Injection of adipose tissue into corporal depressions to improve contour is not a new procedure. According to the literature, the grafted fat undergoes ischemia, producing a local inflammatory process and reabsorption of part of the injected volume, and the desired result is not achieved. Starting from the premise that vascular insufficiency occurs in the core of grafted tissue, leading to reabsorption, the authors of this paper studied the outcome of injection of small volumes of fat into facial depressions. The subjects, 16 patients with facial depressions (12 with Romberg's syndrome and 4 with lupus), were subjected to small volumes of adipose tissue grafting. Three to seven sessions of fat grafting were necessary to obtain a uniform facial contour. The interval between each procedure was 2–3 months. Ultrasonography and biopsies were performed. The cutaneous ultrasound demonstrated viable adipose tissue, confirming the pathological result.