Event Abstract Back to Event The influence of estrogen on trigeminal nociception in ovariectomized rats Z. Oláh1*, A. Fejes1, J. Tajti1, L. Vécsei1 and Á. Párdutz1 1 University of Szeged, Department of Neurology, Hungary Migraine is essential in scientific research, since about 10% of population is concerned. Its pathomechanism is not clearly known, but the activation of the trigeminal system is essential. Strong sexual dimorphism with a suspected hormonal background is present since ¾ of migraineurs are female. Estrogen may have a key role here but the exact influence of estrogen on trigeminal pain sensation has not been established yet. We examined, how trigeminal activation evoked by unilaterial formalin injection into the upper lip of adult rats changes in two groups: ovariectomized females without (ovx) and with pretreated with estrogen (ovx+E). Four hours after formalin injection, caudal trigeminal nucleus (TNC) was removed for c-Fos immunohistochemistry to determine local neuronal activity of the second order trigeminal neurons. In both groups formalin caused a significant increase in c-Fos immunoreactivity in the TNC compared to the untreated side. In ovx animals the ipsilateral c-Fos increase was significantly lower compared to the animals in the ovx+E group. Our results indicate that estrogen or its depletion can modulate the trigeminal activation. In this experimental setting the lack of estrogen had an antinociceptive effect. Estrogen receptors are present in all areas relevant in nociception, including TNC, thus estrogen may influence neuronal activity evoked by pain in TNC. Keywords: Sensory and motor activity, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Sensory and motor activity Citation: Oláh Z, Fejes A, Tajti J, Vécsei L and Párdutz Á (2011). The influence of estrogen on trigeminal nociception in ovariectomized rats. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00009 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. Z. Oláh, University of Szeged, Department of Neurology, Szeged, Hungary, olah.zita87@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Z. Oláh A. Fejes J. Tajti L. Vécsei Á. Párdutz Google Z. Oláh A. Fejes J. Tajti L. Vécsei Á. Párdutz Google Scholar Z. Oláh A. Fejes J. Tajti L. Vécsei Á. Párdutz PubMed Z. Oláh A. Fejes J. Tajti L. Vécsei Á. Párdutz Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.