Purpose: this study evaluates the effectiveness of a health education intervention program on treatment adherence of COPD outpatients.
 Methodology: This randomized controlled trial was conducted in 2022 with 90 COPD outpatient people. Self-management education was developed on the basis of the Theory of Planned Behavior. Medication adherence was assessed using Test of Adherence to Inhalers (TAI-10), and the practice checklist of breathing exercises, respectively.
 Findings: At beginning, there were no significant differences between-group regarding participants’ medication adherence. After 3 months’ intervention, the rates showed a significant increasing for treatment adherence in intervention group (P < 0.05).
 Unique contribution to theory, practice, and policy (recommendations): Health education interventions have proven effective in increasing treatment adherence of outpatients with COPD. So, an intervention program should be conduct on a larger scale to improve treatment adherence for COPD patients in the future.