This paper focuses on the dynamic modeling, controller design, and simulation verification of a new cable-driven underwater vehicle model system, which is proposed for future application on a tension leg platform. Compared with conventional underwater vehicles, the proposed cable-driven underwater vehicle model system has a unique structure and subjects to not only unknown underwater disturbances but also time-varying nonlinear cable tractions. To achieve accurate and robust trajectory tracking control, a universal high-order nonlinear dynamic model is established with multisource uncertainties, and an integrated estimation-based adaptive backstepping terminal sliding mode controller is designed. The proposed controller utilizes the integrated estimation method to handle the multisource unknown uncertainties, where recurrent radial basis function neural network and disturbance observer are employed for the estimations of uncertainties, and adaptive robust methods are utilized for compensations of estimation errors. The backstepping terminal sliding mode control method is utilized to improve the tracking performance and converging rate. In addition, the issue of “explosion of complexity” occurred in a traditional backstepping design is tackled by an adaptive control method, and the input saturation problem is solved by anti-windup compensator. Based on the Lyapunov analysis, all closed-loop signals are proved to be uniformly ultimately bounded. The numerical simulations show that the developed controller is not only robust against environmental disturbances and adaptive to unknown time-varying uncertainties but also able to steer the trajectory tracking errors along the prescribed transient, thus leading to effective cable-driven underwater vehicle model system control.