The prognostic significance of globulinuria in the nephrotic syndrome; an electrophoretic study of urinary proteins in the nephrotic syndrome and acute glomerulonephritis.

Abstract

Globulin was detected in protein-containing urine for the first time in 1866, by Lehman. 1 From then on, several studies * have dealt with a possible relationship of globinuria to the outcome of renal diseases. Discrepancies in the results and conclusions obtained may be due to the use of older, inaccurate methods and to the fact that single or few examinations were done in individual cases. Further confusion also derived from the poorly defined classification of cases used for investigation, usually grouped under the term of Bright's disease. We will confine our communication to 11 children who suffered from acute postinfectious hemorrhagic glomerulonephritis and to 32 children suffering from the nephrotic syndrome. According to a recently proposed classification, 10 children who had the nephrotic syndrome in its so-called pure form were not separated from children who at one time or another had the disease with hematuria, hyperten sion, or azotemia. According