Abstract
Objective: The study was designed as formulation, standardization, and evaluation of polyherbal dispersible tablet prepared for the management of kidney disorders. To overcome the problem of dyspepsia in geriatric patients by the use of polyherbal dispersible tablets.Methods: Dispersible tablets were prepared using aqueous root extract powder of the selected plant viz. A. officinalis, B. diffusa, C. papaya, C. fistula, C. intybus, F. hispida, F. indica, C. nurvala, S. virgaurea, and V. negundo with the help of superdisintegrant addition technique using crospovidone, sodium starch glycolate and croscarmellose sodium in different percentage. Evaluation assessments such as the substantial test, weight variation, hardness, friability, content uniformity, disintegration, in vitro dispersion, stability study and IR compatibility were carried out.Results: Micromeritics of extracts powder were determined for all formulation, which signifying good flow properties. The substantial examination was established, which comply with official requirements for uniformity test, and the drug content was close to 100% in all formulations. Disintegration time was observed for all formulation in which the polyherbal formulation-3 (PHF-3) showing 1.10±0.10 min; during in vitro dispersion time, all formulation showed appropriate dispersion in which the PHF-3 captivating 2.00±0.45 min only. The IR compatibility shows none chemical interaction between the extracts and excipients.Conclusion: The PHF-3 showed satisfactory disintegration and in vitro dispersion time due to crospovidone and reported as the best formulation. The stability study and IR compatibility validate the PHF may represent new easily swallow dispersible tablet that may enhance drug permeability and advance bioavailability for nephrotic patients.
Highlights
The current trends for surviving long and healthy life entirely dependent on the traditional medication systems in which Ayurveda is one of the most favorable systems because of it possess several natural elements to eliminate the critical causes of the disease by restoring the equilibrium and preventing further reoccurrence [1]
The basic characterization of powder and micromeritic properties of formulations containing polyherbal aqueous root extracts powder used for preparing dispersible tablets mentioned in table 1
Polyherbal dispersible tablets were compressed each of 550 mg weight on a 10-station Mini Press-I rotary tablet compression machine fitted with 12 mm punches size
Summary
The current trends for surviving long and healthy life entirely dependent on the traditional medication systems in which Ayurveda is one of the most favorable systems because of it possess several natural elements to eliminate the critical causes of the disease by restoring the equilibrium and preventing further reoccurrence [1]. The Indian philosophy behind Ayurveda is to prevent unnecessary suffering of survival when curing the human ailments and well-known for the significant biodiversity centers through concerning 45,000 herbal plant species out of which about 15,000 medicinal plants have been recorded to curing different human ailments by using single or multiple herbs for the complete elimination of disease [3]. The polyherbal formulation contains two or more herbs with different phytoconstituents possessing similar or dissimilar therapeutic potential have been collectively producing desirable effects during the management of human ailments [6, 7]. The popularity of the polyherbal formulation is outstanding because of their wide therapeutic range i.e., effective at a low dose and safe at high dose, though produces fewer side effects whilst misused [8, 9]
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