Vegetables are nutritionally rich, high-valued crops and remunerative enough to replace subsistence farming. However, vegetables are highly sensitive to climatic vagaries and sudden irregularities in weather factors at any phase of crop growth can affect the normal growth, flowering, fruit development and subsequently the yield. Grafting in vegetable has emerged as a promising surgical alternative over relatively slow conventional breeding methods aimed at increasing tolerance to biotic and abiotic stresses. It provides an opportunity to transfer some genetic variations of specific traits of rootstocks to influence the phenotype of scion. Thus, genetic potential of various rootstocks in vegetable crops has proven to be a better alternative to chemical sterilants against many soil-borne diseases. The higher physiological activities like antioxidant content, lipoxygenase activity, osmotic adjustment, membrane selectivity, development of adventitious root and aerenchymatous tissue in plants grafted onto potential rootstocks provide broad insight into stress response mechanisms and thus, grafting is proposed to mitigate the adverse impact of climate change on productivity and quality of vegetables crops.