Addictive Substances Research Articles

Conservative therapy after self-mutilation of the scrotum resulting in bilateral testicular underperfusion

We report the case of a patient with massive penile and scrotal swelling due to use of a compression ring with auto-erotic intent and under the influence of addictive substances. Based on the patient history, the mechanical pressure on the scrotum was about 30hours (h). The Doppler sonogram showed no central perfusion in either testicle. Conservative treatment with antibiotics and analgesics was initiated with aslight increase in inflammatory parameters and local edema and necrosis formation. Follow-up showed regression of swelling, healing of necrosis and improvement of laboratory parameters. Testosterone substitution therapy was necessary due to the bilateral testicular atrophy that developed.

Decreased functional connectivity in salience network is associated with symptom severity in betel quid-dependent chewers.

Betel quid (BQ) is the fourth most popular psychoactive agent worldwide. Neuroimaging studies have showed that substance-addicted individuals including alcohol, heroin, nicotine and other addictive substance exhibit altered activity patterns of the salience network (SN). However, no study has yet investigated the neural correlates of the resting-state SN and BQ dependence (BQD)-related physiopathological characteristics. Thirty-two BQ-dependent (BQD) chewers and 32 healthy controls were recruited to participate in this study. Resting-state functional magnetic resonance imaging (fMRI) data were analysed by independent component analysis (ICA). BQD chewers exhibited decreased functional connectivity in bilateral insula, anterior cingulate cortex (ACC), medial superior frontal gyrus (MSFG) and inferior orbital frontal gyrus (IOFG) [false discovery rate (FDR) correction, p < 0.05]. In the BQD group, the decreased functional connectivity in left ACC correlated negatively with BQDS (BQD Scale) and the duration of BQ. We reported decreased functional connectivity in resting-state SN of BQD individuals. The decreased functional connectivity in left ACC correlated negatively with BQDS and the duration of BQ. Our findings provided evidence for the importance of the SN in the pathophysiology of BQD and indicated that the SN dysfunction might provide a potential mechanism in BQD development.

ANALYSIS OF THE RELATIONSHIP BETWEEN CHARACTERISTICS OF TEENAGERS AND FAMILY FUNCTIONS ON TEENAGERS’ BEHAVIOR FOR CONSUMING DRUGS IN EAST JAVA

This research aims to analyze the relationship between the characteristics of teenagers and family functions as well as the understanding of narcotics, psychotropics, and addictive substances on the behavior of teenagers consuming drugs in East Java as a response variable with a binary scale. The data source obtained through secondary data from the Performance Survey and Accountability Program 2019 with the observation unit teenagers aged 10-24 years. The sample used is 4,649. The analytical method used is descriptive statistics, the Chi-square method, and Odds Ratio (OR). The percentage of adolescent consuming drugs is 4.1% descriptively. The relationship analysis shows that the variables significantly related to young people's behavior in consuming drugs are gender, place of residence, level of education, age group, religious values, and psychological consequences. From the OR figures concluded that young males are 3.2 times more at risk of consuming drugs than young females. From the aspect of family function, it can be inferred that the percentage of young substance abusers from families who apply religious values is greater than those who do not. The findings of this research show that the risk of young people from families who practice religious functions becoming substance abusers are 1.61 times more compared to families who do not practice it. The understanding of drugs is not always related to teenagers' behavior in consuming drugs, because those who understand the psychological consequences of substance abuse are also 1.64 times more at risk of using drugs compared to teenagers who do not understand.

Development of sets-based science e-module to improve critical thinking skills of grade viii students on additive and addictive substances material

The critical thinking skills of junior high school students in Jember are still low, the existing learning is still teacher-centered, and the students lack initiative in asking questions. Based on the results of the national examination of additives and addictive substances, in the last five years, it is relatively low. Through these data, it is known that there are problems related to critical thinking, namely additives and addictive substances. The research aims to develop a SETS-based (Science, Environmental, Technology, and Society) science e-module on additive and addictive substances material to improve students’ critical thinking skills. This type of research is Research and Development (R&amp;D) uses a 4D development model. The SETS-based science e-module on additive and addictive substances material developed was tested on research subjects, namely 23 students of class VIII-I, SMP Negeri 1 Jember. The research instruments include validation sheets, learning implementation sheets, pre-test, and post-test questions, and response questionnaires. The validation result of the development of SETS-based science e-module on additive and addictive substances material was stated as valid, with a score of 79%. The practicality of learning was stated with a score of 3,64%, with a very practical category. The N-gain test score of 0,81 with a high category, so that the SETS-based science e-module on additive and addictive substances material can improve students’ critical thinking skills. The results of the student's response questionnaires obtained a score of 89% in the very good category. Based on these data, the development of SETS-based science e-module on additive and addictive substances improves students’ critical thinking skills.

Prevalence of substance use among Iranian male adolescents:Systematic review and meta-analysis.

Background and aimsSubstance use among adolescents is one of the most challenging behavioral disorders with direct consequences. It is of the essence (that) the prevalence of substance use is investigated among Iranian male adolescents.MethodsThe present study is a systematic review and meta‐analysis. All published articles titled “prevalence of substance use among Iranian adolescents” authored in Persian and English from 2004 to 2020 on Pub Med, Scopus, SID, and Google Scholar, a top list of academic research databases, were reviewed. Thirty‐three out of 805 articles, hinge on the inclusion and exclusion criteria, were eligible. Statistical analysis carried out in STATA 14.0.Q index, I2 index, and χ 2 test were applied.ResultsOverall prevalence reported with (95% confidence interval) for substance use 7% (4%–11%), methamphetamine 4% (3%–6%), tobacco 10% (3%–19%), and any addictive substances 4% (2%–7%) among male adolescents respectively. Besides, overall prevalence of alcohol consumption reported 10% (8%–11%).ConclusionThe prevalence of substance use among male adolescents is high, so it is indispensable for researchers to pay special attention to this issue.

Copper content in Areca nut as an emerging etiology for liver disease – A Comprehensive Review

Areca nut (AN) is the fourth most widely used addictive substance and chewed regularly by at least 10% of the world population. AN cause many harmful effects on the human body in general as well as in the oral cavity. Amongst this one of the vital organs being damaged due to AN consumption is liver for which a number of mechanisms are reported to be responsible. Frequently alkaloids in AN are considered as the main culprit. But, other components like copper (Cu) content in AN is also believed to play a role in the pathogenesis of liver fibrosis. It is stated that an adult Indian chewing AN daily consumes over 5 mg of Cu per day, of which the substantial amount is absorbed. However, the recommended intake per day is 0.9 mg. Excess Cu acts by upregulating lysyl oxidase activity, which enhances collagen synthesis and inhibits collagen degradation leading to fibrosis of tissues. Another reason for liver toxicity could be reactive oxygen species generated by Cu content in AN. Thus, it may be stated that Cu in AN can be one of the risk factors inducing liver damage. The present review highlights the role of Cu content of AN in the development of liver fibrosis.

Aktualisasi Pemberdayaan Keluarga Dalam Pemberantasan Penyalahgunaan Narkoba

The phenomenon of abuse of narcotics and illegal drugs among the younger generation is currently increasing. The condition of deviant behavior of the younger generation can endanger the survival of our nation's development because they are increasingly fragile and devoured by addictive substances that destroy nerves. Our young generation can no longer think clearly, as a result, the assets of this strong and intelligent nation will only be a memory. The family as a micro community in society has an important role in controlling and eradicating the dangers of drugs. Actualizing the function of the family as a forum for empowerment is one of the pillars that needs to be done and therefore family resilience is the basic foundation of the strength of the sustainability of national development. The Thematic Community Service Program by LPPM UNG in 2021 is oriented to assisting the community in combating drug abuse which is currently rife in society in general. The programs that will be delivered by students will refer to assistance activities to the community to be equally resilient and responsive in eradicating drug abuse. The target of the theme is "Community Empowerment in the Eradication of Drug/Narcotics Abuse to Realize a Shining Village (Drug Clean)". then one of the strategic programs developed is to actualize the function of the family as a forum for empowerment in eradicating drug abuse. It is important to do this because through such a program it will have an effect on increasing public knowledge and being able to innovate in handling and eradicating Drug Abuse and Illegal Drugs in the Village Community. The results of the program's achievements indicate that the actualization of family empowerment through the Thematic KKN program is the participation of families and rural communities to provide support for efforts to eradicate and control drugs which in turn becomes an effective alternative solution on the one hand and as a form of achieving drug-free villages. (Shine) on the other side.

Residential addiction treatment providers: Identifying the role of social context in worker health and turnover

Increased lethality and availability of addictive substances has strained US addiction treatment services, further exacerbating workforce shortages in these settings. The emotional and physical health toll of providing treatment may contribute to shortages. This community-initiated qualitative study aimed to identify conditions that affect provider health and turnover in residential addiction treatment from a Total Worker Health® perspective. Providers (direct service, supervisors, leaders) working in nonprofit residential treatment facilities in Massachusetts were recruited by role and geography to participate in interviews and focus groups. NVivo12 facilitated coding and analysis. 25% of transcripts were double coded to assess interrater reliability and coding consistency (mean Kappa = 0.82). Providers (N = 49) participated in 33 interviews and 4 focus groups. Many participants reported personal addiction histories. Analysis revealed how socio-contextual factors originating outside of residential facilities were dominant influences on “downstream” working conditions, worker health, staff turnover, and by extension, client care. Four primary socio-contextual themes surfaced:1) Changes in type and potency of substances and client need not reliably accompanied by shifts in treatment practices; 2) challenges balancing state requirements and state-provided resources; 3) influence of structural discrimination and addiction stigma on pay and professional advancement; and 4) geographic location of facilities shape work and quality of life. Results were used to develop a conceptual model for residential addiction treatment to illustrate pathways by which ecological factors interact to affect provider health and turnover. Findings indicate that protecting health and wellbeing of providers—many of whom are in addiction recovery themselves— is integral to improving addiction treatment. From this workforce's perspective, recent changes in socio-contextual factors have intensified already challenging working conditions (job demands, pay, advancement), negatively impacting worker health, turnover, and client care. Any interventions to improve treatment outcomes or working conditions in nonprofit addiction facilities must consider larger socio-contextual factors influencing these organizations.

A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment.

Substance use disorders (SUDs) constitute a growing global health crisis, yet many limitations and challenges exist in SUD treatment research, including the lack of objective brain-based markers for tracking treatment outcomes. Electroencephalography (EEG) is a neurophysiological technique for measuring brain activity, and although much is known about EEG activity in acute and chronic substance use, knowledge regarding EEG in relation to abstinence and treatment outcomes is sparse. We performed a scoping review of longitudinal and pre-post treatment EEG studies that explored putative changes in brain function associated with abstinence and/or treatment in individuals with SUD. Following PRISMA guidelines, we identified studies published between January 2000 and March 2022 from online databases. Search keywords included EEG, addictive substances (e.g., alcohol, cocaine, methamphetamine), and treatment related terms (e.g., abstinence, relapse). Selected studies used EEG at least at one time point as a predictor of abstinence or other treatment-related outcomes; or examined pre- vs. post-SUD intervention (brain stimulation, pharmacological, behavioral) EEG effects. Studies were also rated on the risk of bias and quality using validated instruments. Forty-four studies met the inclusion criteria. More consistent findings included lower oddball P3 and higher resting beta at baseline predicting negative outcomes, and abstinence-mediated longitudinal decrease in cue-elicited P3 amplitude and resting beta power. Other findings included abstinence or treatment-related changes in late positive potential (LPP) and N2 amplitudes, as well as in delta and theta power. Existing studies were heterogeneous and limited in terms of specific substances of interest, brief times for follow-ups, and inconsistent or sparse results. Encouragingly, in this limited but maturing literature, many studies demonstrated partial associations of EEG markers with abstinence, treatment outcomes, or pre-post treatment-effects. Studies were generally of good quality in terms of risk of bias. More EEG studies are warranted to better understand abstinence- or treatment-mediated neural changes or to predict SUD treatment outcomes. Future research can benefit from prospective large-sample cohorts and the use of standardized methods such as task batteries. EEG markers elucidating the temporal dynamics of changes in brain function related to abstinence and/or treatment may enable evidence-based planning for more effective and targeted treatments, potentially pre-empting relapse or minimizing negative lifespan effects of SUD.

GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders.

Substance use disorders (SUDs) are chronic, lifelong disorders that have serious consequences. Repeated substance use alters brain function. G-protein-activated inwardly rectifying potassium (GIRK) channels are expressed widely in the brain, including the reward system, and regulate neuronal excitability. Functional GIRK channels are identified as heterotetramers of GIRK subunits (GIRK1–4). The GIRK1, GIRK2, and GIRK3 subunits are mainly expressed in rodent brain regions, and various addictive substances act on the brain through GIRK channels. Studies with animals (knockout and missense mutation animals) and humans have demonstrated the involvement of GIRK channels in the effects of addictive substances. Additionally, GIRK channel blockers affect behavioral responses to addictive substances. Thus, GIRK channels play a key role in SUDs, and GIRK channel modulators may be candidate medications. Ifenprodil is a GIRK channel blocker that does not have serious side effects. Two clinical trials were conducted to investigate the effects of ifenprodil in patients with alcohol or methamphetamine use disorder. Although the number of participants was relatively low, evidence of its safety and efficacy was found. The present review discusses the potential of GIRK channel modulators as possible medications for addiction. Therapeutic agents that target GIRK channels may be promising for the treatment of SUDs.

Comparison of the psychoactive activity of four primary Areca nut alkaloids in zebrafish by behavioral approach and molecular docking

Areca palm nut (Areca catechu) has been listed as one of the most addictive substances, along with tobacco, alcohol, and caffeine. It belongs to the family Arecaceae and is widely used in Asia. Areca nut contains seven psychoactive alkaloids; however, the effects of these alkaloids on behaviors are rarely to be addressed in zebrafish. Therefore, this study aims to compare the psychoactive and potential adverse effects of four primary alkaloids (arecoline, arecaidine, guvacine, and guvacoline) isolated from areca nut on zebrafish. We found that four alkaloids induced hyperactivity-like behaviors in zebrafish larvae. Cooperating the results with the previous study, molecular docking scores suggested these alkaloids might bind to multiple muscarinic acetylcholine receptors (mAChRs), and various best binding modes were shown. According to the adult zebrafish behavioral test, arecoline was found to slightly increase the locomotor activity and caused tightening shoaling formations of adult zebrafish. Meanwhile, zebrafish exposed to arecaidine have reduced aggressiveness and conspecific social interaction. Similar to arecaidine, guvacoline treatment also caused abnormalities in zebrafish social behaviors. Furthermore, the fish displayed abnormal exploratory behaviors after being exposed to guvacoline. Interestingly, altered fear response behaviors were only displayed by guvacine-treated fish besides their lower locomotor activity. Based on the results of molecular docking, we hypothesize that the behavior alterations might be a consequence of the interaction between alkaloids and multiple mAChRs in the nervous system. In summary, our study found that each alkaloid specifically affects adult zebrafish behaviors.

Withdrawal: A key consideration in evaluating whether highly processed foods are addictive.

Researchers are currently debating whether theories of addiction explain compulsive overeating of highly processed (HP) foods (i.e., industrially created foods high in refined carbohydrates and/or fat), which contributes to obesity and diet-related disease. A subset of individuals consumes HP foods with behavioral phenotypes that mirror substance use disorders. Withdrawal, the emergence of aversive physical and psychological symptoms upon reduction or cessation of substance use, is a core component of addiction that was central to historical debates about other substances' addictive potential (e.g., nicotine and cocaine). However, no one has systematically considered evidence for whether HP foods cause withdrawal, which represents a key knowledge gap regarding the utility of addiction models for understanding compulsive overeating. Thus, we reviewed evidence for whether animals and humans exhibit withdrawal when reducing or eliminating HP food intake. Controlled experimental evidence indicates animals experience HP food withdrawal marked by neural reward changes and behaviors consistent with withdrawal from other addictive substances. In humans, preliminary evidence supports subjective withdrawal-like experiences. However, most current human research is limited to retrospective recall. Further experimental research is needed to evaluate this construct. We outline future research directions to investigate HP food withdrawal in humans and consider potential clinical implications.

PERAN ORANG TUA DALAM UPAYA PENANGGULANGAN REMAJA PENGGUNA NARKOBA (STUDI KASUS DI JORONG TAPIAN NANTO, KECAMATAN SIJUNJUNG, KABUPATEN SIJUNJUNG)

drug Abuse is a reality encountered within society. Nationally, the outbreak of drug abuse is not only carried out by adults, but also children who are still undergoing basic education are not spared from committing abuse. The purpose of this study was to find out and analyze the role of parents in efforts to overcome adolescent drug users (Case Study in Jorong Tapian Nanto, Sijunjung District, Sijunjung Regency). The theory used in this study is The theory of the functional social conflict is one of the conflict theories that was first introduced in 1956 through Lewis Coser's work entitled The functions of Social Conflict which was lifted from his doctoral dissertation. The results showed that the role of parents in efforts to overcome adolescent drug users is divided into 4, namely 1) the role of parents as motivators, 2) the role of parents as facilitators, 3) the role of parents as mediators, 4) the role of parents in dealing with the problem of addiction to addictive substances where in this study it was found that parents have performed all four roles well, but drug use by adolescents is due to the influence of friends. Peer. So although it can be supervised by parents, but outside the home, adolescent associations are difficult to supervise.

PENDIDIKAN AGAMA ISLAM BAGI REMAJA KORBAN PENYALAHGUNAAN NAPZA (Narkotika, Alkohol, Psikotropika, dan Zat Adiktif)

Abstract&#x0D; &#x0D; The problem of drug abuse (narcotics, alcohol, psychotropic and addictive substances) has become an inseparable part and the problem of juvenile delinquency today. Blurring of Islamic values in the eyes of a teenagers one of the reasons is because they are exposed to a variety of contradictions and moral experience which causes them confused to choose which the best one for them. With religion, people can concern to the real purpose that is aimed to Rahmatan lil'alamin religion as a religion that came to identify his people to worship Allah primarily. &#x0D;

Ameliorative effects of varenicline and bupropion on morphine-induced conditioned place preference in rats

Background: Rewarding properties of morphine constitue the principal reasons for drug-craving behaviors which appear during morphine addiction. Varenicline and bupropion were reported to have some positive effects on addictive substances by different studies. In this study, the effects of varenicline and bupropion on morphine rewarding properties were investigated via conditioned place preference (CPP) in rats.Methods: Conditioning was performed by intraperitoneal (i.p.) administration of morphine (10 mg/kg, i.p., 1, 3, 5, and 7 days) and saline (2,4, 6, and 8 days). To evaluate the development of dependence, subcutaneous administration of varenicline (0.5, 1 and 2 mg/kg, s.c.) or bupropion (5, 10 and 20 mg/kg, i.p.) was carried out 15 minutes before the administration of morphine. To evaluate the expression of dependence, varenicline or bupropion was administered 15 minutes before the test on 9th day. To investigate the extinction of the reward effect, drugs were tested daily on days 14, 18, and 22 and evaluated for reinstatement on 23rd day.Results: Systemic morphine administration statistically significant produced CPP. Varenicline and bupropion did not reduce the development of morphine-induced CPP. In addition, varenicline and bupropion decreased expression, reinstatement and accelerated the extinction of morphine-induced CPP. Unlike varenicline, bupropion statistically significant produced CPP and altered locomotor activity.Conclusions: These data suggest that varenicline and bupropion may be useful therapeutic pharmacological agents to reduce morphine dependence. The results of our research provide preliminary evidence to highlight the importance of the effects of varenicline and bupropion on morphine dependence. In the future, it would be appropriate to conduct mechanistic studies to explain the underlying mechanisms by using different methods on the subject.

Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats

Nicotine, the primary addictive substance in tobacco, produces the psychomotor, rewarding, and reinforcing effects of tobacco dependence by stimulating nicotinic acetylcholine receptors (nAChRs) in the brain. The present study determined that α4β2 nAChRs regulate locomotor sensitization by altering dopamine concentration in the nucleus accumbens (NAc) after systemic challenge exposure to whole cigarette smoke condensate (WCSC). Rats were administered subcutaneous injection of WCSC (0.2 mg/kg nicotine/day) for 7 consecutive days and then re-exposed to WCSC after 3 days of withdrawal. Challenge exposure to WCSC significantly increased locomotor activity. This increase was decreased by the subcutaneous injection of the α4β2 nAChR antagonist, DHβE (3 mg/kg), but not by the intraperitoneal injection of the α7 nAChR antagonist, MLA (5 mg/kg). In parallel with a decrease in locomotor activity, blockade of α4β2 nAChRs with DHβE decreased dopamine concentration in the NAc which was elevated by challenge exposure to WCSC. These findings suggest that challenge WCSC leads to the expression of locomotor sensitization by elevating dopamine concentration via stimulation of α4β2 nAChRs expressed in neurons of the NAc in rats.

Sexual and addictive risk behaviors and sexually transmitted infections in illegal gold miners in French Guiana: A multicenter observational study.

ObjectivesCommon representations of the world of gold mining–especially illegal–are usually negative: the activity conjures up images of drug trafficking, human exploitation, the sex trade, environmental destruction, and infectious diseases, in particular sexually transmitted infections (STIs). The aim of the present article is to describe the levels of risk behaviors such as transactional sex, multiple sexual partners, and the frequency of condom use, addictive substance consumption, and the prevalence of STIs among the population of illegal gold miners in French Guiana (FG), a French overseas entity in Amazonia, in order to guide potential interventions.MethodsAn observational multicenter cross-sectional study was carried out from October to December 2019 along the two borders of FG with Suriname and Brazil at rest sites used by the miners.ResultsAmong the 499 participants, transactional sex was very prevalent, declared by 33.5% of men and 8.4% of women. Condoms were more frequently used for transactional sex than with a non-commercial partner (93.4% versus 42.1%). More women were tested for HIV than men (91.1% versus 55.2%). Excessive alcohol consumption (57.3%%) and tobacco use (41.2%) were very frequent, but cocaine or crack consumption was low (1.2%), which refuted our initial assumption. Consumers of alcohol had more sexual partners and reported condom use more frequently. Prevalence of HIV, HCV, HBV, and syphilis was respectively 0.5% (95% CI: 0.1–2.1), 2.1% (95% CI: 0.7–3.6), 1.6% (95% CI: 0.3–2.8), and 12.4% (95% CI: 9.0–15.7), which was higher than in the local population, especially for syphilis.ConclusionThis study documents for the first time the risk behaviors of gold miners in FG. Although the level of condom use was high, the prevalence of STIs combined with the high rate of transactional sex should encourage an increase in prevention and screening, in particular through rapid tests, given the mobility of the population concerned.

PENGEMBANGAN E-MODUL INTERAKTIF BERBASIS INKUIRI TERBIMBING MATERI ZAT ADIKTIF DAN PSIKOTROPIKA UNTUK SISWA KELAS XI SMA

The purpose of this research development is to produce teaching material products in the form of interactive inquiry-based e-modules guided by addictive substances and psychotropic substances to assist the learning process. This type of research uses a 4-D development model consisting of 4 stages, namely define, design, development, and disseminate, the research is carried out only until the development stage. The interactive e-module is accessed via a google drive link. The development of interactive e-modules produced through the validation stages, namely validation of material experts, validation of design experts, and student response trials. Validation from material experts gets a percentage of 95%, for design experts scores a percentage of 95%, and student response trials are 93%. Based on the percentage obtained, this learning media is included in the "Very Good" category so that it is suitable for use in the learning process.&#x0D;

Legal Reconstruction of Underaged Drug Abuser Rehabilitation Based on Justice Value

The purpose of this research is to analyze and find the weakness in the regulation of rehabilitation for underaged narcotics abusers and how to reconstruct the law based on Justice Value. This study uses a constructivism paradigm with a sociological juridical approach to solve research problems by examining secondary data and primary data by finding the legal reality experienced in the field as well as qualitative descriptive methods, namely where the data obtained are then arranged systematically so that a comprehensive picture will be obtained, where later the data will be presented descriptively. Based on the research it can be seen that the ideal Legal protection for children as narcotics abusers has not been achieved yet because there are still found cases where children who abuse narcotics are punished with imprisonment because of the law on child protection and the law on narcotics does not see in eye-to-eye regarding child narcotics abusers as the law on narcotics still treat Underaged Drug Abusers the same as adult. Therefore, it is necessary to carry out legal reconstruction in the Law of the Republic of Indonesia Number 35 of 2009 concerning Narcotics concerning General Provisions of Article 1, Article 103 where the provisions become, the addition of paragraphs in Chapter I on General Provisions in Article 1 so that Article 1 consists of 23 reconstruction paragraphs included in Article 1 paragraph (16), namely Children who are Victims of Narcotics Abuse, are children who are persuaded, deceived, cheated, forced, and/or threatened to use narcotics, alcohol, psychotropic substances, and other addictive substances. Article 103 becomes (1) Judges who examine cases of Narcotics Addicts are obliged to: a. decide to order the person concerned to undergo treatment and/or treatment through rehabilitation if the Narcotics Addict is proven guilty of committing a Narcotics crime; or b. stipulates to order the person concerned to undergo treatment and/or treatment through rehabilitation if the Narcotics Addict is not proven guilty of committing a Narcotics crime; c. In the event that a child commits an act of planting, maintaining, possessing, storing, controlling, or providing Narcotics Category I, II, II, he/she is obliged to obtain a rehabilitation decision; d. The rehabilitation of children who abuse narcotics is carried out in accordance with applicable laws and regulations.

Assessment of Mental Health and Well-Being during Covid 19 Pandemic among Moroccan Medical Students

Introduction: lockdown was experienced as a source of frustration for those who suffered from it. The purpose of this survey is to assess well-being and psychological impact of lockdown on Moroccan medical students during COVID-19 pandemic. Equipment and methods: This is an observational cross-sectional studyusing a self-questionnaire for medical students in Morocco. The Peri-traumatic Distress Inventory and the Warwick-Edinburgh Mental Wellness Scale were integrated into it. Statistical analysis were performed using SPSS software Results: 505 medical students from Morocco participated. Univar ate and multivariateanalysisweredonerevealingseveralsignificantcorrelationsbetween the Warwick-Edinburg BEM score and the Peri-Trauma Distress Inventory and several parameters. Discussion: A non-negligible proportion of medical students are suffering from depression, anxiety, burn-out and more generally, a sense of unease and psychological stress. Anxiety and fear of social distancing drive students to consult social networks. The Warwick-Edinburg BEM score was found to be significantly correlated with the time spent doing sports, creative activities, talking with relatives. Regarding eating habits, confinement is accompanied by negative emotions responsible for food restriction, emotional eating and hyperphagicfits. However, we did not find an increase in the consumption of addictive substances. Conclusion: The novelty of the pandemic, caused by the COVID-19, has a psychological impact on the general population and specifically on medical students. There is a need to remain vigilant about the remote onset of psychological disorder samong medical students in Morocco