Objective To regulate human immune system,relieve leukopenia and corresponding symptoms of systemic lupus erythematosus(SLE) patients,such as insomnia with ear acupoint pressing therapy,search for its evidence-based nursing methods.Methods Patients were randomly divided into control group and treatment group,30 cases each group.The control group received routine medical care and nursing.Besides routine therapy and nursing,patients in treatment group received ear acupoint pressing of the kidney,epinephros etc.The data was analyzed.Results WBC in treatment group after received the therapy of ear acupoint pressing was( 6.74 ± 1.29 ) × 109/L,and in control group was( 4.32 ± 1.18 ) ×109/L,and the difference was statistically significant(t =2.20,P <0.05 ).There was no significant difference on the ahypnia,weak and poor appetite between two groups before and after intervention( P > 0.05 ).Conclusions Ear acupoint pressing therapy can relieve leucopenia among SLE patients. Key words: Acupressure; Lupus erythematosus,systemic; Leukocyte count; Nursing