Marginal fit is an important factor for the long-term success of ceramic restorations; however, it is difficult to compare results from studies on marginal accuracy of zirconium oxide-based restorations that used various computer-assisted systems, because different methods were used to obtain the data. The purpose of this study was to analyze the effect of different manufacturing techniques on the marginal adaptation of zirconia ceramic copings. An extracted mandibular first premolar was prepared for a complete coverage restoration and subsequently duplicated 40 times in a liquid crystal polymer (LCP). Ceramic copings (n=10) were fabricated on the LCP models using the following systems: glass-infiltrated zirconia-toughened alumina (In-Ceram Zirconia) and yttrium cation-doped tetragonal zirconia polycrystals (In-Ceram YZ, Cercon, and Procera Zirconia). The absolute marginal discrepancy of the cores was assessed by using an image analysis system. The data were analyzed using 1-way ANOVA and Scheffé's test (α=.05). The mean marginal openings were 29.98 ± 3.97 μm for the In-Ceram Zirconia group, 12.24 ± 3.08 μm for the In-Ceram YZ group, 13.15 ± 3.01 μm for the Cercon group, and 8.67 ± 3.96 μm for the Procera group. Significant differences were found among the 4 systems (P<.05). The marginal accuracy achieved for the 4 zirconia-based ceramic crown systems analyzed was within the range of clinical acceptance (120 μm).