Limits Of Activity Research Articles

On the limits of economic activity: bridging degrowth and modern monetary theory for socio-ecological sustainability and justice

This paper advances recent work exploring synergies and tensions between two schools of political-economic thought—degrowth and modern monetary theory (MMT)—and posits that this synergy warrants closer attention from International Political Economy and Environment (IPEE) scholars. Thus far, degrowth policies have largely been proposed upon the assumption that governments are limited in budgetary terms. MMT theorists have offered an alternative perspective on fiscal policy space but generally provide insufficient ecological considerations. This paper asks how each school’s underlying assumptions about the limits of economic activity might inform the other’s framework of action. We find that while there are tensions between the two schools’ economic philosophies, there are possibilities for cross-fertilization, which ought to interest IPEE scholars. MMT could engage degrowth’s perspective of ecological limits and global socio-ecological justice in its discussions about what economies can ‘afford’, whereas degrowth could use MMT insights to shift from a ‘pay for’ to a ‘resource’ frame, while centering abundance before limits. Meanwhile, IPEE can provide insights to an MMT-informed degrowth transition by grounding this debate in material analyses of class and power. Our findings suggest that degrowth and MMT could provide a normative direction for IPEE research centered around meeting material needs within planetary boundaries.

Influence of Joint Stiffness on Three-dimensional Deformation Mechanisms of Pipelines under Tunnel Active Face Instability

Although extensive research has been conducted in literature to investigate tunnelling effects on pipelines, the performance of existing jointed pipelines subjected to excessive tunnel movement has not been investigated. This study sets out to examine the effects of tunnel active instability on three-dimensional deformation patterns of existing pipelines using physical model tests. Tunnelling induced ground / pipeline settlement, joint rotation, and bending strain under various horizontal tunnel face movements are systematically explored. Results show that the tunnel face pressure at the active limit state is practically independent of tunnel cover to diameter ratio (C/D). Existing pipelines that fall within a range of 0.1 D ~ 0.5 D ahead of the tunnel face experience excessive settlements, significant bending strains and joint rotation. The measured peak settlement of pipelines at 0.3 D in front of the tunnel face exceeds the allowable limit, and the maximum settlements in the jointed pipeline are up to 2.67 times those observed in the continuous pipeline. Meanwhile, the joint rotation angle and settlement induced in the jointed pipeline are greatly affected by the C/D ratio and decrease by up to 55.5% and 22.0% with an increasing C/D ratio from 1.0 to 1.5.

“Shade Never Made Anybody Less Gay”: Taylor Swift’s Performance of Allyship and the Neoliberalization of Activism

ABSTRACT With the release of the singles “You Need to Calm Down” and “The Man” in 2019 and 2020, singer-songwriter Taylor Swift positioned herself as an ally to the LGBTQ+ community and a feminist artist. Swift’s longstanding pursuit of authenticity manifested as an attempt to be taken seriously as a political actor. “You Need to Calm Down” equates Swift’s own position as a controversial celebrity with structural homophobia while “The Man” is a neoliberal feminist manifesto that foregrounds dominance as feminist progress without examination of class- and race-based oppression. These examples illustrate the limitations of celebrity activism and allyship and the commodification of activism.

Correlation of Vitamin D Levels with Severity of Asthma in Children Between 6 to 12 Years

Background: Millions of children worldwide suffer from chronic asthma, a serious respiratory disease that has a major influence on everyday living and health outcomes. There are significant public health concerns regarding the estimated 10-15% frequency of asthma in children in India. Vitamin D, which is recognized for its immunomodulatory qualities, according to recent studies reduces the severity. In this study, children aged 6 to 12 years old's vitamin D levels and the severity of their asthma were examined. Materials and Methods: At a tertiary care teaching hospital, 100 children between the ages of 6 and 12 who were presenting with acute exacerbations of bronchial asthma were the subjects of a prospective cohort study from August 2021 to August 2022. ELISA was used to evaluate serum 25-hydroxyvitamin D levels, and the GINA recommendations were used to determine the severity of asthma. Based on their levels of vitamin D, the kids were divided into three groups: sufficient (>30 ng/mL), insufficient (20–30 ng/mL), and deficient (<20 ng/mL). Children who were deficient in vitamin D were given supplements and monitored for three months. With SPSS 27, statistical analysis was carried out. Findings: The results of the study showed a strong correlation between increased asthma severity and inadequate asthma control and reduced vitamin D levels. Children with the most acute and uncontrollably asthmatic episodes were those with low vitamin D levels (<20 ng/mL). Significant improvements in asthma control, decreased activity limits, and decreased need for rescue medication were noted after three months of vitamin D administration. Conclusion: This study shows a clear link between children's asthma control issues and higher asthma severity when there is a vitamin D Deficiency. Supplementing with vitamin D significantly improved asthma outcomes, indicating a possible therapeutic role for this nutrient. Future studies with larger sample sizes and longer follow-up periods are recommended to validate these findings and further elucidate the underlying mechanisms.

Lanthanide metal-organic framework functionalized with 10-hydroxybenzo[h]quinoline for ratiometric sensing to real-time determine monophenolase activity through indicator displacement assay

Tyrosinase monophenolase activity plays a crucial role in various biological processes and industrial applications, making the development of continuous monophenolase assays highly significant. In this study, ratiometric fluorescence sensing using a dual-emission sensor was established to determine monophenolase activity in real-time by integrating indicator displacement assay with lanthanide metal-organic frameworks (MOFs). Europium MOFs functionalized with 10-hydroxybenzo[h]quinoline (HBQ) were fabricated by conjugating an HBQ guest fluorophore to the 3,5-dicarboxyphenylboronic acid (DBA) ligand using a solvothermal method. The conjugated HBQ served as an optical indicator at 510 nm with large Stokes shift, whereas the Eu-MOFs acted as a fluorescent internal standard at 616 nm for dual emission. DBA acts as an antenna ligand and provides a competitive receptor site for L-3,4-dihydroxyphenlalanine (L-DOPA) and HBQ. L-DOPA competitively binds to DBA owing to its higher affinity and displaces the conjugated HBQ, resulting in the quenching of HBQ and Eu-MOFs fluorescence. A linear change in the dual-emission intensity ratio was observed as a ratiometric response towards L-DOPA. The sensor quantified L-DOPA with a detection limit of 0.13 μM. Monophenolase activity was correlated with the real-time change in the ratiometric signal using L-DOPA as the product of the enzymatic reaction. A progression curve for the formation of L-DOPA was constructed to calculate the initial rate, yielding a low detection limit for monophenolase activity of 0.15 U·mL−1. The method has been successfully applied to real samples, kinetic studies, and high-throughput screening of inhibitors. This sensing platform opens a new avenue for determining tyrosinase activity.

Improving the performance of grid‐connected inverters during asymmetrical faults and unbalanced grid voltages

AbstractThe increasing penetration of the distributed energy resources (DER) in the power grid, which, while having significant advantages, also pose significant challenges. The behaviors of DERs differ from those of synchronous generators, particularly in abnormal conditions. For this reason, the power grid enforces grid codes to ensure that DERs perform properly in different conditions. For instance, short circuit faults and unbalanced grid voltage are severe transient events that inverters need to be able to pass through without disconnecting from the grid. Furthermore, the inverters are required to support the grid voltage by regulating the active and reactive power injections. This article proposes a voltage support control scheme to support grid voltage during asymmetrical voltage drop by utilizing an optimization problem. In this optimization problem, the active and reactive powers injected into the grid will be obtained optimally by considering constraints such as instantaneous active and reactive power oscillation magnitudes and peak current limitation. To aid in this purpose, the corresponding mathematical formulations such as instantaneous active and reactive power oscillation magnitudes will be obtained by using the currents and voltages in stationary reference frame. The proposed scheme will be verified by simulating it in MATLAB/Simulink under three different scenarios and tested on a real‐time experimental Opal‐RT platform.

Analytical solution of overlying pressure for shallowly buried underwater box tunnel: A case study of box jacking in Suzhou, China

Accurately predicting the overlying pressure is crucial for determining an appropriate cover depth of underwater box tunnels to avoid the uplifting failure. Based on the project of box jacking crossing the Beijing-Hangzhou Grand Canal in Suzhou, the characteristics of overlying pressure variation during tunneling are investigated. The monitoring results reveal that the fluctuation of overlying pressure is weakened during the rapid tunneling process. A modified analytical model for vertical earth pressure is conceived, in which the active and passive limit states for multi-layered soils are both considered. The probable range of overlying pressure obtained by the proposed model is suitable to cover the actual values. The anti-floating behavior of underwater box tunnels for two different working conditions is discussed by calculating the minimum cover depth. Using the calibrated analytical models, a parametric study is conducted to explore the influence of injection pressure, hardened slurry unit weight, soil internal friction angle, soil cohesion, and tunnel geometry. It is found that the injection pressure during the construction process is crucial for determining the necessary cover depth, and the change of box tunnel height makes it easier to trigger the variation of minimum cover depth.

Limits of Prosecutorial Intervention: Conceptual Foundations of the Study

The relevance of developing a theory about the limits of prosecutorial activity aimed at realizing the purpose of the Prosecutor’s Office of the Russian Federation is substantiated. The theory of prosecutorial activity is at the stage of formation, but the parallel development of its basic concepts, which, without a doubt, includes the fundamental category «limits of intervention (activity),» contributes to the creation of a coherent and consistent doctrine of prosecutorial activity. The development of any scientific theory, as is known, is preceded by the conceptualization of knowledge. The author made an attempt to determine the conceptual basis for the formation of a holistic doctrine about the limits of prosecutorial activity. The study of the limits of prosecutorial intervention requires tracking and consideration at the ideological, theoretical and factual levels, which predetermined the designation in the article as the conceptual basis for the study of its problem, the original terminology, the purpose of developing this theory, the expected results, theoretical and empirical foundations of the study, as well as a brief justification of individual approaches and methods for studying the limits of prosecutorial intervention.

THE SUITABILITY OF ACTIVITIES IN THE TRADE SUB-ZONE (THE CORRIDOR OF LETDA SUJONO ROAD, MEDAN TEMBUNG SUB-DISTRICT, MEDAN CITY)

The development of population and infrastructure in cities can enhance the local economy, as seen in the Letda Sujono Road corridor. This area, located between Medan City and Deli Serdang Regency and near the Bandar Selamat Toll Gate, has seen significant growth in trade and service activities. This growth has spurred the development of housing, public services, commercial spaces, warehousing, and industry, increased land demand and causing potential land-use conflicts and traffic issues. Inappropriate space utilization can lead to urban sprawl, often due to inadequate spatial planning control. The Medan City Detailed Spatial Plan (DSP or Rencana Detail Tata Ruang (RDTR)) designates the Letda Sujono Road corridor as a Trade Sub-zone, with zoning regulations limiting some activities to 10% of the block area. Aims: The objective of this study was to study the suitability of existing activities with the zoning plan which has been regulated in the Medan City Detailed Spatial Plan as a space control content in order to create safe, comfortable and sustainable spatial planning. Methodology and results: This study uses a qualitative descriptive method with spatial analysis to assess the alignment of current activities with the DSP zoning plan. Conclusion, significance and impact study: The findings reveal that 60.84% of the activities are suitable, while 39.16% are not. Some blocks, particularly Block 17-07-01 (Tembung), have exceeded the 10% activity limit, indicating that zoning plans have not been fully realized, with unauthorized activities such as integrated schools and vehicle-related services still present.

Field-Driven Solid-State Defect Control of Bilayer Switching Devices.

We develop a framework for controlling and investigating reversible ionic transfer between two solid metal oxides layers by examining field-driven changes in electrical properties of the thin film bilayer oxide system Pr0.1Ce0.9O2/La1.85Ce0.15CuO4 (PCO/LCCO). We show that we can reversibly redistribute oxygen ions by applied voltage in a highly controlled and reversible fashion near ambient temperatures over large oxygen ion activity limits, which, for the first time, is directly interpretable by defect chemical models. This allowed us to determine how defect concentrations in each layer systematically varied with voltage and the subsequent impact on each film's conductance. These results showcase the relevance and applicability of defect chemical models, traditionally considered only at elevated temperatures, to the development of bilayer devices of importance to neuromorphic memory applications. This allows for a more systematic approach for studying and understanding the solid-solid exchange process in electrochemically controlled microelectronic devices. Moreover, our work sets the foundation for the development of large-area field-driven defect-controlled bilayer switching devices with potential application to a broad array of functionally modulated devices.

The Performance of a Circular Excavation Supported by a Prefabricated Recyclable Structure in a Full-Scale Test

Excavations for underground structures, such as working shafts, underground grain silos, and parking garages, are characterized by uniformity, consistent dimensions, large quantities, and strict timelines. Prefabricated recyclable supporting structures (PRSS) are gaining attention over traditional retaining structures due to their standardized design, efficient construction, and reusability, which suit such excavations better. To validate their performance, full-scale tests are conducted to analyze the deformation and stress characteristics of PRSS. The results show that the average maximum lateral displacement of supporting pile is 0.07% of the excavation depth (He), roughly half that of steel plate. Differences in ground surface settlement behind steel plates and the supporting piles are not as significant as those in their lateral displacements. While the displacement of the supporting piles is insufficient to induce soil movement into the active limit state on the non-excavation side, the circular excavation’s arching effect reduces the earth pressure on this side of the supporting piles below the active earth pressure limit. Furthermore, the earth pressure acting on the steel plates is lower than that acting on the supporting piles, suggesting the presence of a soil arching effect between two adjacent piles. These findings offer valuable insights for guiding the construction of PRSS.

Synthesis of histidine, serine and folic acid-functionalized and boron and iron-doped graphene quantum dot with excellent optical behavior and peroxidase-like activity for colorimetric and fluorescence detection of H2O2 in food

Low fluorescence under visible light excitation and catalytic activity limit many applications of graphene quantum dots in optical detection, biosensing, catalysis and biomedical. The paper reports design and synthesis of histidine, serine and folic acid-functionalized and boron and iron-doped graphene quantum dot (Fe/B-GQD-HSF). The Fe/B-GQD-HSF shows excellent fluorescence behavior and peroxidase-like activity. Excitation of 330 nm ultraviolet light produces the strongest blue fluorescence and excitation of 480 nm visible light produces the strongest yellow fluorescence. The specific activity reaches 92.67 U g−1, which is higher than that of other graphene quantum dots. The Fe/B-GQD-HSF can catalyze oxidation of 3,3′,5,5′-tetramethylbenzidine with H2O2 to form blue compound. Based on this, it was used for colorimetric and fluorescence detection of H2O2. The absorbance at 652 nm linearly increases with the increase of H2O2 concentration between 0.5 and 100 μM with detection limit of 0.43 μM. The fluorescence signal linearly decreases with the increase of H2O2 concentration between 0.05 and 100 μM with detection limit of 0.035 μM. The analytical method has been satisfactorily applied in detection of H2O2 in food. The study also paves one way for design and synthesis of functional graphene quantum dots with ideal fluorescence behavior and catalytic activity.

Detection of neurophysiological markers of cognitive reserve: an EEG study.

Cognitive reserve (CR) is a property of the brain that allows for better-than-expected cognitive performance relative to the degree of brain change over the course of life. However, neurophysiological markers of CR remain under-investigated. Electroencephalography (EEG) features may function as suitable neurophysiological markers of CR. To assess this, we investigated whether the dorsal attention network (DAN) and ventral attention network (VAN) activities, as measured during resting-state EEG, moderate the relationship between hippocampal volume and episodic memory. Participants were recruited as part of the National Center for Geriatrics and Gerontology-Study of Geriatric Syndromes. Hippocampal volume was determined using magnetic MRI, and episodic memory was measured using word lists. After testing the effect of hippocampal volume on memory performance using multiple regression analysis, we evaluated the interactions between hippocampal volume and DAN and VAN network activities. We further used the Johnson-Neyman technique to quantify the moderating effects of DAN and VAN network activities on the relationship between hippocampal volume and word list memory, as well as to identify specific ranges of DAN and VAN network activity with significant hippocampal-memory association. A total of 449 participants were included in this study. Our analysis revealed significant moderation of DAN with a slope of β = -0.00012 (95% CI: -0.00024; -0.00001, p = 0.040), and VAN with a slope of β = 0.00014 (95% CI: 0.00001; 0.00026, p = 0.031). Further, we found that a larger hippocampal volume was associated with improved memory performance, and that this association became stronger as the DAN activity decreased until a limit of DAN activity of 944.9, after which the hippocampal volume was no longer significantly related to word-list memory performance. For the VAN, we found that a higher hippocampal volume was more strongly associated with better memory performance when VAN activity was higher. However, when VAN activity extended beyond -914.6, the hippocampal volume was no longer significantly associated with word-list memory. Our results suggest that attentional networks help to maintain memory performance in the face of age-related structural decline, meeting the criteria for the neural implementation of cognitive reserve.

Of sacred animals: the limits of animal rights activism and political veganism in India

ABSTRACT In India, the rise of right-wing politics in the form of what Sahana Udupa terms 'enterprise Hindutva' has triggered conflicting reactions to everyday incidents, highlighting the need for a new language to address unique problems faced by vegans and animal rights activists whose politics clash with Hindutva's anti-secular discourse. 'Sacred animals' as a conceptual framework provides an important entry point into the culturally specific socio-political tensions behind complexities that limit the possibilities of viable intersectional standpoints that engage animal rights activism and political veganism. From a postsecular perspective, the relevance and unique challenges of these movements in India are evaluated, noting that existing posthumanist theories fail to address these new issues adequately. Incidents of mob lynching and violence by the cow vigilantes are recontextualized as structural symptoms instead of sporadic occurrences. The backlash against rightist tendencies has given a critical validation to irrational disregard for political veganism and animal rights activism, based on their perceived alignment with right-wing ideology. Examining food politics around beef, mockery of vegetarianism, and everyday situations where 'veg' becomes a tag of inferior quality, this study challenges unfounded associations and assumptions that undermine the disruptive potential of animal rights activism.

A sensitive benzothiazole fluorescent probe for the detection of γ-glutamyl transpeptidase activity and its application.

A sensitive benzothiazole fluorescent probe (PBZO) for the detection of γ-glutamyl transpeptidase (GGT) activity was developed. Based on the enzymatic hydrolysis of peptide bonds by glutamyl transpeptidase, it can be specifically recognized by PBZO. The PBZO has a good linear relationship with different gradients of GGT activity at the emission wavelength of 560 nm, the Stokes shift reached 215 nm, and the detection limit of GGT activity is 0.1644 U/ml. With the increase of GGT concentration in the probe solution, the color of the solution gradually changed from orange to dark yellow under the 365 nm UV lamp. The same color change was also observed on the probe test paper. In addition, there is a linear relationship between the GGT activity and the R-value of the probe solution. More importantly, the probe has a good recovery rate in serum. Therefore, this probe can be used as a convenient tool for detecting GGT activity.

Coordinated voltage control for large-scale wind farms with ESS and SVG based on MPC considering wake effect

The wake effect reduces the wind speed at downstream wind turbines (WTs), making it necessary for the central controller to collect wind power generation data from each WT. However, wind farms (WFs) face a more complex problem in maintaining the voltage stability at the WT terminal while following the transmission system operator (TSO) instructions due to the information collection as well as the possible data loss during transmission. Therefore, this study proposes a coordinated control method for WTs and multiple power sources based on model predictive control under wake disturbance conditions, aiming to reduce the average voltage deviation in WT terminals and go close to the rated voltage and ensure effective compliance with TSO commands in large-scale WFs. Accordingly, the Jensen wake model was utilized to accurately calculate the available active and reactive power limits for each WT. Energy storage systems and static Var generators were modeled to coordinate and maintain the voltage in all WT terminals within the feasible range, providing peak shaving and valley filling support to reduce wind energy waste and shortfall, thereby enhancing the economic and operational reliability of WF. Further, the effectiveness of the proposed method was validated in MATLAB/Simulink.

A Fluorescent Probe for the Detection of γ‐Glutamyl Transpeptidase Activity and its Application in Garlic

AbstractA fluorescent probe (probe 1) was developed for detection the activity of γ‐glutamyl transpeptidase (GGT). Probe 1 could recognize GGT by the enzymatic hydrolysis of peptide bond by GGT. There has a linear relationship between the fluorescence intensity of probe 1 at 416 nm and the activity of GGT, and the detection limit of GGT activity was 0.0796 U/mL. And the color of the probe solution gradually changed from light blue to bright yellow with the increase of GGT activity under 365 nm ultraviolet light. Importantly, the activity of GGT was linearly related to the photo of the probe solution with B/(R+G) value. Probe 1 could detect GGT activity by smartphone without professional equipment. Furthermore, the probe has been successfully applied to detect of GGT activity in garlic.

The Potential and Limits of Spontaneous Labor Activism on Social Media: The Search for Justice among Chinese Restaurant Workers

The Potential and Limits of Spontaneous Labor Activism on Social Media: The Search for Justice among Chinese Restaurant Workers

Calculation of support forces at the excavation face of a shallow buried shield tunnel in dense sandy soil considering construction disturbances

ABSTRACT Too little support force at the palm surface during shield excavation can lead to destabilization of soil before the excavation face and cause ground subsidence. Construction disturbances during excavation can affect the mechanical properties of the surrounding soil, which cannot be ignored when determining the needed support force at an excavation face. Based on the Mohr – Coulomb yield criterion, the collapse of dense sandy soils before the excavation face of shallowly buried shield tunnels is simulated using PLAXIS 3D to determine the collapse mode. Furthermore, the prismatic body in the traditional 3D wedge model is modified to an inverted elliptical-truncated cone with a certain inclination so that the collapse zone is closer to real sliding soils, and the disturbance ratio r is introduced as an index to consider a construction disturbance. The expression of the active limit support force with respect to wedge inclination is derived, and the maximum support force is determined by trial and error to be the minimum support force needed. The results of the modified 3D curved model are in good agreement with the numerical simulation results, as well as the results of theoretical methods and model tests.

Design and evaluation of mRNA encoding recombinant neutralizing antibodies for botulinum neurotoxin type B intoxication prophylaxis

ABSTRACT Among all natural and synthetic toxins, botulinum neurotoxins (BoNTs), produced by Clostridium botulinum in an anaerobic environment, are the most toxic polymer proteins. Currently, the most effective modalities for botulism prevention and treatment are vaccination and antitoxin use, respectively. However, these modalities are associated with long response time for active immunization, side effects, and donor limitations. As such, the development of more promising botulism prevention and treatment modalities is warranted. Here, we designed an mRNA encoding B9-hFc – a heavy-chain antibody fused to VHH and human Fc that can neutralize BoNT serotype B (BoNT/B) effectively – and assessed its expression in vitro and in vivo. The results confirmed that our mRNA demonstrates good expression in vitro and in vivo. Moreover, a single mRNA lipid nanoparticle injection effectively prevents BoNT/B intoxication in vivo, with effects comparable to those of protein antibodies. In conclusion, we explored and clarified whether mRNA drugs encoding neutralizing antibodies prevent BoNT/B intoxication. Our results provide an efficient strategy for further research on the prevention and treatment of intoxication by botulinum toxin.