Adaptive Processes Research Articles

Genetic variation of HPA axis activity in farm animals and beyond.

Many experimental data in several species clearly demonstrate the important genetic contribution to variations in HPA axis activity. The influence of corticosteroid hormones on adaptive processes and on production traits such as growth rate, feed efficiency, carcass composition and meat quality is a strong impetus to the search for the molecular bases of these differences for efficient genetic selection. Three main sources of genetic variability have been documented so far in farm animal species, the adrenal cortex sensitivity to ACTH regulating corticosteroid hormone production, the bioavailability of corticosteroid hormones and especially corticosteroid-binding globulin capacity, and glucocorticoid receptor function. The effect of single mutations may be dependent on the genetic background and genetic variation of cortisol levels may have different functional consequences depending on the molecular mechanisms responsible for this change. Understanding the genetic basis of HPA axis activity allows the development of genomic tools and breeding technologies aimed at improving adaptive capacity and stress tolerance in farm animals and their use as valuable models for the genetic study of the HPA axis and the correlation with adaptation, metabolism and other functions regulated by adrenal hormones, and associated pathologies (obesity, cardiovascular, etc.). The next step will be to explore HPA axis variability from a system genetics perspective including the multiple sources of variation and their interactions. This multifactorial approach is a prerequisite to the use of the HPA axis phenotypes in the genetic selection for more productive and robust animals, with a high level of production of quality products.

Oxygen-dependent alternative mRNA splicing and a cone-specific motor protein revealed by single-cell RNA sequencing in hypoxic retinas

Restricted oxygen supply in the aging eye may lead to hypoxic conditions in the outer retina and contribute not only to physiological aging but also to nonhereditary degenerative retinal diseases. To understand the hypoxic response of specific retinal cell types, we performed single-cell RNA sequencing of retinas isolated from mice exposed to hypoxia. Significantly upregulated expression of marker genes in hypoxic clusters confirmed a general transcriptional response to hypoxia. By focusing on the hypoxic response in photoreceptors, we identified and confirmed a kinesin motor protein (Kif4) that was specifically and strongly induced in hypoxic cones. In contrast, RNA-binding proteins Rbm3 and Cirbp were differentially expressed across clusters but demonstrated isoform switching in hypoxia. The resulting short variants of these gene transcripts are connected to epitranscriptomic regulation, a notion supported by the differential expression of writers, readers and erasers of m6A RNA methylations in the hypoxic retina. Our data indicate that retinal cells adapt to hypoxic conditions by adjusting their transcriptome at various levels including gene expression, alternative splicing and the epitranscriptome. Adaptational processes may be cell-type specific as exemplified by the cone-specific upregulation of Kif4 or general like alternative splicing of RNA binding proteins.

Pangenome-Wide Association Study in the Chlamydiaceae Family Reveals Key Evolutionary Aspects of Their Relationship with Their Hosts

The Chlamydiaceae are a family of obligate intracellular bacteria known for their unique biphasic developmental cycle. Chlamydial are associated with various host organisms, including humans, and have been proposed as emerging pathogens. Genomic studies have significantly enhanced our understanding of chlamydial biology, host adaptation, and evolutionary processes. In this study, we conducted a complete pangenome association analysis (pan-GWAS) using 101 genomes from the Chlamydiaceae family to identify differentially represented genes in Chlamydia and Chlamydophila, revealing their distinct evolutionary strategies for interacting with eukaryotic hosts. Our analysis identified 289 genes with differential abundance between the two clades: 129 showed a strong association with Chlamydia and 160 with Chlamydophila. Most genes in Chlamydia were related to the type III secretion system, while Chlamydophila genes corresponded to various functional categories, including translation, replication, transport, and metabolism. These findings suggest that Chlamydia has developed a high dependence on mammalian cells for replication, facilitated by a complex T3SS for intracellular manipulation. In contrast, the metabolic and functional diversity in Chlamydophila allows it to colonize a broad range of hosts, such as birds, reptiles, amphibians, and mammals, making it a less specialized clade.

Cross-cultural adaptation, reliability and validity of the persian version of the functional assessment scale for acute hamstring injuries

BackgroundThe Functional Assessment Scale for Acute Hamstring Injuries (FASH) which measure symptom’s severity and impact on physical activity and sports ability in individuals with acute hamstring muscle injury, is not available in Persian. The aim of this study was to translate and cross-culturally adapt the FASH questionnaire to Persian and to assess the psychometric properties of the translated version.MethodsThe Persian-translation and cross-cultural adaptation processes were based on World Health Organization method. A total of 160 participants compromising of four groups: (1) acute hamstring injury (N = 40), (2) other lower extremity injury (N = 40), (3) risk of acute injury (N = 40), and (4) healthy control (N = 40) were recruited to complete the Persian version of FASH (FASH-P) questionnaire twice with an interval of 48–60 h. The Short Form Health Survey (SF-36) and Lower Extremity Functional Scale (LEFS) were used to assess the criterion validity. Test-retest reliability, internal consistency, criterion validity, Dimensionality and floor/ceiling effects were evaluated to assess the FASH-P psychometric properties.ResultsThe FASH questionnaire were translated to Persian without any major problems. The FASH-P showed excellent power of differentiation because the scores were significantly different among the four groups. Regarding psychometric performances, excellent test–retest reliability (Intraclass correlation coefficient of 0.997) and a high level of internal consistency (Cronbach’s alpha of 0.966) were observed. The FASH-P total score was significantly correlated with SF-36 and LEFS questionnaires representing an excellent criterion validity. No floor or ceiling effect were found for total score in Hamstring muscle injury group.ConclusionsDue to the excellent psychometric performance, the FASH-P can be used as a reliable and valid tool for evaluating the severity of symptoms and sports ability in Persian-speaking patients with hamstring muscle injury.

The Synergic Immunomodulatory Effect of Vitamin D and Chickpea Protein Hydrolysate in THP-1 Cells: An In Vitro Approach

Vitamin D (VD), a crucial micronutrient, regulates bone health and immune responses. Recent studies suggest that VD may confer protective effects against chronic inflammatory diseases. Additionally, plant-based peptides can show biological activities. Furthermore, the supplementation of protein hydrolysates with VD could potentially enhance the bioactivity of peptides, leading to synergistic effects. In this study, THP-1 cells were exposed to low concentrations of Lipopolysaccharide (LPS) to induce inflammation, followed by treatment with vitamin D at different concentrations (10, 25, or 50 nM) or a chickpea protein hydrolysate (“H30BIO”) supplemented with VD. The cytotoxicity of VD was evaluated using viability assay to confirm its safety. The cytokine secretion of TNF-α, IL-1β, and IL6 was assessed in the cell supernatant, and the gene expression of TNF-α, IL-1β, IL6, IL8, CASP-1, COX2, NRF2, NF-ĸB, NLRP3, CCL2, CCR2, IP10, IL10, and RANTES was quantified by qRT-PCR. Treatment with VD alone significantly decreased the expression of the pro-inflammatory genes TNF-α and IL6, as well as their corresponding cytokine levels in the supernatants. While IL-1β gene expression remained unchanged, a reduction in its cytokine release was observed upon VD treatment. No dose-dependent effects were observed. Interestingly, the combination of VD with H30BIO led to an increase in TNF-α expression and secretion in contrast with the LPS control, coupled with a decrease in IL-1β levels. Additionally, genes such as IP10, NF-κB, CCL2, COX2, NRF2, and CASP-1 exhibited notable modulation, suggesting that the combination treatment primarily downregulates NF-κB-related gene activity. This study demonstrates a synergistic interaction between VD and H30BIO, suggesting that this combination may enhance pathways involving TNF-α, potentially aiding in the resolution and modulation of inflammation through adaptive processes. These findings open new avenues for research into the therapeutic applications of enriched protein hydrolysates with VD to manage low-grade inflammatory-related conditions.

Analisis Konvergensi dan Divergensi Komunikasi Antarbudaya: Studi Kasus Komunikasi Mahasiswa Papua di Universitas Mataram

Intercultural communication issues often pose challenges in higher education environments, especially in universities with diverse students from various cultural backgrounds. The University of Mataram, as one of Indonesia's higher education institutions, has a number of students from Papua who face difficulties in adapting to the local culture. This study aims to analyze the convergence and divergence in intercultural communication between Papua students and other students, particularly local students, at the University of Mataram, and to identify the factors influencing their adaptation and integration processes. The findings of this study reveal that Papua students encounter several challenges in communicating and adapting to the local culture at the University of Mataram. Key factors influencing the convergence and divergence in communication include language differences, social norms, and cultural practices. On the other hand, there are also some adaptation mechanisms utilized by Papua students to overcome these challenges, such as forming support groups and participating in local cultural activities

Digital image processing to detect adaptive evolution.

In recent years, advances in image processing and machine learning have fueled a paradigm shift in detecting genomic regions under natural selection. Early machine learning techniques employed population-genetic summary statistics as features, which focus on specific genomic patterns expected by adaptive and neutral processes. Though such engineered features are important when training data is limited, the ease at which simulated data can now be generated has led to the recent development of approaches that take in image representations of haplotype alignments and automatically extract important features using convolutional neural networks. Digital image processing methods termed α-molecules are a class of techniques for multi-scale representation of objects that can extract a diverse set of features from images. One such α-molecule method, termed wavelet decomposition, lends greater control over high-frequency components of images. Another α-molecule method, termed curvelet decomposition, is an extension of the wavelet concept that considers events occurring along curves within images. We show that application of these α-molecule techniques to extract features from image representations of haplotype alignments yield high true positive rate and accuracy to detect hard and soft selective sweep signatures from genomic data with both linear and nonlinear machine learning classifiers. Moreover, we find that such models are easy to visualize and interpret, with performance rivaling those of contemporary deep learning approaches for detecting sweeps.

Adaptive fixed-time fuzzy control for delayed recycling continuous stirred tank reactor with asymmetric time-varying full-state constraints

Recently, there are some results concerning stability and finite-time stability control for continuous stirred tank reactors (CSTR). However, when considering the control of time-delay CSTR systems or fixed-time stability of CSTR systems, there are relatively few articles involved. In this paper, we first consider the CSTR system that includes both of the above factors simultaneously, that is, the adaptive fixed-time fuzzy control design problem for a CSTR with a delayed recycle stream and asymmetric time-varying full-state constraints. Firstly, based on existing works, we present an improved practical fixed-time stability criterion, which can be applied to more complex nonlinear systems. Then, we construct time-varying asymmetric integral barrier Lyapunov functions to handle asymmetric time-varying full-state constraints. Next, fuzzy logic systems are used to approximate the unknown functions of the system, and a sliding mode differentiator is introduced to avoid the “explosion of complexity” of the time derivative of the virtual controller. Furthermore, using the improved practical fixed-time stability criterion, we present the adaptive fixed-time fuzzy controller design processes that can ensure tracking performance in a fixed-time, and states of the system never violate their constraint bounds. Finally, a simulation example is provided to verify the effectiveness of the proposed control strategy.

Genomic insights into climate change-induced forest dieback in Abies alba hotspots of decline

AbstractUnderstanding adaptive genetic responses to climate change is an issue of utmost importance to improve conservation policies and adaptive management. This study deeps on it, focusing on rear-edge silver fir (Abies alba) forests, where decline has been reported and linked to climatic stressors, such as warming and recurrent drought events. Hotspots and coldspots of forest decline and mortality were defined. Different sets of single nucleotide polymorphisms (SNPs), namely genome-wide and adaptive, were used to study their genetic characteristics, aiming to identify differences in genetic diversity between vigor classes (declining and non-declining trees) and age cohorts (adult trees and saplings). Global DNA methylation levels were assessed to investigate a possible role of epigenetic processes in adaptation to stressful environments. Parentage and relatedness analysis were conducted to track the genetic lineage of trees from each site. Our findings indicate that, even though adaptive SNPs seem to provide more insightful information than the genome-wide set, the optimal approach for evolutionary studies is a combination of both. Changes in adaptive genomic diversity and DNA methylation were observed between vigor classes, revealing the existence of a molecular basis behind the ongoing decline events in silver forests. Besides, trees’ relatives display a higher mixture of origins in coldspots, which could provide a temporary refuge for the species’ genetic diversity and adaptive potential. All in all, both genetic and epigenetic characteristics should be considered in order to comprehend how forest trees respond to climate stress to achieve adaptation to climate change.

Adrenal Disorders in Pregnancy. A Comprehensive Review and Prospects for Future Research

Introduction and purpose: Adrenal disorders cover a spectrum of conditions, including adrenal insufficiency, Cushing's syndrome and others. Each disorder has its own implications for pregnancy and requires an individualised approach. This review aims to provide a comprehensive overview of adrenal disorders during pregnancy, such as endogenous Cushing's syndrome, adrenal insufficiency, primary aldosteronism, and pheochromocytoma. Brief description of the state of knowledge: During pregnancy, a number of adaptive processes take place in a woman's body including changes in the endocrine system. Given all these changes, adrenal diseases pose both diagnostic and therapeutic challenges. The symptoms of adrenal diseases often overlap with those observed during physiological pregnancy. Adrenal disorders during pregnancy if unrecognised or treated inadequately, can lead to negative consequences for the mother and foetus, indicating the importance of awareness of these conditions among physicians. Conclusions: Treating and diagnosing adrenal diseases during pregnancy is a major challenge for doctors. It is crucial to diagnose adrenal diseases in pregnant women as early as possible, and to meticulously plan pregnancies for women diagnosed before conception to prevent the negative consequences of untreated adrenal disorders. Optimal control of treatment before conception should be sought. Access to specialised centres with multidisciplinary teams experienced in treating these conditions is crucial for optimal maternal and foetal care.

An Evolutionary Game Analysis of China’s Power Battery Export Strategies Under Carbon Barriers

With the continuous evolution of international trade, the global market has been steadily expanding while also facing increasing challenges, particularly in relation to the introduction of environmental policies such as carbon barriers. Our research explores how China’s power battery manufacturers can adapt their export strategies to the EU’s carbon barrier policies. Additionally, we examine the roles of government regulations, research institutions, and manufacturers in either facilitating or hindering compliance with carbon reduction objectives. Using evolutionary game theory, we construct models involving government entities, manufacturers, and research institutions to systematically analyze market evolution, strategic interactions, and outcomes among these stakeholders. Our analysis focuses on understanding the competitive dynamics faced by exporting countries under stringent environmental policies and provides strategic insights to guide export strategies. Taking the EU’s carbon barrier policy as a case study, we explore Chinese battery manufacturers’ adaptive strategies and decision-making processes as they respond to shifting market demands and regulatory environments. The findings not only offer valuable insights into exporting countries but also provide policymakers with information on international trade and industrial policy design. Furthermore, we validate our model through numerical simulations and conduct sensitivity analyses on key parameters. The results underscore the importance of governmental adoption of punitive and incentive policies, revealing their substantial impact on stakeholder behavior. Additionally, the study highlights how participants’ pre-cooperation losses and post-cooperation gains influence participation rates and the speed at which stakeholder consensus is reached. By offering a novel approach with which to address carbon barrier challenges, this research contributes valuable perspectives on environmental regulations’ strategic and policy implications in global trade.

A Scoping Study of Cultural Adaptation Frameworks.

Translating evidence-based intervention in public health is important to improve health behaviors and other outcomes and reduce health disparities. Culturally adapting intervention is one approach to reaching different cultural groups. The goals of this paper were to compile definitions of program adaptations, identify processes and steps in cultural adaptations, and pose recommendations for future research related to cultural adaptations. We performed a scoping review of cultural adaptation frameworks or models for public health. Studies were coded for definitions of adaptation, cultural adaptation, other cultural concepts, process steps, community engagement, and public health topic. We found 15 frameworks that described cultural adaptation concepts and processes, and nine had varying definitions of cultural adaptations. All frameworks included tasks of information gathering about the community and developing a preliminary adapted program; over 50% had making refinements to the adapted program after some pilot testing. Only one framework mentioned the role of experts in the adaptation or enhancement process, and one mentioned dissemination. Thirteen articles (86.7%) reported the inclusion of community engagement in the adaptation process. These data present key definitions related to cultural adaptation and themes related to the process of cultural adaptation. We also report on key steps for conducting cultural adaptations. Findings can be utilized to guide future adaptations of evidence-based interventions to ensure culturally competent research and practice.

Adaptation Processes of Koreans in Surkhandaryo Province

Article is devoted to the study of adaptation processes and socio-economic integration of Koreans who settled in Surkhandarya region as a result of the deportation of Koreans from the Far East to Uzbekistan SSR in 1937. Through historical and sociological methods of analysis, the article examines Koreans' contribution to agriculture, their integration into local society, and their efforts to preserve their cultural heritage. Based on archival materials, statistical analyzes are presented about the activities of the collective farm “Iskra” in Shorchi district, the production of agricultural products and labor standards. The results of the study shed light on Koreans` adaptation to the new social environment and their contributions to society.

Biochemical Blood Parameters in the Treatment for Dyspepsia

Many issues of newborn calves diseases etiology have not been fully studied and the practical experience of many veterinarians shows with proper diagnosis and treatment that it is possible to achieve a sharp reduction in the young animals mortality. With the birth of calves complex adaptation processes to new conditions occur. The next level of development depends on immunity development. Although a range of different drugs are used to treat dyspepsia in newborn calves, they are not always successful, and it depends on the complex of measures used. The aim of the conducted research is to study the state and dynamics of metabolism in the neonatal period with dyspepsia in newborn calves; to study the effectiveness of the probiotic, along with its impact on the clinical situation; to determine the effectiveness of the drug when used for therapeutic and prophylactic purposes. Probiotic Vetom-15.1 was used in different age groups. As a result, it was found that biochemical blood parameters improved significantly.

Phraseological Quotations: Two Shavian Case Studies

Abstract Phraseological Units (PUs) in a language often include quotations and the so-called authorial “winged words” (“geflügelte Worte” in Gläser 1986), which have a single known author. These units, by gaining popularity among the members of a community of speakers, take on a life of their own as PUs. This study illustrates how these quotations acquire meanings and uses that do not match those of the original formulation they derive from, which, in turn, sheds light on how linguistic expressions at large reach conventionalization through language change. Bernard Shaw (1856–1950) ranks high among the authors who have contributed most to the English Phrasicon. This study investigates two case studies where quotations by Shaw have made their way into the English language as PUs. These quotations, however, are often used, as we shall see, in a way that differs from the sense they had in their original context. This study analyses how some novel PUs are coined and can help us map the processes of semantic adaptation these PUs undergo as they become conventional. It also provides insights into what constitutes a PU and how their defining characteristics apply in these cases.

Molecular cloning and characterization of a brassinosteriod biosynthesis-related gene PtoCYP90D1 from Populus tomentosa

Brassinosteroids (BRs), one of the major classes of phytohormones are essential for various processes of plant growth, development, and adaptations to biotic and abiotic stresses. In Arabidopsis, AtCYP90D1 acts as a bifunctional cytochrome P450 monooxygenase, catalyzing C-23 hydroxylation in the brassinolide biosynthetic pathway. The present study reports the functional characterizations of PtoCYP90D1, one of the AtCYP90D1 homologous genes from Populus tomentosa. The qRT-PCR analysis showed that PtoCYP90D1 was highly expressed in roots and old leaves. Overexpression of PtoCYP90D1 (PtoCYP90D1-OE) in poplar promoted growth and biomass yield, as well as increased xylem area and cell layers. Transgenic plants exhibited a significant increase in plant height and stem diameter as compared to the wild type. In contrast, the CRISPR/Cas9-generated mutation of PtoCYP90D1 (PtoCYP90D1-KO) resulted in significantly decreased biomass production in transgenic plants. Further studies revealed that cell wall components increased significantly in PtoCYP90D1-OE lines but not in PtoCYP90D1-KO lines, as compared to wild-type plants. Overall, the findings indicate a positive role of PtoCYP90D1 in improving growth rate and elevating biomass production in poplar, which will have positive implications for its versatile industrial or agricultural applications.

Unravelling Antimicrobial Resistance in Mycoplasma hyopneumoniae: Genetic Mechanisms and Future Directions.

Antimicrobial resistance (AMR) in Mycoplasma hyopneumoniae, the causative agent of Enzootic Pneumonia in swine, poses a significant challenge to the swine industry. This review focuses on the genetic foundations of AMR in M. hyopneumoniae, highlighting the complexity of resistance mechanisms, including mutations, horizontal gene transfer, and adaptive evolutionary processes. Techniques such as Whole Genome Sequencing (WGS) and multiple-locus variable number tandem repeats analysis (MLVA) have provided insights into the genetic diversity and resistance mechanisms of M. hyopneumoniae. The study underscores the role of selective pressures from antimicrobial use in driving genomic variations that enhance resistance. Additionally, bioinformatic tools utilizing machine learning algorithms, such as CARD and PATRIC, can predict resistance traits, with PATRIC predicting 7 to 12 AMR genes and CARD predicting 0 to 3 AMR genes in 24 whole genome sequences available on NCBI. The review advocates for a multidisciplinary approach integrating genomic, phenotypic, and bioinformatics data to combat AMR effectively. It also elaborates on the need for refining genotyping methods, enhancing resistance prediction accuracy, and developing standardized antimicrobial susceptibility testing procedures specific to M. hyopneumoniae as a fastidious microorganism. By leveraging contemporary genomic technologies and bioinformatics resources, the scientific community can better manage AMR in M. hyopneumoniae, ultimately safeguarding animal health and agricultural productivity. This comprehensive understanding of AMR mechanisms will be beneficial in the adaptation of more effective treatment and management strategies for Enzootic Pneumonia in swine.

ROS as Signaling Molecules to Initiate the Process of Plant Acclimatization to Abiotic Stress.

During their life cycle, plants constantly respond to environmental changes. Abiotic stressors affect the photosynthetic and respiratory processes of plants. Reactive oxygen species (ROS) are produced during aerobic metabolism and play an important role as regulatory mediators in signaling processes, activating the plant's protective response to abiotic stress and restoring "oxidation-reduction homeostasis". Cells develop normally if the rates of ROS production and the ability to neutralize them are balanced. To implement oxidation-reduction signaling, this balance must be disrupted either by an increase in ROS concentration or a decrease in the activity of one or more antioxidant systems. Under abiotic stress, plants accumulate excessive amounts of ROS, and if the ROS content exceeds the threshold amount dangerous for living organisms, it can lead to damage to all major cellular components. Adaptive resistance of plants to abiotic stressors depends on a set of mechanisms of adaptation to them. The accumulation of ROS in the cell depends on the type of abiotic stress, the strength of its impact on the plant, the duration of its impact, and the recovery period. The aim of this review is to provide a general understanding of the processes occurring during ROS homeostasis in plants, oxidation-reduction processes in cellular compartments in response to abiotic stress, and the participation of ROS in signaling processes activating adaptation processes to abiotic stress.

Longitudinal association of stress with mental health in the context of COVID-19: The mediating role of psychological flexibility and emotional schemas.

Stress is a known contributor to psychosocial pathological conditions and reduction of well-being. The literature has highlighted the role of emotional schemas and psychological flexibility as psychological processes underlying this relationship in the short term. This two-wave longitudinal study analyses the mediating role of psychological flexibility and emotional schemas in the relationship between stress responses to COVID-19-related events and mental health 6 months later. Two hundred and seventy-six individuals were included in this study, completing measures of stress responses, emotional schemas, psychological flexibility and positive and negative mental health. Negative evaluation of emotions was a significant mediator in the longitudinal relationship between stress responses and negative mental health. Valued action and openness to experience mediate the longitudinal relationship between stress responses and positive mental health. This study underscores the importance of the different dimensions of psychological processes, suggesting that over time, more maladaptive psychological processes play a significant role in elucidating the relationship between stress responses and negative mental health. Similarly, it suggests that more adaptive processes may help explain the relationship between stress responses and positive mental health. This contributes to a better understanding of the stability of these processes, which is important for determining which intervention targets should be prioritised.

Immigrant Youth Adaptation and Risk Involvement: The Case of Immigrant Youth From France and the Former Soviet Union in Israel

Immigration is challenging for youth as it requires reorganization of their developmental system and can increase their vulnerability to risk factors. Adaptation processes may be affected further by the cultural context in which they take place. This study explored immigration and adaptation experiences among youth at risk, who had immigrated to Israel from France and from the Former Soviet Union (FSU), and the impact of these experiences on the youth’s involvement in risk behaviors. The 27 participants interviewed for this qualitative study were 11 immigrant youth from France, 10 from the FSU, and 6 practitioners who work with immigrant youth at risk. Data analysis indicates that immigration is a significant life event that affects all spheres of the youth’s lives: identity, relationships with parents and peers, and school integration. Based on the participants’ interviews, we conceptualized adaptation as a multilevel process, related to youth’s potential involvement in risk behaviors. Moreover, immigrant youth’s experiences on different levels are shaped by their culture of origin—a matrix in which their adaptation and risk behavior occur. The findings, derived from a comprehensive perspective of both the youth and the practitioners, have substantial implications for practice and policy to enhance immigrant youth’s constructive adaptation. Specifically, we emphasize the key role of pre- and post-migration preparation that targets immigrant youth and their parents, and Israeli education institutions that receive immigrants.