Acute Postinfectious Glomerulonephritis Research Articles

Primary Acute Glomerular Disorders in the Elderly

Most physicians think of acute glomerulonephritis as a disease of children and young adults. Indeed, the majority of series show a strong predilection of this illness for the young age groups,^1-3its incidence peaking between the ages of 3 and 7 years.⁴However, elderly patients are not immune to the disorder and acute glomerulonephritis has been reported to develop at a very late age.^5-8Cases among the aged continue to occur, even in an era in which acute poststreptococcal glomerulonephritis is becoming a rarity in the pediatric services of developed countries⁹and when the incidence of streptococcus-related diseases seems to be declining.¹⁰ The clinical features of acute postinfectious glomerulonephritis in the elderly do not differ appreciably from those in other age groups and basically reflect an acute nephritic syndrome with azotemia, oliguria, hypertension, edema, hematuria, and varying degrees of proteinuria. Hypocomplementemia is frequently found during

The prognostic significance of globulinuria in the nephrotic syndrome; an electrophoretic study of urinary proteins in the nephrotic syndrome and acute glomerulonephritis.

Globulin was detected in protein-containing urine for the first time in 1866, by Lehman. 1 From then on, several studies * have dealt with a possible relationship of globinuria to the outcome of renal diseases. Discrepancies in the results and conclusions obtained may be due to the use of older, inaccurate methods and to the fact that single or few examinations were done in individual cases. Further confusion also derived from the poorly defined classification of cases used for investigation, usually grouped under the term of Bright's disease. We will confine our communication to 11 children who suffered from acute postinfectious hemorrhagic glomerulonephritis and to 32 children suffering from the nephrotic syndrome. According to a recently proposed classification, 10 children who had the nephrotic syndrome in its so-called pure form were not separated from children who at one time or another had the disease with hematuria, hyperten sion, or azotemia. According