Most of the mechanical dynamic systems are subjected to parametric uncertainty, unmodeled dynamics, and undesired external vibrating disturbances while are motion controlled. In this regard, new adaptive and robust, advanced control theories have been developed to efficiently regulate the motion trajectories of these dynamic systems while dealing with several kinds of variable disturbances. In this work, a novel adaptive robust neural control design approach for efficient motion trajectory tracking control tasks for a considerably disturbed non-linear under-actuated quadrotor system is introduced. Self-adaptive disturbance signal modeling based on Taylor-series expansions to handle dynamic uncertainty is adopted. Dynamic compensators of planned motion tracking errors are then used for designing a baseline controller with adaptive capabilities provided by three layers B-spline artificial neural networks (Bs-ANN). In the presented adaptive robust control scheme, measurements of position signals are only required. Moreover, real-time accurate estimation of time-varying disturbances and time derivatives of error signals are unnecessary. Integral reconstructors of velocity error signals are properly integrated in the output error signal feedback control scheme. In addition, the appropriate combination of several mathematical tools, such as particle swarm optimization (PSO), Bézier polynomials, artificial neural networks, and Taylor-series expansions, are advantageously exploited in the proposed control design perspective. In this fashion, the present contribution introduces a new adaptive desired motion tracking control solution based on B-spline neural networks, along with dynamic tracking error compensators for quadrotor non-linear systems. Several numeric experiments were performed to assess and highlight the effectiveness of the adaptive robust motion tracking control for a quadrotor unmanned aerial vehicle while subjected to undesired vibrating disturbances. Experiments include important scenarios that commonly face the quadrotors as path and trajectory tracking, take-off and landing, variations of the quadrotor nominal mass and basic navigation. Obtained results evidence a satisfactory quadrotor motion control while acceptable attenuation levels of vibrating disturbances are exhibited.