Activity Of Metal Complexes Research Articles

Synthesis, Characterization, Biological Evaluation, DFT, and Molecular Docking Study of a Co(II) Complex Derived from ON Donor Bidentate Schiff Base Ligand

AbstractThe utilization of biologically active metal complexes in medicine is gaining recognition as an alternative approach to traditional biologically active organic molecules, which often exhibit undesirable side effects. This study focuses on the synthesis and characterization of a Co(II) complex derived from the (E)‐2‐((2‐hydroxybenzylidene)amino)‐5‐methylbenzonitrile ligand system (HL) and cobalt(II) acetate tetrahydrate in a dichloromethane/methanol solution. A comprehensive characterization strategy was employed, involving proton and carbon nuclear magnetic resonance, infrared, electronic spectra, PXRD, SEM‐EDX, and mass spectroscopies, as well as elemental analysis (CHN and Co), TGA, and molar conductance, to confirm the chemical structures of the ligand and its complex. The infrared spectral data revealed the ligand as a bidentate ligand, chelating the Co(II) ion through the oxygen and nitrogen atoms of the phenolate and imine groups. Additionally, PXRD and SEM analyses indicated crystalline and amorphous properties for the ligand and complex, respectively. Assessment of antimicrobial potential using a modified disc diffusion method, with streptomycin as the positive control, demonstrated the complex's enhanced antibacterial activity compared to the ligand against all tested bacteria, showing a concentration‐dependent response. Similarly, antioxidant studies revealed promising results, with the complex exhibiting superior DPPH radical scavenging activity (IC50 values: ligand 64.5 μg.mL−1, complex 43.1 μg.mL−1). Theoretical analysis through DFT calculations and molecular docking provided insights into the electronic properties and binding affinity of the ligand and complex, supporting the experimental findings and affirming the biological activities exhibited by the compounds. Overall, this research showcases the synthesis, characterization, and biological evaluation of a promising Co(II) complex, highlighting its potential as an effective antimicrobial and antioxidant agent.

Synthesis and Photo/Radiation Chemical Characterization of a New Redox-Stable Pyridine-Triazole Ligand.

Photocatalysis using transition-metal complexes is widely considered the future of effective and affordable clean-air technology. In particular, redox-stable, easily accessible ligands are decisive. Here, we report a straightforward and facile synthesis of a new highly stable 2,6-bis(triazolyl)pyridine ligand, containing a nitrile moiety as a masked anchoring group, using copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction. The reported structure mimics the binding motif of uneasy to synthesize ligands. Pulse radiolysis under oxidizing and reducing conditions provided evidence for the high stability of the formed radical cation and radical anion 2,6-di(1,2,3-triazol-1-yl)-pyridine compound, thus indicating the feasibility of utilizing this as a ligand for redox active metal complexes and the sensitization of metal-oxide semiconductors (e. g., TiO2 nanoparticles or nanotubes).

In-silico DFT studies and molecular docking evaluation of benzimidazo methoxy quinoline-2-one ligand and its Co, Ni, Cu and Zn complexes as potential inhibitors of Bcl-2, Caspase-3, EGFR, mTOR, and PI3K, cancer-causing proteins

We present here the design, Density Functional Theory (DFT) and Molecular Docking studies of Benzimidazo Methoxy Quinoline-2-one (BMQ) ligand-coordinated transition metal complexes (Co, Ni, Cu, and Zn). Two types of metal coordination, namely imidazole-metal (Im-metal) and quinoline-metal (Q-metal), are proposed in the metal coordination process. The observed lower negative values of both metal coordination on molecular optimization, confirmed structural stability of metal complexes compared with BMQ ligand. An average energy difference of -18.7152 eV lower energy of Im-metal complexes with reference to Q-metal complexes illustrated the more coordination capability of imidazole-imine functionality. Molecular stability and reactivity of the proposed complexes have been assessed through frontier molecular orbital (FMO), and molecular electrostatic potential (MEP) map studies. The molecular descriptor values, calculated from the FMO studies, elucidate the higher probability and strong protein binding affinity for the Im-metal complexes. To predict their antiproliferative properties, BMQ-transition metal complexes are computationally analyzed with proteins Bcl-2, Caspase-3, EGFR, mTOR, and PI3K. Based on these results, four active metal complexes are selected and subjected to in-silico ADMET profiling to evaluate their pharmacological potential. From all the findings, a new mechanism for molecular design aimed at target-oriented protein binding is concluded

Self-Assembled Supported Ionic Liquids.

Separation and reuse of the catalytically active metal complexes are persistent issues in homogeneous catalysis. Supported Ionic Liquid Phase (SILP) catalysts, where the catalytic center is dissolved in a thin film of a stable ionic liquid, deposited on a solid support, present a promising alternative. However, the dissolution of the metal center in the film leaves little control over its position and its activity. We present here four novel, task-specific ionic liquids [FPhn ImH R]I (n=1, 2; R=PEG2 , C12 H25 ), designed to self-assemble on a silica surface without any covalent bonding and offering a metal binding site in a controlled distance to the support. Advanced multinuclear solid-state NMR spectroscopic techniques under Magic Angle Spinning, complemented by molecular dynamics (MD) simulations, allow us to determine their molecular conformation when deposited inside SBA-15 as a model silica support. We provide here conceptual proof for a rational design of ionic liquids self-assembling into thin films, opening an avenue for a second, improved generation of SILP catalysts.

Dehydroacetic acid a privileged medicinal scaffold: A concise review.

From the last decade, research on dehydroacetic acid (DHA) and its derivatives has increased immensely due to its significant role in various fields, including medicine, cosmetics, food industry, and so on. In the medicinal area, DHA plays an essential role in developing novel action-based drugs, which are helpful for treating various diseases. Besides its plethora of biological applications, its chelating ability offers the easiest synthetic route for synthesizing more active metal complexes. DHA derivatives along with their metal complexes show a number of biological activities and also exhibit various interactions with multiple biological targets. This article summarizes recent medicinal applications (2000-onwards) of DHA-based compounds and their analogs, along with their structure-activity relationship (SAR) analysis. Their interactions with different target enzymes are also discussed. This information derived from SAR analysis would be helpful for medicinal chemists working on the development of drugs based on heterocyclic frameworks, particularly those based on the DHA scaffold.

Unravelling the Molecular Structure and Confining Environment of an Organometallic Catalyst Heterogenized within Amorphous Porous Polymers.

The catalytic activity of multifunctional, microporous materials is directly linked to the spatial arrangement of their structural building blocks. Despite great achievements in the design and incorporation of isolated catalytically active metal complexes within such materials, a detailed understanding of their atomic-level structure and the local environment of the active species remains a fundamental challenge, especially when these latter are hosted in non-crystalline organic polymers. Here, we show that by combining computational chemistry with pair distribution function analysis, 129 Xe NMR, and Dynamic Nuclear Polarization enhanced NMR spectroscopy, a very accurate description of the molecular structure and confining surroundings of a catalytically active Rh-based organometallic complex incorporated inside the cavity of amorphous bipyridine-based porous polymers is obtained. Small, but significant, differences in the structural properties of the polymers are highlighted depending on their backbone motifs.

Aufklärung der molekularen Struktur und des Confinements eines in amorphen porösen Polymeren heterogenisierten metallorganischen Katalysators**

AbstractDie katalytische Aktivität multifunktionaler, mikroporöser Materialien hängt direkt von der räumlichen Anordnung ihrer Strukturbausteine ab. Trotz großer Erfolge bei dem Design und der Heterogenisierung isolierter, katalytisch aktiver Metallkomplexe in solchen Materialien bleibt ein detailliertes Verständnis ihrer Struktur auf atomarer Ebene und der lokalen Umgebung der aktiven Spezies eine grundlegende Herausforderung, insbesondere wenn diese in amorphe organische Polymere eingebaut sind. Hier zeigen wir, dass durch die Kombination von Computerchemie mit Paarverteilungsfunktionsanalyse, 129Xe NMR‐ und dynamischer Kernpolarisations NMR‐Spektroskopie eine sehr genaue Beschreibung der Molekülstruktur und der Umgebung eines katalytisch aktiven, Rh‐basierten organometallischen Komplexes möglich ist, der in die Poren eines amorphen Bipyridin‐basierten porösen Polymers eingebaut ist. Kleine, aber signifikante Unterschiede in den strukturellen Eigenschaften der Polymere in Abhängigkeit ihrer Funktionalisierung werden hervorgehoben.

Incorporating Catalytic Units into Nanomaterials: Rational Design of Multipurpose Catalysts for CO2 Valorization.

ConspectusCO2 conversion to valuable chemicals is effective at reducing CO2 emissions. We previously proposed valorization strategies and developed efficient catalysts to address thermodynamic stability and kinetic inertness issues related to CO2 conversion. Earlier, we developed molecular capture reagents and catalysts to integrate CO2 capture and conversion, i.e., in situ transformation. Based on the mechanistic understanding of CO2 capture, activation, and transformation at a molecular level, we set out to develop heterogeneous catalysts by incorporating catalytic units into nanomaterials via the immobilization of active molecular catalysts onto nanomaterials and designing nanomaterials with intrinsic catalytic sites.In thermocatalytic CO2 conversion, carbonaceous and metal-organic framework (MOF)-based catalysts were developed for nonreductive and reductive CO2 conversion. Novel Cu- and Zn-based MOFs and carbon-supported Cu catalysts were prepared and successfully applied to the cycloaddition, carboxylation, and carboxylative cyclization reactions with CO2, generating cyclic carbonates, carboxyl acids, and oxazolidinones as respective target products. Reductive conversion of CO2, especially reductive functionalization with CO2, is a promising transformation strategy to produce valuable chemicals, alleviating chemical production that relies on petrochemistry. We explored the hierarchical reductive functionalization of CO2 using organocatalysts and proposed strategies to regulate the CO2 reduction level, triggering heterogeneous catalyst investigation. Introducing multiple active sites into nanomaterials opens possibilities to develop novel CO2 transformation strategies. CO2 capture and in situ conversion were realized with an N-doped carbon-supported Zn complex and MOF materials as CO2 adsorbents and catalysts. These nanomaterial-based catalysts feature high stability and excellent efficiency and act as shape-selective catalysts in some cases due to their unique pore structure.Nanomaterial-based catalysts are also appealing candidates for photocatalytic CO2 reduction (PCO2RR) and electrocatalytic CO2 reduction (ECO2RR), so we developed a series of hybrid photo-/electrocatalysts by incorporating active metal complexes into different matrixes such as porous organic polymers (POPs), metal-organic layers (MOLs), micelles, and conducting polymers. By introducing Re-bipyridine and Fe-porphyrin complexes into POPs and regulating the structure of the polymer chain, catalyst stability and efficiency increased in PCO2RR. PCO2RR in aqueous solution was realized by designing the Re-bipyridine-containing amphiphilic polymer to form micelles in aqueous solution and act as nanoreactors. We prepared MOLs with two different metallic centers, i.e., the Ni-bipyridine site and Ni-O node, to improve the efficiency for PCO2RR due to the synergistic effect of these metal centers. Sulfylphenoxy-decorated cobalt phthalocyanine (CoPc) cross-linked polypyrrole was prepared and used as a cathode, achieving the electrocatalytic transformation of diluted CO2 benefiting from the CO2 adsorption capability of polypyrrole. We fabricated immobilized 4-(t-butyl)-phenoxy cobalt phthalocyanine and Bi-MOF as cathodes to promote the paired electrolysis of CO2 and 5-hydroxymethylfurfural (HMF) and obtained CO2 reductive products and 2,5-furandicarboxylic acid (FDCA) efficiently.

Paramagnetic Relaxation Agents for Enhancing Temporal Resolution and Sensitivity in Multinuclear FlowNMR Spectroscopy.

Sensitivity in FlowNMR spectroscopy for reaction monitoring often suffers from low levels of pre-magnetisation due to limited residence times of the sample in the magnetic field. While this in-flow effect is tolerable for high sensitivity nuclei such as 1 H and 19 F, it significantly reduces the signal-to-noise ratio in 31 P and 13 C spectra, making FlowNMR impractical for low sensititvity nuclei at low concentrations. Paramagnetic relaxation agents (PRAs), which enhance polarisation and spin-lattice relaxation, could eliminate the adverse in-flow effect and improve the signal-to-noise ratio. Herein, [Co(acac)3 ], [Mn(acac)3 ], [Fe(acac)3 ], [Cr(acac)3 ], [Ni(acac)2 ]3, [Gd(tmhd)3 ] and [Cr(tmhd)3 ] are investigated for their effectiveness in improving signal intensity per unit time in FlowNMR applications under the additional constraint of chemical inertness towards catalytically active transition metal complexes. High-spin Cr(III) acetylacetonates emerged as the most effective compounds, successfully reducing 31 P T1 values four- to five-fold at PRA concentrations as low as 10 mM without causing adverse line broadening. Whereas [Cr(acac)3 ] showed signs of chemical reactivity with a mixture of triphenylphosphine, triphenylphosphine oxide and triphenylphosphate over the course of several hours at 80° C, the bulkier [Cr(tmhd)3 ] was stable and equally effective as a PRA under these conditions. Compatibility with a range of representative transition metal complexes often used in homogeneous catalysis has been investigated, and application of [Cr(tmhd)3 ] in significantly improving 1 H and 31 P{1 H} FlowNMR data quality in a Rh-catalysed hydroformylation reaction has been demonstrated. With the PRA added, 13 C relaxation times were reduced more than six-fold, allowing quantitative reaction monitoring of substrate consumption and product formation by 13 C{1 H} FlowNMR spectroscopy at natural abundance.

Functional Monolayers on a Superatomic Pegboard.

We advance the chemistry of apical chlorine substitution in the 2D superatomic semiconductor Re6Se8Cl2 to build functional and atomically precise monolayers on the surface of the 2D superatomic Re6Se8 substrate. We create a functional monolayer by installing surface (2,2'-bipyridine)-4-sulfide (Sbpy) groups that chelate to catalytically active metal complexes. Through this reaction chemistry, we can create monolayers where we can control the distribution of catalytic sites. As a demonstration, we create highly active electrocatalysts for the oxygen evolution reaction using monolayers of cobalt(acetylacetonate)2bipyridine. We can further produce a series of catalysts by incorporating organic spacers in the functional monolayers. The structure and flexibility of the surface linkers can affect the catalytic performance, possibly by tuning the coupling between the functional monolayer and the superatomic substrate. These studies establish that the Re6Se8 sheet behaves as a chemical pegboard: a surface amenable to geometrically and chemically well-defined modification to yield functional monolayers, in this case catalytically active, that are atomically precise. This is an effective method to generate diverse families of functional nanomaterials.

Chiral Hydroxamic Acid Ligands in Asymmetric Synthesis: The Evolution of Metal‐Catalyzed Oxidation Reactions

AbstractAsymmetric oxidation reaction is one of the significant pathways in stereoselective reactions, which is a prominent performer in academic and industrial research. However, ligands are vital for planning an ideal metal‐catalyzed asymmetric oxidation reaction as they interact with the metal to construct catalytically active metal complexes, which can catalyze numerous asymmetric reactions. Designing and synthesizing novel chiral ligands is essential for researchers in modern asymmetric synthesis. In this course, exploring the applicability and the survey of hydroxamic acid as a vital ligand has been presented, which is essential for various metal‐catalyzed transformations.

Synthesis and Characterization of some biologically active transition metal complexes for a ligand derived from dimedone with mixed ligands.

The aim of the work is synthesis and characterization of bidentate ligand
 [3-(3-acetylphenylamino)-5,5-dimethylcyclohex-3-enone][HL], from the
 reaction of dimedone with 3-amino acetophenone to produce the ligand
 [HL], the reaction was carried out in dry benzene as a solvent under reflux.
 The prepared ligand [HL] was characterized by FT-IR, UV-Vis
 spectroscopy, 'H, 8C-NMR spectra, Mass spectra, (C.H.N) and melting
 point. The mixed ligand complexes were prepared from ligand [HL] was
 used as a primary ligand while 8-hydroxy quinoline [HQ] was used as a
 secondary ligand with metal ion M(IT).Where M(IT) = (Mn ,Co ,Ni ,Cu ,Zn
 ,Cd and Pd) at reflux ,using ethanol as a solvent, KOH as a base.
 Complexes of the composition [M(L)(Q)] with (1:1:1) molar ratio were
 prepared . All the complexes were characterized by spectroscopic methods
 (FT-IR, UV-Vis spectroscopy) along with elemental analysis (A.A),
 chloride content and melting point measurements were carried out, together
 with conductivity and magnetic susceptibility. These measurements showed
 tetrahedral geometry around (Mn", Col, Ni, Cu", Zn! and Cd") ions and
 square planner around (Pd") ion. The biological activity of the ligands
 [HL],[HQ] ] and complexes (MLQ): were studied using inhibition method.

Efficient electrocatalytic H2O2 evolution utilizing electron-conducting molecular wires spatially separated by rotaxane encapsulation

Immobilization of a catalytically active metal complex onto an electrode surface in highly dispersed form is crucial to assure high catalytic activity observed in solution. In this report, mononuclear CoII chlorin complexes were successfully immobilized on a conductive metal-oxide electrode by using electron conducting molecular wires comprising phenylene–ethynylene-based π-conjugation covered by a linked permethylated α-cyclodextrin to enhance electrocatalysis for selective two electron reduction of molecular oxygen to hydrogen peroxide. First, the rotaxane-encapsulation effect of the molecular wire on electron transfer was examined by the comparison of electrochemical behaviors of ferrocene (Fc) molecules immobilized on an ITO substrate using the molecular wires with or without rotaxane encapsulation. Then, electrodes were modified with metalloporphyrinoids, i.e., RhIII(OEP)Cl (OEP = 2,3,7,8,12,13,17,18-octaethylporphyrin) and CoII chlorin through coordination with the molecular wires with pyridine moieties at the end. The electrocatalytic O2 reduction was performed with CoII chlorin immobilized on an electron-conductive metal-oxide substrate by molecular wires. The turnover frequency for H2O2 production using the CoII chlorin coordinated by molecular wires with rotaxane encapsulation was 331 ± 75, which is significantly higher than that of 82 ± 8 obtained for CoII chlorin immobilized by that without rotaxane encapsulation. These results clearly indicate that the molecular wires with rotaxane encapsulation are beneficial for CoII chlorin complexes to exhibit high electrocatalytic activity and selectivity to H2O2.

N-heterocyclic carbene-ligated metal complexes and clusters for photocatalytic CO2reduction

N-heterocyclic carbenes are structurally versatile ligands, which have strong σ-donor properties to form covalent bonds with metal centers. This frontier article provides a review on active NHC-stabilized metal complexes and clusters for photocatalytic CO2reduction.

A metal-organic framework-supported dinuclear iron catalyst for hydroboration of carbonyl compounds.

Preparation of catalytically active dinuclear transition metal complexes with an open coordination sphere is a challenging task because the metal sites tend to be "saturated" with excess donor atoms around during synthesis. By isolating the binding scaffolds with the metal-organic framework (MOF) skeleton and installing metal sites through post-synthetic modification, we succeed in constructing a MOF-supported metal catalyst, namely FICN-7-Fe2, with dinuclear Fe2 sites. FICN-7-Fe2 effectively catalyses the hydroboration of a broad range of ketone, aldehyde, and imine substrates with a low loading of 0.05 mol%. Remarkably, kinetic measurements showed that FICN-7-Fe2 is 15 times more active than its mononuclear counterpart FICN-7-Fe1, indicating that cooperative substrate activation on the two Fe centres significantly enhances the catalysis.

Bilateral metalloheterocyclic systems based on palladacycle and piperidine-2,4-dione pharmacophores.

The design of molecules with effective anticancer properties constructed from both dually active metal complex and organic fragments is a novel trend in medicinal chemistry. This concept suggests the impact of a drug on several biological targets or the synergistic action of both fragments as a single unit. We propose that the combination of a Pd-metallocomplex fragment and an organic unit can be an interesting model for anticancer drug discovery. The first phase in the development of such suggested molecules is the synthesis of bilateral metallosystems containing bioactive 6-substituted piperidin-2-one and a palladated N-phenylpyrazolic fragment. Both fragments were incorporated into one molecule through the fused pyrazole-piperidine-2-one unit followed by pyrazol-directed cyclopalladation of the phenyl-group with Pd(OAc)2. An effect of acceleration of the rate of the palladation by NH-lactam was observed. The synthesized hybrid palladacycles have been characterized and tested for their cytotoxic activity on three cancerous cell lines as PPh3 complexes, revealing structures with potential for further development and structural optimization.

The two-electron reduced A cluster in acetyl-CoA synthase: Preparation, characteristics and mechanistic implications

Acetyl-CoA synthase (ACS) is a central enzyme in the carbon and energy metabolism of certain anaerobic species of bacteria and archaea that catalyzes the direct synthesis and cleavage of the acetyl CC bond of acetyl-CoA by an unusual enzymatic mechanism of special interest for its use of organonickel intermediates. An Fe4S4 cluster associated with a proximal, reactive Nip and distal spectator Nid comprise the active site metal complex, known as the A cluster. Experimental and theoretical methods have uncovered much about the ACS mechanism, but have also opened new unanswered questions about the structure and reactivity of the A cluster in various intermediate forms. Here we report a method for large scale isolation of ACS with its A cluster in the acetylated state. Isolated acetyl-ACS and the two-electron reduced ACS, produced by acetyl-ACS reaction with CoA, were characterized by UV–visible and EPR spectroscopy. Reactivity with electron acceptors provided an assessment of the apparent Em for two-electron reduction of the A cluster. The results help to distinguish between alternative electronic states of the reduced cluster, provide evidence for a role of the Fe/S cluster in catalysis, and offer an explanation of why one-electron reductive activation is observed for a reaction cycle involving 2-electron chemistry.

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion: A Mini Review

Bacterial infections are a major cause for impulsive deaths in human beings.Bacterial infections of the respiratory, gastrointestinal and central nervoussystem account for the majority of cases of sudden casualties. Readily availabledrugs are getting ineffective by each passing day as the mutation is veryfast in these pathogenic microbes resulting in drug resistance. The growingresistance of bacteria necessitates the development of new and effectivecompounds of desired characteristics that could bar the rapid development ofbacterial cell inside of the host body. Along with cellular resistance for clinicalantibiotics, co-bacterial infections during microbial attacks (viz. virus, fungus,protozoans etc.) also demand for some novel antibacterial drugs having highefficacy and minimal side effects on human body. These antibiotics shouldalso be compatible with remedies ongoing for core microbial infections. So,in demand of search for effective antibacterial moieties, the scope of transitionmetal complexes as drug gives a good signal against the pathogenic bacteriaby inhibiting their growth. The action of metal complexes on bacterial cellmay be due to impremiablity, enzymatic interruptions, ribosomal interactions,disturbance in the path of protein synthesis, denaturing of genetic materialsetc. inside the cell. Metals in complexes may interrupt the lipophilisity throughthe bacterial cell wall. Inclusion of metal ions in organic moieties behavingas ligand delocalize π-electrons upon the entire chelate ring and this chelationresults in overlapping of ligand orbital and partial sharing of (+)ve chargeof metal ion with donor atoms. These structural modifications in metal andorganic lone pair donor species are the supposed reasons for their enhancedantimicrobial activities against pathogenic microbes. The present reviewfocuses on the impact of recently synthesized, well characterized mono andbinuclear transition metal complexes of Cu ions that have the potential to be the drug of the decade in medicinal inorganic chemistry for treating the bacterial diseases.

Electrophotochemical Metal-Catalyzed Decarboxylative Coupling of Aliphatic Carboxylic Acids.

An electrophotochemical dual metal-catalyzed protocol for decarboxylative arylation of simple aliphatic carboxylic acids with aryl halides is reported. The relative stabilities of catalytically active metal complexes simultaneously generated at anode and cathode are the key design elements for the success of this convergent paired electrolysis. This new electrophotocatalytic method is mild, robust, and most importantly, capable of accommodating simple primary aliphatic acids including acetic acid - ubiquitous and variegated structural motifs yet remain oddly challenging substrates - directly as native functional groups for decarboxylative C(sp2 )-C(sp3 ) bond formation.

Silver Complexes of N-Heterocyclic Carbenes as Anticancer Agents: A Review

This review covers the explanation of all the biological efficiencies of the N-Heterocyclic Carbenes (NHCs). Most of the reviews of NHCs focused on its chemical and physical applications, we have noted the properties, types and applications of metal complexes of NHCS. Our principle aim is to throw a light on the biological applications of the complexes. N heterocyclic carbenes (NHC) have been discovered in the 90's and have been marking an important place in organic chemistry. NHCs contain divalent carbon atoms. It is bound to at least one nitrogen atom. Presence of heteroatoms imparts them a wide range of electronic behavior. They create stable bonds and compounds making them excellent ligands in coordination chemistry. Silver metal complexes of organic ligands had been an interesting research area for the pharmaceutical researchers. Because of the electron donating ability of NHCs, the formation of Ag metal complexes had been pursued by many inorganic chemists and they were evaluated for various biological activities. Thus, in this review we have listed out the Ag-NHCs which have anticancer potential and its use as cytotoxic therapeutic agents. This article concludes with the basic concept that, how to design efficient Ag-NHCs in order to develop efficient, biologically active metal complex derivatives.