Friction and wear phenomena are common problems in sliding equipment, so materials with excellent antifriction and wear resistance properties are getting increasingly more attention. Two-dimensional (2D) materials, such as graphene and molybdenum disulfide, have always been the research hotspots on account of their special structures and excellent tribological properties. In 2011, MXene, an important member of the 2D material family, was launched. With excellent properties such as ultra-high strength, rich surface end groups, and relatively low cost, MXenes have great potential as lubricant additives. Although these properties have proved to be the reason why MXenes are impressive, the preparation of MXenes composites and the understanding of their mechanical and tribological mechanisms remain to be further investigated. In addition, the abundant surface end groups of MXenes nanosheets make them relatively easy to be functionalized, which has attracted widespread attention. This review aims to comprehensively understand the tribological properties of MXenes nanolayers and to summarize and sort out recent research progress. First, the preparation of MXenes is reviewed, and then the latest research progress of MXenes in liquid lubrication, solid lubrication, and solid–liquid hybrid systems since the advent of MXenes is summarized. Finally, some current problems are presented and an outlook on the development of MXenes is given.