You have accessJournal of UrologyStone Disease: Evaluation II1 Apr 2015MP80-07 VITAMIN D AND SERUM LIPID PROFILE: ASSOCIATION WITH 24-HOUR URINE PARAMETERS Aaron Potretzke, Jeffrey Larson, Joel Vetter, and Alana Desai Aaron PotretzkeAaron Potretzke More articles by this author , Jeffrey LarsonJeffrey Larson More articles by this author , Joel VetterJoel Vetter More articles by this author , and Alana DesaiAlana Desai More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2843AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Vitamin D and dyslipidemia have been linked to kidney stones and 24-hour urine parameters indicative of stone risk. There is also evidence that vitamin D levels affect lipid profiles. To our knowledge, no study has assessed the relationship of vitamin D and lipids with 24-hour urine parameters in a multivariable statistical model. We sought to elucidate the independent associations of vitamin D and lipids with 24-hour urine parameters. METHODS A retrospective review of patients with urolithiasis who underwent a 24-hour urine, serum vitamin D, and fasting lipid profile collection within 180 days was conducted. Due to collinearity in the lipid profile parameters (total cholesterol, non-HDL cholesterol, HDL, and TG), four multivariate linear regression models were constructed for each of the 24-hour urine components, including: pH, calcium, sodium, oxalate, uric acid, potassium, magnesium, phosphorus, and citrate. The analyses were designed to control for age, BMI, diabetes, hypertension, and vitamin D. RESULTS A total of 60 patients with mean age 56.2 years and BMI 31.1 kg/m2 met criteria. Diabetes and hypertension were present in 23% and 45% of patients, respectively. On multivariate analysis, only vitamin D was shown to significantly correlate to urine calcium (p = 0.008) (see Table 1). Total cholesterol and HDL each had a significant, inverse relationship with urine oxalate (p = 0.009 and 0.035, respectively). Neither vitamin D nor any lipid parameter correlated to pH, sodium, uric acid, potassium, magnesium, phosphorus, or citrate. CONCLUSIONS Vitamin D is directly associated with urine calcium, independent of lipid levels. Vitamin D may be more important than lipid parameters in affecting patients' urine calcium and therefore stone risk. The impact of having a normal serum vitamin D has not yet been clarified and requires future study. Associations with urine calcium levels Estimate of urine calcium (mg/24 hours)∗ p value Age∗∗ (years) -1.1 0.572 BMI∗∗ (kg/m2) 4.9 0.190 Diabetes mellitus∗∗ 67.5 0.173 Hypertension∗∗ -31.2 0.537 Total cholesterol (mg/dL) 0.6 0.286 HDL (mg/dL) 0.3 0.785 Non-HDL (mg/dL) 0.7 0.284 Triglycerides (mg/dL) 0.2 0.361 Vitamin D (ng/mL) 2.5 0.008 ∗ estimates are for an increase in one unit of the clinical variable. ∗∗ estimates and p values are derived from a multivariate model which included non-HDL cholesterol. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e1021 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Aaron Potretzke More articles by this author Jeffrey Larson More articles by this author Joel Vetter More articles by this author Alana Desai More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...