African Studies Research Articles

Persistent low-level viraemia is associated with non-infectious comorbidities in an observational cohort in four African countries.

People living with HIV (PLWH) have higher rates of non-infectious comorbid diseases (NCDs) than individuals without HIV. We characterized the risk of NCDs among PLWH with undetectable viral load and persistent low-level viraemia (pLLV) in the African Cohort Study (AFRICOS). We secondarily quantified the role of immune activation in the association between LLV and NCDs. AFRICOS enrols participants in 12 clinics in Uganda, Kenya, Tanzania and Nigeria. Participants on antiretroviral therapy ≥ 6 months without an NCD at enrolment were included. PLLV was defined as at least two consecutive visits with a detectable viral load <1000 copies/ml. We examined elevated blood pressure, hypercholesterolemia, hyperglycaemia, renal insufficiency and a composite variable of any NCD. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard modelling. Among a subset of participants with biomarker data, we assessed the interaction between viral load and 13 biomarkers in the association with any NCD. From 23 January 2013 to 1 December 2022, 1755 participants met the inclusion criteria for these analyses. At the first eligible visit, the majority of participants had an undetectable viral load (n = 1375, 78.35%). Participants with pLLV had an increased rate of developing any NCD (aHR: 1.22, 95% CI: 1.02-1.47) compared to participants with an undetectable viral load. There was a statistically significant interaction between LLV and TNF-α, CCL2/MCP-1 and TNF-RII in the association with any NCD. PLLV was significantly associated with NCDs and immune inflammation in this population. Aggressive management of LLV may positively impact NCDs in PLWH.

Multi-Tier Land Use and Land Cover Mapping Framework and Its Application in Urbanization Analysis in Three African Countries

The population of Africa is expected to rise to 2.5 billion by 2050, with more than 80% of this increase concentrated in cities. Africa’s anticipated population growth has serious implications for urban resource utilization and management, necessitating multi-level monitoring efforts that can inform planning and decision-making. Commonly, broad extent (e.g., country level) urban change analyses only examine a homogenous “developed” or “built-up” area, which may not capture patterns influenced by the heterogeneity of landscape features within urban areas. Contrarily, studies examining landscape heterogeneity at a finer resolution are typically limited in spatial extent (e.g., single city level). The goal of this study was to develop and test a hierarchical integrated mapping framework using globally available Earth Observation data (e.g., Landsat, Sentinel-2, Sentinel-1, and nightlight imagery) and accessible methodologies to produce national-level land use (LU) and urban-level land cover (LC) map products which may support a range of global and local monitoring and planning initiatives. We test our multi-tier methodology across three rapidly urbanizing African countries for the 2016–2020 period: Ethiopia, Nigeria, and South Africa. The initial output of our methodology includes annual national land use maps (Tier 1) for the purpose of delineating the dynamic boundaries of individual urban areas and monitoring national LU change. To complement Tier 1 LU maps, we detailed urban heterogeneity through LC classifications within urban areas (Tier 2) delineated using Tier 1 LU maps. Based on country-optimized sets of selected features that leverage spatial/texture and temporal dimensions of available data, we obtained an overall map accuracy of between 65 and 80% for Tier 1 maps and between 60 and 80% for Tier 2 maps, dependent on the evaluation country, although with consistent performance across study years providing a solid foundation for monitoring changes. We demonstrate the potential applications for our products through various analyses, including urbanization-driven LU change, and examine LC urban patterns across the three African study countries. While our findings allude to general differences in urban patterns across national scales, further analyses are needed to better understand the complex drivers behind urban LC configurations and their change patterns across different countries, city sizes, and rates of urbanization. Our multi-tier mapping framework is a viable strategy for producing harmonious, multi-level LULC products in developing countries using publicly available data and methodologies, which can serve as a basis for a wide range of informative and insightful monitoring analyses.

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

Genome-Wide Association Studies (GWAS) over-represent European ancestries, neglecting all other ancestry groups and low-income nations. Consequently, polygenic risk scores (PRS) more accurately predict complex traits in Europeans than African Ancestries groups. Very few studies have looked at the transferability of European-derived PRS for behavioural and mental health phenotypes to Africans. We assessed the comparative accuracy of depression PRS trained on European and African Ancestries GWAS studies to predict major depressive disorder (MDD) and related traits in African ancestry participants from the UK Biobank. UK Biobank participants were selected based on Principal component analysis clustering with an African genetic similarity reference population, MDD was assessed with the Composite International Diagnostic Interview (CIDI). PRS were computed using PRSice2 software using either European or African Ancestries GWAS summary statistics. PRS trained on European ancestry samples (246,363 cases) predicted case control status in Africans of the UK Biobank with similar accuracies (R2 = 2%, β = 0.32, empirical p-value = 0.002) to PRS trained on far much smaller samples of African Ancestries participants from 23andMe, Inc. (5045 cases, R² = 1.8%, β = 0.28, empirical p-value = 0.008). This suggests that prediction of MDD status from Africans to Africans had greater efficiency relative to discovery sample size than prediction of MDD from Europeans to Africans. Prediction of MDD status in African UK Biobank participants using GWAS findings of likely causal risk factors from European ancestries was non-significant. GWAS of MDD in European ancestries are inefficient for improving polygenic prediction in African samples; urgent MDD studies in Africa are needed.

Erotic Black Diaspora

“The Erotic Black Diaspora: From Your Hands to Mine” is a theoretical exploration of how the erotic informs Black feminist politics, kinship, love, and spirituality throughout the African diaspora. Through an interdisciplinary approach rooted in literary studies, history, African and African diaspora studies, women’s and gender studies, and Black queer studies, as well as archival research, a close reading of letters sent to Black feminist, writer, and poet Audre Lorde reveals how the erotic functions within Black feminist spaces, particularly in the late 1970s–mid 1980s. In using Audre Lorde’s definition of the erotic, as she defines it in “Uses of the Erotic: The Erotic as Power,” this paper argues that the Erotic Black Diaspora is a way of reading Black feminist love, language, and action. Recognizing the diversity within Afro-diasporic experiences, the Erotic Black Diaspora privileges the erotic (platonic and/or romantic) feelings and expressions across continents cultivated between same-sex-loving and queer individuals throughout the African diaspora. Positioning Black feminist archives, in particular correspondence sent between Black feminist foremothers, as a counter-archive to institutions of oppression informs one’s understanding of the ethics of Black feminist politics, love, spirituality, and community building.

(Un)rooted spaces of belonging: migrant kinship structures in Nadifa Mohamed’s Black Mamba Boy

While African intercontinental migration to Western countries continues to receive vigorous scholarly attention in African literary studies, this article draws its focus to intracontinental migration during the 1930s and 1940s in Nadifa Mohamed’s Black Mamba Boy (2010). After the protagonist Jama loses his mother, he searches for his father across East and North Africa in a quest to solidify his brittle familial bonds. As Jama constantly refashions his kinship bonds throughout his peregrinations, familial belonging lies at the thematic core of the narrative, which necessitates a more thorough discussion of family structures alongside Mohamed’s realistic portrayal of African geographies transformed by Italian and British colonization to better analyze how kinship operates as a mode of resistance against such forces. Considering Mohamed’s exploration of familial roles in different East African societies, I argue that this novel showcases how migration paradoxically destabilizes and reshapes traditional African family systems foiled by colonial violence. It does so by portraying Africans’ creative resilience in engendering new familial/communal spaces while concomitantly dislodging geographically fixed ideas of belonging. To deploy this analysis, I combine geocriticism and Black Geographies to examine how varied spaces and places shape the characters’ identities and the familial connections they construe. In making this argument, I demonstrate that families/communities mark belonging more significantly than citizenship in the context of migration and buttress space-making for East African migrants in Mohamed’s narrative.

Blood transcriptomic signatures for symptomatic tuberculosis in an African multicohort study.

Multiple host blood transcriptional signatures have been developed as non-sputum triage tests for tuberculosis (TB). We aimed to compare the diagnostic performance of 20 blood transcriptomic TB signatures for differentiating between symptomatic patients who have TB versus other respiratory diseases (ORD). As part of a nested case-control study, individuals presenting with respiratory symptoms at primary healthcare clinics in Ethiopia, Malawi, Namibia, Uganda, South Africa and The Gambia were enrolled. TB was diagnosed based on clinical, microbiological and radiological findings. Transcriptomic signatures were measured in whole blood using microfluidic real-time quantitative PCR. Diagnostic performance was benchmarked against the World Health Organization Target Product Profile (TPP) for a non-sputum TB triage test. Among 579 participants, 158 had definite, microbiologically confirmed TB, 32 had probable TB, while 389 participants had ORD. Nine signatures differentiated between ORD and TB with equivalent performance (Satproedprai7: area under the curve 0.83 (95% CI 0.79-0.87); Jacobsen3: 0.83 (95% CI 0.79-0.86); Suliman2: 0.82 (95% CI 0.78-0.86); Roe1: 0.82 (95% CI 0.78-0.86); Kaforou22: 0.82 (95% CI 0.78-0.86); Sambarey10: 0.81 (95% CI 0.77-0.85); Duffy9: 0.81 (95% CI 0.76-0.86); Gliddon3: 0.8 (95% CI 0.75-0.85); Suliman4 0.79 (95% CI 0.75-0.84)). Benchmarked against a 90% sensitivity, these signatures achieved specificities between 44% (95% CI 38-49%) and 54% (95% CI 49-59%), not meeting the TPP criteria. Signature scores significantly varied by HIV status and country. In country-specific analyses, several signatures, such as Satproedprai7 and Penn-Nicholson6, met the minimal TPP criteria for a triage test in Ethiopia, Malawi and South Africa. No signatures met the TPP criteria in a pooled analysis of all countries, but several signatures met the minimum criteria for a non-sputum TB triage test in some countries.

1096 The African Surgical Outcomes Study in Paediatric Patients (ASOS-Paeds) and Global Paediatric Perioperative Mortality - a Meta-analysis

Abstract Aim There is little data for surgical outcomes of children in Africa. This is of particular importance as children constitute 40% of the African population, compared to a global average of 25%. As part of ASOS-Paeds - a prospective cohort study of children undergoing surgery in African countries, we undertook a meta-analysis to synthesise the evidence on global paediatric perioperative mortality. Method We searched MEDLINE, Embase and WHO Global Index Medicus for studies published within the last decade, reporting paediatric perioperative mortality. We included studies with ≥200 children that reported perioperative mortality for multiple surgical specialties and procedures. Perioperative mortality was defined as death within 30 days of surgery. For meta-analysis, proportions were combined using a random effects model. Results After screening 13,258 s and reviewing 158 full-text reports, data from 9 studies were eligible for synthesis along with data from ASOS-Paeds. The meta-analysis included 579,733 children from Africa, Europe, and North America. The pooled perioperative mortality rate per 1,000 children (95% CI) was 17.91 (9.78, 26.04) in Africa compared to 2.18 (0.95, 3.42) in Europe and North America. This equates to excess paediatric perioperative mortality in Africa between 6 (in the best-case scenario) to 25 (in the worst-case scenario) per 1,000 children. Conclusions Perioperative mortality for children undergoing surgery in Africa is 8-fold higher than in Europe and North America. Access to safe and affordable anaesthesia and surgery should be a public health priority and urgent action is needed to improve surgical outcomes for children in Africa.

The “I” as Implicated Subject: Performative Confession in Rian Malan’s My Traitor’s Heart

Confessional forms of autobiographical writing have predominated in post-apartheid South African literary studies. This paper discusses Rian Malan’s My Traitor’s Heart, published in 1990 during drastic social and political changes in South Africa’s transition to democracy. It was one of the first and most prominent examples of this genre. Focusing on Malan’s perspective as a white Afrikaner and an “implicated subject”, this study explored how his confessional account grappled with the existential dilemma of post-apartheid Afrikaner identity. Malan simultaneously affirmed his Afrikaner identity to confront his implication in apartheid and sought to establish a legitimate place for this identity within the new multicultural society. Through a close reading of Malan’s strategic performance, this paper argues that his work offers a means of reimagining the collective self in a new community and understanding historical injustices from a multidimensional perspective. Ultimately, My Traitor’s Heart contributes to the post-apartheid project of envisioning a more inclusive psychological and topographical construction of individual and collective identity, with the implicated subject as its centre.

African Literary Future/isms: Collective and Speculative Approaches

This article assesses how the ‘collective’ and the ‘speculative’ emerge as intertwined conceptual models for imagining and concretising notions of the ‘future’ in contemporary African literatures. We argue that contemporary literary production from the continent is engaged in acts of conceptual and linguistic-decentring, or what Ngũgĩ wa Thiong’o has developed as a theory of ‘globalectics’ (2012). Beginning with Yvonne Adhiambo Owuor’s channelling of a Pan-African collective consciousness in her keynote address to the European Conference on African Studies (2023), we move on to explore three aspects of African literary futures/isms: first, the idea of historical repair and the notion that the speculative mode often hinges on multidirectional community-making by reconfiguring the past; second, the way speculative ventures establish new material networks and readerships through South–South translation projects that themselves project speculative cartographies of connection and the revival of historical ties; third, how continental African speculative fiction disrupts the binaries between the local and the global by creating new spatial imaginaries invested in cosmological and philosophical materialities. We conclude that such a diverse focus allows us to open out the terms of our discussion to the wider implications of decolonial future-making from the perspective of a de-hierarchical, globalectically oriented view of contemporary African writing. As such, we imagine this article as an act of collaborative co-creation which is in conversation with two contemporary African writers – Novuyo Rosa Tshuma and Wole Talabi – whose works are among those discussed in the piece. Their interviews form the ‘Appendix’ to this article, and offer new directions for creative and critical re-negotiations of African literary futures.

Defining Sustainable Placemaking in Spatial Planning: Lessons from a South African Case Study

This study explores the concept of sustainable placemaking from a spatial planning perspective, focusing on Marabastad, a township in South Africa. Drawing on the New Urban Agenda and Sustainable Development Goals, this research seeks to understand how placemaking can contribute to the creation of liveable, resilient, and sustainable human settlements. Through a review of the placemaking literature and a case study, this study examines the evolution of placemaking towards sustainability and its application in diverse cultural, geographic, and socio-economic contexts. The findings reveal the importance of creating and enhancing places that are environmentally responsible, socially inclusive, economically viable, and culturally meaningful. The Marabastad case study illustrates the challenges and possibilities of sustainable placemaking in a multicultural and urbanising community. Economic interventions (e.g., tourism promotion and community markets), social interventions (e.g., education and community events), and environmental interventions (e.g., infrastructure upgrades and preservation of cultural sites) are proposed to address the complex challenges faced by Marabastad. This study emphasises the role of spatial planners in advancing theories and practises of sustainable placemaking, highlighting the need for context-specific approaches to promote inclusive and resilient urban environments.

A South African case study on anatomical embalming for human body donation programmes with toxicological considerations

Body embalming, a practice with deep historical roots across various cultures, forms the backbone of contemporary human body donation educational programmes. In this study, we explored current embalming practices within six South African human anatomical dissection programmes, focusing on the use and volumes of key chemicals—formalin, phenol, and alcohol—and their associated health risks and potential toxicity. We measured and compared aspects of embalming practices such as the duration of body preservation and the annual intake of bodies. Variations in embalming practices and chemical ratios across different South African universities were found. However, the consistent use of formalin, phenol and alcohol were observed across all six programmes. Formaldehyde concentrations used in South African dissection programmes were within the generally acceptable international range. Regarding arterial embalming, South African dissection programmes showed widespread adherence to international embalming practices, with one programme using a substantially lower concentration of formalin. The dual nature of formaldehyde as both an effective preservative and a recognised carcinogen was underscored in relation to human health regarding chemical toxicity. Phenol, like formaldehyde, was consistently used as it is important for the inhibition of bacterial and fungal growth. Alcohol was also consistently used, but there was much greater variation in its volume across South African institutions. Our data showed a slight positive relationship between storage duration and the volumes of formalin and phenol in human embalming fluid. South African regulators enforce stricter exposure limits than those set by the World Health Organisation and various European agencies. While South African institutions operate within internationally acceptable ranges of chemical use that both maximise preservation and minimise toxicity, we acknowledge that these data are preliminary. Further investigation is encouraged to ensure embalming practices effectively protect all those involved and support the educational goals of human anatomical dissection programmes in South Africa.

Enhancing Energy Supply Reliability for University Lecture Halls Using Photovoltaic-Battery Microgrids: A South African Case Study

Institutions of higher learning in South Africa are grappling with occasional power outages in lecture halls, leading to disruptions in academic activities and occasional loss of lecture hours. Therefore, this study presents a comprehensive evaluation of a grid-connected solar PV/Li-ion battery microgrid (μG) system aimed at maintaining a constant power supply to selected lecture halls at a university in the Western Cape, South Africa. The microgrid design, modelling, and simulations, conducted in the MATLAB/Simulink environment, include the solar PV, Li-ion battery, energy consumption of the lecture halls (load profile), boost converter, bidirectional converter, and grid. Using the detailed design, modelling, and simulation, the study evaluates the economic and environmental impacts of integrating μGs, focusing on enhancing energy reliability, reducing operational costs, and mitigating CO2 emissions. The results indicate that integrating the microgrid resulted in a significant 51% reduction in energy cost and a decrease in greenhouse gas emissions by 530 kgCO2e per hour. In Cases 2 and 4, where the battery supplied power, the annual battery degradation costs are 6.08% and 14.9% of the initial cost, respectively. The μG ensures an uninterrupted power supply and improves the overall reliability of the university’s energy infrastructure. It promotes environmental sustainability goals of zero emissions and maintains continuous academic activities during grid outages. Furthermore, it fosters a conducive learning environment, supports innovation and creativity in sustainable energy technologies, and sets a standard for other higher education institutions to integrate renewable energy-powered μGs.

Decolonizing Theories of Regional Integration

Interview with Dr. Ernest Toochi Aniche, Federal University Otuoke, Nigeria Ernest Toochi Aniche, PhD, is a Senior Lecturer and the Acting Head of the Department of Political Science, Federal University Otuoke, Bayelsa State, Nigeria. He holds BSc, MSc, and PhD degrees from the Department of Political Science, University of Nigeria with a specialization in International Relations. He is developing a new theory of African Integration (Post-Neofunctionalism), deconstructing the traditional Neo-functionalist approach. Dr. Aniche is a prolific scholar with over a hundred publications, including articles in dozens of the world’s most renowned African studies journals. He has also published co-edited books and authored and co-authored chapters in books published by reputable publishers such as Routledge (Taylor &amp; Francis), Palgrave Macmillan (Springer Nature), Rowman &amp; Littlefield International, Lexington Books, and Oxford University Press. The highlight of his career was co-editing books with the African scholar legend, Professor Toyin Falola. He is on the editorial boards of journals and publishers, particularly Springer Nature (SN) Social Sciences, Ubuntu: Journal of Conflict and Social Transformation, and Cambridge Scholars Publishing. In his interview, he explains what prompted him to develop his own theory of African integration, which would actually contribute to the development of the continent. He explains the reasons for the crisis tendencies of modern African regionalism, a manifestation of which is the creation of the Sahel State Alliance. He pays particular attention to the prospects for decolonizing social knowledge about Africa. He provides inspiring cases of those African intellectuals who were able to transform the study of politics from Political Science in Africa to African Political Science, as well as to decolonize African regionalism and African border and migration studies.

Investigating Pedagogical Competencies of Post Graduate Certificate in Education Students to Teach Accounting: A South African Case Study

This paper documents the pedagogical competencies of Post Graduate Certificate in Education (PGCE) students prepared to teach Accounting. There is an arguably perspective that students who tailored their teaching qualification through the PGCE programme are not competent to teach at a school level compared to students who did an Initial Teacher Education Bachelors degree. Further, there is an observation that school principals prefer to employ B.Ed. teachers than PGCEs underpinned by the thinking that the former are better prepared in terms of pedagogy. The Social Learning theory foregrounded this study and sought to respond to two questions: What are the pedagogical competencies of PGCE students to teach Accounting? How can pedagogical competency be enhanced in the PGCE programme? This study adopted a qualitative approach and a constructivist paradigm to understand the research phenomenon. Semi-structured interviews were conducted with three school mentors and thematic analysis was employed to analyse the data. The study found that PGCE students are pedagogically incompetent to teach Accounting since they possess insufficient subject knowledge, limited conceptualisation of teaching strategies, and PGCE students dawdle to complete Accounting content. Furthermore, pedagogical competency among PGCE can be enhanced through programme development splitting into two phases and content modules development. In light of the above findings, this study recommends that PGCE students must be provided continuous professional development which would act as a bridge to the perceived incompetency among PGCE students in South Africa. The study also concludes that the PGCE programme among universities must focus more on pedagogical competency through Social Learning theory as it can fully capacitate students to achieve the expected competencies in teaching. The study contributes knowledge and proposes suggestions to improve teaching training programmes, particularly PGCE among South African universities. Keywords: Accounting, PGCE Students, Pedagogical Competencies, Social Learning, Professional Development

Breast cancer in women by HIV status: A report from the South African National Cancer Registry.

Breast cancer (BC) is the leading cause of cancer-related morbidity and mortality in women living in South Africa, a country with a high HIV burden. However, characteristics of the double burden of HIV and BC in South Africa have not been properly investigated. We described characteristics of BC cases by HIV status in South Africa. In this nationwide South African study, we obtained BC records for women aged ≥15 years diagnosed in the public health sector between January 2004 and December 2014. We included records from the National Cancer Registry that had been linked to HIV-related laboratory records from the National Health Laboratory Service. We assessed the odds of being HIV positive versus HIV negative in relation to patient-, cancer-, and municipality-related characteristics. From 2004-2014, 40 520 BC cases were diagnosed in women aged ≥15 years. Of these, 73.5% had unknown HIV status, 18.7% were HIV negative, and 7.7% were HIV positive. The median age at BC diagnosis was 43 years (interquartile range [IQR]: 37-52) in HIV positive and 57 years (IQR: 46-68) in HIV negative women, respectively. The odds of being HIV positive was higher for women who were aged 30-34 years compared to women aged 35-39 years at cancer diagnosis (odds ratio [OR] 1.38, 95% confidence interval [CI] 1.10-1.71), Black versus non-Black (OR 6.41, 95% CI 5.68-7.23), diagnosed with cancer in rural versus urban areas (OR 1.59, 95% CI 1.40-1.82) and diagnosed in municipalities with low and middle (OR 3.46, 95% CI 2.48-4.82) versus high socioeconomic position (OR 2.69, 95% CI 2.11-3.42). HIV status was unknown for the majority of BC patients. Among those with known HIV status, being HIV positive was associated with a younger age at cancer diagnosis, being Black and receiving care in municipalities of poor socioeconomic position. Future studies should examine opportunities to integrate HIV and BC control programs.

The Aftermath – What Future for African Studies (in Europe?). A View From Behind the Scenes of ECAS9

The Aftermath – What Future for African Studies (in Europe?). A View From Behind the Scenes of ECAS9

Sustainability Hermeneutics: The New Task of African Biblical Studies

As a new and emerging approach to biblical interpretation, Sustainability Hermeneutics (SH) combines aspects of the environment, economy, and society in its interpretation of biblical texts. Such an approach to biblical interpretation shows the interaction of the environment, economy and society in biblical texts in line with the understanding of sustainability. It is therefore integrative and holistic. This article argued that such an approach holds so much promise for African Biblical Studies (ABS) at a time when the African continent is faced with myriads of developmental issues. While Sustainability Hermeneutics ingrains biblical texts into an integrative African worldview, the article also argued that the urgency of the use of Sustainability Hermeneutics in African Biblical Studies lies in the fact that the Bible and its messages still make sense to many African Christians. So, Sustainability Hermeneutics, if well utilised in African Biblical Studies, will motivate many African Christians to take actions that will lead to sustainable African societies.

Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis

BackgroundScreening for sickle cell traits before marriage or producing children is one of the outstanding preventive measures for sickle cell disease (SCD).The disease is a collection of inherited blood disorders that impact millions globally, with a predominant 75% occurrence in the sub-Saharan region. With increasing burden of SCD on the continent amidst a cost effective prevention method, no study has systematically reviewed or presented meta-analytic uptake or practice of premarital sickle cell trait screening.MethodsThis review systematically explored the uptake or practice of premarital genotype screening in Africa. We searched PubMed and Scopus databases for African studies on premarital screening for sickle cell traits.ResultsOur results indicate that the pooled uptake of premarital sickle cell trait screening in Africa is 47.82% (95% CI: [46.53–49.11]; I2: 98.95% [98.74–99.13]). Our review observed, a significant relationship between the awareness of sickle cell disease and the uptake of genotype screening; F(1, 13) = 12.04, p = 0.004). The model explained approximately 48.08% of the variation in genotype screening (R² = 0.4808) and predicted a 0.729 increase in the likelihood of genotype screening uptake for every unit rise in sickle cell disease awareness (β = 0.729, p = 0.004). Additionally, Pearson correlation (r = 0.6934) indicated a moderately strong positive correlation between the two variables.ConclusionWith over 75% of the global burden of sickle cell disease domiciled in Africa, the continent cannot overlook the cost of hemoglobinopathies. The uptake of sickle cell traits screening is suboptimal across the continent. To achieve the mandate of sustainable development goal number (3); to end preventable deaths of newborns and children under 5 years of age by 2030, there is need to intensify campaigns on premarital genetic screening through education and other health promotion tools.

Variability of polygenic prediction for body mass index in Africa

BackgroundPolygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent. Studies to understand the factors that affect PRS variability within Africa are required.MethodsUsing the first multi-ancestry genome-wide association study (GWAS) meta-analysis for BMI involving continental Africans, we derived a multi-ancestry PRS and compared its performance to a European ancestry-specific PRS in continental Africans (AWI-Gen study) and a European cohort (Estonian Biobank). We then evaluated the factors affecting the performance of the PRS in Africans which included fine-mapping resolution, allele frequencies, linkage disequilibrium patterns, and PRS-environment interactions.ResultsPolygenic prediction of BMI in continental Africans is poor compared to that in European ancestry individuals. However, we show that the multi-ancestry PRS is more predictive than the European ancestry-specific PRS due to its improved fine-mapping resolution. We noted regional variation in polygenic prediction across Africa’s East, South, and West regions, which was driven by a complex interplay of the PRS with environmental factors, such as physical activity, smoking, alcohol intake, and socioeconomic status.ConclusionsOur findings highlight the role of gene-environment interactions in PRS prediction variability in Africa. PRS methods that correct for these interactions, coupled with the increased representation of Africans in GWAS, may improve PRS prediction in Africa.

Gender-Based Violence in Some Pentecostal Churches—A South African Study

One of the most devastating practices to be normalised in modern times is gender-based violence. Women and girls in South Africa can no longer enjoy the freedom that was promised by the country’s Freedom Charter during the dawn of democracy. Rape, killing and other forms of female persecution have become common practices, and the most worrying part of this is that the perpetrators of this violence seem to enjoy more freedom than their victims. Unfortunately, this kind of violence is no longer a secular issue but something that is now encountered in religious circles, places in which most people would hope to be sheltered and protected. The article investigates these kinds of violence within the parameters of religious institutions, specifically Pentecostal churches, and also makes some suggestions as to what kinds of approaches we need as a country to eliminate this pandemic. This article uses a desktop/secondary approach to gather data and to reach the conclusions made as a bases for the argument.