Advisory Board Members Research Articles

Meet the Advisory Board Member

Meet the Advisory Board Member

Guided STEM Activity Kits for Parents With Preschool Children: Design, Frequency of Use, and Parent Evaluation

ABSTRACT Parents boost STEM skills by scaffolding children’s attention and discovery during play, but many need support doing so. Using human-centered design (HCD) methods, we created activity kits fostering parents’ (a) involvement in and (b) valuing of parent-child play to promote preschoolers’ STEM skills. Study 1 documents how HCD methods informed the design of guided activity kits. In initial home visits, we videorecorded six parent-child dyads playing with basic building materials. Play revealed minimal parental STEM scaffolding and talk. Collaborating with 18 families and drawing on prior research, parent interviews, videotaped play sessions, and advisory-board members’ expertise, the interdisciplinary research team designed and refined activity kit prototypes. Study 2 was a randomized field test comparing use and evaluation of final guided kits (n = 50) versus basic kits (n = 25) that contained identical building materials and challenges but omitted scaffolding guides. Both groups received kits by mail every other week for 10 weeks. Relative to parents given basic kits, parents given guided kits (a) reported significantly more sustained use of the kits across the 10 weeks, (b) felt more self-efficacy in fostering their child’s STEM learning, and (c) judged that their child had achieved greater STEM-skill learning from program use.

Patients with Atopic Dermatitis Not on Systemic Therapy have High Rates of Severe, Uncontrolled Disease, and Considerable Impact on Quality of Life

Patients with Atopic Dermatitis Not on Systemic Therapy have High Rates of Severe, Uncontrolled Disease, and Considerable Impact on Quality of Life

Interview with FocalPlane Scientific Advisory Board member Kota Miura

ABSTRACT Kota Miura is the Vice-Chair of the Network of European Bioimage Analysts (NEUBIAS) and a freelance bioimage analyst. For his PhD, Kota studied cell migration in true and cellular slime molds where he was introduced to bioimage analysis, which became the focus of his research. After moving to EMBL at Heidelberg in Germany, Kota was instrumental in running the EMBL bioimages analysis courses and in founding NEUBIAS. We caught up with Kota to discuss his career, his hopes for the future of bioimage analysis and how FocalPlane can benefit the microscopy community.

Guest Editorial: Unleasing the Power of Customer Advisory Boards Combined With a Customer Value-Based Strategy

_ In today’s rapidly evolving business landscape, innovation has become the key to success. Companies that can adapt, innovate, and stay ahead of the curve not only survive, but thrive. To achieve this, a fresh approach to innovation is required: one that harnesses the collective wisdom of customer advisory boards and prioritizes a strategy based on customer value. In this article, we delve into the value of co-creating innovation through these two critical elements. The Power of Customer Advisory Boards Customer advisory boards are invaluable assets for any forward-thinking, innovative organization. They are not just a forum for feedback, but a mechanism for co-creating value and fostering innovation. They serve as a strategic tool for an organization to gain valuable insight, enhance customer relationships, and drive innovation. The facilitated collaboration leads to improved products, market-driven innovation, stronger customer relationships, and market success. The diverse backgrounds and expertise of the customers who make up an advisory board provide a holistic perspective that internal teams might lack. Here’s how advisory boards contribute to innovation. Unbiased Insights and Feedback. Customer advisory board members bring fresh eyes to a company’s products and challenges and provide a structured platform for customers to voice their opinions, share experiences, and offer feedback on products and services as well as the overall customer journey. They offer impartial insights and constructive criticism, allowing for a more accurate assessment of innovation efforts. Market Validation. These boards typically comprise individuals with deep industry knowledge. Their expertise helps identify emerging trends and opportunities, ensuring that innovation efforts are aligned with industry advancements and customer expectations; thus, avoiding costly misinnovation from misalignment with the market. This ensures that when a product is developed, there is market demand for the product. Enhanced Customer Relationships. Customer advisory boards can open doors to new partnerships, collaborations, and resources. They connect organizations to a broader ecosystem, fostering innovation through collaboration. Co-Creation of Solutions. Customer advisory boards enable collaborative problem solving and solutions. Customers, as experts in their fields, actively participate in ideation and development of new products and features to solve their challenges and address future business requirements. This co-creation ensures solutions meet specific customer needs driven by current challenges. A collective voice of the board ensures solutions and products are not too customized for a specific customer but fit the needs of the broader market experiencing the same challenges.

LEADING ADVANCE CARE CONVERSATIONS: DEVELOPMENT OF AN INTERVENTION PLATFORM

Abstract The LEAD Guide (Life-Planning in Early Alzheimer’s and Other Dementias) is an advance care planning guide designed specifically for people with dementia and their care partner. It addresses changes in cognition and goals of care, including values and preferences, for end-of-life care and support across the disease continuum. The goal of using the guide is to create a shared understanding of the care recipient’s end-of-life care preferences. We developed an interactive web-based format of the LEAD Guide, an enhanced extension of the original paper guide, for a pilot behavioral intervention. The LEAD Intervention guided community-based Alzheimer’s disease and related dementias (ADRD) dyads (N=60 dyads; persons concerned, at risk, or with a dementia diagnosis and their care partners) through advance care planning (ACP) conversations and documentation. The intervention model included the LEAD Guide, interactive instructions, and educational material about ACP in the context of dementia. We developed the LEAD Intervention using an interactive design and beta testing process (including surveys and focus groups) with our community advisory board members. The board members included professional dementia experts, community partners, and ADRD dyads. Board members were enthusiastic about the LEAD Intervention and provided suggested revisions in three areas; technology (navigation of web-based documents, webpage design), personalization (the need to personalize emails and surveys to individual participants), and evaluation (creating simple scaled and open-text questions to obtain feedback on the intervention activities). Creating a feasible, acceptable, and efficacious intervention requires a multi-faceted approach that incorporates input from end users using community-based participatory research methods.

Understanding Stakeholder Dissemination Preferences for an Agriculture, Forestry, and Fishing Injury Surveillance System

ABSTRACT Researchers and epidemiologists are working to improve the capture of agriculture, forestry, and fishing (AgFF) injuries in a variety of ways. A critical component of any surveillance system is the dissemination of information. The purpose of this paper is to report on a survey conducted with AgFF injury surveillance stakeholders to understand preferred dissemination strategies. The survey was distributed using REDCap via web link to organizational stakeholders, which included advisory board members, safety trainers, industry managers and workers, and research collaborators. In total, there were 75 respondents (21% response rate). Occupation and industry influenced preference in update methods. Regarding the length and breadth of updates, 63% of respondents prefer reports (one to five pages), followed by 57% desiring a summary (less than one page), while only 24% wanted a detailed analysis. Social media and news preferences were also different among stakeholders. Surveillance data were desired for 1) trend analysis, 2) tailoring activities and solutions for education, training, outreach and interventions and 3) for research purposes such as grant proposals and evaluation. The dissemination of injury surveillance data should be tailored to the intended audience. Greater attention needs to be paid to the ways in which we share our findings.

Interview with FocalPlane Scientific Advisory Board member Jennifer Waters

ABSTRACT Jennifer Waters is Director of the Nikon Imaging Center and Lecturer in Cell Biology at Harvard Medical School, USA. Jennifer started using microscopes during her undergraduate studies and continued developing her technical skills during her PhD at University of North Carolina (UNC) at Chapel Hill. After completing her PhD, Jennifer was appointed to a faculty position teaching microscopy at Wake Forest before she moved to her current position at Harvard Medical School. We caught up with Jennifer to discuss her career, her passion for microscopy education, and the merger of Microlist and FocalPlane, the microscopy community site hosted by The Company of Biologists (https://focalplane.biologists.com/).

Engaging communities to inform the development of a diverse cohort of cancer survivors: formative research for the eat move sleep study (EMOVES)

BackgroundThere are more than 18 million cancer survivors in the United States. Yet, survivors of color remain under-represented in cancer survivorship research (Saltzman et al. in Contemp Clin Trials Commun 29:100986, 2022; Pang et al. in J Clin Oncol 34:3992–3999, 2016; Lythgoe et al. in Prostate Cancer Prostatic Dis 24:1208–1211, 2021). Our long-term goal is to enroll and follow a cohort of historically under-represented cancer survivors, to better understand modifiable risk factors that influence clinical and quality of life outcomes in these populations. Towards that goal, we describe herein how we applied community-based participatory research approaches to develop inclusive study materials for enrolling such a cohort.MethodsWe implemented community engagement strategies to inform and enhance the study website and recruitment materials for this cohort including: hiring a dedicated engagement coordinator/community health educator as a member of our team; working with the Helen Diller Family Comprehensive Cancer Center Office of Community Engagement (OCE) and Community Advisory Board members; presenting our educational, research, and study recruitment materials at community events; and establishing a community advisory group specifically for the study (4 individuals). In parallel with these efforts, 20 semi-structured user testing interviews were conducted with diverse cancer survivors to inform the look, feel, and usability of the study website.ResultsEngagement with community members was a powerful and important approach for this study’s development. Feedback was solicited and used to inform decisions regarding the study name (eat move sleep, EMOVES), logo, study website content and imagery, and recruitment materials. Based on community feedback, we developed additional educational materials on healthy groceries and portion size in multiple languages and created a study video.ConclusionsIncluding an engagement coordinator as a permanent team member, partnering with the institutional community outreach and engagement resources (i.e., OCE), and allocating dedicated time and financial support for cultivating relationships with stakeholders outside the university were critical to the development of the study website and materials. Our community guided strategies will be tested as we conduct enrollment through community advisor networks and via the state cancer registry.

Digitally supported lifestyle program to promote brain health among older adults (LETHE pilot trial) – Study design and progress

AbstractBackgroundDementia prevention is a global public health priority. The FINGER multimodal lifestyle intervention is the only intervention model so far that has demonstrated significant cognitive and other health benefits in at‐risk older adults. LETHE proposes a new multimodal precision prevention approach where FINGER intervention is complemented with digital tools to optimize intervention delivery, personalize recommendations based on individual risk profile, and support risk factor self‐management. The multinational 2‐year randomized controlled LETHE pilot trial aims to test the feasibility of a digitally supported, adapted FINGER intervention among older adults at risk of cognitive decline and dementia.MethodA total of 160 individuals aged 60‐77 years and with risk factors for dementia but no substantial cognitive impairment are recruited at four sites (Austria, Finland, Italy, Sweden; N = 40 per country). Digital readiness and experience with smart devices are required. Participants are randomized 1:1 to 1) structured multimodal lifestyle intervention (dietary guidance, exercise, cognitive training, vascular/metabolic risk management, social stimulation, sleep/stress management) where in‐person individual and group‐based activities are supported with the LETHE smartphone app developed in the project; or 2) self‐guided lifestyle intervention (regular health advice and access to a simplified app with no personalized/interactive content). Both groups wear a smartwatch to gather passive data (e.g., activity, sleep). Primary outcomes are retention rate, adherence to intervention and engagement with the app, and change in dementia risk based on validated risk scores (CAIDE, LIBRA). Secondary outcomes are lifestyle changes and changes in cognition, stress‐related symptoms, sleep, health‐related quality of life, and health literacy. Participant experiences will also be explored. The LETHE Advisory Board (members of the public) provided feedback on the trial protocol.ResultTrial is registered at ClinicalTrials.gov (NCT05565170), and ethical approval has been obtained in each country. Recruitment started in September 2022 and will be completed in Spring 2023. Updates and results on study progress will be presented.ConclusionLETHE pilot trial will inform about the feasibility of technological solutions and a digitally assisted lifestyle program to support brain health among older adults. If proved to induce sustained behavioural changes, digital tools could offer potential for large‐scale, cost‐effective dementia prevention programs.

Abstract C018: Cultural variables underlying obesity in Asians: Implications for understanding cancer risk behaviors in Filipinos

Abstract Obesity is associated with 13 different types of cancers (Steele et al., 2017) and in 2014, overweight- and obesity-related cancers accounted for 40% of all cancers that were diagnosed (Steele et al., 2014). Moreover, there are significant disparities associated with obesity in the United States. Filipinos Americans are disproportionately affected by higher obesity rates compared to other Asian American groups (Bates et al., 2008; Maxwell et al., 2012). Filipino immigrants are also at increased risk for hypertension and diabetes due to higher central adiposity (higher waist circumferences) and increased fat intake compared to other racial/ethnic groups (Vargas & Jurado, 2015). The purpose of this presentation is to describe the design and development of an ongoing pilot study examining how cultural variables (e.g., acculturation, acculturative stress, ethnic identity, and cultural values) contribute to the understanding of disparities in modifiable risk factors (e.g., diet, physical activity body image) associated with overweight or obesity among Filipino adults. This culture and health assessment can inform future interventions that are uniquely tailored to the Filipino American community. This study can also serve as a guide for future researchers interested in 1) assessing cultural variables associated with race and ethnicity as it relates to diet, physical activity and body image and 2) developing questionnaires that are feasible to use for a particular racial or ethnic group. The study aims to: 1) develop culturally appropriate materials and measures to successfully assess diet, physical activity and body image, 2) examine the feasibility and acceptability of selected questionnaires administered during planned interviews, and 3) obtain pilot data can be used to guide a future larger study with Filipinos. In partnership with the Filipino Young Leaders Program (FYLPRO) and Filipino Health Community Advisory Board members, this study will enroll 25 Filipino Americans and immigrants, ages 18-65, with body mass index ≥ 18.5 kg/m2. Participants will complete an interview focused on health, culture, diet, physical activity and body image. Additionally, objective measures (e.g., weight, height, body fat) will be collected. This research study is a work in progress. The presentation will describe the purpose and development of a study that will help to inform future community-based, culturally tailored cancer risk reduction interventions focused on overweight and obesity among Filipino adults. Citation Format: Lisa Sanchez-Johnsen, Jacob Less, Angela Rose David, Nicole Aniceto, Irma Rodas, David Sedillo, Sumihiro Suzuki, Annabelle Santos Volgman, Melissa Palma. Cultural variables underlying obesity in Asians: Implications for understanding cancer risk behaviors in Filipinos [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr C018.

Abstract C104: Addressing health disparities: Enhancing knowledge and screening practices for liver disease risk factors among African Americans

Abstract Background: Liver cancer poses a significant health burden globally, with racial and ethnic disparities in its incidence. Among these disparities, the Black population in the United States faces a heightened risk of liver cancer due to the higher prevalence of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. This study aimed to evaluate the effectiveness of a culturally tailored educational intervention designed to enhance awareness of liver cancer prevention and screening among at-risk populations. Methods: Descriptive statistics were used to characterize participant demographics and clinical factors. Paired t-tests assessed the difference in knowledge scores before and after the intervention. Poisson regression with robust variance estimation determined the association between physicians' recommendations for testing and patients receiving blood tests. Results: The study included 137 African American participants. Prior to the intervention, the majority were aware that casual contact does not transmit HBV or HCV (79.6%) and that sharing needles for tattoos or drug injection can transmit the viruses (77.4%). The mean knowledge score increased significantly from 6.61 pre-intervention to 8.44 post-intervention (p-value<0.001). Poisson regression analysis showed that African American adults were less likely to receive physician recommendations for blood tests for HBV (RR=0.95, 95%CI:0.87,1.04) and HCV (RR=0.91, 95%CI:0.83,1.00) compared to other racial/ethnic groups. Conclusions: The culturally tailored educational intervention effectively improved knowledge of HBV and HCV among African American participants, indicating the importance of culturally sensitive programs in reducing liver cancer disparities. Efforts to increase awareness of liver disease and promote testing within the healthcare system are crucial for reducing the morbidity and mortality associated with HBV and HCV infections among African Americans. Character count (with spaces): 1,963 Acknowledgment: This study was supported by TUFCCC/HC Regional Comprehensive Cancer Health Disparity Partnership, Award Number U54 CA221704(5) from the National Cancer Institute of National Institutes of Health (NCI/NIH) and by NIGMS/NIH award # 1SC3GM131949[GXM1] . The author team would like to thank Community Advisory Board members, leaders, and staff members for collaborating with community/faith-based organization partners. We also acknowledge the research team staff of Planning Evaluation Core under TUFCCC/HC Regional Comprehensive Cancer Health Disparity Partnership for their support and contribution for their support and contributions to Community Outreach Core's data management. Its contents are solely the authors' responsibility and do not necessarily represent the official views of the NCI/NIH or the NIGMS/NIH. Citation Format: Jade A. Truehart, Thoin F. Begum, Keshanti Bruce, Lin Zhu, Ming-Chin Yeh, Evelyn Gonzalez, Marilyn A. Fraser, Ada Wong, Steven Zhu, Nathaly Rubio-Torio, Grace X. Ma, Yin Tan. Addressing health disparities: Enhancing knowledge and screening practices for liver disease risk factors among African Americans [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr C104.

Abstract C065: Developing and sustaining an NCI U54 CPACHE partnership

Abstract Purpose: The South Carolina Cancer Disparities Research Center (SC CADRE) is a mature and vibrant multi-institutional Comprehensive Partnership to Advance Cancer Health Equity (CPACHE) enterprise between South Carolina State University (SCSU), an institution serving underserved health disparity populations and underrepresented students (ISUPS) and the Medical University of South Carolina-Hollings Cancer Center (MUSC-HCC), an NCI-designated Cancer Center. Methods: The SC CADRE was built on a foundational relationship that began in 2009, including three consecutive inter-institutional Department of Defense Summer Undergraduate Prostate Cancer Research Training grants and an NCI CPACHE P20 grant. Awarded in 2017, the inaugural U54 SC CADRE had four main goals: 1) further elucidating the biological and social contributors to cancer disparities; 2) enhancing the pipeline of diverse cancer researchers; 3) increasing the number of NIH research proposals led by SCSU faculty as independent investigators; and 4) including greater community engagement in cancer research. Results: Since 2017, the U54 partnership has produced 77 peer-reviewed publications (8 included inter-institutional co-authors) and, not counting the SC CADRE research project awards, 33 grants have been funded (9 were awarded to SCSU investigators as PIs or MPIs), and a national virtual cancer health equity symposium was established. Four ESIs were hired (three at SCSU). An inaugural Biorepository was created at SCSU. Cancer research education was provided for 640 undergraduate students at SCSU, including 22 SC CADRE Scholars. The SC CADRE team members serve as Advisory Board members of South Carolina’s statewide cancer control consortium, the South Carolina Department of Health and Environmental Control, ISUPS and other colleges/universities in South Carolina, and statewide faith-based, professional, and civic organizations. These combined efforts have led to an overall 30% representation of diverse participants in the MUSC-HCC’s cancer clinical trial accruals. Conclusions: While much work remains, mammography and colorectal cancer screening rates, and HPV vaccination rates, are now higher in South Carolina than in the US. The longstanding academic partnership between SCSU and MUSC-HCC, leveraging each entity’s research and educational strengths and community relationships, has positioned the SC CADRE to transform cancer health outcomes in South Carolina and beyond. Citation Format: Marvella E. Ford, Tammy Loucks, James Stukes, Cammie Berry, Joni Nelson, Kathleen Cartmell, Audrey McCrary-Quarles, Amy Martin, Joseph Tahsoh, Alexander Alekseyenko, Janae Sweeney, Steven Carroll, Debra McAlister, Ellen Gomez, Yaoling Long, David P. Turner, Judith D. Salley. Developing and sustaining an NCI U54 CPACHE partnership [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr C065.

The BCPC Congress 2023

The 2023 British Crop Production Council (BCPC) Congress was held at the Cedar Court Hotel, Harrogate, UK from 7–8 November and was entitled "Shaping the future of crop protection". On the evening before the main Congress, Sarah Cowlrick (Association of Independent Crop Consultants) and Hazel Doonan (Agricultural Industries Confederation) were presented with the BCPC Award for their outstanding contributions to the crop production sector. In presenting the awards, BCPC Advisory Board Member Jim Orson commented "both recipients, in different organisations, are at the very centre of training and support for Integrated Pest Management (IPM) within the sector, carefully and brilliantly ensuring that farmers receive informed advice on managing their crops. Not only do they do that, but they also give of their time to support other industry initiatives."

Abstract A042: Community advisory board members’ perspectives on genetic literacy and patient-caregiver communication of prognostic genomics for localized prostate cancer

Abstract Background: The National Comprehensive Cancer Network (NCCN) recommends the use of tissue-based genetic tests, such as Decipher, Prolaris, and Confirm mdx for localized prostate cancer, to help patients and caregivers make more informed treatment decisions at the time of diagnosis. However, while much enthusiasm currently exists for the burgeoning field of genomic medicine, prostate cancer disparities continue to persist in underserved communities despite the existence of evidence-based treatment guidelines. Methods: A diverse 15-member Community Advisory Board (CAB) representing rural and urban communities in Duval County, Florida were recruited from May to June 2023, to build a community-academic partnership, for the development and implementation of a genetic literacy patient-caregiver educational intervention for localized prostate cancer. The 15-member CAB was divided into groups of 5 for focus group discussions. Qualitative and quantitative data from CAB members were integrated to gain better understanding of the facilitators and barriers for prostate cancer genetic literacy in underserved communities. Results: The thematic analysis reveals several key themes related to prostate cancer, screening, treatment, and genetics. These themes reflect the diverse perspectives and experiences of the CAB members regarding prostate cancer, ranging from personal anecdotes to broader societal issues. Participants expressed thoughts related to fear, lack of knowledge, cultural beliefs, and access to healthcare. The discussion on prostate cancer and tissue based genetic testing highlighted the complexities surrounding prostate cancer and the need for further education, awareness, and access to affordable healthcare for all individuals at risk. Conclusion: CAB members emphasized the importance of improving access to information, promoting education, and addressing cultural barriers to ensure that individuals are informed about available options for prostate cancer diagnosis and treatment. Citation Format: Ewan K. Cobran, Jocelyn Turner, Folakemi Odedina, Alan H. Bryce, Christopher Williams, Jose Rodriguez, Roger Williams, Woodrow Nathan, Thomas Bryant III, LoveVonia Nathan, Laureen Husband. Community advisory board members’ perspectives on genetic literacy and patient-caregiver communication of prognostic genomics for localized prostate cancer [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A042.

2280. Surveillance of Life-Long Antibiotics (SOLLA) 2: Patients on Life-Long Antibiotics in an Australian Healthcare Network

Abstract Background There is a range of conditions for which long-term antibiotics are prescribed, most of which lack high quality evidence. Apart from promoting antimicrobial resistance, long-term antibiotics also impact the individual patient, disrupting the normal microbiome, and increasing the risk of infection with multi-resistant organisms (MROs). Previous work conducted at Monash Health, in Victoria, Australia, in 2014 noted great heterogeneity in both indications for prolonged antibiotic courses and the antimicrobial agents used. Methods The current study aimed to reassess prescribing trends within the same health network, across two time periods in 2019 and 2021. Outpatient prescriptions were extracted from the Monash Health pharmaceutical database at two time points, from 1st January 2019 – 30th June 2019, and 1st January 2021 – 30th June 2021. Results From 4,704 outpatient prescriptions, 929 patients were identified as being on either one or more antibiotics for an intended duration of ≥ 12 months. There were a total 536 (57.7%) males and 393 females (42.3%), with a mean age of 58.20 years. Sixty-eight patients died between the two follow-up periods. Data was separated into 3 groups: primary prophylaxis in the setting of immunosuppression (n = 687), secondary prophylaxis for infections deemed incurable (n = 78), and “Other” (n = 164). Six hundred and four patients (88%) on primary prophylaxis were for Pneumocystis jirovecii pneumonia, and 83 (12%) post splenectomy. Trimethoprim/sulfamethoxazole was predominantly prescribed for PJP prophylaxis (n = 583), followed by dapsone (n = 21). Prosthetic joint infections made up 57 (73%) of those on suppressive antibiotics for infections deemed incurable. An array of antibiotics was utilised to treat them, as seen in Figure 1. The “Other” category included those on antibiotics for difficult to treat infections, such as mycobacterial infections (n = 43), chronic airways disease (n = 38), spontaneous bacterial peritonitis (n = 23) and recurrent urinary tract infections (n = 12). Data on comorbidities, hospitalisations and MROs between groups can be viewed in Table 1. Conclusion Further research is needed. Prospective data examining long-term patient outcomes, and patterns of prescribing across different health networks would be of benefit. Disclosures Jillian Lau, MBBS, FRACP, Gilead: Advisor/Consultant|Gilead: Grant/Research Support|MSD: Grant/Research Support|Viiv Healthcare: Advisor/Consultant Ian Woolley, MBBS, FRACP, DTM&H, MD, Gilead: Educational support, investigator for Gilead supported trial|MSD: educational support, participation in a clinical trial|Pfizer: Educational support|ViiV: Educational Programs, Advisory Board member, ViiV sponsored trials

Community advisory board members' perspectives on their contributions to a large multistate cluster RCT: a mixed methods study.

Community advisory boards (CABs) are an established approach to ensuring research reflects community priorities. This paper examines two CABs that are part of the HEALing Communities Study which aims to reduce overdose mortality. This analysis aimed to understand CAB members' expectations, experiences, and perspectives on CAB structure, communication, facilitation, and effectiveness during the first year of an almost fully remote CAB implementation. Current literature exploring these perspectives is limited. We collected qualitative and survey data simultaneously from members (n = 53) of two sites' CABs in the first 9 months of CAB development. The survey assessed trust, communication, and relations; we also conducted 32 semi-structured interviews. We analyzed the survey results descriptively. The qualitative data were analyzed using a deductive codebook based on the RE-AIM PRISM framework. Themes were drawn from the combined qualitative data and triangulated with survey results to further enrich the findings. CAB members expressed strong commitment to overall study goals and valued the representation of occupational sectors. The qualitative data described a dissonance between CAB members' commitment to the mission and unmet expectations for influencing the study within an advisory role. Survey results indicated lower satisfaction with the research teams' ability to create a mutually beneficial process, clear communication, and sharing of power. Building a CAB on a remote platform, within a study utilizing a community engagement strategy, still presents challenges to fully realizing the potential of a CAB. These findings can inform more effective operationalizing of community-engaged research through enhanced CAB engagement.

Development of Youth-Centered Health Messaging Posters for High School-Based Health Clinics in Hawaii.

Youth may be reluctant to seek health care from school health providers due to feeling embarrassed or stigmatized in the health office environment or worried about their confidentiality. The purpose of this project was to create a set of youth-centered health posters that promote youth engagement with nursing staff and to standardize health messaging across high schools in Hawaii school-based clinics. Two community advisory boards, 1 composed of 10 youth stakeholders (mean age 17 years) and the other of 7 adult stakeholders, informed poster development utilizing web-based discussion groups. The discussions were transcribed, and additional data was collected using field notes and anonymous digital messages. Adult advisory board members also provided feedback on suggested poster text through an online survey. Youth and adult advisory board participants identified 4 key health concerns facing youth: confidentiality, sexual health, relationships, and mental health. Based on input from the 2 advisory boards, 4 posters were developed, each centered on 1 key health issue. School-based posters can convey important messages to help youth understand their health care rights and responsibilities, as well as identify important issues open for discussion with nurses. Posters are an underutilized tool for school health providers to create welcoming, inclusive health care environments and facilitate health-related conversations with youth. This paper describes participant feedback about the characteristics of a memorable poster and briefly outlines current knowledge and recommendations for school health providers regarding each of the 4 health issues.

New advisory board members speak on challenges and opportunities in chemical biology

Cell Chemical Biology has recently added several advisory board members from China in an effort to better represent our authorship and readership. In this Voices piece, a few of the new members introduce themselves, give their perspective on challenges and opportunities in chemical biology, and discuss how they plan to contribute to the field through their new position.

Meet the Editorial Advisory Board Member

Meet the Editorial Advisory Board Member