The emergence of fundamentally new products is conditioned both by the development of techniques and technologies and by the emerging new needs and conditions of economic and social life of society. In this case, the process of achieving product dominance in the market has a progressive cyclical character in the form of a spiral pattern, the movement along which occurs with acceleration. At the current stage of economic development, most states have problems expanding sales of products and capturing new markets. These problems today are described in the works of various scientists; the research of the authors touches upon the issues of economic development. Today’s economic conditions, which are characterized by the application of sanctions pressure on a large scale, do not assess the opposite effect, when the countries that are subjected to this pressure, and the countries that organize this pressure, suffer economic damage. Some suffer damage in the form of reduced ability to produce knowledge-intensive products by providing them with imported materials and components, others who exert this pressure, by reducing the sales of their products, and in this case, it is relevant to build a mechanism for assessing mutual structural links for import substitution of high-tech transfer in the management of the life cycle of radical new products, which in our view is useful for those or other countries. The hypothesis is that the modeling of mutual structural relations of high-tech transfer in the management of the life cycle of radical new products will significantly improve the mechanisms of industrial policy management and national technological security and ensure sustainable economic development. The aim of the study is the task of developing a mechanism of mutual structural links and assessing the synergetic economic effect based on the approach of intersectoral links, interactions and interdependencies. In the course of the research, the following tasks are solved: the necessity to adequately replace high-tech imports within the framework of national technological security is substantiated, for this purpose it is necessary to create unique equipment for the system of RNP production; the assessment of the possibility of realization of such a task is carried out; the assessment of high-tech competencies of science and production, technical and resource readiness (configuration of the RNP system) is necessary, and a complex model for the assessment of structural and mutual linkages in the economy of innovation is developed. The modeling performed by the authors allowed us to assess the structure of domestic high-tech imports and the coefficients of mutual linkage of imports. The practical significance of the study lies in the fact that the conducted research makes it possible to significantly improve the efficiency of management of innovation processes of high-tech transfer to ensure the creation of a system of production of radically new products at the levels of organization, industry or national economy, which will ensure stable economic development. For this purpose, the structure and dynamics of high-tech imports of the Russian Federation have been analyzed and calculated, taking into account critical technologies and industries. The multiplier effects in high-tech industries of the Russian economy taking into account imports were analyzed on the basis of the latest actual detailed data of Rosstat. The estimation of the mutual relationship of imports and application of the developed toolkit for the example “Mechanical equipment, machine tools and other equipment for general or special purposes” is carried out.