Chitosan In Acid Solution Research Articles

All-natural water-resistant paper coated by chitosan nanowhiskers through hydrophilic-to-hydrophobic self-assembly

Although chitosan-coated hydrostable papers are promising alternatives to non-degradable plastic-coated papers, an acidic chitosan solution is not eco-friendly. Therefore, we developed a non-acidic aqueous coating technique for preparing all-natural water-resistant papers using chitosan nanowhiskers (CSWs). As the CSWs disperse in water after synthesis, they form a hydrophobic layer on the paper after the coating process owing to the hydrophilic-to-hydrophobic self-assembly. Quantum simulations reveal that the repulsion between protonated amine groups contributes to water dispersibility; however, their interfibrillar interaction after coating is hardly dissociated by water. Together with soybean oil, the CSW- and oil-coated papers (C/O-papers) exhibit significantly higher water contact angles (95.8°) and absorption (6.0%) than control paper (21.9° and 91.9%, respectively). Moreover, the C/O-papers had a 16.0- and 9.1-fold higher mechanical modulus and strength (1498.5 and 31.0 MPa, respectively) than control paper (93.8 and 3.4 MPa, respectively) under wet conditions. Therefore, bio-renewable water-resistant paper has great potential for preparing disposable materials.

Properties of Nanocomposites Based on Platinum Nanoparticles Stabilized by Chitosan

AbstractPlatinum nanoparticles were obtained chemically in acetic acid solutions of chitosan from the precursor H2PtCl6 using sodium borohydride as a reducing agent with simultaneous UV irradiation. The compositions were studied by SAXS, TEM, dynamic light scattering, FTIR‐spectroscopy, differential scanning calorimetry, dynamic mechanical analysis, and atomic force microscopy. Nanoparticles are characterized by a narrowly dispersed size distribution while the effect of the conformation of chitosan macromolecules on their characteristics is manifested. The SAXS method showed that in a chitosan solution with a semi‐flexible coil conformation of macromolecules, 96.8 % of the formed nanoparticles are characterized by an average radius of 1.4 nm. According to the TEM results, platinum nanoparticles are characterized by a crystal structure and a particle diameter of about 1.3–5.0 nm. A different picture is observed for platinum nanoparticles formed in chitosan with the rigid rod conformation of macromolecules – only 91 % of platinum nanoparticles had an average radius of 1.4 nm. The TEM method showed these nanoparticles turned out to be about 1 nm in size, and they did not crystallize, but remained amorphous. The introduction of platinum nanoparticles into the polysaccharide matrix significantly shifts the glass transition temperature of chitosan toward lower values by 20 and 10 °C respectively, and increases the tensile strength of the composites by 35 MPa.

One‐Pot Scalable Fabrication of Chitosan‐Capped Antibacterial Sulfur Nanoparticles from Elemental Sulfur

AbstractSulfur nanoparticles (SNPs) have shown good potential in numerous fields due to their unique composition and properties. However, the direct utilization of abundant and inexpensive elemental sulfur for the large‐scale fabrication of high‐quality SNPs is still in its infancy. Herein, a simple one‐pot approach for the preparation of SNPs is presented, and gram‐scale SNPs can be readily prepared in one batch in the laboratory. By adding elemental sulfur‐ethylenediamine precursor to the acidic chitosan (CS) solution, chitosan‐capped sulfur nanoparticles (CS‐SNPs) can be formed immediately. Benefiting from the capping of CS, CS‐SNPs simultaneously possess small and uniform size with an average diameter of 19 nm, good aqueous dispersibility and stability, and favorable antioxidant capability against 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) free radicals. Moreover, CS‐SNPs also exhibit fine antibacterial activity against Staphylococcus aureus, and the minimum and optimal inhibitory concentrations are 256 and 512 µg mL−1, respectively. Considering the easy fabrication process and attractive attributes of CS‐SNPs, this investigation not only offers an effective method for the scalable fabrication of robust SNPs but also provides a feasible way for the value‐added utilization of elemental sulfur.

Chitosan-multilayered graphene oxide hybrid beads for Zn 2+ and metoprolol adsorption

Chitosan (CS) hydrogel beads and hybrid beads made of a blending of CS hydrogels and Multilayer Graphene Oxide (MGO) were synthesized. The hybrid beads were prepared by gelation in NaOH solution of a 1 wt% CS acid solution with addition of MGO at either 1.5 wt% or 3 wt% loading rates. Prepared beads were characterized by infrared spectroscopy, thermogravimetric analysis (TGA), scanning electron cryo-microscopy and Brunauer–Emmett–Teller (BET) specific surface area measurements. Zn 2+ and Metoprolol (MTP) adsorption kinetics and isotherms were studied on the pristine and hybrid CS hydrogel beads. The adsorption kinetics of Zn 2+ and MTP in hybrid beads is limited by the diffusion to the MGO sites depending on their accessibility. While pure CS is not efficient for the MTP adsorption, the Langmuir-type isotherms of the 3 wt% MGO hydrogel beads (dose: 5 mg/100 mL) show 163 mg·g -1 maximum adsorption uptake. The MTP adsorption kinetics and isotherm suggest a MTP trapping on the MGO anionic sites (carboxylate groups) by electrostatic interactions. The Zn 2+ adsorption capacities are the highest for the 3 wt% MGO hydrogel beads (236 mg·g -1 ), and only of 40 mg·g -1 for the pure CS beads. The presence of Zn 2+ adsorption sites in the hybrid bead, such as MGO carboxylate groups giving electrostatic interactions, and CS amine groups leading to complexation, provides synergic adsorption effects. The competitive adsorption of Zn 2+ with respect to MTP in equimolar mixture was observed on hybrid beads (dose: 200 mg/100 mL) at 2 mmol·L -1 initial total concentration. At pollutant initial total concentration lower than 1.5 mmol·L -1 , no competition occurs. The regeneration at pH 4 of the hybrid beads toward MTP or Zn 2+ adsorption was found to be 35–40% of the initial adsorption uptake for five adsorption/regeneration cycles.

Integration of Chitosan and Sugar Cane Bagasse as Adsorbent for Remazol Red Dyes Removal

In this study, the sugarcane bagasse biomass was modified and purpose as a bio-adsorbent to remove Remazol red dye from wastewater. The sugarcane bagasse was calcined at 200˚C, followed by the treatment with 1% chitosan solution. The adsorbent was morphologically characterized using FTIR, SEM, XRD analysis to study further the effect of chemical modification techniques on calcined biomass of sugarcane bagasse. Treated calcined sugarcane showed an irregular surface and appearance of pores effects of an acidic chitosan solution. It also clarified the presence of an active site for dye absorption on the adsorbent's surface, which is necessary for the dye adsorption attachment site. The adsorption performance revealed that treated sugarcane bagasse performed better with an optimum adsorbent dosage of 150 mg at an equilibrium time of 60 min. Remazol Red removal favored acidic conditions at pH 4 and decreased as dye concentration increased. With an R2 value, the equilibrium data adsorption fitted well with the Langmuir adsorption isotherm.

Modified Starch Highly Porous Materials

A technique for starch modification by graft polymerization of acrylamide has been developed. The obtained copolymer is soluble in a wide range of pH 2 - 12. The modification of starch made it possible to freely combine it with aqueous acid solutions of chitosan, in order to achieve a synergistic effect of their properties. A porous material based on modified starch and its mixtures with chitosan, which has high sorption characteristics, has been developed. The resulting material is promising as a sorbent of heavy metal ions and packing materials for transportation and storage.

Highly Elastic Anti-fatigue and Anti-freezing Conductive Double Network Hydrogel for Human Body Sensors

As a functional material, conductive hydrogel has been widely used due to its stretchability and flexibility, especially in the field of flexible wearable sensors. However, preparing a hydrogel sensor with high elasticity, fatigue resistance, and low-temperature resistance is still challenging. In this work, a novel hydrogel was synthesized with acrylic acid and sodium p-styrene sulfonate in an acidic solution of chitosan under ultraviolet light. Then, the hydrogel was immersed in the sodium chloride solution to obtain a chitosan/poly(acrylic acid-sodium p-styrene sulfonate)/sodium chloride (CS/P(AA-co-SS)/NaCl) dual network (DN) hydrogel. The sodium chloride caused the molecular chains of the hydrogel to entangle. The hydrogel shows excellent mechanical properties (tensile strength is as high as 532.2 kPa, elongation at break is as high as 620%, energy to break is 1200 kJ/m³, compressive strength at 80% is 661 kPa, and compressive toughness is 83.5 kJ/m³) and high electrical conductivity (up to 4.5 S/m). At the same time, the hydrogel possesses excellent resilience and fatigue resistance due to hydrogen bonds, electrostatic interactions, and the existence of hydrophobic domains. Moreover, the hydrogel also exhibits outstanding frost resistance, excellent mechanical properties, and electrical conductivity even at −20 °C. The wearable sensor made of the CS/P(AA-co-SS)/NaCl DN hydrogel will have high sensitivity (under 100% strain, gauge factor = 2.4) and repeatability, which can accurately detect various movements of the human body.

Electrochemical detection of riboflavin using tin-chitosan modified pencil graphite electrode

Abstract We here report a simple fabrication of tin incorporated chitosan polymer matrix coated pencil graphite electrode Sn/Cs/PGE for the electrochemical detection of riboflavin (RF). The tin incorporated chitosan polymer was prepared by mixing tin chloride in an aqueous acidic chitosan solution and the fabrication of Sn/Cs/PGE was done by simple immersion method for the first time. The surface characterization of the electrode sensor was carried out by Fourier transform infrared (FTIR), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy and elemental mapping analysis. Electrochemical characterization was performed by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) using 0.1 M KCl containing K3[Fe(CN)6]. These results revealed that the Sn/Cs/PGE shows a sensitive and fast electrocatalytic response towards the sensing of RF in physiological pH with a wide linear range (10 to 1200 nM) and low limit of detection (5.56 nM) compared to other electrodes. Moreover, the Sn/Cs/PGE possesses better stability with the anti-inference ability and the practical feasibility of the fabricated electrode shows satisfactory results towards the medicinal and food analysis.

Influence of selective acid-etching on functionality of halloysite-chitosan nanocontainers for sustained drug release

The functionality of halloysite (Hal) nanotubes as drug carriers can be improved by lumen enlargement and polymer modification. This study investigates the influence of selective acid etching on Hal functionalization with cationic biopolymer chitosan. Hal was subjected to lumen etching under mild conditions, loaded under vacuum with nonsteroidal antiinflammatory drug aceclofenac, and incubated in an acidic solution of chitosan. The functionality of pristine and etched Hal before and upon polymer functionalization was assessed by ζ-potential measurements, structural characterization (FT-IR, DSC and XRPD analysis), cell viability assay, drug loading and drug release studies.Acid etching increased specific surface area, pore volume and pore size of Hal, decreased ζ-potential and facilitated binding of the cationic polymer. XRPD and DSC analysis revealed crystalline structure of etched Hal. Successful chitosan binding and drug entrapment were further confirmed by FT-IR and DSC studies. XRPD showed surface polymer binding. DSC and FT-IR analyses confirmed the presence of the entrapped drug in its crystalline form. Drug loading was increased for ≈81% by selective lumen etching. Slight decrease of drug content occurred during chitosan functionalization due to aceclofenac diffusion in the polymer solution. The drug release was more sustained from etched Hal nanocomposites (up to ≈87% for 12 h) than from pristine Hal (up to ≈97% for 12 h) due to more intensive chitosan binding. High human fibroblast survival rates upon exposure to pristine and etched Hal before and after chitosan functionalization (>90% in the concentration of 1000 μg/mL) confirmed that both lumen etching under mild conditions and polymer functionalization had no significant effect on cytocompatibility.Based on these findings, selective lumen etching in combination with polycation modification appears to be a promising approach for improvement of Hal nanotubes functionality by increasing payload, polymer binding capacity, and sustained release properties with no significant effect on their cytocompatibility.

Flow-driven Surface Instabilities of Tubular Chitosan Hydrogel.

Spatial structures break their symmetry under the influence of shear stress arising from fluid flow. Here, we present surface instabilities appearing on chitosan tubes when an acidic solution of chitosan with various molecular weight is injected into a pool of sodium hydroxide solution. At slow flow rates wrinkle‐to‐fold transition takes place along the direction of the flow yielding a banded structure. For greater injection rates we observe coexisting modes of wrinkles and folds which are stabilized to periodic wrinkles when the alkaline concentration is increased. The instabilities are characterized by the scaling laws of the pattern wavelength and amplitude with the tube characteristics. Our experimental adaptation of mechanical instabilities provides a new in situ method to create soft biomaterials with the desired surface morphology without the use of any prefabricated templates.

Extending the Shelf Life of Strawberries by the Sonochemical Coating of their Surface with Nanoparticles of an Edible Anti-Bacterial Compound

The current paper presents the coating of harvested strawberries with edible nanoparticles of Chitosan. The NPs were formed by the application of ultrasonic waves on an acidic solution of chitosan. In a one-step process the nanoparticles were created and subsequent to their formation they were deposited on the strawberries surface. The shelf life of the NPs coated was compared with the deposition of the same amount of non-sonicated chitosan, i.e., coating of individual chitosan molecules on the fruit. The characterization of the coated fruits was carried out by monitoring the weight loss. TSS (total soluble solids), pH, TA (titratable acidity), and Vitamin C. Finally, the freshness of the strawberries was determined by eye observation. In addition, the characterization of the chitosan NPs was also conducted in this study by (DLS) dynamic light scattering and (SEM) scanning electron microscopy.

Recycling of Wash Water as a Way to Reduce the Environmental Load and Increase the Utilization Rate of Raw Materials

The problem of recovering the protein and other valuable components from wash water (low-concentrated suspensions) exists in almost all areas of the food industry. Research in this field is quite successful and is mainly based on the processes of evaporation, flotation, the use of force fields, and other physical and chemical methods. The variety of proposed methods for extracting the protein substances, the permanent search for new methods confirm the incompleteness and urgency of the problem under study. The possibility was demonstrated and the conditions for purification of wash waters of minced meat production and technological liquids for processing the algae were determined. The use of an acidic solution of chitosan was proposed for cleaning the wash water of minced meat production. Considering the ability of chitosan to sediment from solutions having a pH in the range of 5,6, crystalline sodium bicarbonate was used to adjust the pH value. The calculation showed that 0,66 g of sodium bicarbonate was required to neutralize a 2% solution of chitosan in 2% acetic acid. The largest mass of the sediment was obtained at the ratio of wash water / chitosan solution as 25/2 – 25/4. Ultrafiltration was used for the purification of technological waters for processing the algae. The results of the study showed that after passing through the filtration bed, the purified water contained 4 times less mineral components and organic substances compared to the original content.

Preparation of highly effective antibacterial coating with polydopamine/chitosan/silver nanoparticles via simple immersion

In this study, we report a simple and facile method to fabricate an antibacterial composite coating by combining polydopamine (PDA), chitosan (CS) and silver nanoparticles (AgNPs) on urinary catheter and titanium (Ti) surfaces. The preparation consists of a co-deposition of PDA and CS in acid solution and subsequently immersion into silver nitrate (AgNO3) solution. This approach allows the antibacterial PDA/CS/AgNPs coating to be prepared for several hours by the simple immersion process under friendly conditions, and the surface morphology for coated catheters illustrated that CS plays a key role in improvement of the coating smoothness. The antibacterial tests against S. aureus were performed on the measurements of the inhibition halo and adhered bacterial numbers. The results showed that the PDA/CS/AgNPs-coated catheter has long-lasting stability for more than 30 days and antibacterial activity against S. aureus, and the antiadhesion rates of PDA/CS/AgNPs-coated Ti surface are 91 % and 85 % for live and dead bacteria, respectively. The PDA/CS/AgNPs coating based on the simple immersion has great potential in practical application for antibacterial urinary catheters and other biomedical devices.

Rapid hemostatic chitosan/cellulose composite sponge by alkali/urea method for massive haemorrhage

Here, a simple and efficient strategy to produce porous and hydrophilic chitosan/cellulose sponge using surfactant and pore-forming agent is demonstrated. The preparation of composite sponge by LiOH/KOH/urea solvent system effectively solve the problems of uneven distribution of chitosan, poor softness and acid residue caused by soaking in chitosan acid solution. The obtained chitosan/cellulose sponges exhibit high water absorption capacity and rapid shape recoverability, as well as good mechanical properties. Effective inhibitory on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa are particularly proved. Besides, the result of the dynamic whole blood clotting time indicated that the chitosan/cellulose composite sponge has better coagulation ability than those of traditional gauze and gelatin sponge. Animal experiment further showed that rapid hemostasis within 34 s can be reached with the composite sponge. Better biocompatibility of the composite sponge is proved by the results of hemocompatibility and cytotoxicity, indicating an excellent candidate for rapid hemostasis in massive haemorrhage.

Chitosan-coated nonwoven polyethylene terephthalate material for efficient removal of cationic and anionic dyes from aqueous solution

ABSTRACT A simple dye adsorbent based on polyethylene terephthalate – PET functionalised by chitosan‘Chit-Pet-T’ was developed to remove cationic (MG, CV) and anionic (SY, DB71, AY17) synthetic dyes from aqueous solutions. In the first part of this study, the surface of the non-woven PET material was activated by using an aqueous solution of NaOH (0.5 M), and then the surface of the alkaline activated PET was functionalised by treatment with an acidic aqueous solution of chitosan. The Chit-Pet-T was then characterised by physicochemical methods: X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), zeta potential,energy-dispersive X-ray spectroscopy (EDS), air permeability and water contact angle measurements (WCA). The physicochemical characterisation of Chit-Pet-T confirmed the successful immobilisation of the chitosan on the surface of the non-woven PET with a coating ratio of 46%. The dye adsorption studies show that the capacity of Chit-Pet-T to adsorb the studied dyes is affected significantly by the initial pH, Chit-Pet-T dose, ionic strength, temperature and initial dye concentration. The removal rate (R) reached the maximum value at pH = 11 and pH = 2 for the cationic (MG: 91%, CV: 90%) and anionic (SY: 95%, DB71: 96%, AY17: 94%) dyes, respectively, within 300 min, under a wide range of temperature, with dye solution of 0.1 M. The Langmuir isotherm model could be best adequate to describe the dye adsorption onto Chi-Pet-T and the thermodynamic parameters indicated that the adsorption was a spontaneous exothermic process. The excellent performance and regeneration capabilities demonstrate that Chi-Pet-T can be used as a potential efficient and recyclable adsorbent for removal of cationic and anionic dyes from wastewaters.

Dexterous and friendly preparation of N/P co-doping hierarchical porous carbon nanofibers via electrospun chitosan for high performance supercapacitors

Abstract Fabricating continuous porous carbon nanofibers (CNFs) based on biomass materials still remains challenging for current supercapacitors (SCs) results from the limitation of carbon yield and molecular flexibility. In this work, P and N dual-doped 1D porous carbon nanofibers (PNF) are prepared through a controllable way by electrospinning phytic acid solution of chitosan (CS)/ polyvinylpyrrolidone (PVP) with subsequent crucial segmented carbonization. Due to the ultra-high specific surface area, extremely low charge transfer resistance, and the contribution of N, P dual doping to pseudocapacitors, the obtained PNF exhibits the highest specific capacitance of 358.7 F g−1 at a current density of 1 A g−1. More notably, a symmetrical SC assembled by PNF achieves an outstanding capacitance of 94 F g−1 at a current density of 0.5 A g−1, and a high energy density of 13.1 W h kg−1 at a power density of 248 W kg−1, furthermore, a high capacitance retention of 87.5% is performed after 10,000 cycles. It is firmly believed that the research on the preparation method and performance of carbon nanofibers involved in this article is of profound inspiration for mobile power sources.

Cellular Response to Vitamin C-Enriched Chitosan/Agarose Film with Potential Application as Artificial Skin Substitute for Chronic Wound Treatment.

The treatment of chronic wounds is still a meaningful challenge to physicians. The aim of this work was to produce vitamin C-enriched chitosan/agarose (CHN/A) film that could serve as potential artificial skin substitute for chronic wound treatment. The biomaterial was fabricated by a newly developed and simplified method via mixing acidic chitosan solution with alkaline agarose solution that allowed to obtain slightly acidic pH (5.97) of the resultant material, which is known to support skin regeneration. Vitamin C was immobilized within the matrix of the film by entrapment method during production process. Produced films (CHN/A and CHN/A + vit C) were subjected to comprehensive evaluation of cellular response with the use of human skin fibroblasts, epidermal keratinocytes, and macrophages. It was demonstrated that novel biomaterials support adhesion and growth of human skin fibroblasts and keratinocytes, have ability to slightly reduce transforming growth factor-beta 1 (TGF-β1) (known to be present at augmented levels in the epidermis of chronic wounds), and increase platelet-derived growth factor-BB (PDGF-BB) secretion by the cells. Nevertheless, addition of vitamin C to the biomaterial formulation does not significantly improve its biological properties due to burst vitamin release profile. Obtained results clearly demonstrated that produced CHN/A film has great potential to be used as cellular dermal, epidermal, or dermo-epidermal graft pre-seeded with human skin cells for chronic wound treatment.

Flexible monolithic phase change material based on carbon nanotubes/chitosan/poly(vinyl alcohol)

Currently, most reported composite phase change materials (PCMs) are powdery shape, which require secondary processing for practical applications. Although some monolithic composite PCMs have been developed, their flexibility usually undergoes a remarkable reduction or even complete disappearance when supporting materials are infiltrated with PCMs. To solve this problem, we fabricated a flexible supporting material with a folded layer-bridge network structure by dispersing carbon nanotubes (CNTs) in acetic acid solution of chitosan (CS) with poly(vinyl alcohol) (PVA) using a directional freezing method. Then CS/PVA/CNTs (CPC) scaffold was infiltrated with polyethylene glycol (PEG) to prepare PEG@CPC composite PCM. The resulting flexible composite PCM displays excellent mechanical properties, such as high tensile strength of 2.42 MPa and bending resistance of >100 cycles. Moreover, it displays outstanding thermal properties, such as high crystallinity of close to 100% and encapsulation ratio of 92.6 wt%. This work provides a simple method for preparation of flexible monolithic composite PCMs for many potential applications, such as wearable fitting-skin temperature-controlled materials.

Strong, Machinable, and Insulating Chitosan-Urea Aerogels: Toward Ambient Pressure Drying of Biopolymer Aerogel Monoliths.

Biopolymer aerogels are an emerging class of materials with potential applications in drug delivery, thermal insulation, separation, and filtration. Chitosan is of particular interest as a sustainable, biocompatible, and abundant raw material. Here, we present urea-modified chitosan aerogels with a high surface area and excellent thermal and mechanical properties. The irreversible gelation of an acidic chitosan solution is triggered by the thermal decomposition of urea at 80 °C through an increase in pH and, more importantly, the formation of abundant ureido terminal groups. The hydrogels are dried using either supercritical CO2 drying (SCD) or ambient pressure drying (APD) methods to elucidate the influence of the drying process on the final aerogel properties. The hydrogels are exchanged into ethanol prior to SCD, and into ethanol and then heptane prior to APD. The surface chemistry and microstructure are monitored by solid-state NMR and Fourier transform infrared spectroscopy, scanning electron microscopy, and nitrogen sorption. Surprisingly, large monolithic aerogel plates (70 × 70 mm2) can be produced by APD, albeit at a somewhat higher density (0.17-0.42 g/cm3). The as prepared aerogels have thermal conductivities of ∼24 and ∼31 mW/(m·K) and surface areas of 160-170 and 85-230 m2/g, for SCD and APD, respectively. For a primarily biopolymer-based material, these aerogels are exceptionally stable at elevated temperature (TGA) and char and self-extinguish after direct flame exposure. The urea-modified chitosan aerogels display superior mechanical properties compared to traditional silica aerogels, with no brittle rupture up to at least 80% strain, and depending on the chitosan concentration, relatively high E-moduli (1.0-11.6 MPa), and stress at 80% strain values (σ80 of 3.5-17.9 MPa). Remarkably, the aerogel monoliths can be shaped and machined with standard tools, for example, drilling and sawing. This first demonstration to produce monolithic and machinable, mesoporous aerogels from bio-sourced, renewable, and nontoxic precursors, combined with the potential for reduced production cost by means of simple APD, opens up new opportunities for biopolymer aerogel applications and marks an important step toward commercialization of biopolymer aerogels.

Obtaining and Properties of L-Aspartic Acid Solutions of Chitosan

Conditions for obtaining L-aspartic acid solutions of chitosan were considered: dissolution of the polymer with the formation of chitosan aspartate occurs in pH range of 3.6–3.8 at a minimum stoichiometric ratio of [acid]/[chitosan (−NH2)] ∼ 0.43. The hydrodynamic, electrochemical, optical and biological properties of aqueous solutions of chitosan aspartic acid salt are investigated. It has been established that macromolecules of polymeric salt exhibit properties of a polyelectrolyte with a partially compensated charge in an aqueous medium. Huggins constants and temperature viscosity coefficients were calculated, which indicate an increased rigidity of the chitosan macrochain in the studied solutions and deterioration in the polymer—solvent interaction with increasing temperature. Chitosan aspartate powders in the form of lamellar microparticles with fractal ordering were isolated. Low biocompatibility and antibacterial activity of the polymeric salt are demonstrated, which allows recommending the production of biomedical products on its basis.