Abstract
In this study, we report a simple and facile method to fabricate an antibacterial composite coating by combining polydopamine (PDA), chitosan (CS) and silver nanoparticles (AgNPs) on urinary catheter and titanium (Ti) surfaces. The preparation consists of a co-deposition of PDA and CS in acid solution and subsequently immersion into silver nitrate (AgNO3) solution. This approach allows the antibacterial PDA/CS/AgNPs coating to be prepared for several hours by the simple immersion process under friendly conditions, and the surface morphology for coated catheters illustrated that CS plays a key role in improvement of the coating smoothness. The antibacterial tests against S. aureus were performed on the measurements of the inhibition halo and adhered bacterial numbers. The results showed that the PDA/CS/AgNPs-coated catheter has long-lasting stability for more than 30 days and antibacterial activity against S. aureus, and the antiadhesion rates of PDA/CS/AgNPs-coated Ti surface are 91 % and 85 % for live and dead bacteria, respectively. The PDA/CS/AgNPs coating based on the simple immersion has great potential in practical application for antibacterial urinary catheters and other biomedical devices.
Highlights
Urinary catheter is used on an intermittent or indwelling basis for the patient in order to relieve urinary retention and incontinence
We report a simple and facile method to fabricate an antibacterial composite coating by combining polydopamine (PDA), chitosan (CS) and silver nanoparticles (AgNPs) on urinary catheter and titanium (Ti) surfaces
In preparation of PDA/ CS/AgNPs-coated catheter, it was found that the temperature, the im mersion time and the concentrations of CS, dopamine hydrochloride and ammonium persulfate (AP) affect the thickness and morphology of the coating as well as the size of AgNPs
Summary
Urinary catheter is used on an intermittent or indwelling basis for the patient in order to relieve urinary retention and incontinence. To further improve antibacterial efficiency, the anti bacterial composite of CS and silver nanoparticles (AgNPs) were pre pared since AgNPs have the broad-spectrum antimicrobial activity [20]. This composite exhibited more effective antibacterial activities and low cytotoxicity [17,10,11,12,13,14,15,16,17,18,19]. We report a simple immersion method to prepare the PDA/CS/AgNPs composite coating on the urinary catheter and Ti sur faces, which only takes for a few hours. The PDA/AgNPs coating was prepared on the urinary catheter to test the antimicrobial difference between the PDA/AgNPs and PDA/CS/AgNPs coatings in this work, which can be used to illustrate the effect of CS on preventing bacteria adhesion for the PDA/CS/AgNPs coating
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
