexus of functional autonomy, depression, and resilience among elderly individuals

Population aging is a global reality that presents challenges to society. Issues such as functional autonomy, depression, and resilience stand out in promoting healthy aging. Functional autonomy, essential for independent daily activities, can be affected by depression, a common issue among the elderly, impairing motivation. Resilience, which is crucial for facing adversities, also influences well-being. The proposed study investigates the relationship among these factors in the elderly population, utilizing an interdisciplinary approach and quantitative methodology. The study's population comprises elderly individuals receiving care in Basic Health Units. Preliminary results indicate a good level of functional autonomy in the sample and associate depression with resilience. The research aims to promote effective interventions for quality of life and to comprehend the interconnection of these factors, thereby promoting healthy aging.

Clinical-functional vulnerability index in elderly individuals participating in a supervised physical exercise program

The article aimed to assess the clinical-functional vulnerability index (CFVI) of elderly individuals participating in a supervised physical exercise program (SPEP) lasting 16 weeks. A total of 105 volunteers (X̅ = 67 ± 6.50 years) participated in the study, and they were assessed using the CFVI-20 instrument before and after the 16-week intervention with SPEP. A reduction in CFVI was observed (∆% = -7.30%), but it remained in the Moderate Risk range (7 to 14). Reductions were noted in mobility subfacets (∆% = -100%), highlighting a decrease in frailty concerning reach, grip, pinch, aerobic and/or muscular capacity, gait, and sphincteric continence. This resulted in an increase in the Robust classification (∆% = 16.25%) and a decrease in the Risk (∆% = -13.60%) and Fragile (∆% = -24.21%) classifications. The findings indicate the importance of SPEP for health and reducing public spending on elderly individuals.

Cardiac risk in elderly individuals attended by basic health units

The objective was to assess the cardiac risk of elderly individuals attending Basic Health Units (UBS) in the North and South zones of Aracaju, SE. To achieve this objective, the study employed the Framingham Risk Score, which takes into account multiple cardiovascular risk factors, including age, blood pressure, heart rate, cholesterol levels, body composition, and other pertinent indicators. It's worth noting that some of these factors can be modified, while others cannot. A total of 76 elderly individuals participated in the study ( = 67 ± 6.07 years). The highest mean values for cardiovascular risk factors were found for total cholesterol ( = 199.10 ± 43.57 mg/dL) and low density lipoprotein ( = 129.57 ± 34.85 mg/dL), followed by the systolic blood pressure ( = 124.8 ± 19.88 bpm). The cardiovascular risk of the sample group was characterized as high ( = 0.29% ± 1.5%). Furthermore, the mentioned percentage delta reflects the change in value over a specific period, providing insights into relative changes in a dynamic context. The outcome of this study was a comprehensive assessment of the cardiac risk in these UBS attendees, contributing to the understanding and appropriate treatment of cardiovascular conditions in this population.

Functional autonomy of elderly individuals participating in a supervised physical exercise program

This study aims to identify the effect of a supervised physical exercise program on the levels of functional autonomy (FA) in elderly individuals. It was conducted as a quasi-experimental study. In the diagnostic assessment, data on Functional Autonomy were collected using the protocol of the Latin American Development Group for Maturity (GDLAM). The 66 elderly women (X̅ = 67.11 ± 5.75 years) in the sample group underwent 16 weeks of muscular strength and flexibility training, followed by a summative assessment. A reduction in the times of all battery tests was observed: W10M (∆% = -8.40%), RSP (∆% = -16.44%), RVDP(∆% = -2.01%), SRWC (∆% = -5.34%), and PTTs (∆% = -19.73%), indicating an improvement in FA (∆% = -11.39%, p < 0.001). Analyzing the study's results, it is evident that, following the intervention, a significant improvement in the average classification of the sample group occurred. The initial AI score would have fallen within the regular classification in the diagnostic evaluation (28.11 - 33.71), with an average of 31.07. However, after the intervention, a reduction in the time taken to complete the activities led to a shift to the good qualification range (22.82 - 28.10), with an average summative AI assessment of 27.53. The study confirms the enhancement of FA in elderly individuals participating in a physical exercise program.

Sarcopenia and dinapenia in elderly individuals participating in a supervised exercise program

This study assessed the effects of a supervised exercise program on the prevention of sarcopenia and dynapenia in the elderly. 90 elderly individuals ( = 67.40 ± 6.59 years) from Primary Health Care, most of whom had chronic diseases and were on medication, participated in the study. They underwent assessments of calf circumference (CC) and muscle strength (MS) before and after 16 weeks of training in four experimental groups, with two one-hour sessions per week. Additionally, sociodemographic data were collected. The results revealed significant gains in CC (∆% = 3.94, p = 0.003) and MS (∆% = 23.54, p = 0.0034) after the program. These findings highlight the effectiveness of an MS training program in preventing sarcopenia and dynapenia. It can be concluded that regular physical exercise plays a significant role in improving the health and quality of life of older individuals.

Depression in elderly individuals in physical exercise program

In contemporary society, population aging has become an increasingly relevant and complex reality. The care for the mental well-being of this population has become a priority in healthcare, in order to prevent the development of diseases such as depression. One of the tools used in mental health care is physical exercise, and this study aims to assess the influence of this type of activity on the levels of depression in the elderly in a city in Brazil. The research utilized a quasi-experimental methodology to examine the impacts of a physical fitness program on senior citizens served by the Basic Health Units of Aracaju, lasting for 16 weeks. The sample included 92 elderly participants (mean age: 68.24 ± 5.84), with a higher proportion of females (83.69%). The exercise program was supervised and personalized, with a focus on intensity controlled by perceived effort.The tool suggested by the Center for Epidemiologic Studies Depression Scale was employed to evaluate signs of depression prior to and following the intervention. The results revealed a reduction in depression levels (∆% = -1.64%, p = 0.0032). It is concluded that the exercise program had a beneficial effect on the depressive symptoms of the elderly, highlighting its relevance as a complementary intervention in improving mental health in this population.The results underscore the significance of physical exercise in enhancing the psychological well-being of elderly individuals receiving care in primary healthcare settings.

Factors Related to Caregivers' Intention to Vaccinate Their Elderly Family Members with Major Neurocognitive Disorders against COVID-19.

Vaccination helps reduce the risk of coronavirus disease 2019 (COVID-19) infection in elderly individuals with major neurocognitive disorders (MNDs). However, some caregivers are hesitant to have their elderly family members with MNDs vaccinated against COVID-19. This study explored the factors influencing caregivers' intentions to vaccinate elderly family members with MNDs against COVID-19. A total of 232 caregivers of elderly family members with MNDs participated in this study. In this survey, data regarding COVID-19 vaccination acceptance, fear, side effects, family members' attitudes toward vaccination, mental health status, neuropsychiatric symptoms, and cognitive impairments were collected from the elderly participants with MNDs. The associations between these variables and the caregivers' intention to vaccinate their elderly family members with MNDs against COVID-19 were examined using a multivariable linear regression analysis model. The results revealed that caregivers' perceived familial support for vaccination, the perceived value of vaccination, and autonomy to vaccinate elder family members were positively correlated with caregivers' intention to vaccinate elderly family members with MNDs, whereas elderly family members' age was negatively correlated with caregiver intentions. This study demonstrated that caregiver factors (perceived familial support, value of vaccination, and autonomy) and elderly family members' age were correlated with caregiver intention. These factors should be considered in developing interventions to enhance caregivers' intentions to vaccinate their elderly family members with MNDs against COVID-19.

The Effect of Family Social Support, Physical Health, and Religiosity on the Quality of Life and Happiness of the Elderly in Tabanan Regency

This research aimed to explore the impact of family social support, physical health, and religiosity on the quality of life and happiness among elderly individuals in Tabanan Regency. Employing both quantitative and qualitative approaches, primary and secondary data were collected using a questionnaire as the main instrument. Structural Equation Modeling (SEM) was utilised in order to test the research hypotheses. The study utilised a non-probability sampling method employing accidental sampling to gather data from a cohort of 203 elderly individuals aged 60 years and older residing in Tabanan Regency. The independent variables were family social support, physical health, and religiosity, with quality of life serving as the mediating variable, and happiness as the dependent variable. Descriptive statistical techniques and differential analysis were applied to examine the relationships among these variables. The results revealed that family social support significantly influenced the quality of life and happiness of the elderly. Physical health also positively contributed to both quality of life and happiness. While religiosity has a significant relationship with the quality of life and happiness of the elderly, its impact is less pronounced compared to the other factors. The scientific novelty of this research stems from its integrated approach in analysing multidimensional factors - family social support, physical health, and religiosity - and their collective impact, thereby offering fresh perspectives on the mediating role of quality of life. Practically, the study offers valuable information for policymakers and practitioners to develop targeted interventions that enhance elderly well-being. The use of SEM further provides a robust methodological framework for future research.

Financial Policies for Single-Person Household Housing in South Korea

We investigated the determinants of awareness, utilization, and satisfaction regarding financial aid programs for single-person households in South Korea and proposed policy enhancements. Our analysis employed logistic regression on microdata from the “2020 Housing Survey” by Statistics Korea, covering the nation and all age groups. We categorized single-person household traits affecting program awareness, utilization, and satisfaction into demographic, socio-economic, housing, and housing perception factors. The dependent variables included awareness, utilization status, and satisfaction levels of government-sponsored financial support programs, which were measured on a four-point Likert scale. The independent variables encompassed demographic, socio-economic, and housing characteristics, which were analyzed comprehensively. We identified factors that influenced awareness, utilization, and satisfaction and recommended tailored policy measures. The findings revealed lower awareness among elderly individuals, women, rural residents, and rental households. Moreover, older age, lower income, rental, and one-room dwelling households exhibited lower utilization rates, with decreased housing and residential environment satisfaction correlating with diminished program satisfaction. Due to the diverse characteristics of single-person households, strategic interventions are crucial. Measures to bridge information gaps, establish comprehensive long-term support systems, and develop differentiated policies tailored to single-person household traits are imperative for improving financial aid programs for this demographic.

Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9.

Aging contributes significantly to cardiovascular diseases and cardiac dysfunction, leading to the upregulation of matrix metalloproteinase-9 (MMP-9) in the heart and a significant decrease in hydrogen sulfide (H2S) content, coupled with impaired cardiac diastolic function. This study explores whether supplementing exogenous hydrogen sulfide during aging ameliorates the decline in H2S concentration in the heart, suppresses MMP-9 expression, and improves the age-associated impairment in cardiac morphology and function. We collected plasma from healthy individuals of different ages to determine the relationship between aging and H2S and MMP-9 levels through Elisa detection and liquid chromatography-tandem mass spectrometry (LC/MC) detection of plasma H2S content. Three-month-old mice were selected as the young group, while 18-month-old mice were selected as the old group, and sodium hydrosulfide (NaHS) was injected intraperitoneally from 15 months old until 18 months old as the old + NaHS group. Plasma MMP-9 content was detected using Elisa, plasma H2S content, cardiac H2S content, and cystathionine gamma-lyase (CSE) activity were detected using LC/MC, and cardiac function was detected using echocardiography. Heart structure was assessed using hematoxylin and eosin staining, Masone staining was used to detect the degree of cardiac fibrosis, while western blot was used to detect the expression of MMP-9, CSE, and aging marker proteins. Knockdown of MMP-9 and CSE in H9c2 cells using small interfering RNA was carried out to determine the upstream-downstream relationship between MMP-9 and CSE. H2S content in the plasma of healthy individuals decreases with escalating age, whereas MMP-9 level rises with age progression. Aging leads to a decrease in H2S levels in the heart and plasma of mice, severe impairment of cardiac diastolic function, interstitial relaxation, and fibrosis of the heart. Supplementing with exogenous H2S can improve these phenomena. H2S maintains the structure and function of the heart by inhibiting the expression of MMP-9 during the aging process.

(129) WOMEN WHO REPORT PAIN WITH SEX HAVE VARYING MICROBIOME PROFILES BASED ON AGE

Abstract Introduction Even though the vaginal microbiome (VM) is a known contributor to vaginal epithelial health, the VM of women who report pain with sex has not been characterized. It is known that the VM shifts during menopause, therefore we segmented out analysis based on menopausal status. Objective An observational analysis comparing the vaginal microbiome composition and symptom profiles in individuals of both menopausal and reproductive age who experience moderate to severe pain with sex and those that do not report pain with sex. Methods This study involved the collection of self-reported health profiles and shotgun metagenomic analysis of vaginal samples from two distinct demographic groups: menopausal women and women of reproductive age (defined as non-pregnant, non-menopausal, and aged under 40 years). The focus was on identifying the microbial composition in individuals experiencing moderate to severe sexual intercourse pain and those without any reported pain, excluding samples from individuals with mild pain. An additional criterion for inclusion was a reported history of sexual activity within the preceding 30 days. The menopausal group comprised 157 individuals reporting pain and 367 individuals without pain. In the reproductive age cohort, there were 968 participants with pain and 968 age-matched controls without pain. Statistical analysis between the pain and control groups in both cohorts revealed no significant differences in body mass index (BMI, menopause p = 0.74, reproductive p = 0.19), reported hormone use (menopause p = 0.2, reproductive p = 0.24), or history of previous infections (menopause p = 0.29, reproductive p = 0.09). Results In both the menopausal and reproductive-aged cohorts, individuals experiencing pain during sexual intercourse exhibited a higher prevalence of symptomatic conditions, as illustrated in Figure 1 A & B. Reported symptoms included increased severity of burning, itchiness, vaginal and vulvar pain, erythema, dysuria, and vaginal dryness. A significant correlation was observed between these enhanced symptomatology and variations in vaginal microbiome compositions among the menopausal group, as depicted in Figure 2 A & B. Specifically, pain during sexual intercourse in menopausal women was linked to elevated vaginal microbiota (VM) diversity (p=0.047) and a reduction in lactobacilli levels (p=0.06). Conversely, in the reproductive-aged cohort, a higher VM diversity was noted in the control group (p=0.014), with no significant differences in Lactobacillus or Gardnerella concentrations between those experiencing pain and the control group. Conclusions Preliminary examination of the vaginal microbiome in women who self-report moderate to severe pain with sex reveals significant differences, particularly in menopausal women experiencing pain. These individuals exhibited a more diverse vaginal microbiome and lower levels of Lactobacillus. This study underscores the need for further research to explore the potential of targeted microbiome modifications as a therapeutic approach to alleviate pain symptoms in this demographic. Disclosure Yes, this is sponsored by industry/sponsor: Evvy. Clarification: Industry initiated, executed and funded study. Any of the authors act as a consultant, employee or shareholder of an industry for: Evvy.

Predicting brain age across the adult lifespan with spontaneous oscillations and functional coupling in resting brain networks captured with magnetoencephalography

Abstract The functional repertoire of the human brain changes dramatically throughout the developmental trajectories of early life and even all the way throughout the adult lifespan into older age. Capturing this arc is important to understand healthy brain ageing, and conversely, how injury and diseased states can lead to accelerated brain ageing. Regression modelling using lifespan imaging data can reliably predict an individual’s brain age based on expected arcs of ageing. One feature of brain function that is important in this respect, and understudied to date, is neural oscillations—the rhythmic fluctuations of brain activity that index neural cell assemblies and their functioning, as well as coordinating information flow around networks. Here, we analysed resting-state magnetoencephalography (MEG) recordings from 367 healthy participants aged 18 to 83, using two distinct statistical approaches to link neural oscillations and functional coupling with that of healthy ageing. Spectral power and leakage-corrected amplitude envelope correlations were calculated for each canonical frequency band from delta through gamma ranges. Spatially and spectrally consistent associations between healthy ageing and neurophysiological features were found across the applied methods, showing differential effects on neural oscillations, with decreasing amplitude of low frequencies throughout the adult lifespan, and increasing high-frequency amplitude. Functional connectivity within and between resting-state brain networks mediated by alpha coupling generally decreased throughout adulthood and increased in the beta band. Predictive modelling of brain age via regression showed an age-dependent prediction bias, resulting in overestimating the age of younger people (<40 years old) and underestimating the age of older individuals. These findings evidence strong age-related neurophysiological changes in oscillatory activity and functional networks of the brain as measured by resting-state MEG and that cortical oscillations are moderately reliable markers for predictive modelling. For researchers in the field of predictive brain age modelling with neurophysiological data, we recommend attention is paid to predictive biases for younger and older age ranges and consider using specific models for different age brackets. Nevertheless, these results suggest brain age prediction from MEG data can be used to model arcs of ageing throughout the adult lifespan and predict accelerated ageing in pathological brain states.

Polypharmacy, drug interactions, and iatrogenesis

This study aimed to comprehensively address therapeutic challenges in medication use among the elderly. The research utilized the Medication Use Instrument within the Falls Risk Assessment Battery (BARQ) to collect and analyze data on medication consumption. Sixty-three elderly individuals (X̅ = 67.40 ± 6.62 years) participated in the research. Results revealed that 20.63% were at high risk (score > 11), 3.17% at moderate risk (score 8-10), 15.89% at elevated risk (score 5-7), and 60.31% at low risk (score 0-4) of iatrogenic effects. Notably, a 16-week personalized exercise program led to a significant reduction in medication consumption, resulting in a decrease in high-risk participants (% = -75.39). In conclusion, this research highlights polypharmacy issues and associated complications in the elderly, emphasizing the potential for iatrogenic harm. Exercise programs show promise in mitigating these risks by reducing medication dependency and promoting overall well-being.

Sociodemographic profile, nutritional status and physical activity level of elderly people participating in a physical exercise program

To analyze the sociodemographic profile, nutritional status, and physical activity (PA) level of older people participating in a physical exercise program. 64 seniors (= 71.04±6.86 years) from the Academia Carioca Program, evaluated by anamnesis, International Physical Activity Questionnaires (IPAQ), modified Baecke for seniors, and body mass index (BMI). The group showed prevalence of 81.15% female, 34.38% with incomplete primary education, 64.06% taking care of the house/family, 42.20% divorced/widowed, 53.12% with income up to two minimum wages, 84.38% with preexisting diseases, 75.00% with a family history of diseases, 96.87% non-smokers, 67.19% do not drink. The Baecke score was = 17.83±5.24 (significant level of PA). According to the IPAQ, 70.30% were active. BMI was = 29.27±4.39kg/m2 (overweight). Despite the participants presenting themselves as active, the verified BMI is still in the overweight range, demonstrating that PA is insufficient to regularize the BMI values of elderly individuals.

Epidemiological analysis of cardiac risk factors in elderly people

This study analyzed cardiac risk factors found in older adults, highlighting the increased incidence of cardiovascular diseases with advancing age. A total of 372 elderly individuals were evaluated at Basic Health Units, and divided into sedentary and active groups. Research emphasized the importance of physical activity in reducing cardiovascular risk, using the Framingham Score to identify high cardiovascular risk and to guide interventions. The sociodemographic analysis included age group, ethnicity, marital status, education, income, and family history of diseases. Bayesian inferences were conducted to assess the number of simultaneous changes in variables and calculate the proportion of individuals with potential cardiac risk. The final conclusion of Bayesian inferences indicates that approximately 29.0% of individuals in the sample may bear potential cardiovascular risk due to two or more alterations in the evaluated variables.

Impact of a supervised exercise program on the quality of life of elderly individuals

The study aimed to assess the impact of a supervised strength exercise program on the quality of life (QoL) of elderly individuals. The experimental group consisted of 92 elderly people of both genders (mean age = 67 ± 6.07 years), who participated in a supervised physical exercise program. All participants completed a medical history questionnaire, the Revised Physical Activity Readiness Questionnaire (rPAR-Q) to ensure the physical well-being of the participants, and the World Health Organization Quality of Life (WHOQOL-OLD) before (pre-training) and after (post-training) the exercise program. The results showed that the QoL of the study participants was characterized as "High" (mean = 17.81 ± 2.17) in the pre-training assessment, increasing by 4.8% (p = 0.003) in the post-training assessment (mean = 18.66 ± 1.67). The outcome of this study allows us to conclude that participating in a supervised strength exercise program has a positive impact on the quality of life of elderly individuals.

The relationship between spiritual well-being and surgical fear in elderly patients with gonarthrosis.

Gonarthrosis is a chronic degenerative joint disease characterised by prolonged pain, affecting ~10% of men and 18% of women aged 60 and older worldwide. Surgical interventions are commonly employed in patients with gonarthrosis to minimise disability, alleviate pain, and improve overall quality of life. However, surgical treatment remains a feared experience. This study was conducted to identify the levels of spiritual well-being and surgical anxiety in elderly patients diagnosed with gonarthrosis who are scheduled for surgical intervention. The aim was to examine the relationship between these factors and identify influencing elements. This descriptive and correlational study was conducted between September 2022 and June 2023 in the orthopaedics and traumatology service of a state hospital, involving 105 patients aged 65 and above with gonarthrosis and admitted for treatment. Data were collected using the Personal Information Form, Surgical Fear Questionnaire, and Three-Factor Spiritual Well-being Scale. Data were analyzed with descriptive statistical tests, Mann-Whitney U-test, Kruskal-Wallis test, and Spearman correlation analysis. The short-term surgical fear of patients was 11.69 ± 7.55, the long-term surgical fear was 10.70 ± 9.53, and the total surgical fear was 22.40 ± 14.69 points, indicating a low level. Single and inexperienced elderly patients had higher levels of surgical fear (P < 0.05). The spiritual well-being levels of elderly patients (transcendence, 59.65 ± 12.20; harmony with nature, 29.10 ± 4.65; anomy, 26.34 ± 5.28; total score, 115.10 ± 17.83) were high. The spiritual well-being levels of elderly individuals whose income matched their expenses were higher (P < 0.05). There was a statistically significant negative relationship between the level of anomy in elderly patients with gonarthrosis and surgical fear (P < 0.05). In elderly patients with planned surgical interventions for gonarthrosis. It was determined that the levels of surgical fear were low, and the levels of spiritual well-being were high. The study identified that the level of anomy had an impact on surgical fear. It is recommended that healthcare professionals be aware of the influence of spiritual well-being on surgical fear and provide spiritual support to elderly patients.

Prescribed Medical Cannabis Use Among Older Individuals: Patient Characteristics and Improvements in Well-Being: Findings from T21.

Previous research has suggested that the use of cannabis-based medicinal products is increasing most rapidly among older aged individuals (65+ years). Despite this, little is known about the characteristics of older people using cannabis-based medicinal products and their effectiveness. We aimed to document the characteristics, outcomes and prescribing patterns of individuals aged 65+ years receiving prescribed cannabis compared to younger individuals receiving prescribed cannabis. Data from T21, an observational study of patients seeking treatment with medicinal cannabinoids, including self-report ratings of quality of life (assessed via the EQ-5D-5L), general health (assessed via the visual analogue scale of the EQ-5D-5L), mood (assessed via the Patient Health Questionnaire-9) and sleep (assessed using four items derived from the Pittsburgh Sleep Quality Index) were available at treatment entry [n = 4228; 198 (4.7%) 65+ years] and at a 3-month follow-up [n = 2455; 98 (4.2%) = 65+ years]. Relative to younger individuals, those aged over 64 years were more likely to be female (52.5% vs 47.0%; p < 0.001), more likely to report pain as their primary condition (76.3% vs 45.6%; p < 0.001) and less likely to report current daily use (20.2% vs 60.3%, p < 0.001). They received fewer cannabis-based medicinal products (mean = 1.4 vs 2.1; F(1,2199) = 32.3, p < 0.001) and were more likely to receive a prescription for a cannabidiol dominant oil (17.5% vs 5.7%; p < 0.001) and less likely to receive a prescription for delta-9-tetrahydrocannabinol dominant flower (32.5% vs 75.2%; p < 0.001). There were significant improvements across all measures of well-being (p < 0.001), but the extent of improvements in sleep were more marked in younger individuals (p < 0.001). There are important differences between individuals aged 65+ years and younger individuals receiving cannabis-based medicinal products. Older aged individuals experience considerable improvement in health and well-being when prescribed cannabis-based medicinal products.

J-shaped association of the triglyceride glucose-body mass index with new-onset diabetes

The triglyceride glucose-body mass index (TyG-BMI) is a convenient and clinically significant indicator of insulin resistance. This study aims to investigate the correlation between TyG-BMI and the onset of new-onset diabetes and determine an optimal reflection point for TyG-BMI. An analysis was conducted on 1917 participants from the risk evaluation of cancers in Chinese diabetic individuals: a lONgitudinal (REACTION) study. Participants were categorized based on their TyG-BMI, and the relationship between TyG-BMI and the incidence of new-onset diabetes was explored through logistic regression models, smoothed curve fitting with restricted cubic spline, and a two-piecewise logistic regression model. The mean age of the participants was 57.60 ± 8.89 years, with 66.5% being females. The mean TyG-BMI was 223.3 ± 32.8. Ultimately, 137 individuals (7.1%) progressed to diabetes after three years. After adjusting for covariates, TyG-BMI exhibited a positive correlation with new-onset diabetes (odd ratios (OR) for each standard deviation increase = 1.330, 95% CI 1.110–1.595). The relationship between TyG-BMI and new-onset diabetes was non-linear, with a inflcetion point at 202.9. This study reveals a positive non-linear relationship between TyG-BMI and the risk of new-onset diabetes in Chinese middle-aged and elderly individuals. When TyG-BMI exceeds 202.9, there is a significantly heightened risk of new-onset diabetes. These findings offer valuable insights for preventing new-onset diabetes.