Body Scan Research Articles

Педиатрическая рентгенография: проблемы и решения

Background: Because of children's distinct physiological and anatomical features, pediatric radiography necessitates particular techniques. Recent advances in medical physics have considerably improved the accuracy and safety of pediatric radiological procedures. However, these developments bring new obstacles. Objective: This article evaluates the most recent advances in medical physics relevant to pediatric radiography, highlights the accompanying problems, and provides feasible solutions to improve clinical results and patient safety. Methods: A thorough literature analysis focused on current research and technology advancements in pediatric radiology. The main advances in imaging technology, radiation dose control, and diagnostic accuracy were examined. Expert comments and case studies were also analyzed for common issues and solutions. Results: Low-dose imaging methods, such as digital radiography, pediatric-specific computed tomography (CT), and magnetic resonance imaging (MRI), have advanced significantly. These enhancements have resulted in better image quality and lower radiation exposure. However, patient size heterogeneity, motion artifacts, and the necessity for age-specific procedures remain common. Conclusion: Medical physics advancements have significantly enhanced pediatric radiology, allowing for higher diagnostic capabilities while reducing hazards. To address the remaining difficulties, radiologists must continue research, adopt standardized methods, and get continual education. Future advances should focus on lowering radiation exposure and enhancing imaging technologies' flexibility to meet pediatric patients' demands.

Region of interest determination algorithm of lensless calcium imaging datasets.

Advances in fluorescence imaging technology have been crucial to the progress of neuroscience. Whether it was specific expression of indicator proteins, detection of neurotransmitters, or miniaturization of fluorescence microscopes, fluorescence imaging has improved upon electrophysiology, the gold standard for monitoring brain activity, and enabled novel methods to sense activity in the brain. Hence, we developed a lightweight and compact implantable CMOS-based lensless Ca2+ imaging device for freely moving transgenic G-CaMP mouse experiments. However, without a lens system, determination of regions of interest (ROI) has proven challenging. Localization of fluorescence activity and separation of signal from noise are difficult. In this study, we report an ROI selection method using a series of adaptive binarizations with a gaussian method and morphological image processing. The parameters for each operation such as the kernel size, sigma and footprint size were optimized. We then validated the utility of the algorithm with simulated data and freely moving nociception experiments using the lensless devices. The device was implanted in the dorsal raphe nucleus to observe pain-related brain activity following a formalin test to stimulate pain. We observed significant increases in fluorescence activity after formalin injection compared to the control group when using the ROI determination algorithm.

Implementing Continuous Integration/Continuous Deployment (CI/CD) Pipelines for Large-Scale iOS Applications

Continuous integration and continuous deployment pipelines have become essential components of modern software development, particularly in creating large-scale iOS apps. The automation of procedures for creating, testing, and deploying is facilitated by them, which results in an increase in both the speed and reliability of the release process. The complexity and scope of the codebase, the need for rigorous testing across a broad range of devices and operating system versions, and the regular necessity of updates to address bugs or bring new features all contribute to the conclusion that continuous integration and continuous delivery pipelines are an integral component of major iOS projects. The integration of continuous integration with continuous delivery provides developers with the assurance that code changes are automatically tested and delivered, hence lowering the need for human intervention, and reducing the chance of mistakes. In addition, this arrangement makes it possible to do parallel testing, which is useful when working with many test cases and device configurations. It is also possible to design continuous integration and continuous delivery pipelines to do tests for code quality, security scans, or other automated checks, which will ensure that the codebase is not compromised.By increasing communication among development teams, continuous integration and continuous delivery pipelines in big iOS projects provide yet another key advantage. It guarantees that every member of the team always has access to the most recent version of the code, which is essential in situations when many teams are working on various aspects or components of the application. In addition, continuous integration and continuous delivery pipelines enhance software quality by accelerating feedback loops, which enables engineers to resolve problems more expediently. Nevertheless, the establishment of continuous integration and continuous delivery pipelines for large-scale iOS apps involves several issues, such as the management of build times, the certification of compatibility with various devices, and the upkeep of the infrastructure. It is necessary to carefully design and optimize the CI/CD procedures to overcome these problems. This may be accomplished by choosing the appropriate tools and configurations adapted to the project's requirements.

Trunk-to-leg volume and appendicular lean mass from a commercial 3-dimensional optical body scanner for disease risk identification

Body shape expressed as the trunk-to-leg volume ratio is associated with diabetes and mortality due to the associations between higher adiposity and lower lean mass with Metabolic Syndrome (MetS) risk. Reduced appendicular muscle mass is associated with malnutrition risk and age-related frailty, and is a risk factor for poor treatment outcomes related to MetS and other clinical conditions (e.g.; cancer). These measures are traditionally assessed by dual-energy X-ray absorptiometry (DXA), which can be difficult to access in clinical settings. The Shape Up! Adults trial (SUA) demonstrated the accuracy and precision of 3-dimensional optical imaging (3DO) for body composition as compared to DXA and other criterion measures. Here we assessed whether trunk-to-leg volume estimates derived from 3DO are associated with MetS risk in a similar way as when measured by DXA. We further explored if estimations of appendicular lean mass (ALM) could be made using 3DO to further improve the accessibility of measuring this important frailty and disease risk factor. SUA recruited participants across sex, age (18-40, 40-60, >60 years), BMI (under, normal, overweight, obese), and race/ethnicity (non-Hispanic [NH] Black, NH White, Hispanic, Asian, Native Hawaiian/Pacific Islander) categories. Each participant had whole-body DXA and 3DO scans, and measures of cardiovascular health. The 3DO measures of trunk and leg volumes were calibrated to DXA to express equivalent trunk-to-leg volume ratios. We expressed each blood measure and overall MetS risk in quartile gradations of trunk-to-leg volume previously defined by National Health and Nutrition Examination Survey (NHANES). Finally, we utilized 3DO measures to estimate DXA ALM using ten-fold cross-validation of the entire dataset. Participants were 502 (273 female) adults, mean age=46.0±16.5y, BMI=27.6±7.1kg/m2 and a mean DXA trunk-to-leg volume ratio of 1.47±0.22 (females: 1.43±0.23; males: 1.52±0.20). After adjustments for age and sex, each standard deviation increase in trunk-to-leg volume by 3DO was associated with a 3.3 (95% odds ratio [OR]=2.4-4.2) times greater risk of MetS, with individuals in the highest quartile of trunk-to-leg at 27.4 (95% CI: 9.0-53.1) times greater risk of MetS compared to the lowest quartile. Risks of elevated blood biomarkers as related to high 3DO trunk-to-leg volume ratios were similar to previously published comparisons using DXA trunk-to-leg volume ratios. Estimated ALM by 3DO was correlated to DXA (r2=0.96, root mean square error=1.5kg) using ten-fold cross-validation. Using thresholds of trunk-to-leg associated with MetS developed on a sample of US-representative adults, trunk-to-leg ratio by 3DO after adjustments for offsets showed significant associations to blood parameters and MetS risk. 3DO scans provide a precise and accurate estimation of ALM across the range of body sizes included in the study sample. The development of these additional measures improves the clinical utility of 3DO for the assessment of MetS risk as well as the identification of low muscle mass associated with poor cardiometabolic and functional health.

Cross-Domain Image Classification via Multimodal Augmentations and Bacterial Foraging Optimization

Identification of diseases from body scans requires design of pre-processing, filtering, segmentation, feature representation, classification & post-processing operations. Existing deep learning-based classification models use context-specific segmentation followed by convolutions or transformer-based classification techniques. However, the majority of these models do not perform correlative analysis between different disease types. This limitation restricts their scalability and applicability in clinical scenarios. To address these limitations, this research work proposed IMAC-MOC, a model that integrates multimodal augmentations to enhance performance in cross-domain and multi-organ image classification. The proposed model initially collects large-scale scans at organ-level like MRI, CT scan, Kidney Scans, etc. and represents them via multimodal feature sets. These feature maps are combined and processed via a Bacterial Foraging Optimizer (BFO) which assists in identification of high variance inter-class feature sets.

Computational Methods for Image Analysis in Craniofacial Development and Disease

Observation is at the center of all biological sciences. Advances in imaging technologies are therefore essential to derive novel biological insights to better understand the complex workings of living systems. Recent high-throughput sequencing and imaging techniques are allowing researchers to simultaneously address complex molecular variations spatially and temporarily in tissues and organs. The availability of increasingly large dataset sizes has allowed for the evolution of robust deep learning models, designed to interrogate biomedical imaging data. These models are emerging as transformative tools in diagnostic medicine. Combined, these advances allow for dynamic, quantitative, and predictive observations of entire organisms and tissues. Here, we address 3 main tasks of bioimage analysis, image restoration, segmentation, and tracking and discuss new computational tools allowing for 3-dimensional spatial genomics maps. Finally, we demonstrate how these advances have been applied in studies of craniofacial development and oral disease pathogenesis.

Updated reference values for BMD and lean mass measured by DXA in Thai children.

This study established normative references for total body less head (TBLH) BMD, lumbar spine (L1-L4) BMD, and both total and appendicular lean mass (LM) in Thai children and adolescents (aged 5-18years) using DXA. This work expands upon 2014 normative data for Thai children, which included L2-L4 BMD, total body BMD (head included), and total LM. We reanalyzed total body and lumbar spine DXA scans (Lunar Prodigy Pro, GE Healthcare; enCORE version 7.53) from 174 boys and 193 girls, using upgraded software (enCORE version 17SP2) for TBLH BMD, L1-L4 BMD, and LM analysis. The "enhanced" mode was applied for TBLH BMD and LM. Adjustments for total and appendicular LM were made relative to squared height (m2) to account for body size variability. Normative data stratified by sex and Tanner stage were generated for TBLH BMD, L1-L4 BMD, and LM indices. Weight and Tanner stage significantly determined BMD and LM. Adolescent girls exhibited higher LSBMD values due to earlier pubertal onset. Boys showed higher LM indices with more rapid gains during growth spurts. This study provides updated normative reference values for BMD (TBLH and L1-L4) and LM (total and appendicular) in Thai children and adolescents, measured via DXA. These references will enhance the assessment of low bone mass and LM deficits in Thai pediatric populations, particularly in those with chronic illnesses.

The relationships between patellofemoral bone remodeling, cartilage composition, and vertical loading rate: PET/MRI in isolated patellofemoral osteoarthritis

ObjectiveLoading is invariably an important factor of consideration for understanding the causality flow and parallel existence of articular cartilage and subchondral bone changes. The goal of this study was to investigate the patterns of subregional 18NaF-SUV vs. T1p-T2 associations and vertical ground reaction force loading rates; in isolated patellofemoral-joint-osteoarthritis (PFJ-OA) patients. MethodThirty-five isolated PFJ-OA patients, with no tibiofemoral involvement, underwent simultaneous scans in a 3.0T whole-body hybrid PET-MRI scanner. MRI WORMS assessments were performed to identify/confirm isolated PFJ-OA knees from bilateral scans. T1p-T2 relaxation and SUV values were automatically computed for both trochlear and patellar cartilage and subchondral bone subregions (deep, superficial, lateral, and medial). Maximum vertical impact loading rates (Loading-RateNorm) were calculated from walking trials. Relationships were explored between SUV uptake, T1p-T2 values, and Loading-RateNorm via linear mixed-effects modeling. ResultsSignificant and complex association patterns were noted between medial and lateral bone 18NaF-SUV uptakes vs. medial and lateral cartilage sub-regional T1p and T2. SUVMean and SUVMax were positively associated with deep cartilage subregional T1pand T2 values; and negatively associated with superficial cartilage subregional T1p-T2 values in both medial and lateral regions. Both medial and lateral bone 18NaF-SUVMean and SUVMax uptakes remained positively associated with the individual gait characteristics, i.e., peak vertical impact loading rates (Loading-RateNorm). ConclusionEvidence of simultaneous, complementary, cross-sectional associations between T1p-T2 values and peak vertical loading rates with 18NaF-SUV, have been rare in the isolated PFJ-OA cohort. The clinical implications of such novel associations remain of utmost importance from a gait retraining perspective.

Match Point: Nuclear Medicine Imaging for Recurrent Thyroid Cancer in TENIS Syndrome-Systematic Review and Meta-Analysis.

Background/Objectives: Disease recurrence and resistance to radioiodine (RAI) therapy are major challenges in the management of differentiated thyroid cancer (DTC). In particular, the TENIS (Thyroglobulin Elevated Negative Iodine Scintigraphy) syndrome, characterised by elevated thyroglobulin (Tg) serum levels in addition to a negative radioiodine whole body scan (WBS), complicates disease monitoring and treatment decisions. Conventional imaging techniques often fail to detect disease in WBS-negative patients with rising Tg levels, leading to limitations in therapeutic intervention. This systematic review and meta-analysis aims to evaluate the diagnostic accuracy of nuclear imaging modalities in detecting disease recurrence in patients with the TENIS syndrome and to provide insights to guide therapeutic approaches in this complex clinical scenario. Methods: A comprehensive search of PubMed/MEDLINE and EMBASE databases up to March 2024 was performed according to PRISMA guidelines. Eligible studies were selected, and quality assessment was performed with the QUADAS-2 tool. For each study, relevant data were extracted and synthesised. A meta-analysis of the diagnostic accuracy of [18F]FDG PET/CT was performed, and patient-based pooled sensitivity and specificity were calculated using a random-effects model. Statistical heterogeneity between studies was assessed using the I2 statistic. Results: Of the 538 studies initially identified, 22 were included in the systematic review, of which 18 were eligible for meta-analysis. The eligible studies, mainly focused on [18F]FDG PET/CT, showed variable sensitivity and specificity for the detection of RAI-refractory thyroid cancer lesions. For [18F]FDG PET/CT, pooled estimates displayed a sensitivity of 0.87 (95% CI: 0.82-0.90) and a specificity of 0.76 (95% CI: 0.61-0.86), with moderate heterogeneity between studies. Conclusions: [18F]FDG PET/CT remains central in the detection of disease recurrence in patients with the TENIS syndrome. The emergence of novel radiopharmaceuticals with specific molecular targets is a promising way to overcome the limitations of [18F]FDG in these patients and to open new theranostics perspectives. This review highlights the great potential of nuclear medicine in guiding therapeutic strategies for RAI-refractory thyroid cancer.

PETcoil: first results from a second-generation RF-penetrable TOF-PET brain insert for simultaneous PET/MRI

Simultaneous positron emission tomography (PET)/magnetic resonance imaging provides concurrent information about anatomic, functional, and molecular changes in disease. We are developing a second generation MR-compatible RF-penetrable TOF-PET insert. The insert has a smaller scintillation crystal size and ring diameter compared to clinical whole-body PET scanners, resulting in higher spatial resolution and sensitivity. This paper reports the initial system performance of this full-ring PET insert. The global photopeak energy resolution and global coincidence time resolution, 11.74 ± 0.03 % FWHM and 238.1 ± 0.5 ps FWHM, respectively, are preserved as we scaled up the system to a full ring comprising 12, 288 LYSO-SiPM channels (crystal size: 3.2 × 3.2 × 20 mm3). Throughout a ten-hour experiment, the system performance remained stable, exhibiting a less than 1% change in all measured parameters. In a resolution phantom study, the system successfully resolved all 2.8 mm diameter rods, achieving an average VPR of 0.28 ± 0.08 without TOF and 0.24 ± 0.07 with TOF applied. Moreover, the implementation of TOF in the Hoffman phantom study also enhanced image quality. Initial MR compatibility studies of the full PET ring were performed with it unpowered as a milestone to focus on looking for material and geometry-related artifacts. During all MR studies, the MR body coil functioned as both the transmit and receive coil, and no observable artifacts were detected. As expected, using the body coil also as the RF receiver, MR image signal-to-noise ratio exhibited degradation (∼30%), so we are developing a high quality receive-only coil that resides inside the PET ring.

Advancements of the 21st century and Their Implications on Medical Research and Diagnosis

Throughout the 20th century, new research and new demands have led to an increased amount of technology used in medicine. These methods have led to early detection, better context of conditions, increased efficiency, and brighter prospects for the future of medical diagnosis. However, the increasing use of AI and genetics in medicine has called for checks and further clinical trials to determine how ethical these practices might be. The debate surrounding the integration of Artificial Intelligence has created further controversy—that is, what technologies should be used and what technologies should not be used. To determine a solution, certain factors should be considered including the comfort of patients during treatments including advanced technology, the risk factor of integrating AI into procedures, and the efficiency of technology compared to traditional medical practices. For example, imaging technologies such as X-ray and sonography are found to be more comfortable for patients due to their long-standing familiarity, yet their precision and accuracy fall short in comparison to advanced Imaging technologies such as CT, MRI, and PET scans. There has also been discussion of the use of genetic testing such as chromosomal microarrays. Advances in genetic testing have led to the ability to detect conditions in embryos which can be beneficial, but the manipulation of the embryos could raise ethical concerns. Past ethical grey areas, there have been amazing prospects for the future of medicine and these innovations, such as the use of non-invasive testing which is an emerging alternative to traditional surgical methods. Through extensive literary research, this paper considers the multiple aspects that should contribute to deciding to implement technological advancements brought in the 21st Century. By investigating previous integrations of innovations within medicine, this research could envision a risk-free and more ethical approach to advancing medicine with technology.

Impact of Guided Endodontics on the Success of Endodontic Treatment: An Umbrella Review of Systematic Reviews and Meta-Analyses.

Endodontic treatment, essential for preserving teeth affected by pulp or periapical diseases, often encounters challenges such as complex root canal anatomies and calcifications that can hinder success. Traditional techniques, although effective, are limited in addressing these complexities. Guided endodontics, which utilizes advanced imaging and navigation technologies, promises enhanced accuracy and precision, potentially improving treatment outcomes. Thus, this umbrella review aims to assess whether guided endodontics influences the outcome of endodontic treatment by synthesizing evidence from multiple systematic reviews and meta-analyses. Comprehensive searches were conducted in PubMed, Scopus, EBSCOhost, and Cochrane databases to identify relevant studies. Additionally, grey literature was searched. The umbrella review protocol was developed and registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42024564150). Inclusion criteria comprised randomized controlled trials (RCTs), randomized clinical trials, case series, and case reports. Exclusion criteria included reviews, non-English language articles, in vitro studies, ex vivo studies, randomized experimental (in vitro) studies, narrative reviews, and expert opinions. Studies involving patients undergoing guided endodontic treatment with dynamic and static navigation systems were included. The interventions aimed at improving the accuracy and precision of endodontic procedures, particularly in challenging cases such as locating calcified canals and performing microsurgery. The study involved three reviewers who independently appraised the systematic reviews for eligibility, data extraction, and review quality. The quality of the systematic reviews was evaluated using the "A Measurement Tool to Assess Systematic Reviews 2" (AMSTAR2) assessment tool. The methodological quality of the systematic reviews was assessed. A pooled review of the studies showed that guided endodontics demonstrated more precise and better results than conventional endodontic procedures.

Precision Test of a Multifunctional Scan Body for the Scan and Cross-Mount of an Edentulous Arch: A Pilot Case-Control Study.

The primary goal of this pilot study was to evaluate, via 3D analysis, the scan body precision of an intraoral digital scan utilizing a custom multifunctional scan body compared to that of digitized stone models fabricated from a conventional open tray impression in the fully edentulous maxilla and mandible. The secondary goal of this study was to showcase a method for utilizing the scan body library to generate a fixed fiducial marker for the cross-mount of an edentulous arch. Comparative analysis was performed as a case-control study. A custom scan body was utilized to generate the positions of the titanium bases from the intraoral models and digitized stone models of three maxillary arches (All-On-6, All-On-5, and All-On-4) and two mandibular arches (both All-On-4). The titanium base positions were compared using advanced 3D inspection software. The mean ± SD deviation was 30.38 ± 17.78 μm (95% CI: [14.8 to 45.97 μm]), with mean deviations of 38.73 ± 19.24 μm (95% CI: 16.96 to 60.5 μm) in the maxilla and 17.85 ± 0.92 μm (95% CI: 16.58 to 19.12 μm) in the mandible. The present results were promising, showing that deviations between the intraoral impressions and the digitized stone models fell within established tolerance ranges. Initial studies showed promising results that the digital workflow could be implemented with success similar to the conventional approach. Using the scan body library to generate a fiducial marker successfully demonstrated an efficient method for cross-mounting the edentulous arch.

Ultrack: pushing the limits of cell tracking across biological scales.

Tracking live cells across 2D, 3D, and multi-channel time-lapse recordings is crucial for understanding tissue-scale biological processes. Despite advancements in imaging technology, achieving accurate cell tracking remains challenging, particularly in complex and crowded tissues where cell segmentation is often ambiguous. We present Ultrack, a versatile and scalable cell-tracking method that tackles this challenge by considering candidate segmentations derived from multiple algorithms and parameter sets. Ultrack employs temporal consistency to select optimal segments, ensuring robust performance even under segmentation uncertainty. We validate our method on diverse datasets, including terabyte-scale developmental time-lapses of zebrafish, fruit fly, and nematode embryos, as well as multi-color and label-free cellular imaging. We show that Ultrack achieves state-of-the-art performance on the Cell Tracking Challenge and demonstrates superior accuracy in tracking densely packed embryonic cells over extended periods. Moreover, we propose an approach to tracking validation via dual-channel sparse labeling that enables high-fidelity ground truth generation, pushing the boundaries of long-term cell tracking assessment. Our method is freely available as a Python package with Fiji and napari plugins and can be deployed in a high-performance computing environment, facilitating widespread adoption by the research community.

Gallbladder Carcinoma: A Review of Literature

Gallbladder cancer (GBC) is the most common cancer of the biliary tract but the sixth most common cancer of the gastrointestinal tract. This tumor has a very high death rate. It is impossible to emphasize how crucial early diagnosis is because GBC grows subtly when it is discovered later. A number of environmental and genetic factors have been linked to the beginning of GBC. Environmental variables such as cholelithiasis, chronic inflammation of the biliary tract, and parasite infections are known to have a substantial impact on the development of gallbladder cancer. Congenital causes include abnormalities in the pancreaticobiliary duct junction and biliary cysts. Over the last ten years, advancements in imaging technology coupled with a more aggressive and drastic surgical approach have enhanced patient outcomes and contributed to longer survival times for GBC patients. This review article focuses on the epidemiology of GBC, its risk factors, and clinical characteristics.

Effects of aperture shapes on imaging spatial quality from end-to-end perspective

With the continuous advancement of optical imaging technology and the increasing requirement for remote sensing applications, high-resolution spatial imaging technology has been extensively researched. Subject to the diffraction limitation, the optical aperture is continuously increasing to obtain more target details, which leads to larger satellite platforms and higher manufacturing costs. In order to balance the cost of satellite platforms and the imaging quality of space cameras, this paper focuses on the optical aperture, which affects both of the above by conducting an end-to-end analysis of the space imaging process to examine its effects on overall imaging spatial quality. This paper formulates the optical aperture optimization problem by establishing the evaluation functions for deployment cost and imaging quality. Two types of optical systems commonly used in space imaging, the coaxial reflective optical system with annular aperture and the topologically compact optical system with square aperture are studied based on the proposed optimization model. Their imaging characteristics and design principles are summarized. The optimization model proposed can be applied to the optical aperture design of any manufacturable optical system to guide the design of the entire space camera and even the satellite platforms.

Clinical applications, safety profiles, and future developments of contrast agents in modern radiology: A comprehensive review

AbstractContrast agents have transformed the field of medical imaging, significantly enhancing the visualisation of internal structures and improving diagnostic accuracy across X‐rays, computed tomography, magnetic resonance imaging (MRI), and ultrasound. This review explores the historical development, physicochemical properties, and mechanisms of action of iodinated, gadolinium‐based, barium sulfate, microbubble, and nanoparticle contrast agents. It highlights key advancements, including the transition from high‐osmolar to low‐ and iso‐osmolar iodinated agents, the integration of gadolinium in MRI, and the innovative use of microbubbles and nanoparticles. The review critically examines the safety profiles and adverse reactions of these contrast agents, categorising them into hypersensitivity and physiological reactions. It outlines risk factors, common misconceptions, and management strategies for adverse reactions, emphasising the importance of personalised approaches in clinical practice. Additionally, it delves into broader implications, including ethical considerations, environmental impact, and global accessibility of contrast media. The review also discusses technological advancements such as targeted contrast agents and the integration of artificial intelligence to optimise contrast dosage. By synthesising current knowledge and emerging trends, this review underscores the pivotal role of contrast agents in advancing medical imaging. It aims to equip clinicians, researchers, and policymakers with a thorough understanding to enhance diagnostic efficacy, ensure patient safety, and address ethical and environmental challenges, thereby informing future innovations and regulatory frameworks to promote equitable access to advanced imaging technologies globally.

Diagnostic accuracy and clinical impact of renal biopsy cytology.

The role of fine needle biopsy cytology in the workup of renal mass lesions remains controversial. With advances in imaging technology and clinical management for renal masses, a critical reevaluation of the role of renal biopsy is needed. This study was designed to provide a comprehensive evaluation of the performance and clinical impact of fine needle biopsy in patients with renal masses. A 5-year retrospective study of ultrasound or computer tomography (CT)-guided fine needle biopsies of renal masses diagnosed via cytopathology was conducted. Overall diagnostic rate, sensitivity, and diagnostic accuracy were calculated. Further analysis of the impact of fine needle biopsy cytology on clinical management was performed. A total of 227 cases of fine-needle aspiration and/or biopsy (FNA/B) of renal masses were identified, including 76 with subsequent nephrectomies. Complications were rare (<1%). The diagnostic rate and sensitivity of FNA/B were 83.3% and 89.5%, respectively. Diagnostic accuracy was 98.7% at the major categorical level and 94.7% at the tumor subtype level. Subsequent clinical actions were associated with a definitive cytologic diagnosis of malignancy/neoplasia (p < .05) and were affected by tumor subtype (p < .05). This study demonstrates that FNA/B of renal masses is a safe and reliable minimally invasive diagnostic tool with excellent accuracy in confirmation of malignancy and subclassification of tumors. Diagnoses made on FNA/B play a key role in guiding a personalized clinical treatment plan.

Naturalistic approach to investigate the neural correlates of a laundry cycle with and without fragrance.

Advancements in brain imaging technologies have facilitated the development of "real-world" experimental scenarios. In this study, participants engaged in a household chore - completing a laundry cycle - while their frontal lobe brain activity was monitored using fNIRS. Participants completed this twice using both fragranced and unfragranced detergent, to explore if fNIRS is able to identify any differences in brain activity in response to subtle changes in stimuli. Analysis was conducted using Automatic IDentification of functional Events (AIDE) software and fNIRS correlation-based signal improvement (CBSI). Results indicated that brain activity, particularly in the right frontopolar and occasionally the left dorsolateral prefrontal cortex, was more pronounced and frequent with the unfragranced detergent than the fragranced. This suggests that completing tasks in an environment where a pleasant and relaxing fragrance is present might be less effortful compared to an odourless environment.

Cylindrical Microwave Body Scanner—Part II: System Evaluation by Image Quality Assessment

Cylindrical Microwave Body Scanner—Part II: System Evaluation by Image Quality Assessment