Addition Of Hydroxypropyl Methylcellulose Research Articles

Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion

We present hot melt extrusion (HME) for the design of floating multiparticulates. Metoprolol succinate was selected as the model drug. Our foremost objective was to optimize the components Eudragit® RS PO, polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) to balance both buoyancy and controlled release. Gas generated by sodium bicarbonate in acidic medium was trapped in the polymer matrix to enable floating. Eudragit® RS PO and PEO with sodium bicarbonate resulted in multiparticulates which exhibited rapid flotation within 3min but inadequate total floating time (TFT) of 3h. Addition of HPMC to the matrix did not affect floating lag time (FLT), moreover TFT increased to more than 12h with controlled release of metoprolol succinate. Floating multiparticulates exhibited t50% of 5.24h and t90% of 10.12h. XRD and DSC analysis revealed crystalline state of drug while FTIR suggested nonexistence of chemical interaction between the drug and the other excipients. The assay, FLT, TFT and the drug release of the multiparticulates were unchanged when stored at 40°C/75%RH for 3 months confirming stability. We present floating multiparticulates by HME which could be extrapolated to a range of other drugs. Our approach hence presents platform technology for floating multiparticulates.

Laser-assisted vascular welding: optimization of acute and post-hydration welding strength

Liquid solder laser-assisted vascular welding using biocompatible polymeric scaffolds (ssLAVW) is a novel technique for vascular anastomoses. Although ssLAVW has pronounced advantages over conventional suturing, drawbacks include low welding strength and extensive thermal damage. To determine optimal ssLAVW parameters for maximum welding strength and minimal thermal damage. Substudy 1 compared breaking strength (BS) of aortic strips welded with electrospun poly(ε-caprolactone) (PCL) or poly(lactic-co-glycolic acid) (PLGA) scaffold, 670-nm laser, 50-s single-spot continuous lasing (SSCL), and semi-solid solder (48% bovine serum albumin (BSA)/0.5% methylene blue (MB)/3% hydroxypropylmethylcellulose (HPMC)). Substudy 2 compared the semi-solid solder to 48% BSA/0.5% MB/0.38% genipin and 48% BSA/0.5% MB/3% HPMC/0.38% genipin solder. Substudy 3 compared SSCL to single-spot pulsed lasing (SSPL). PCL-ssLAVW yielded an acute BS of 248.0 ± 54.0 N/cm2 and remained stable up to 7d of hydration. PLGA-ssLAVW obtained higher acute BS (408.6 ± 78.8 N/cm2) but revealed structural defects and a BS of 109.4 ± 42.6 N/cm2 after 14 d of hydration. The addition of HPMC and genipin improved the 14-d BS of PLGA-sLAVW (223.9 ± 19.1 N/cm2). Thermal damage was reduced with SSPL compared with SSCL. PCL-ssLAVW yielded lower but more stable welds than PLGA-ssLAVW. The addition of HPMC and genipin to the solder increased the post-hydration BS of PLGA-ssLAVW. SSPL regimen reduced thermal damage. PLGA-ssLAVW using 48% BSA/0.5% MB/3% HPMC/0.38% genipin solder and SSPL constitutes the most optimal welding modality. Surgical patients requiring vascular anastomoses may benefit from the advantages that ssLAVW potentially offers over conventional sutures (gold standard). These include no needle trauma and remnant suture materials in the patient, reduction of foreign body reaction, immediate liquid-tight sealing, and the possibility of a faster and easier procedure for minimally invasive and endoscopic anastomotic techniques.

Designing self-nanoemulsifying delivery systems to enhance bioaccessibility of hydrophobic bioactives (nobiletin): Influence of hydroxypropyl methylcellulose and thermal processing

Emulsion-based delivery systems are widely utilized for encapsulation of hydrophobic bioactive compounds. However, they must be carefully designed to retain and stabilize the encapsulated components during storage, and to release them after ingestion. In the present work, the influence of hydroxypropyl methylcellulose (HPMC) addition and heat treatment on the retention and release of a model hydrophobic nutraceutical (nobiletin) in nanoemulsions prepared by self-emulsification was investigated. Physical stability was assessed by measuring nobiletin retention, crystal morphology, and droplet size during storage. Further, the bioaccessibility of nobiletin was evaluated using a simulated gastrointestinal model. The results indicated that the presence of HPMC in the aqueous phase improved the retention of nobiletin in the nanoemulsions, without promoting any physical instability. The saturation concentration of nobiletin in the nanoemulsions increased from 4.5 to 6.0 mg/mL in the presence of HPMC. Heating the nanoemulsions promoted rapid droplet coalescence above a critical temperature. The combination of HPMC addition and heat treatment increased the retention time of nobiletin in nanoemulsions. Neither HPMC addition nor heat treatment affected the bioaccessibility (around 85%) of nobiletin when it was fully dissolved in the nanoemulsions. However, when nobiletin was not fully dissolved in the nanoemulsions, HPMC addition (from 52 to 59% without heat treatment) and heat treatment (from 52% to 82% without HPMC and from 59% to 84% with HPMC) increased the bioaccessibility. These findings are useful for the rational design and fabrication of nanoemulsion-based delivery systems with high loading efficiency and good release characteristics.

Preparation and in vivo evaluation of a dutasteride-loaded solid-supersaturatable self-microemulsifying drug delivery system.

The purpose of this study was to prepare a dutasteride-loaded solid-supersaturatable self-microemulsifying drug delivery system (SMEDDS) using hydrophilic additives with high oral bioavailability, and to determine if there was a correlation between the in vitro dissolution data and the in vivo pharmacokinetic parameters of this delivery system in rats. A dutasteride-loaded solid-supersaturatable SMEDDS was generated by adsorption of liquid SMEDDS onto Aerosil 200 colloidal silica using a spray drying process. The dissolution and oral absorption of dutasteride from solid SMEDDS significantly increased after the addition of hydroxypropylmethyl cellulose (HPMC) or Soluplus. Solid SMEDDS/Aerosil 200/Soluplus microparticles had higher oral bioavailability with 6.8- and 5.0-fold higher peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) values, respectively, than that of the equivalent physical mixture. A linear correlation between in vitro dissolution efficiency and in vivo pharmacokinetic parameters was demonstrated for both AUC and Cmax values. Therefore, the preparation of a solid-supersaturatable SMEDDS with HPMC or Soluplus could be a promising formulation strategy to develop novel solid dosage forms of dutasteride.

New methods for amlodipine and valsartan native spectrofluorimetric determination, with factors optimization study

Four native fluorescence methods were suggested for simultaneous determination of amlodipine (AML) and valsartan (VAL). These methods were based on excitation of both drugs at λex 300nm, in one step, to give maximum emission at λem 378 and 496nm for AML and VAL, respectively. The first method, single λex method, was used without any additions. The sensitivity of this method was further increased by the addition of hydroxy propylmethyl cellulose (HPMC) surfactant, β-cyclodextrin, or ferric oxide magnetite nanoparticles, in the other three methods. Different types of surfactants, and different concentration levels of both β-cyclodextrin and ferric oxide nanoparticles, were scanned to determine the optimum conditions for enhancing the sensitivity. Some factors affecting the fluorescence intensity of both cited drugs, like the type and volume of the added solvent (to be used as a sensing agent), and pH of measurement were studied and optimized. The proposed methods could be used in determination of AML and VAL in bulk powder, their laboratory prepared mixtures and pharmaceutical formulations. The obtained results were statistically compared to each other and to that of some reported methods. The specificity of the developed methods was investigated, and the methods were validated according to ICH guidelines.

In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance

Periodontitis is the primary cause of tooth loss in adults and a very wide-spread disease. Recently, composite implants, based on a drug release rate controlling polymer and an adhesive polymer, have been proposed for an efficient local drug treatment. However, the processes involved in implant formation and the control of drug release in these composite systems are complex and the relationships between the systems’ composition and the implants’ performance are yet unclear. In this study, advanced characterization techniques (e.g., electron paramagnetic resonance, EPR) were applied to better understand the in-situ forming implants based on: (i) different types of poly(lactic-co-glycolic acid) (PLGA) as drug release rate controlling polymers; (ii) hydroxypropyl methylcellulose (HPMC) as adhesive polymer; and (iii) doxycycline or metronidazole as drugs. Interestingly, HPMC addition to shorter chain PLGA slightly slows down drug release, whereas in the case of longer chain PLGA the release rate substantially increases. This opposite impact on drug release was rather surprising, since the only difference in the formulations was the polymer molecular weight of the PLGA. Based on the physico-chemical analyses, the underlying mechanisms could be explained as follows: since longer chain PLGA is more hydrophobic than shorter chain PLGA, the addition of HPMC leads to a much more pronounced facilitation of water penetration into the system (as evidenced by EPR). This and the higher polymer lipophilicity result in more rapid PLGA precipitation and a more porous inner implant structure. Consequently, drug release is accelerated. In contrast, water penetration into formulations based on shorter chain PLGA is rather similar in the presence and absence of HPMC and the resulting implants are much less porous than those based on longer chain PLGA.

Effect of pH and interaction between egg white protein and hydroxypropymethylcellulose in bulk aqueous medium on foaming properties

Egg white protein (EW) is used as surface-active ingredient in aerated food and hydroxypropylmethylcellulose (HPMC) is a polysaccharide that behaves as a surfactant. This study aimed at investigating the effects of process parameters biopolymer concentration (2.0–5.0%, w/w), EW:HPMC ratio (2:1–18:1), pH (3.0–6.0), and the influence of biopolymers’ behavior in aqueous solution at different pH on the foaming properties (overrun, drainage, and bubble growth rate). Process parameters had effect on foaming properties. The pH was the major factor influencing the type of EW/HPMC interaction and affected the foaming properties of biopolymer mixture. At pH 3.0, EW and HPMC showed thermodynamic compatibility leading to better foaming properties, higher foaming capacity, and stability than without HPMC addition whereas at pH 4.5 and 6.0, EW and HPMC are incompatible that causes lower stability concerning the disproportionation comparing to foam without HPMC. At pH between 3.0 and 4.5, HPMC improves foaming properties of aerated products.

The Influence of Methylcellulose on the Hydration Process of C3S, C3A and Mixture of these Phases

The paper presents the results of investigation over influence of 0.3% addition of hydroxypropyl methylcellulose (MC) of 40 and 70 Pa·s viscosity on the hydration process of main clinker phases: C3S and C3A and also their mixture, both in presence and absence of gypsum.During the research it has been indicated that methylcellulose inhibits the hydration process of clinker phases, analyzed both separately and in their mixture. Moreover, presence of that additive reduces reactivity of calcium sulphatedihydrate what leads to formation of decreased amounts of ettringite. No significant differences resulting from viscosity of used methylcellulose were observed.Investigation over the influence of that admixture on the hydration process of tricalcium aluminate indicated that addition of methylcellulose inhibits hydration process of C3A with water. Similar influence of that admixture was observed in the case of C3A hydration in presence of gypsum. A lot of gypsum remains in the reaction mixture. Little amounts of ettringite are forming, however, there is no monosulphate. Inhibition of sulphate ions reaction with C3A is slightly higher in the case of methylcellulose of higher plastic viscosity.Also in the hydration examinations of tricalcium silicate methylcellulose addition caused a retardation of alite reaction with water. In first hydration hours of alite with MC addition there were no peaks of portlandite in the XRD pattern. In the presence of gypsum the influence of methylcellulose addition on the hydration course was significantly weaker. Simultaneously no significant differences related to the influence of different plastic viscosity of methylcellulose were observed.Similar course of reactions was observed in the case of hydration of alite and tricalcium aluminate mixture in the presence of gypsum and methylcellulose. After one week of hydration significant amounts of unreacted gypsum are still remaining. However, little amounts of ettringite are created.

A multivariate study of the correlation between addition of maltodextrin, MCG, HPMC and psyllium on the quality of instant fried noodles

The influence of changes in the composition of the recipe and frying temperature on selected quality parameters of fried instant noodles was discussed. Using high-protein wheat flour (semolina) as the base material in production of instant noodles with addition of hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCG), maltodextrin and psyllium were evaluated for oil uptake, moisture content, colour and hardness. The results were analysed by Principal Component Analysis (PCA). The results showed that changes in the quality parameters of instant noodles were dependent on both the type and amount of additional recipe ingredient as well as the temperature of the frying process. The addition of HPMC (in amount of 0.4%) reduced oil content up to 7% compared to the control sample. Incorporation of MCG (0.8% and 1.0%) and psyllium (3.0% and 5.0%) into the formulation reduced the value of moisture in the final product. The heat treatment parameters had a major impact on oil uptake of instant noodles with an inverse correlation between moisture and oil content.

Optimisation of rheological properties of gluten-free doughs with HPMC, psyllium and different levels of water

Hydrocolloids have traditionally been investigated as an alternative to gluten for making good quality products for coeliac patients. This study investigated the interactions between hydroxypropylmethylcellulose (HPMC) (2–4 g/100 g of flour), psyllium (0–4 g/100 g of flour) and water level (90–110 g/100 g of flour) in gluten-free breadmaking. Psyllium incorporation reduced the pasting temperature and compliance values, and increased elastic (G′) and viscous (G″) moduli values. In contrast, HPMC addition had no important effects on pasting properties and compliance values, but also increased G′ and G″ values. Psyllium inclusion reduced bread specific volume and increased bread hardness, while there were hardly differences in the bread specific volume and hardness between the percentages of HPMC studied. In addition, when the dough hydration level was increased, there was a decrease in the influence of hydrocolloids on dough rheology and specific volume and hardness of breads.

Inhibiting potential of hydroxypropyl methylcellulose on acid corrosion of mild steel and aluminium

Purpose The aim of this paper is to appraise the inhibiting potential of hydroxypropyl methylcellulose (HPMC) on the corrosion of mild steel and aluminium in sulphuric and hydrochloric acid solutions. Design/methodology/approach The effects of two different corrodents on the dissolution of mild steel and aluminium were examined. Corrosion rates were determined using the weight loss technique. Inhibition efficiency was estimated by comparing the corrosion rates in absence and presence of the additive. The kinetics and mechanism of HPMC adsorption were investigated by impedance study while the anodic and cathodic partial reactions were studied by polarization measurements. Findings The results reveal that corrosion rate of mild steel and aluminium decreased with addition of HPMC. The corrosion rate and inhibition efficiency were found to depend on the concentration of the inhibitor. The polarization data indicated that the inhibitor was of mixed-type, with predominant effect on the cathodic partial reaction. electrochemical impedance spectroscopy confirms that corrosion inhibition was by adsorption on the metal surface following Freundlich adsorption isotherm via physisorption mechanism. Originality/value Hydroxypropyl methylcellulose has been studied for the first time as an inhibitor of mild steel and aluminium corrosion and the results suggest that the inhibitor could find practical applications in corrosion control in HCl and H2SO4 acid media. The findings are particularly useful, considering the fact that HPMC is a good film former and viscosity enhancer which could also be used in paint formulation.

Rheological and gel properties of hydroxypropyl methylcellulose/hydroxypropyl starch blends

This work focuses on the study of rheological and gel properties of hydroxypropyl methylcellulose (HPMC)/hydroxypropyl starch (HPS) blends. It was found that both rheological properties in solution and gel behaviors in hydrogel of the blends depended on polymer/solvent concentration, HPMC/HPS ratio, and temperature. At higher temperature, all the blending samples showed hydrogel behavior, while at lower temperature, the suspensions with higher HPS ratio displayed hydrogel-like behavior but the gels were able to be destroyed at higher frequencies. With an increase of the HPS ratio, the fluid behavior index deceases, meaning the solution shows more obvious pseudoplastic behavior. However, the fluid consistency index increases, meaning that viscosity increases with increase of HPS content. The strength of HPMC gel was weakened by additional of HPS at higher temperature, while the HPS gel was weakened by addition of HPMC at lower temperatures. Viscosities of both HPMC and HPS were balanced by the blending at different temperatures since one is thermal and other is cool gel, which improves the processability for many applications.

Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification

Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate. Three poorly-permeable drugs (atenolol, metformin hydrochloride, and furosemide) exhibiting negative food effect, and one highly-soluble and highly-permeable (metoprolol tartrate), serving as a negative control, were selected for the study. In vitro and in silico tools were used to evaluate the influence of media viscosity on drug bioperformance under fasted and fed conditions. The obtained results demonstrated that increased medium viscosity in the presence of food is one of the key factors limiting oral absorption of drugs with limited permeability and absorption restricted to the upper parts of the intestine, while having negligible effect on pharmacokinetic profile of drugs with pH- and site-independent absorption. Dissolution medium pH 4.6 with the addition of hydroxypropyl methylcellulose was suggested to simulate postprandial gastric conditions for drugs whose solubility under these conditions is not the limiting factor for drug absorption. In addition, drug formulation was found to be an interfering factor in relation to the impact of medium viscosity on the rate and extent of drug absorption.

Effects of HPMC (Hydroxypropyl methylcellulose) on oil uptake and texture of gluten-free soy donut

We developed a gluten-free soy donut with HPMC (Hydroxypropyl methylcellulose) and investigated the effects of HPMC on the quality of a soy donut depending on the different ways of its addition. Soy donuts were prepared under three conditions: only soy (S), HPMC added soy (SH), and HPMC added and coated soy (SHC). A wheat donut was used as a control. The results showed that the S donut had approximately two times lower oil uptake and moisture loss compared to wheat control; however, the S donut had 30% less specific volume and three times harder texture. HPMC addition in soy donut (30.7 N) resulted in a decrease in the hardness to 23.5 N for SH and 20.8 N for SHC. In addition, the incorporation of HPMC gave soy donuts the further decrease in the oil uptake and moisture loss. For the method of adding HPMC, the SHC donut had less oil uptake and a softer texture than the SH. Among soy donuts, SHC has the desirable intensities of sensory attributes (texture and mouthfeel), resulting in the highest overall preference score, closer to that of the wheat donut. The addition of HPMC improves the quality of gluten-free donuts made entirely with soy flour.

Hydroxypropyl Methylcellulose Reduces Particle Adhesion and Improves Recovery of Herbal Extracts During Spray Drying of Chinese Herbal Medicines

The effectiveness of hydroxypropyl methylcellulose (HPMC) as an anti-adherent during spray drying of traditional Chinese herbal extracts was explored. A small amount of HPMC (minimum concentration 8%) was sufficient to overcome problematic particle adhesion, whereas a large amount of maltodextrin (50%) was required for the same effect. HPMC exerted a strong anti-adhesive effect that was independent of the type of HPMC, raw materials used, and the process used to synthesize HPMC. The anti-adhesion mechanism was studied through an analysis of the surface tension of the prepared solutions before spray drying, the glass transition temperature (T g ), and X-ray photoelectron spectroscopy (XPS) of spray-dried powders. The T g of powders containing more than 8% HPMC was approximately 40°C and did not increase linearly with the HPMC concentration. The surface tension of Crataegi fructus extract was 54.1 ± 0.2 mN/m and further decreased to 46.6 ± 0.2 mN/m upon addition of HPMC to 24%. When the concentration of HPMC increased to 8%, potassium could not be detected on the surface of dried powders by XPS. These results suggest that modification of the surface properties of sprayed droplets/particles by HPMC increased the HPMC surface coverage of the particles and reduced adhesion during spray drying.

자포니카형 쌀 품종 차이가 글루텐 프리 쌀 식빵의 품질에 미치는 영향

The purpose of this study is to investigate the effect of rice cultivar on the quality of gluten-free rice bread. Three different type of japonica rice cultivars (Seolgaeng, Goami, and Baegjinju) were used in this study. Rice flour was produced by dry milling and using a 200 mesh sieve. Rice bread was prepared using the straight dough method with an addition of hydroxypropyl methylcellulose as a dough improver. Rice bread dough was divided into 170 g and then fermented prior to baking. Gluten-free rice bread prepared using flour from the Seolgaeng cultivar showed the largest volume (446±11.7 mL) and a uniformly distributed pore structure in bread crumbs whose hardness value was 2.66±0.2 N. Rice bread prepared using flour from Goami and Baegjinju cultivars showed rough crumb surface and hard crumb texture. The low damaged starch content (4.5%) and intermediate amylose content (19.3%) of the Seolgaeng cultivar contributed to produce superior qualities such as large volume and soft crumb texture in rice bread.

Effect of HPMC concentration on β-cyclodextrin solubilization of norfloxacin

The effect of hydroxypropyl methylcellulose (HPMC) concentration on β-cyclodextrin (β-CD) solubilization of norfloxacin was examined. The solubility and dissolution of norfloxacin/β-CD and norfloxacin/β-CD/HPMC inclusion complexes were studied. The presence of β-CD increased significantly the solubility and dissolution of norfloxacin. The addition of HPMC until 5% (w/w) improved the solubilization of norfloxacin but further addition above 5% (w/w), decreased norfloxacin solubilization. Fourier transformed Infra-red (FTIR) showed that norfloxacin was successfully included into β-CD. Differential scanning calorimetry (DSC) showed that the norfloxacin endothermic peak shifted to a lower temperature with reduced intensity indicating the formation of inclusion complex. The addition of HPMC reduced further the intensity of norfloxacin endothermic peak. Most of the sharp and intense peaks of norfloxacin disappeared with the addition of HPMC. In conclusion, the concentration of hydrophilic polymer used to enhance β-CD solubilization of poorly soluble drugs is very critical.

Influence of onion powder and its hydrocolloid blends on pasta dough, pasting, microstructure, cooking and sensory characteristics

The present study aims to study the influence of onion powder in pasta processing. Pasta samples at level of 5%, 10% and 15% of substitution of onion powder with Triticum durum flour were prepared. Based on the results, 10% level was optimized and different hydrocolloids like Xanthan Gum, HPMC (Hydroxy propyl methyl cellulose), Guar Gum, Gum Arabica and Fructo-oligo saccharide were added to improve the quality characteristics of the pasta. Onion pasta prepared with these hydrocolloids showed all the quality characteristics comparable to control. Cooking loss of all pasta ranged between 3.6% and 4.9%. Texture studies showed the increase in the shear value with the addition of HPMC (2.14) than control (1.16). Color analysis showed values comparable to control. Descriptive sensory analysis indicated the acceptance of the onion incorporated pasta by panelists. Based on the spectrophotometric analysis, 30.8 mg/100 g (W/W) of total quercetin content was present in onion powder and 2.192 mg/100 g (W/W) of optimized pasta i.e.,71% quercetin retention was found in the optimized onion pasta sample. Hence, study concludes that onion pasta with better quality and sensory characteristics can be developed with HPMC.

The association of hydrogel and biphasic calcium phosphate in the treatment of dehiscence-type peri-implant defects: an experimental study in dogs

Hydrogel polymers have many applications in regenerative medicine. The aim of this study in dogs was to investigate bone regeneration in dehiscence-type peri-implant defects created surgically and treated with (i) biphasic calcium phosphate (BCP) granules alone; (ii) a composite putty hydroxypropyl methylcellulose (HPMC)/BCP (MBCP/putty); and (iii) a polymer crosslinked membrane of silanized-HPMC (Si-HPMC/BCP) compared with empty controls. At 3 months, new bone formation was significantly more important in defects filled with HPMC/BCP or Si-HPMC/BCP compared with spontaneous healing in control (P = 0.032 and P = 0.046 respectively) and more substantial compared with BCP alone. Furthermore, new bone formation in direct contact with the implant surface was observed in all three groups treated with BCP. The addition of HPMC to the BCP granules may have enhanced the initial stability of the material within the blood clot in these large and complex osseous defects. The Si-HPMC hydrogel may also act as an occlusive membrane covering the BCP, which could improve the stability of the granules in the defect area. However, the crosslinking time of the Si-HPMC is too long for easy handling and the mechanical properties remain to be improved. The composite MBCP/putty appears to be a valuable bone-graft material in complex defects in periodontology and implantology. These encouraging results should now be confirmed in clinical studies.

Fine particle size chestnut flour doughs rheology: Influence of additives

Mixing properties of chestnut flour with typical particle size distribution of wheat flour, incorporated with chia flour (2.5%, 4.0%, 5.0%, 6.0%, 7.5%, flour basis, f.b.), hydroxypropyl methyl cellulose (HPMC) and guar gum (0.5%, 1.0%, 1.5%, 2.0%, f.b.) were determined at 30°C using Mixolab® apparatus. The rheological characterisation at 30°C was achieved by steady shear rate (0.01–10s−1), oscillatory (1–70rads−1 at 0.1% strain) and creep-recovery (loading of 50Pa for 60s) tests. Thermal behaviour of all chestnut flour doughs was also depicted. These rheological properties were significantly modified by the presence of chia flour and hydrocolloids. The values of apparent viscosity at each shear rate as well as the values of storage and loss moduli at each angular frequency decreased with chia flour, HPMC or guar gum addition. Creep-recovery data showed that the addition of chia flour at 6.0% (56.5%), HPMC at 2.0% (63.7%) or guar gum at 2.0% (64.5%) improved significantly the doughs elasticity in comparison to chestnut flour (20.2%). The flow curves and mechanical spectra were successfully fitted using Cross and power models, respectively.