The accurate prediction of reference crop evapotranspiration is of great significance to climate research and regional agricultural water management. In order to realize the high-precision prediction of ETO in the absence of meteorological data, this study use XGBoost to select key influencing factors and BP algorithm to construct ETO prediction model of 12 meteorological stations in South West China in this study. ACO, CSO and CS algorithms are used to optimize the model and improve the adaptability of the model. The results show that Tmax, n and Ra can be used as the input combination of ETO model construction, and Tmax is the primary factor affecting ETO. ETO model constructed by BP algorithm has good goodness of fit with the ETO calculated by FAO-56 PM and ACO, CSO and CS have significant optimization effect on BP algorithm, among which CSO algorithm has the best optimization ability on BP, with RMSE, R2, MAE, NSE, GPI ranging 0.200-0.377, 0.932-0.984, 0.140-0.261, 0.920-0.984, 1.472-2.000, GPI ranking is 1-23. Therefore, the input combination (Tmax, n and Ra) and CSO-BP model are recommended as a simplified model for ETO prediction in Southwest China.