Introduction. Optimal nutrition of premature baby should ensure him adequate growth without metabolic and other complications in the short term, with the realization of genetic potential and development in the long-term perspective. The most valuable product for such infants is breast milk, which has nutritional, immunological, psychological, social and economic benefits over milk mixtures. However, in all cases, it is not possible to feed a premature infant with suckling breast milk (difficult conditions are menses, the presence of contraindications for breastfeeding). In such circumstances, the physician poses the question of choosing a mixture of enteral nutrition that would provide the body of a premature baby with all the necessary nutrients, allow for adequate growth rates of increase in feeding volume and minimize the development of complications.The aim of the study. To analyze the outcomes of children with very low body weight at birth, depending on the nature of the enteral nutrition.Materials and methods. Clinical and laboratory examination of 68 premature infants with very low body weight at birth (1000 g-1500 g) was conducted. Of the 24 children (Group I), enteral nutrition was carried out from the first hours of life with breast milk, in the 44 (second group) newborns - early enteral nutrition with a mixture of PreNAN Gold. Exclusion criteria: congenital malformations and abnormalities requiring surgical intervention, conditions delaying the early onset of enteral nutrition.A daily clinical assessment of the general condition of newborns, neurological status, weighing, monitoring of growth parameters, head circumference and abdomen were carried out. All children were thoroughly examined before each feeding for the purpose of identifying symptoms of tolerance to enteral nutrition, monitoring the results of laboratory and additional research methods in accordance with the protocols for the provision of newborns approved by the orders of the Ministry of Health of Ukraine.Results and discussion. Part of the children of the second group for 4-5 days of life, in addition to the mixture, began to receive and strained breast milk (they are classified in IIa subgroups). The weight loss of newborns who fed with the PreNAN Gold blend was probably lower compared to those in Group I infants. The average increase in the daily volume of enteral nutrition during the first week of life did not differ significantly in all groups of children. The achievement of full volume of enteral nutrition was most rapidly observed in newborn infants receiving breast milk. However, body weight gain was better for babies on artificial feeding. Cases of intolerance to enteral nutrition were almost the same in all infant groups, but the incidence of necrotizing enterocolitis did not differ with all types of enteral nutrition. In newborns who received PreNAN Gold, the stomach did not contain pathological impurities. Data from laboratory studies in Group II (total protein, urea, creatinine) were within the age range. Allergic reactions were not registered.Conclusions. The use of the PreNAN Gold blend for the feeding of prematurely born infants with a very low body weight at birth allows them to fully provide their body with all necessary nutrients, allow them to maintain proper rates of increase in feeding volume, promote adequate body weight gain, minimize the development of NEC and disturb the tolerance to enteral food. The mixture is well tolerated by infants, does not cause allergic reactions, the liquid form simplifies its use.
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