Consequences Of Accidents Research Articles

Cytochalasins as Modulators of Stem Cell Differentiation.

Regenerative medicine aims to identify new research strategies for the repair and restoration of tissues damaged by pathological or accidental events. Mesenchymal stem cells (MSCs) play a key role in regenerative medicine approaches due to their specific properties, such as the high rate of proliferation, the ability to differentiate into several cell lineages, the immunomodulatory potential, and their easy isolation with minimal ethical issues. One of the main goals of regenerative medicine is to modulate, both in vitro and in vivo, the differentiation potential of MSCs to improve their use in the repair of damaged tissues. Over the years, much evidence has been collected about the ability of cytochalasins, a large family of 60 metabolites isolated mainly from fungi, to modulate multiple properties of stem cells (SCs), such as proliferation, migration, and differentiation, by altering the organization of the cyto- and the nucleo-skeleton. In this review, we discussed the ability of two different cytochalasins, cytochalasins D and B, to influence specific SC differentiation programs modulated by several agents (chemical or physical) or intra- and extra-cellular factors, with particular attention to human MSCs (hMSCs).

Proactive Emergency Response Strategies for First Responders to Hydrogen Gas Leakages in Vehicles

The widespread use of fossil fuels in automobiles has become a concern, particularly in light of recent frequent natural disasters, prompting a shift towards eco-friendly vehicles to mitigate greenhouse gas emissions. This shift is evident in the rapidly increasing registration rates of hydrogen vehicles. However, with the growing presence of hydrogen vehicles on roads, a corresponding rise in related accidents is anticipated, posing new challenges for first responders. In this study, computational fluid dynamics analysis was performed to develop effective response strategies for first responders dealing with high-pressure hydrogen gas leaks in vehicle accidents. The analysis revealed that in the absence of blower intervention, a vapor cloud explosion from leaked hydrogen gas could generate overpressure exceeding 13.8 kPa, potentially causing direct harm to first responders. In the event of a hydrogen vehicle accident requiring urgent rescue activities, the appropriate response strategy must be selected. The use of blowers can aid in developing a variety of strategies by reducing the risk of a vapor cloud explosion. Consequently, this study offers a tailored response strategy for first responders in hydrogen vehicle leak scenarios, emphasizing the importance of situational assessment at the incident site.

Identifying Key Issues in Integration of Autonomous Ships in Container Ports: A Machine-Learning-Based Systematic Literature Review

Background: Autonomous ships have the potential to increase operational efficiency and reduce carbon footprints through technology and innovation. However, there is no comprehensive literature review of all the different types of papers related to autonomous ships, especially with regard to their integration with ports. This paper takes a systematic review approach to extract and summarize the main topics related to autonomous ships in the fields of container shipping and port management. Methods: A machine learning method is used to extract the main topics from more than 2000 journal publications indexed in WoS and Scopus. Results: The research findings highlight key issues related to technology, cybersecurity, data governance, regulations, and legal frameworks, providing a different perspective compared to human manual reviews of papers. Conclusions: Our search results confirm several recommendations. First, from a technological perspective, it is advised to increase support for the research and development of autonomous underwater vehicles and unmanned aerial vehicles, establish safety standards, mandate testing of wave model evaluation systems, and promote international standardization. Second, from a cyber–physical systems perspective, efforts should be made to strengthen logistics and supply chains for autonomous ships, establish data governance protocols, enforce strict control over IoT device data, and strengthen cybersecurity measures. Third, from an environmental perspective, measures should be implemented to address the environmental impact of autonomous ships. This can be achieved by promoting international agreements from a global societal standpoint and clarifying the legal framework regarding liability in the event of accidents.

The effect of using Filtered Containment Venting System on variation in dose with distance in the prompt accident consequence assessment

ABSTRACT In a nuclear emergency, consequence assessment based on the plant conditions using a simple method is important for a prompt response. Response Technical Manual (RTM-96) is a manual calculation method for prompt dose projection at arbitrary distances by converting pre-calculated doses with the conversion factor based on distance and weather. However, the ‘conversion factor’ in RTM-96 does not consider accident scenarios with filtered containment venting system (FCVS). Therefore, in this study, we defined the ratio of effective dose between 1 km and an arbitrary distance as the ‘Distance Conversion Factor (DCF)’ and aimed to clarify the difference between DCFs by accident scenarios, focusing on the presence or absence of FCVS. The results showed that the differences in DCFs for different accident scenarios were minor in the case of no rainfall. In contrast, in the case of rainfall, DCF differed significantly with scenarios with FCVS and those with containment failure. Therefore, the authors propose that DCFs with rainfall should be calculated separately for several representative accident scenarios rather than uniformly for all accident scenarios, as in the conventional method. The results can contribute to developing a new prompt consequence assessment method, such as RTM-96, which considers FCVS.

Implementation of Internet Safety and Health Monitoring (K3) based on Internet of Things (IoT)

The use of computers in the future can dominate human work and defeat human computing capabilities such as controlling electronic equipment remotely using internet media, IoT (Internet of Things) allows users to manage and optimize electronics and electrical equipment that uses the internet for Automation of Occupational Health and Safety (OHS) Internet-Based Electricity Of Things (IoT). Design of Automation Occupational Health and Safety (OHS) Electricity Based on the Internet of Things (IoT). which is used to test the installation of research instrument equipment. This needs to be done to ensure that the installation and research instruments function properly at the actual time of the experiment. Devices that have been made by the researchers can work well as expected, where the automation of the protection of Occupational Health and Safety (OHS) Internet-Based Electricity of Things (IoT) so that it can provide initial help in the event of work accidents caused by gas leakage and fire monitored online by panel space operators. That's because most of the interactions between IoT devices with Users occur in digital form. Besides, expertise in reading digital data to support the decision-making process is also very crucial from the results of the calculation of the implementation of data monitoring of Occupational Health and Safety (OHS) Internet-Based Electricity of Things (IoT) with an average of 3.54 and the eigenvalues value approaching 29.4, indicating that the majority of workers in a private hospital in Malang City strongly agrees with the application of Internet If Things in the private hospital in Malang City Environment.

ОСОБЕННОСТИ ОБЕСПЕЧЕНИЯ БЕЗОПАСНОСТИ НАСЕЛЕНИЯ ПРИ АВАРИЯХ С РАЗГЕРМЕТИЗАЦИЕЙ ЦИСТЕРН С АВАРИЙНО ХИМИЧЕСКИ ОПАСНЫМИ ВЕЩЕСТВАМИ, ПЕРЕВОЗИМЫМИ АВТОМОБИЛЬНЫМ ТРАНСПОРТОМ В АРКТИЧЕСКОЙ ЗОНЕ

The article raises the issue of ensuring the safety of the population during the transportation of emergency chemically dangerous substances by road on the routes of movement in the Arctic zone. The analysis of the predicted possible consequences for accidents with the depressurization of tanks with emergency chemically hazardous substances transported in the Arctic zone at extremely low temperatures was carried out, a comparative analysis of the consequences of accidents at various weather conditions of the Arctic zone and central Russia. The depths of chemical infection are calculated with various parameters of depressurization of the tank in areas of emergency braking and in the stop area. Features of the transportation of emergency chemically hazardous substances are given at extremely low temperatures and recommendations for ensuring the safety of the population on the routes of transport
 in the settlements of the Arctic zone.

Experimental study on leakage characteristics of gas-liquid two-phase flow in a horizontal pipe

Oil and gas pipeline leakage accidents caused by aging and third-party damage have increased, resulting in polluting the ecological environment and jeopardizing life and property safety. A detailed and systematic investigation on the leak characteristics of oil and gas two-phase pipelines is significantly urgent. The leak experiments were performed on a horizontal tube with a diameter of 32 mm. There was a 3 mm round leakage hole at the bottom of the tube. The distance of the leakage hole from the pipe inlet was 4.8 m. Three inlet flow patterns, including stratified flow, slug flow, and annular flow via adjusting the gas superficial velocity (1.73 m/s ≤ USG ≤ 24.19 m/s) and liquid superficial velocity (0.017 m/s ≤ USL ≤ 0.415 m/s), were obtained. The conclusions point out that the type of leakage, whether it is mainly liquid or both gas and liquid, depends on the USG. The degree of phase separation in stratified flow is the greatest among the three inlet flow patterns, with a maximal phase separation efficiency (η) of 0.403. Slug flow has the least phase separation degree. Interestingly, the η is directly proportional to the inlet mass fraction only for slug flow. The harmonic frequency that appeared in the power spectral density curves for the pressure difference of leakage hole in slug flow, indicates that leakage is not a standard periodic event. The liquid velocity loss is primarily related to the gas leakage mechanism. These findings can provide new insights into two-phase pipeline leak detection and accident consequence prediction.

RETRACTED ARTICLE: Preliminary risk assessment of in-vessel leakage accident in ITER

The ITER project is one of the largest international cooperative scientific projects in the world, aiming to verify the feasibility of magnetic confinement controlled nuclear fusion technology and provide a technical basis for the subsequent construction of fusion energy power stations. The success or failure of ITER will greatly affect the commercialization process of fusion energy. The probabilistic safety assessment (PSA) was a powerful means to evaluate the risk and reliability of nuclear facility and achieved great success in safety assessment of fission power plants. Based on this, the PSA progress for ITER was proposed in this paper. And the in-vessel leakage accident was investigated to verify the effectiveness of proposed method. The result shows the maximum possible radiological consequences of ITER in-vessel leakage accident of ITER is 1.6E−3 mSv, and the frequencies of this consequence is 1.63E−8/year. The reason of this consequence was also discussed in this paper. Those result could provide some valuable reference for radiation risk assessment and safety supervision of fusion commercial reactor in the nuclear future.

Multiphysics analysis of a metal hydride moderated megawatt heat pipe reactor with burnable poisons

With the development of nuclear energy, microreactors have received increasing interest among researchers in recent years. In this paper, a megawatt heat pipe reactor with metal hydride moderators and burnable poisons is proposed. The hydrogen stability of the reactor under accident conditions, including reactivity insertion accidents, loss of power conversion unit heat sink accidents, and heat pipe failure accidents are analyzed. In this work, Gd2O3 is introduced as a burnable poison in the form of mixing with the UO2 fuel. According to the results of the burnable poison design, the 0.1% mass fraction of Gd2O3 is selected as the burnable poison loaded in the core. Safety analysis indicates that the introduction of burnable poisons can be beneficial during the positive reactivity insertion accident as it can reduce the excessive reactivity at BOL, thus reducing power peak and preventing hydrogen dissociation in ZrH1.4 rods. However, during the loss of PCU heat sink accident, ZrH1.4 rods will dissociate regardless of the presence of burnable poisons, whereas YH1.7 rods show better hydrogen stability. Moreover, in the event of the heat pipe failure accident, ZrH1.4 rods are more susceptible to dissociation than YH1.7 rods. As a result, the YH1.7+BP core is a better choice compared with other designs proposed in this paper as it provides a relatively high temperature margin.

INVESTIGATING THE RISK FACTORS AFFECTING THE OCCURRENCE, FREQUENCY, AND SEVERITY OF LARGE TRUCK ACCIDENTS IN AL-NAJAF GOVERNORATE, IRAQ

In spite of the established literature-based evidence regarding the consequences of large truck accidents, limited body of research has been done on the characteristics and risk factors of such road accidents in Iraqi cities and governorates. According to national statistics, there has been a steady increase in the number of trucks and truck-related crashes over the past ten years. This paper aims to investigate the characteristics and risk factors associated with accidents involving large trucks in Al-Najaf governorate. A sample of 400 truck drivers were randomly selected and interviewed to collect the needed accident data. Four generalized linear models have been built; ordinal regression model for total injuries, binary logistic model for fatal accident occurrence, multinomial logit model for accident frequency, and ordinal regression model for accident cost. The analysis results revealed several influential predictors including truck driver age, education level, type of collision, truck speed, truck type, and street lighting condition. The obtained findings should be enlightening and helpful for government organizations looking to promote safety measures for sustainable freight truck transport.

Road accidents on Indian National highways, ambulance reachability and transportation of injured to trauma facility: Survey-based introspection of golden hour.

The transportation system plays a crucial role in the context of socioeconomic development, whereas the highway infrastructure acts as a base for the transportation system. In recent years, a rich impetus has been given to the development of road infrastructure by Indian governance. There is a need to introspect how well the prevailing highway infrastructure is equipped with emergency rescue management during road accidents. Lack of ambulance service and trauma facilities along the highways results in a steady loss of lives and injuries and increases people's exposure to risks. This study aims to determine the response time of ambulance reachability to the accident spot on Indian national highways associated with heavy commercial transportation. Also, determining the time to transport the injured to the nearest trauma facility is another factor included as an objective in this investigation. The study adopted survey-based research, whereby the variables in the questionnaire were designed to record and assess the time for an ambulance to reach the accident spot and, from there, to transport the injured to the trauma management facility on Indian highways. Two hundred twenty-five participants who were either victims/relatives of victims or those involved in the rescue of the injured have participated in the survey. The dates of the accident events were 2017 and 2022. The survey resulted in the identification of two categories of highway accidents. The first category of accidents happened on the highways near city limits/dense settlements, and the second category occurred on the core highways. The percentage of accidents caused on the highways either adjacent to or passing through the city limits/dense settlements was reported to be higher than the accidents on the core highways. Ninety percent of the participants reported successful contact with the ambulance call/service centre, but only ~75% success rate exists for ambulances to reach the accident scene. On the core highways, the time taken for the ambulance to arrive at the accident scene is 25-35 minutes. The results from the survey ascertained that the patients were prioritised for treatment in the nearest hospitals (irrespective of having a trauma facility) at a distance of ~12-20 km, for which the time taken is ~15-25 minutes. Importantly, from the interviews, it is understood that in many cases, these hospitals have further referred to specialty hospitals located in nearby cities or trauma centres with greater facilities. Occasions exist where the injured were taken directly to hospitals 30-40 km from the accident spot, for which the time was more than 40 minutes. The results provide evidence that in either of the accident cases on the highways that are adjacent to/passing through the city limits or on the core highways, the total time for emergency care accessibility is nearly 60 minutes or greater; this implies that in the majority of cases, there is very meagre time left to provide emergency medical care to the needy and injured on the Indian highways to abide by the concept of golden hour. Plausible reforms backed by technology for enabling highways into 'emergency rescuable highways' are highly needed to guarantee a safer and more sustainable transportation system in India.

Research on traffic accident prediction of expressway tunnel based on B-NB model

Objective The study investigates the relationship between traffic accidents in expressway tunnels and their influencing factors, with the aim of predicting traffic accidents within tunnels and presenting reasonable recommendations to improve tunnel safety. Methods The study utilizes a dataset of 586 traffic accidents occurring exclusively within 8 tunnels along a Guangdong Province expressway from 2017 to 2021. It applies the geometric alignment consistency principle to segment road sections, defines tunnel boundaries based on driving behavior, and employs a Bayesian-modified negative binomial regression model (B-NB model) to identify 6 significant variables from a pool of 17 factors. Results The predictive performance of the B-NB model demonstrated similarities to that of the fixed parametric model. This outcome might be attributed to the chosen prior distribution settings and the limited amount of data. Nonetheless, the model effectively captures relationships among variables, leading to improved accuracy in accident prediction and the predictive model achieves a 76.1% accuracy rate. Conclusions Drawing from the estimation results, practical measures are suggested across three dimensions: road geometric alignment design, tunnel traffic safety facilities, and traffic emergency management. These proposals aim to ameliorate the severe consequences of tunnel accidents. Future research will explore an in-depth comparison of estimation results, considering the impact of time and variable correlation on the prediction model by expanding the existing data. This will guide the direction of subsequent research endeavors.

Sodium hypochlorite accident diagnosis and management: Analysis from the literature and the French pharmacovigilance database.

Sodium hypochlorite (NaOCl) is considered as the reference irrigation solution in endodontics. However, NaOCl-related accidents may occur, and non-dentist health professionals might under-recognize this rare adverse effect although it is potentially severe, with possible medical and aesthetic sequelae. We performed a literature review to provide to non-dentist healthcare professionals a large picture of symptoms, management and potential consequences of NaOCl accidents. We queried PubMed and the French Pharmacovigilance database and retrieved 76 cases for analysis (70 from 57 published articles, and six from the database). The analysis showed that patients were mostly women (79%), aged around of 42 years, undergoing upper jawbone (74%) endodontic procedure. NaOCl concentration ranged from 1% to 10%, with 0.5 to 30 mL injected. Most cases (86%) corresponded to an accidental extrusion beyond the root apex to the periapical tissues, followed by tissular injection by error (8%) and extrusion into the maxillary sinus (3%). Local symptoms always occurred within 24 h, mostly pain (99%), edema (89%) and/or ecchymosis (61%). Complications were mainly neurological (29%), necrotic (22%) and cutaneous (9%). Most of patients (76%) fully recovered after medical management but 18 (24%) required surgical management. Any healthcare professional should be aware of the classical symptomatic triad of NaOCl accident with sudden pain, haemorrhage/ecchymosis and swelling, to start or recommend adequate management. Patients should be reassured, but a close follow-up is necessary to avoid delayed complication.

Legal regulation of human protection against the effects of ionizing radiation (implementation of EU standards in the legislation of Ukraine)

The legal regulation of human protection against the effects of ionizing radiation (implementation of EU standards in the legislation of Ukraine) is considered. The legal aspects related to the change of the existing system of radiation protection of a person from the impact of ionizing radiation, which is based on the approach - «practice» and «intervention», to the modern European system of radiation protection, which is based on situational analysis and the key concept of the updated system, have been studied. what is the exposure situation, which is defined as one of three situations: planned situation, emergency exposure situation, existing exposure situation.
 According to the results of the study, the need for a comprehensive approach to the implementation of EU legislation in the legislation of Ukraine «on the example of the Council Directive 2013/59/Euratom» is substantiated. In particular, we believe that it is advisable to do this by one separate law, and not in parts, since without the implementation of the main provisions, the implementation of individual provisions leads to problems with their implementation. In our opinion, the Government of Ukraine should develop an «autonomous road map» for each EU directive, the implementation of which concerns the field of activity of more than one public administration body in the field of nuclear energy use, since some provisions of the Directive are not included in the draft laws on implementation, as they belong to spheres of administration of another state administration body. At the same time, aspects of the extensive legislation regulating relations regarding liquidation of the consequences of the Chernobyl accident should be reflected, in particular in the part of radiation protection, which cannot be reflected in the Directive, but belong to the scope of its regulation. Thus, it will simultaneously allow internal harmonization of legislation and avoid the situation of double interpretation of legislation, will contribute to overcoming contradictions, collisions and gaps in the current legislation of Ukraine.
 In some cases, it is important to carry out the synchronous development of other basic regulatory documents, in particular, new Radiation Safety Norms in order to make a harmonious transition from the existing to a new system of radiation protection of humans against the effects of ionizing radiation. In the future, this will contribute to a more successful systematization and harmonization of the entire array of normative legal acts of nuclear legislation in Ukraine.

Radiological consequence assessment from long term station blackout nuclear accident on Buyende nuclear power plant of Uganda

Uganda’s energy policy of 2023 and Vision 2040 plans to address the country’s electricity shortage by introducing nuclear power of 24,000 MW capacity by 2040. The pioneer nuclear power plants with a generation capacity of 8,400 MW will be built in Buyende District. This study focused on assessing the radiological consequences of potential nuclear accident on any of the four technologies of APR1400, VVER1200, HPR1000, and APR1000. Evaluation of acute and chronic radiation effects from a long-term station blackout accident using RASCAL and GENII codes identified the order of minimum health risks to the public as APR100, HPR1000, VVER1200, and APR1400 if single units are constructed. The total effective dose equivalents and thyroid doses at the exclusion area boundary and emergency protection zone were within the regulatory limits of 250 mSv and 3,000 mSv, respectively for all the reactor technologies.

Screening radiation-differentially expressed circular RNAs and establishing dose classification models in the human lymphoblastoid cell line AHH-1

Purpose In the event of a large-scale radiological accident, rapid and high-throughput biodosimetry is the most vital basis in medical resource allocation for the prompt treatment of victims. However, the current biodosimeter is yet to be rapid and high-throughput. Studies have shown that ionizing radiation modulates expressions of circular RNAs (circRNAs) in healthy human cell lines and tumor tissue. circRNA expressions can be quantified rapidly and high-throughput. However, whether circRNAs are suitable for early radiation dose classification remains unclear. Methods We employed transcriptome sequencing and bioinformatics analysis to screen for radiation-differentially expressed circRNAs in the human lymphoblastoid cell line AHH-1 at 4 h following exposure to 0, 2, and 5 Gy 60Co γ-rays. The dose–response relationships between differentially expressed circRNA expressions and absorbed doses were investigated using real-time polymerase chain reaction and linear regression analysis at 4 h, 24 h, and 48 h post-exposure to 0, 2, 4, 6, and 8 Gy. Six distinct dose classification models of circRNA panels were established and validated by receiver operating characteristic (ROC) curve analysis. Results A total of 11 radiation-differentially expressed circRNAs were identified and validated. Based on dose–response effects, those circRNAs changed in a dose-responsive or dose-dependent manner were combined into panels A through F at 4 h, 24 h, and 48 h post-irradiation. ROC curve analysis showed that panels A through C had the potential to effectively classify exposed and non-exposed conditions, which area under the curve (AUC) of these three panels were all 1.000, and the associate p values were .009. Panels D through F excellently distinguished between different dose groups (AUC = 0.963–1.000, p < .05). The validation assay showed that panels A through F demonstrated consistent excellence in sensitivity and specificity in dose classification. Conclusions Ionizing radiation can indeed modulate the circRNA expression profile in the human lymphoblastoid cell line AHH-1. The differentially expressed circRNAs exhibit the potential for rapid and high-throughput dose classification.

Safety analysis of fire evacuation from Drilling and Production Platforms (DPP)

Offshore platforms are vulnerable to fire accidents and it is essential to conduct safety analysis in case of an evacuation and take measures to improve worker evacuation efficiency and reduce casualties. Based on the proposed Credible and Representative Fire Scenarios (CRFS) methodology, nine fire scenarios were selected and simulated. The safety analysis of fire evacuation was performed based on the coupled injury model and the modified social force model, while the effects of wind direction, wind speed, fire location and pre-evacuation time on the probability of death (POD) were investigated. The results demonstrated that the wind from the stern led to a higher coverage rate of smoke (CRS) on the decks and higher POD values. The wind from the bow, larboard and starboard sides was shown to be more conducive to the dissipation of smoke. As a result, the overall POD values were relatively low. The magnitude of wind speed affects the accumulation behavior of smoke between different decks, and the lower the wind speed, the higher the CRS on the decks and POD of the workers.The pool fire located on the lower deck was more likely to cause injuries than the fire on the working deck. In addition, it was found that the trend between POD and pre-evacuation time shows a non-linear relationship, thus the scenario with the most severe fire threat was used as an example for regression analysis. An approach was proposed to determine the fire-evacuation safety time windows in the event of a fire accident and the time windows in different areas of the nine selected scenarios were predicted. Finally, the time windows obtained from the regression curves and the proposed method were compared.

Analysis of Fire and Explosion Consequences in Accidents Involving Premium Gasoline Tanker Trucks

Analysis of Fire and Explosion Consequences in Accidents Involving Premium Gasoline Tanker Trucks

Ophthalmic implications of biological threat agents according to the chemical, biological, radiological, nuclear, and explosives framework.

As technology continues to evolve, the possibility for a wide range of dangers to people, organizations, and countries escalate globally. The United States federal government classifies types of threats with the capability of inflicting mass casualties and societal disruption as Chemical, Biological, Radiological, Nuclear, and Energetics/Explosives (CBRNE). Such incidents encompass accidental and intentional events ranging from weapons of mass destruction and bioterrorism to fires or spills involving hazardous or radiologic material. All of these have the capacity to inflict death or severe physical, neurological, and/or sensorial disabilities if injuries are not diagnosed and treated in a timely manner. Ophthalmic injury can provide important insight into understanding and treating patients impacted by CBRNE agents; however, improper ophthalmic management can result in suboptimal patient outcomes. This review specifically addresses the biological agents the Center for Disease Control and Prevention (CDC) deems to have the greatest capacity for bioterrorism. CBRNE biological agents, encompassing pathogens and organic toxins, are further subdivided into categories A, B, and C according to their national security threat level. In our compendium of these biological agents, we address their respective CDC category, systemic and ophthalmic manifestations, route of transmission and personal protective equipment considerations as well as pertinent vaccination and treatment guidelines.

The relationship between human error and occupational stress of commissioning workers in nuclear power plants: the mediating effects of anxiety

ABSTRACT The commissioning of a nuclear power plant (NPP) is a high-intensity job with severe consequences in the event of accidents. Commissioning workers are exposed to both mentally and physically demanding conditions, factors that may impose an elevated probability of human errors. This study aimed to explore the relationship between occupational stress (OS) and human error (HE) among commissioning workers in NPPs and verify whether anxiety mediates this relationship. A cross-sectional, descriptive and analytic study was carried out among 215 commissioning workers across three NPP commissioning sites in China, three questionnaires were used to collect data on OS, anxiety, and HE. The analyses were performed using the Process 3.0 macro in SPSS to verify the mediation effect. This study highlights the need for individual stress and anxiety management by providing managers with insight into the mechanism of anxiety in relation to OS and HE, which can effectively reduce the probability of HE and improve the safety of nuclear power systems.