Acid Concentrations In Cerebrospinal Fluid Research Articles

Gamma-Aminobutyric acid concentrations in the cerebrospinal fluid of newborn infants.

gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease with advancing gestational age. No apparent alterations were noted with increasing postnatal age (until 6 weeks of age). Asphyxia but not neonatal sepsis was accompanied by an increase in CSF GABA concentrations compared to respective controls.

Low CSF GABA in Parkinsonian patients who respond poorly to therapy or suffer from the "on-off" phenomenon.

AbstractThe γ‐aminobutyric acid concentration in cerebrospinal fluid was measured by radioreceptor assay in 23 parkinsonian patients (“good responders” and “poor responders” to drug therapy, “on‐off” state) and 11 age‐matched control subjects. Mean concentrations were similar but significantly lower in the poor responders and the “on‐off” state than in the good responders and control subjects. Patients who show good response to drug therapy appear to have a normal level of GABAergic activity that is not altered by drug therapy.

Gamma-Aminobutyric acid concentration in cerebrospinal fluid in schizophrenia.

gamma-Aminobutyric acid (GABA) concentration was determined in cerebrospinal fluid (CSF) of acute and chronic schizophrenic patients, in persons with psycho-organic or personality disorders, and in nonpsychiatric controls. The mean CSF GABA level in the chronic schizophrenic patients was found to be significantly higher than in any of the other groups. No other statistically significant differences were found. Statistical analysis revealed that the elevated CSF GABA concentration in the chronic schizophrenic patients was unlikely to be caused by medication. These results are interpreted as evidence for possible primary or secondary GABAergic overactivity in the brain in chronic schizophrenia.

Measurement of lactic acid in cerebrospinal fluid of patients with infections of the central nervous system.

The concentration of lactic acid in cerebrospinal fluid (CSF) was determined by gas-liquid chromatography in 205 samples of CSF from 97 patients with or without infections of the central nervous system. Patients without infection or those with nonbacterial (presumably viral) meningitis consistently had low concentrations of lactic acid in CSF (i.e., less than or equal to 35 mg/100 ml), whereas patients with bacterial or tuberculosis meningitis consistently had concentrations of lactic acid in CSF of greater than 35 mg/100 ml. There was no overlap in concentrations of lactic acid between these two groups. Further, lactic acid concentrations in CSF from patients partially treated for meningitis were generally greater than 35 mg/100 ml through the third day of therapy and, thereafter, progressively declined to less than 20 mg/100 ml by the seventh to 10th day of therapy. Relapse of bacterial infection was consistently documented by a recurrence of an increased concentration of lactic acid in CSF. Preliminary experience with determination of the concentration of lactic acid in CSF suggests that it may be useful in distinguishing bacterial (with or without positive cultures) and tuberculous meningitis from meningitis due to nonbacterial causes.

Maturational changes of amino acid concentration in cerebrospinal fluid of the rat

The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport from CF, which mature at different times.

Folic acid concentrations in cerebrospinal fluid in relation to anticonvulsant drugs and cerebral atrophy.

Acta Psychiatrica ScandinavicaVolume 47, Issue 2 p. 206-212 FOLIC ACID CONCENTRATIONS IN CEREBROSPINAL FLUID IN RELATION TO ANTICONVULSANT DRUGS AND CEREBRAL ATROPHY Ole Nygaard Jensen, Corresponding Author Ole Nygaard Jensen department of epileptic diseases (Heads: J. Danielsen, V. Fuglsang Frederiksen), and the department of psychiatry (Head: J. Boas), and the Central Laboratory (Head: C. Munk Plum), the Filadelfia Colony, Dianalund, and Dianalund's Sanatorium for Nervous Diseases (Head: P. Dickmeiss), Dianalund, Denmark Elmehusene 159, 2600 Glostrup, Denmark. Licentiate Pharmacist, The Filadelfia Colony, 4296 Dianalund, Denmark.Search for more papers by this authorOle Vendelin Olesen, Corresponding Author Ole Vendelin Olesen department of epileptic diseases (Heads: J. Danielsen, V. Fuglsang Frederiksen), and the department of psychiatry (Head: J. Boas), and the Central Laboratory (Head: C. Munk Plum), the Filadelfia Colony, Dianalund, and Dianalund's Sanatorium for Nervous Diseases (Head: P. Dickmeiss), Dianalund, Denmark Elmehusene 159, 2600 Glostrup, Denmark. Licentiate Pharmacist, The Filadelfia Colony, 4296 Dianalund, Denmark.Search for more papers by this author Ole Nygaard Jensen, Corresponding Author Ole Nygaard Jensen department of epileptic diseases (Heads: J. Danielsen, V. Fuglsang Frederiksen), and the department of psychiatry (Head: J. Boas), and the Central Laboratory (Head: C. Munk Plum), the Filadelfia Colony, Dianalund, and Dianalund's Sanatorium for Nervous Diseases (Head: P. Dickmeiss), Dianalund, Denmark Elmehusene 159, 2600 Glostrup, Denmark. Licentiate Pharmacist, The Filadelfia Colony, 4296 Dianalund, Denmark.Search for more papers by this authorOle Vendelin Olesen, Corresponding Author Ole Vendelin Olesen department of epileptic diseases (Heads: J. Danielsen, V. Fuglsang Frederiksen), and the department of psychiatry (Head: J. Boas), and the Central Laboratory (Head: C. Munk Plum), the Filadelfia Colony, Dianalund, and Dianalund's Sanatorium for Nervous Diseases (Head: P. Dickmeiss), Dianalund, Denmark Elmehusene 159, 2600 Glostrup, Denmark. Licentiate Pharmacist, The Filadelfia Colony, 4296 Dianalund, Denmark.Search for more papers by this author First published: June 1971 https://doi.org/10.1111/j.1600-0447.1971.tb02205.xCitations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume47, Issue2June 1971Pages 206-212 RelatedInformation