Livestock guardian dogs are one of several predator control methods employed by livestock farmers around the world, but little is known about the factors that predict their use. Here we aim to understand the dimensions which influence guardian dog use by farmers. In a quantitative survey among 113 livestock farmers in South Africa, using Boosted Regression Trees, we explored and characterized the factors associated with guardian dog use. We showed that practical factors (e.g., predator type, number of farming enterprises, mitigation methods, and the frequency and extent of specific predator problems) were more likely to be significant determinants of guardian dog use than sociodemographic factors. However, psychosocial constructs relating to wildlife value orientations, empathy for predators, tolerance to predators, tangible and intangible cost, benefits of predators, like or dislike of predators, and number of positive experiences, were also determinants of guardian dog use. Utilizing the foundational constructs of the Theory of Planned Behavior (TPB) and Wildlife Tolerance Model (WTM) we built upon these findings to show that constructs of attitude, subjective norms, and perceived behavioral control explained 49 % of the variance in behavioral intention to use or continue using a guardian dog. The relationship between attitude and the behavioral intent to use or continue using a guardian dog had less significant association with guardian dog use than either perceived behavioral control or subjective norms had. Nonetheless, attitude was most strongly associated with the constructs of belief in a specific non-governmental organization, mutualistic Wildlife Value Orientations and perceptions of affordability, ease of use and the effectiveness of guardian dogs. The TPB model, incorporating elements of the WTM, provides a framework to guide and improve adoption of guardian dog programs or other intervention strategies within conservation contexts.