Human Acclimatization Research Articles

Nomograms for correction of blood Po2, Pco2, pH, and base excess for time and temperature.

Nomograms for correction of blood Po2, Pco2, pH, and base excess for time and temperature.

The Role of the Cerebrospinal Fluid in Human Acclimatization to High Altitude.

s1 April 1963The Role of the Cerebrospinal Fluid in Human Acclimatization to High Altitude.J. W. Severinghaus, M.D.J. W. Severinghaus, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-729_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMeasurements of lumbar CSF during acclimatization to 3,800 m altitude in 4 normal males who live at sea level suggest that CSF pH and bicarbonate adequately represent the chemical environment of the medullary respiratory center chemoreceptor, as might be anticipated from Mitchell's recent localization of this chemoreceptor on the anterolateral surface of the medulla. The acute response to CO2and low and high O2was determined, permitting computation of ventilation response curves to alterations in CSF pH and alveolar Po2. This CSF pH—ventilation response curve (with PI02= 190 mm Hg) was identical before and after acclimatization, whereas the CO... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, Calif. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 729-729KeywordsBicarbonatesCerebrospinal fluidColony stimulating factorPartial pressure of oxygen Issue Published: 1 April 1963 PDF DownloadLoading ...

STUDIES ON ACCLIMATIZATION AND ON THE EFFECT OF ASCORBIC ACID IN MEN EXPOSED TO COLD

This experiment was planned to study the problem of acclimatization in humans and to determine the effect of ascorbic acid in men exposed to cold while being fed a normal or survival ration. Ascorbic acid has greatly improved the resistance of men exposed to cold and fed a survival ration. No beneficial effect was observed when the subjects were fed a normal ration. This difference in response may be due to the fact that the experimental conditions differed somewhat between these two experiments. In any event, the subjects on a restricted food intake were certainly under greater conditions of stress. Evidence of acclimatization was obtained with survival rations but not with normal rations. Some conclusions have been made on the use, by men exposed to cold, of survival rations composed exclusively of carbohydrates. Finally, it is estimated that 2800 calories is the daily requirement for men relatively inactive, wearing only shorts, low shoes, and socks, and exposed to an ambient temperature of 60°F.

STUDIES ON ACCLIMATIZATION AND ON THE EFFECT OF ASCORBIC ACID IN MEN EXPOSED TO COLD

This experiment was planned to study the problem of acclimatization in humans and to determine the effect of ascorbic acid in men exposed to cold while being fed a normal or survival ration. Ascorbic acid has greatly improved the resistance of men exposed to cold and fed a survival ration. No beneficial effect was observed when the subjects were fed a normal ration. This difference in response may be due to the fact that the experimental conditions differed somewhat between these two experiments. In any event, the subjects on a restricted food intake were certainly under greater conditions of stress. Evidence of acclimatization was obtained with survival rations but not with normal rations. Some conclusions have been made on the use, by men exposed to cold, of survival rations composed exclusively of carbohydrates. Finally, it is estimated that 2800 calories is the daily requirement for men relatively inactive, wearing only shorts, low shoes, and socks, and exposed to an ambient temperature of 60°F.