Superdisintegrant Addition Research Articles

Review on Sublingual Tablet

Abstract: Objective: As sublingually given dose forms avoid hepatic metabolism, sublingual medication delivery can be an alternate and superior method to oral drug delivery. For some medications, particularly those prescribed for the treatment of acute diseases, a quick onset of pharmacological activity is frequently required. Sublingual pills dissolve quickly, and the major saliva available is typically enough to achieve dosage form disintegration along with enhanced dissolving and increased bioavailability. Findings: Comparing sublingual pills to traditional dosage forms, it was discovered that the former had superior qualities. Due to their rapid breakdown, tablets taken sublingually had more bioavailability, a quicker onset of action, and improved dissolving characteristics. Rapid disintegration was made possible by the addition of super-disintegrants, and this method can be applied to the treatment of urgent or acute disorders. Conclusion: To make sure a quick onset of action, higher patient compliance, and increased bioavailability, sublingual tablets or any sublingual dosage form might be used. Drugs that undergo significant first pass metabolism or degradation in the GIT can be administered sublingually. When compared to normal oral tablets, drugs given sublingually typically have improved bioavailability, which leads to dose reduction.

Tailored release of fluorescence quenched drug from the electrospun nanofiber mat for the treatment of oral submucosal fibrosis (OSMF)

The aim of the presented work involves the preparation and characterization of polycaprolactone (PCL) electrospun nanofibers mats (ESNF) loaded with the drug losartan potassium (LP) as a potential localized treatment strategy for treating OSMF.ESNF mats were fabricated using PCL as the biodegradable polymer matrix within which the drug of choice – LP and super disintegrant (SD) – PVP were mixed. The formed ESNF mats were subjected to thorough physico-chemical characterization.The electrospinning technique resulted in the fabrication of controlled diameter PCL nanofibers with no beading and uniform thickness. The presence of LP or PVP was dispersed uniformly within the polymer matrix and did not result in clump formation. The average diameter of blank PCL was 170 nm and that of LP and PVP loaded was 610 nm.The drug loading and encapsulation efficiency were calculated based on theoretical loading and quantification of the drug after destroying the mats and were found to be 89–92 %. The ex-vivo release profile of LP from PCL ESNF was designed to be tailored to release the drug in a few hours to a few days by the addition of super disintegrants in the polymer matrix. The addition of PVP was able to tune the release of LP from the PCL ESNF mat from 6 days to 17 days when compared to 21 days for samples without PVP. This was further studied using DOE® software that used mathematical software techniques to give the optimized formulation of the LP and PVP-loaded PCL ESNF mat. This optimized formulation was then incorporated in a buccal patch to design an effective system for localized drug delivery application. The optimized buccal patch design was later validated through a mucoadhesive strength study using pig mucosa. The mucoadhesive strength of the buccal patch in pig mucosa showed a force of detachment of 153.30 N/m2 and a force of adhesion of 0.27 N.Hence, a novel PCL-ESNF mat containing LP along with PVP was designed with a tailorable release profile as a possible localized therapeutic platform to alter the overproduction of collagen to provide a cure for OSMF.

Formulation Optimization and Evaluation of Taste Masked Oro-dispersible Tablet of Levocetrizine Dihydrochloride by Ion Exchange Resin

The aim of this study was to prepare ODT of taste masked levocetrizine dihydrochloride by using ion exchange resin. Levocetrizine Dihydrochloride is bitter in taste, Kyron T-134 a weak cationic exchange resin was used to mask the bitter taste of the drug. The ODTs were prepared by using drug-resin (DRC) complex using batch process. Compression of ODTs was done by using direct compression method with the technique of addition of superdisintegrants. Central composite design (CCD) was applied as an optimization technique. FTIR and DSC studies indicated drug and excipients were compatible with each other. The prepared orodispersible tablet blend and tablets were evaluated for various pre-compression and post-compression parameters. The Batch LH3 was given as optimized batch by central composite design. This optimized batch LH3 was passed all the pre-compression and post- compression parameters. The prepared ODTS showed successfully rapid onset of action with decrease in disintegration time 26 sec and %drug released was found to be 98.26%. It was concluded that levocetrizine dihydrochloride ODTs were prepared successfully by taste masking method using Kyron T-134 ion exchange resin and croscarmellose sodium as Superdisintegrant using CCD. AS per CDER guidelines, it shows DT within 5-30 sec.

Preparation and characterization of hydralazine mouth dissolving tablet by using super-disintegrates

Tablet dosage form is the most popular among all existing conventional dosage forms because of its convenience of self-administration, compactness and easy manufacturing. Many patients find it difficult to swallow tablets and capsules. The difficulty is experienced in particular by pediatric and geriatric patients, but it also applies to people who are ill on bed and to those active working patients who are busy or traveling, especially those who have no access to water. Mouth dissolving tablet was prepared by addition of superdisintegrants (Ac-Di-Sol, Sodium starch glycolate and Crospovidone). The tablets were evaluated for their organoleptic (Color, Odor, Taste), physical (Size, Shape and Texture) and quality control parameters (Diameter, Thickness, Hardness, Friability, Disintegration Time and Wetting Time). Hence, mouth dissolving tablets of resinate can be successfully prepared by superdisintegrants, maintaining their disintegration time less than 1 minute, which provide faster effect and better patient compliance. These tablets may be helpful for geriatric and pediatric patients experience difficulty in swallowing conventional tablets, which leads to poor patient compliance. Thus, it was concluded that the method designed for drug resinate complexation and tablet formulation is simple, rapid, cost effective and highly efficient.

Formulation and Evaluation of Triclosan Dispersible Tablets for Oral Hygiene

In human anatomy mouth is the earliest segment of alimentary canal which receives food and fabricates saliva, and is one of the foundation for bacterial development due to accretion of sugars form food chunks. There have been more than 300 kinds of bacteria set up in the mouth. The purpose of the present study is to investigate the number of microbes’ grown-up at different timings of the day by collecting the samples from individual volunteer oral cavities and counting the colonies; the utmost count was noted as in the range of 190-200 in the evening samples. The same samples were used to calculate minimum inhibitory concentration of Triclosan, the antibiotic formulated for oral hygiene. Triclosan dilutions were prepared and analyzed for the inhibition zones, it resulted that 300mg of the drug have shown satisfactory results. Triclosan was formulated into a dispersible tablet to enable dispersion of tablet into water for rinsing the oral cavity to remove the contaminants. The Dispersion time of the tablet was within the range of 43.66-111.33 second and it was observed that formulation was acceptable with reasonable limits of standard required for dispersible tablets. Addition of superdisintegrant enhanced the dispersion time which facilitates easy mixing of tablet in water. It concludes that superdisintegrant addition technique is a useful method for preparing dispersible tablets by wet granulation method, and Triclosan dispersible tablet further reduces the microbial attack on tooth by rinsing each time after meals, upon doing so on long term basis the dental decays will probably be eradicated.

DEVELOPMENT, EVALUATION AND RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF QUERCETIN, ELLAGIC ACID AND KAEMPFEROL IN A POLYHERBAL FORMULATION

Objective: The current study was planned to develop polyherbal tablet formulation, standardization and evaluation for mitigating the symptoms of polycystic ovarian syndrome (PCOS). To control the issue of PCOS in women by the utilization of newly developed polyherbal tablet formulation.
 Methods: The polyherbal tablets were prepared using a hydroalcoholic extract of the selected medicinal plants viz. Asparagus racemosus, Bauhinia variegata, Caesalpinia bonducella, Saraca asoca, and Symplocos racemosa with the help of a super disintegrant addition technique using crospovidone, kyron T-314 and pregelatinized starch in various percentages. Evaluation assessments such as pre-formulation studies, weight variation, hardness, friability, thickness, disintegration, IR compatibility and simultaneous estimation of quercetin, ellagic acid and kaempferol by RP-HPLC method were done.
 Results: The results reveal that preformulation and evaluation parameters were satisfactory and found to be within an acceptable limit. The Fourier transform infrared spectroscopy (FTIR) compatibility displays no chemical interaction amongst the hydroalcoholic extract of polyherbal formulation and excipients. In simultaneous estimation, the retention time of quercetin, ellagic acid, and kaempferol were found to be 4.86, 6.96 and 10.01 min respectively. The linearity of quercetin, ellagic acid and kaempferol were found in the range of 0-200 µg/ml with correlation coefficients (R2>0.997) within the tested ranges. The LOD and LOQ values of quercetin, ellagic acid and kaempferol were found to be 11.86, 2.63, 5.28 µg/ml and 35.95, 7.98, 16.00 µg/ml respectively. The % RSD values were found to be less than 2 showed the optimized method is precise.
 Conclusion: To conclude, the prepared polyherbal tablet and its quality control analysis revealed satisfactory pharmaceutical properties that fulfill within the limits of pharmacopeial standards. The RP-HPLC method for simultaneous estimation of quercetin, ellagic acid and kaempferol were simple, precise, accurate and consistent for the quantitative analysis and quality control examination of herbal formulations.

Formulation and evaluation of orally disintegrating tablet containing taste masked mirtazapine

Objective: This study aims to prepare the taste-masked granules of Mirtazapine by mass extrusion technique and formulate it into an oral dispersible tablet using different super disintegrates. Methods: Taste masked granules of mirtazapine were prepared by mass extrusion technique using Eudragit EPO in different ratios. The drug-polymer ratio was optimized based on the percent drug release in SSF and SGF. Taste masking efficacy of drug-polymer complex was determined by developing the bitterness threshold value of Mirtazapine. The selected drug-polymer complex was formulated into an oro-dispersible tablet by direct compression method. A randomized design was used to investigate individual effect of three different super disintegrates each in different concentrations. Ten formulations were developed including a controlled formulation without the addition of superdisintegrants. A comparative study was done based on various pre-compression and post-compression parameters. Results: Eudragit EPO was able to mask the bitter taste of Mirtazapine effectively in 1:2 ratio by mass extrusion method. The minimum disintegration time and wetting time was found to be 13.6±2.7 and 18.13±0.24 seconds with the formulation containing crospovidone 5% (F9). It was found that the wetting time and disintegration time followed the order SSG>CCS>CPV. The selected best formulation was subjected to an incompatibility study design. The IR spectrum showed that all the excipients were chemically compatible. Conclusion: Thus, in this study unpalatable taste of Mirtazapine was masked using Eudragit EPO polymer by mass extrusion technique, and superdisintegrants were added to prepare orally disintegrating tablets of Mirtazapine. This research work suggests a rapid, simple and cost effective method for formulating Mirtazapine ODT.

FORMULATION, STANDARDIZATION, AND EVALUATION OF POLYHERBAL DISPERSIBLE TABLET

Objective: The study was designed as formulation, standardization, and evaluation of polyherbal dispersible tablet prepared for the management of kidney disorders. To overcome the problem of dyspepsia in geriatric patients by the use of polyherbal dispersible tablets.Methods: Dispersible tablets were prepared using aqueous root extract powder of the selected plant viz. A. officinalis, B. diffusa, C. papaya, C. fistula, C. intybus, F. hispida, F. indica, C. nurvala, S. virgaurea, and V. negundo with the help of superdisintegrant addition technique using crospovidone, sodium starch glycolate and croscarmellose sodium in different percentage. Evaluation assessments such as the substantial test, weight variation, hardness, friability, content uniformity, disintegration, in vitro dispersion, stability study and IR compatibility were carried out.Results: Micromeritics of extracts powder were determined for all formulation, which signifying good flow properties. The substantial examination was established, which comply with official requirements for uniformity test, and the drug content was close to 100% in all formulations. Disintegration time was observed for all formulation in which the polyherbal formulation-3 (PHF-3) showing 1.10±0.10 min; during in vitro dispersion time, all formulation showed appropriate dispersion in which the PHF-3 captivating 2.00±0.45 min only. The IR compatibility shows none chemical interaction between the extracts and excipients.Conclusion: The PHF-3 showed satisfactory disintegration and in vitro dispersion time due to crospovidone and reported as the best formulation. The stability study and IR compatibility validate the PHF may represent new easily swallow dispersible tablet that may enhance drug permeability and advance bioavailability for nephrotic patients.

Design, Development and Evaluation of Fast Dissolving Tablet of Antiasthmatic Drug

The aim of the work is an attempt to design, development and evaluation of fast dissolving tablets of Levosalbutamol sulphate by direct compression method with the aid of superdisintegrant addition. Levosalbutamol (LS) is the R – enantiomer of short acting beta2 adrenergic receptor agonist of salbutamol used to treat asthma and Chronic obstructive pulmonary disease. Nine formulations were prepared by using three different superdisintegrants in varying concentration in such way that total weight of the tablet remains same. The drug-polymer incompatibility was analysed by FTIR studies. All the formulated tablets were subjected for pre and post-compression evaluation parameters. From the FTIR studies the drug-polymer compatibility were confirmed. The pre-compression parameters like bulk density, tapped density, Carr’s index and angle of repose was determined. The optimized formulation showed acceptable flow properties. The post-compression parameters like the thickness, hardness, friability and in vitro dispersion time, wetting time, water absorption ratio and in- vitro drug release were carried out and the values were found to be within IP limits. Among the nine formulations, the formulation containing Kyron T 314 (F9) showed highest drug release of 97.71 % than other formulations.

Various approaches to enhance the dissolution of Lornoxicam fast dissolving tablets prepared by using different categories of superdisintegrants: A comparative study

Background: Recent developments in fast dissolving tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets.The main objective of the present study is to formulate fast dissolving tablet of Lornoxicam by direct compression method.Methods: Guar gum and crospovidone were used as natural and synthetic superdisintegrants respectively. Fast dissolving tablet of Lornoxicam were prepared by direct compression technique using three different approaches; superdisintegrant addition, sublimation, and solid dispersion.Results: IR and DSC studies showed no interaction between the drug and the excipients. All formulation showed disintegration time ranging from 16.09-42.54 second. Wetting time and disintegration time decreased by increasing the super disintegrant concentration from 2.5% to 5% w/w. Formulae L16 gave the best in- vitro disintegration and dissolution results, which would be due to swelling effect of Gaur gum and amorphization of the drug during the solid dispersion preparation.The best formulation L16 was subjected to stability testing for 3 month and results showed no significant change in appearance, hardness, drug content and dissolution profile of the tablets, hence tablet is stable throughout its stability studies.Conclusion: It was concluded that fast dissolving tablets of Lornoxicam were formulated successfully with desired characteristics which disintegrated rapidly; provided rapid onset of action; and enhanced the patient convenience and compliance.JMMIHS,2018;4(1):86-102

FORMULATION, OPTIMIZATION, AND EVALUATION OF SITAGLIPTIN AND SIMVASTATIN RAPIDLY DISSOLVING TABLETS

Objective: The scope of this work was to formulate sitagliptin and simvastatin rapidly dissolving tablets. However, simvastatin is practically insoluble in water. For improving its poor oral bioavailability and with the aim of facilitating administration to patients facing problems with swallowing rapidly dissolving tablets were preparedMethods: Tablets were prepared using superdisintegrant addition technique using croscarmellose sodium (Ac-di-sol), sodium starch glycolate (explotab) and crospovidone in different percentages. Evaluation tests such as weight variation, thickness, and content variation, and friability, disintegration, wetting time, in vitro dispersion and in vitro dissolution were carried out.Results: The results showed that the presence of crospovidone could enhance the dissolution rate of simvastatin greatly. The best-optimized formulae found were that F8, F9, and F10 which showed good disintegration and the dissolution rate of simvastatin and sitagliptin was more than 90% after 10 min while the dissolution rate for simvastatin and sitagliptin pure standards was 12% and 30%, respectively after 10 min.Conclusion: Some tablet formulae showed acceptable pharmacotechnical properties and complied with compendium requirements. Results of dissolution studies revealed that F8-F10 showed an increase in the dissolved sitagliptin and simvastatin to be more than 90% after 10 min.

The effects of croscarmellose sodium concentration on the physicochemical characteristics of orodispersible tablets of atenolol

Hypertension is the most common cardiovascular diseases suffered by geriatric patients. Their physiological changes make the administration of conventional tablets less effective, especially regarding compliance. One approach to overcome this problem is the development of orodispersible tablets, which soften easily and disintegrate quickly in the oral cavity. Atenolol is a class of β-blocker functioning as an anti-hypertensive drug that has been extensively used in hypertension therapy, and it has the potential to being developed as orodispersible tablets. A faster disintegration of orodispersible tablets will facilitate an earlier onset of dissolution. The addition of superdisintegrants can reduce the disintegration time of these tablets. Croscarmellose sodium is a superdisintegrant that can decrease the disintegration time to less than three minutes. This study aimed to optimize the formula of orodispersible tablets of atenolol using different concentrations of croscarmellose sodium, namely 10% (formula 1) and 20% (formula 2). The physicochemical characteristics of the tablets were evaluated to determine the best formula. The evaluation included a comparison to the control formula (0% of croscarmellose sodium). The results showed that formula 1 (10% of croscarmellose sodium) produced orodispersible tablets with the best physicochemical characteristics regarding tablet hardness, friability, in vitro dispersion time, and disintegration time. Formula 1 (%Q 30 minutes = 98.31%) also met the standard of the dissolution of atenolol tablets set by the Farmakope Indonesia, i.e., the percent of dissolved drug in 30 minutes has to be higher than 85%. The drug dissolution efficiency of formula 1 was twice higher than that of the control formula.

Sublingual Tablets and the Benefits of the Sublingual Route of Administration

Purpose : Sublingual drug delivery can be an alternative and better route when compared to oral drug delivery as sublingually administered dosage forms bypass hepatic metabolism. A rapid onset of pharmacological effect is often desired for some drugs, especially those used in the treatment of acute disorders. Sublingual tablets disintegrate rapidly and the small amount of saliva present is usually sufficient for achieving disintegration of the dosage form coupled with better dissolution and increased bioavailability. Approach : Published articles from PubMed and other standard sources were utilized to review and compile an overview of sublingual tablets and the benefits of the sublingual route of administration. Findings : Sublingual tablets were found to have better characteristics when compared to conventional dosage forms. Sublingually administered tablets achieved better bioavailability, rapid onset of action and better dissolution properties due to fast disintegration. The addition of super-disintegrants facilitated rapid disintegration and this approach can be used to treat acute disorders or emergency conditions. Conclusion : Sublingual tablets or any sublingual dosage form can be used to achieve a rapid onset of action, better patient compliance and increased bioavailability. The sublingual route of administration can be used for drugs which undergo extensive first pass metabolism or degradation in the GIT. Drugs administered sublingually tend to have better bioavailability which correlates to dose reduction when compared to conventional oral tablets.

Comparative study of mode of addition of super Disintegrants on Methocarbamol tablets by Roller Compaction method

Methocarbamol, a BCS class II drug is an antispasmodic agent used to treat the spasms from peripheral musculoskeletal conditions. The research focus in recent years has shifted to the formulation of both fast dissolving and disintegrating tablets that are swallowed and tablets that are intended to dissolving in the oral cavity. Super-disintegrants are now frequently used in tablet formulation to improve the rate and extent of tablet disintegration and thus improve the rate of drug dissolution. The majority of this research has been directed at the function-related properties of the super-disintegrants with special emphasis on correlating these properties to disintegrant efficiency and drug release. The present study was to formulate immediate release tablets using various types of disintegrants in order to investigate the effect of mode of incorporation of disintegrants on release of drug from tablets. Methocarbamol immediate release tablets were prepared by the roller compaction method by using a plasdone S630 as binder and four different disintegrants in combination of three modes of incorporation. The prepared tablets were characterized based upon their physicochemical characteristics. The results showed that F4 (CCS) and F7 (PP-XL) 3 % formulations exhibit faster release when compared to others. It may be concluded that intra-granular addition has given improved drug release from dosage form when compared to extra-granular and both intra and extra-granular addition.

Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent

In the present work, an attempt has been made to formulate oral dispersible tablets of omeprazole by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Three batches omeprazole were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetics and stability studies. Formulations prepared by omeprazole superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to other methods. It was concluded that oral dispersible tablets of anti ulcer agents can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.

Formulation and Evaluation of Fast Dissolving Tablets of Doxazosin Mesylate

The objective of this research was to formulate fast dissolving tablets of Doxazosin mesylate that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Doxazosin mesylate is used for the treatment of the signs and symptoms of benign Prostatic Hyperplasia. Fast dissolving tablets of Doxazosin mesylate were prepared by direct compression method using superdisintegrant addition method, by using sublimation method and effervescent method. Thirty two formulations were prepared and evaluated for hardness, thickness, friability, weight variation, drug content, in vitro disintegration time, in vitro dispersion time, wetting time, water absorption ratio and in vitr o dissolution studies. FTIR and DSC studies revealed that there was no chemical interaction between the drug and the excipients. Formulation S8 was found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. The formulation S8 containing camphor (8%) as subliming agent was found to be the optimized combinations. Stability studies were carried out at 25°C±2°C/60%±5% RH and 40°C±2°C/75%±5% RH for formulation S8 for 60 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, wetting time and in vitro drug release.

Novel use of superdisintegrants as viscosity enhancing agents in biocompatible polymer films containing griseofulvin nanoparticles

The advantages of using superdisintegrants, sodium starch glycolate (SSG), croscarmellose sodium (CCS) and crospovidone (CP) over traditional high molecular weight (MW) viscosity enhancing agents, guar gum (GG), xanthan gum (XG), pectin and high MW HPMC are examined for improving drug content uniformity without compromising dissolution of films containing nanoparticles of griseofulvin (GF), used as a model poorly water-soluble drug. Films were fabricated by preparing low MW HPMC solutions to which a fixed amount of viscosity enhancing agents was added and mixed with GF nanosuspensions produced via wet milling, followed by casting and drying. The addition of superdisintegrants and high MW HPMC led to an increase in viscosity of precursor suspensions without GF particle aggregation, and hence excellent drug content uniformity along with retention of the high surface area of the GF nanoparticles in dried films. In contrast, the addition of XG and pectin resulted in aggregation of GF particles in suspensions, leading to poor content uniformity and incomplete recovery of GF nanoparticles upon redispersion of dried films. In spite of their high precursor viscosity, the films containing superdisintegrants did not lead to increased mechanical strength and demonstrated fast drug release, suggesting faster matrix erosion. In contrast, films with high MW polymers (GG, XG, and pectin and high MW HPMC) had increased mechanical strength and their subsequent slow erosion/disintegration along with longer hydration times resulted in significant delay of drug release, which was found to be directly proportional to their MW. These results demonstrate novel use for superdisintegrants as economical and superior alternative to traditional viscosity enhancing agents in forming drug laden biocompatible polymer films.

Evaluation of fast disintegrating tablets of Nifedipine prepared by Superdisintegrant addition and sublimation methods

Fast disintegrating tablets of nifedipine prepared by superdisintegrant addition and sublimation methods were evaluated. Twelve batches of tablets were formulated by direct compression using varying concentrations of crospovidone and croscarmellose sodium. Camphor was incorporated into six of the batches. Their granules were evaluated for pre-compression and post-compression parameters. FTIR analysis of the drug and excipients was also carried out. Results obtained showed that their granules were free flowing with angle of repose < 26° and Carr’s index < 19 %. The tablets gave hardness of 3.67-5.99 kgf, friability of < 1 %, wetting and disintegration times of < 101 and < 91 secs, respectively. Dissolution profiles showed all the tablets released over 92 % of their drug within 30 mins. FTIR analysis demonstrated no interactions between nifedipine and excipients. The sublimation method in combination with superdisintegrant addition method of formulation yielded fast disintegrating tablets of superior quality than the superdisintegrant addition method alone. DOI: http://dx.doi.org/10.3329/dujps.v13i2.21901 Dhaka Univ. J. Pharm. Sci. 13(2): 199-205, 2014 (December)

Taste Masked Orodispersible Formulation of Fexofenadine Hydrochloride Using Ion Exchange Resins.

The objective of this research work was to mask the intense bitter taste of fexofenadine hydrochloride using weak cation exchange resins and to formulate orodispersible tablet of taste masked drug-resin complex. Five resins indion 204, indion 234, indion 414, kyron T-114 and kyron T-314 were used. Depending on maximum drug loading capacity of resins indion 234 and kyron T-314 were finalized for further study. Drug-resin complex was optimized by considering parameters such as drug to resin ratio, soaking time of resins, stirring time, temperature and pH on maximum drug loading. The drug-resin complex was characterized by Fourier transform infrared spectroscopy. The drug-resin complex was also subjected to various evaluation studies such as taste mask evaluation by panel method, drug content and in vitro drug release at salivary and gastric pH. The orodispersible tablets of taste masked drug-resin complex for indion 234 and kyron T-314 were prepared by direct compression method. Formulated orodispersible tablets were subjected to various evaluation parameters such as diameter and thickness measurement, hardness test, weight variation test, in vitro United States Pharmacopoeia disintegration test, wetting time, test for content uniformity, assay, friability test and in vitro dissolution studies. The results indicate that orodispersible tablets of fexofenadine hydrochloride containing indion 234 and kyron T-314 are palatable and provide quick disintegration and fast drug release without addition of superdisintegrants.

Formulation and in vitro comparative evaluation of orodispersible tablets of Pantoprazole

In the present work, an attempt has been made to formulate oral dispersible tablets of pantoprazole by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Nine batches of tablets were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetic and stability studies. Formulations prepared by superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to formulations prepared by sublimation and effervescent methods. It was concluded that oral dispersible tablets of pantoprazole can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.