Accidental Encounter Research Articles

Accidental Encounter of Repair Intermediates in Alkylated DNA May Lead to Double-Strand Breaks in Resting Cells.

In clinics, chemotherapy is often combined with surgery and radiation to increase the chances of curing cancers. In the case of glioblastoma (GBM), patients are treated with a combination of radiotherapy and TMZ over several weeks. Despite its common use, the mechanism of action of the alkylating agent TMZ has not been well understood when it comes to its cytotoxic effects in tumor cells that are mostly non-dividing. The cellular response to alkylating DNA damage is operated by an intricate protein network involving multiple DNA repair pathways and numerous checkpoint proteins that are dependent on the type of DNA lesion, the cell type, and the cellular proliferation state. Among the various alkylating damages, researchers have placed a special on O6-methylguanine (O6-mG). Indeed, this lesion is efficiently removed via direct reversal by O6-methylguanine-DNA methyltransferase (MGMT). As the level of MGMT expression was found to be directly correlated with TMZ efficiency, O6-mG was identified as the critical lesion for TMZ mode of action. Initially, the mode of action of TMZ was proposed as follows: when left on the genome, O6-mG lesions form O6-mG: T mispairs during replication as T is preferentially mis-inserted across O6-mG. These O6-mG: T mispairs are recognized and tentatively repaired by a post-replicative mismatched DNA correction system (i.e., the MMR system). There are two models (futile cycle and direct signaling models) to account for the cytotoxic effects of the O6-mG lesions, both depending upon the functional MMR system in replicating cells. Alternatively, to explain the cytotoxic effects of alkylating agents in non-replicating cells, we have proposed a "repair accident model" whose molecular mechanism is dependent upon crosstalk between the MMR and the base excision repair (BER) systems. The accidental encounter between these two repair systems will cause the formation of cytotoxic DNA double-strand breaks (DSBs). In this review, we summarize these non-exclusive models to explain the cytotoxic effects of alkylating agents and discuss potential strategies to improve the clinical use of alkylating agents.

데페이즈망 기법을 응용한 NFT 디지털 아트메이크업 디자인 제작

This study produced digital art makeup targeting an AI convergence idol group called ‘aespa’, and then uploaded it to a NFT market place called OpenSea. In the research method, this study analyzed the expression elements of Depaysement used for visual expressions according to the classification criteria by Suzi Gablik. To analyze adjective expressions, this study conducted the SD Method(Semantic Differential Method) developed by American psychologist Charles Egerton Osgood, and the FGI(Focus Group Interview) as a qualitative research method. In the results of this study, first, as the Depaysement technique, there was occurrence of isolation, transformation, synthesis, and accidental encounter. Second, the sensibility vocabulary included grotesque, chic, gorgeous, active, modern, and dynamic. Based on the drawn results, this study established the service marketing environment by producing a digital art makeup work and then uploading it to OpenSea, and also aims to contribute to the creation of differentiated design and development into expanded space by expressing artistic value as online content through the development of art and tech together.

HX and Me: Understanding Allostery, Folding, and Protein Machines.

My accidental encounter with protein hydrogen exchange (HX) at its very beginning and its continued development through my scientific career have led us to a series of advances in HX measurement, interpretation, and cutting edge biophysical applications. After some thoughts about how life brought me there, I take the opportunity to reflect on our early studies of allosteric structure and energy change in hemoglobin, the still-current protein folding problem, and our most recent forward-looking studies on protein machines.

Мотив заключения в рассказах Дж. Рис «From a French Prison» («Из французской тюрьмы»), «The Sidi» («Араб»), «Outside the Machine» («За пределами»)

The article examines the motive of imprisonment (supervision and punishment) in the concept of Jean Rhys’s short stories written in the first half of the XX century. The placement of female (Inez, Madame Tavernier, Mrs. Murphy) and male (the old man and the boy, Sidi) characters in the closed loci of the hospital and prison is seen as an emblem of alienation and identity crisis. The possibilities of philosophical and psychological interpretation of the imprisonment, the key leitmotif of the British writer’s stories, and the accompanying motives of loneliness, accidental encounter, non-involvement, guilt, inner human freedom and existential insight are analyzed in detail. The hospital/prison space turns out to be symbolic, irrational. It acquires metaphysical meaning, correlates with the key ideas of the French philosopher Michel Foucault. Special attention is paid to the representation of the motive of imprisonment in the poetics of the stories «From a French Prison», «The Sidi», «Outside the Machine» (internal psychologism, the unreliability of the narrator, the accentuation of detail).

리좀적 관점에서 바라본 유아들의 바깥놀이

Objectives This article aims at reviewing the processes of experiences and learning in outdoor plays with a rhizomatic perspective, drawing them through a rhizomatic map, confirming authentic values of outdoor plays and their apsects, and making new suggestions for outdoor plays which have been recognized as superficial values on site.
 Methods For this, participatory observation and visual research methods were applied to 52 five-year-old young children of A Kindergarten in B city. And in order to figure out before and after the plays of the children, who cannot be figured out easily by participatory observation and visual research method, and their close relationships, semi-structured interviews were also conducted. The collected data through participatory observation, visual research method, and interviews were analyzed according to the inclusive analytic procedures based on the Pragmatic Eclecticism suggested by Young-cheon Kim(2016) and the validity was secured through the evidence of the ‘Credibility’ of Lincoln and Guba(1985).
 Results Young children’s outdoor plays starting from an accidental encounter with snails on the way to walk on a rainy day were created through endless connections and contacts. Their plays created by an accidental encounter with snails were categorized into an accidental encounter, recreation by chance, connections and connects, creating meaning, entering into the site of learning, dislocating and learning together, and thinking newly and without limit. Young children exist as nomads who reject territorialization, pursue new arrangements and desires which are different from the present time and try deterritorialization. Therefore, young children’s outdoor plays have neither start nor end and show non-linear and rhizomatic characteristics like roots digging into and stretching out underground endlessly.
 Conclusions Young children’s outdoor plays with the rhizomatic characteristics could not be understood with a tree-type perspective concluded with a center and they require teachers and adults to change their perspectives to the rhizomatic one which is not fixed but changing. And young children can meet the world, think and create learning as actors in plays when they have possibilities of changes and dislocation in play venue, time, play methods, etc.

Consumers' acceptance of the first novel insect food approved in the European Union: Predictors of yellow mealworm chips consumption.

Climate and environmental‐related challenges are high on the agenda of the European Union (EU). One priority is to redesign the existing food system into a more sustainable one, where the link between healthy people and a balanced environment is considered. The EU bets on the role of insect farming in supporting the transition toward healthier and future‐proof diets. Following this orientation, we investigated consumers' attitude toward yellow mealworm chips (YMC) and identified the predictors of YMC consumption. The causal relationships between constructs were explored using the structural equation modeling (SEM) based on partial least squares (PLS) using SmartPLS software. The perceived lower environmental impact of YMC compared to meat was the most appreciated characteristic of YMC. The study identified five predictors of YMC consumption, among which the perceived characteristics of YMC have the strongest influence on the consumption probability. Against the expectations of the authors, disgust with the accidental encounter of insects in foods did not influence the probability of eating YMC. Age was another predictor of YMC consumption. It is known that food preferences and eating behaviors are mainly developed during childhood and tend to manifest in adult life. Consequently, it can be inferred that acceptance and preference for insect‐based foods (IBF) should be stimulated from early childhood. Finally, practical implications are advanced as possible solutions to overcome the obstacles toward YMC consumption.

Sternalis - Variation of clinical importance

This case report concerns the presence of an accessory anterior thoracic wall muscle during routine dissection in the Department of Anatomy, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi. A 59 year old male cadaver was being dissected, when a unilateral accessory muscle was found parallel and lateral to the right margin of sternum. Accidental encounter with Sternalis, one of the many names used to denote this muscle, made it apparent that such anatomical variations is not uncommon. A descriptive knowledge of such common anatomical variations is both essential and crucial in realizing that not any human body is alike. Besides theoretical interest & academic curiosity, the implications of these variations is indispensable in diagnostic and surgical disciplines. Keywords: Sternalis, Rectus sternalis, Chest wall, Muscle variation, Human anatomy, Mammography, Rectus sternalis, Anatomical variation, Breast augmentation, Reconstruction, Mammography, Medical education, Sternalis, Chest, Breast, Surgery, Radiography, Mammogram.

Making touch visible with the suture of fantasy with virtual aesthetician in “The Best Facial Clinic” – The glitchy-score of tele-synaesthesia performance in the age of global pandemic

In the wake of the COVID-19 pandemic, we have been adapting as fugitives of this accidental encounter with an “untouchable” virus, while being rendered into the shared virtual arena, where our discursive bodies are situated within, embedded in and tele-commuted to. Our increasing dependence on online interaction and video conferencing during the pandemic is not only facilitating social connectedness, but also contemplating the question: How to elongate our somatosensation and echo the embodied experience of touching through the incorporeal virtual connectivity? This essay focuses on the embodied nature of tele-synaesthesia performance, its potential effect of forging a rhythmic connection from one sensuous modality to another, and the concurrent emergences of glitch and internet latency as non-verbal cues of internet-situated communication. In reference to Laura Mark’s theory of haptic visuality, where vision triggers a tactile experience in the body; Naomi Bennett’s concept of virtual touch, in which an affective sensory response of touch can be elicited through non-tactile senses, Paul Sermon’s artistic production of Telematic Quarantine (2020) and Pandemic Encounter (2020), that telepresents the stories of self (isolation), and in relation to Michel Foucault’s concept Heterotopia in the context of internet-situated performance, I examine the performance work I have been developing during lockdown since March 2020: The Best Facial (2021), supported by Centre for Digital Media Cultures Research and School of Art Postgraduate Research at University of Brighton, a number of sessions of 25-minute 1-to-1 participatory tele-synaesthesia performances that take place on Zoom, where I become a virtual aesthetician and use telepresence to perform meditative virtual facial tactics, and to make tele-contact improvisation upon the surface of the participant’s face to trigger tactile experiences through haptic visuality, virtual touching, and auditory fantasization.

Genre-and-Style Characteristics of Anna Gavalda’s Novella "Petites Pratiques Germanopratines" ("Peculiarities of Saint-Germain Boulevard")

The present research featured short stories by Anna Gavalda, a contemporary French writer. The research objective was to define the genre and style of Petites Pratiques Germanopratines (Peculiarities of Saint-Germain Boulevard) published in Gavalada’s collection of novellas entitled Je Voudrais Que Quelqu’un M’attende Quelque Part (I wish somebody were waiting for me somewhere). The novella demonstrated features common to this type of narration: small volume; few characters; focus on their everyday private life and a singular event that changes it; dramatic nature of the plot development; peripeteia and a manifestly expressed culminating point resulting in a denouement that defeats the reader’s expectancy; prosaically neutral style of narration achieved by the use of neutral and literary-colloquial lexical units, etc. Alongside the typical features, the research revealed some specific characteristics that manifested themselves in the novella under analysis: first-person narrative; elements of psychology introduced into narration, e.g. inner monologues of the protagonist or her inner dialogue with a prospective interlocutor; limited time-and-space composition; cinematic type of dynamic narrative; motifs of road and accidental encounter; antithesis underlying the basic themes embedded in the plot structure; abundance of precedent and toponymic names and artistic details; diversity of linguistic means used to organize the narration and describe the inner world of the protagonist.

Edouard Mesens, a Belgian forefather of the surreal movement in London 1936

The article presents the birth and the origins of English surrealism. Hardly studied from its beginnings, its incipient manifestations began with the exhibitions and manifestations organized in London by the Belgian gallerist and writer Édouard Mesens, acquiring afterwards, insular and specific connotations through the work of surrealist English and Welsh artists and writers in the interwar period. Roland Penrose, Eileen Agar, Paul Nash, David Gascoyne, Humphrey Jennings, among others, consider that Paris is the cradle of the highest and most revolutionary manifestations of art in all its forms in that period of tense peace. After an accidental encounter in Paris, Roland Penrose and Édouard Mesens decide to introduce the Surrealist movement in England in 1936. The personal relations of Édouard Mesens with André Breton, Paul Éluard and Roland Penrose appointed Mesens representative of the English surrealist movement as Director of the London Gallery and editor of the London Bulletin, the official publication of surrealism in London. Besides, through different exhibitions, Édouard Mesens introduces the work of René Magritte and Paul Delvaux in the capital. At the same time, Mesens will take active part in the creation and development of the English surrealist movement and in 1944, he signed, together with J-B Brunius, the manifest “Idolatry and Confusion”. In 1947 the first declaration of the Surrealist Group in England appeared together with the first publications among which we can mention Message from Nowere, Fulcrum, Free Unions Libres or Surrealist transformation. The present article develops the relationship of all these literary and artistic manifestations and explains the connections between Belgian and English surrealism. It also analyzes and presents the work of the main artists, writers, and ideologues of English Surrealism. This constitutes the main and original contribution of this research paper.

Environmental drivers of lesser weever stings on the northeast Atlantic coast (A Lanzada beach, Spain)

Many marine species, including anemones, snails, jellyfish, coral and fish, are venomous to humans, causing serious injuries or even death. Most of these animals live in warm, shallow waters, which increase the chances of an encounter with them. The majority of these interactions with humans are accidental; however, it is not well known under which circumstances (if any) these encounters are more likely to happen. A smart-city initiative was launched for A Lanzada beach (NW Spain) in the summer of 2014. As part of this initiative, lifeguards collated data on all incidents occurring on the beach, including the stings of Echiichthys vipera, the lesser weever. Additionally, a number of environmental parameters were monitored. Using this unique information, statistical models were developed to evaluate under which environmental conditions beach users would be more prone to be stung by lesser weevers. The optimal model showed that stings were more likely at the southern end of this 2.7 km long beach, pointing to differences in sediment composition along the beach as a key factor. Moreover, warmer seawater and higher air temperature increased the chances of being stung. Furthermore, stings increased at low tide and decreased under strong meridional wind conditions. Finally, the number of stings increased with beach occupation up to a levelling-off point. These outcomes suggest that a combination of fish behaviour and favourable climate conditions for beachgoers increases the chances of suffering an accidental encounter with E. vipera. Our results, based on basic environmental information, constitute a simple tool that could be used to provide precautionary advice to beach users to avoid accidental encounters with the lesser weever.

A Brazilian case of Bernard\u2013Soulier syndrome with two distinct founder mutations

Bernard–Soulier syndrome (BSS) is a rare bleeding disorder of autosomal recessive inheritance characterized by macrothrombocytopenia. We report the case of a 14-year-old girl diagnosed with BSS who is a fourth-generation Brazilian of Japanese descent and has a compound heterozygote mutation as the responsible gene. The compound heterozygosity would have occurred from the global and long-term racial migration that brought about an accidental encounter of two rare mutant alleles of different origins.

History as Humanity’s CV: A Conversation with Frank Dikötter

This wide-ranging and often thought-provoking conversation takes us beyond Frank Dikötter’s record of publication in the field of modern Chinese history to look more at the personal experience and background that has shaped his work—his fascination with language, his lack of a “mother tongue,” his permanent status as a foreigner, his accidental encounter with the China field, his views on a host of topics, ranging from the issue of agency, evidence-driven history, archival research, historical memory, the nature of the humanities and the responsibility of the historian to the key driving values of our modern world.

MCCAW, Dick. Bakhtin and Theatre: Dialogues with Stanislavsky, Meyerhold and Grotowski [Bakhtin e o teatro: diálogos com Stanislavsky, Meyerhold and Grotowski]. Abingdon: Routledge, 2015. 264p.

: Dialogues with Stanislavsky, Meyerhold and Grotowski was written by Dick McCaw, a senior lecturer in Drama and Theatre in the Department of Drama and Theatre of Royal Holloway, University of London, and published in 2015 originally in English. There is no Portuguese translation to it yet. of Drama and Theatre of Royal Holloway, University of London, and published in 2015 originally in English. There is no Portuguese translation to it yet. In an unprecedented initiative, the book examines the connections between the thinking of the Russian author Mikhail Bakhtin (1895-1975) and the theatre production of directors and contemporary theatre researchers of Bakhtin’s work: Konstantin Stanislavsky (1863-1938), Vsevelod Meyerhold (1879-1940), and Jerzy Grotowski (1933-1999). This study, which is extremely pertinent and relevant to those who not only research on and/or are interested in theatre studies but also want to know and to deepen their knowledge about Bakhtin’s work, offers a lot more than just a handful of references on the approximations of the Russian philosopher with the theatre production of his time. It presents a detailed outline of the relationships between theatre techniques, content and (aesthetic) form in the light of the philosophy and language studies developed by Bakhtin and the Circle. From a somewhat accidental encounter, during his research for a play with the

Discovering Hominins - Application of Medical Computed Tomography (CT) to Fossil-Bearing Rocks from the Site of Malapa, South Africa.

In the South African context, computed tomography (CT) has been used applied to individually prepared fossils and small rocks containing fossils, but has not been utilized on large breccia blocks as a means of discovering fossils, and particularly fossil hominins. Previous attempts at CT imaging of rocks from other South African sites for this purpose yielded disappointing results. For this study, 109 fossil- bearing rocks from the site of Malapa, South Africa were scanned with medical CT prior to manual preparation. The resultant images were assessed for accuracy of fossil identification and characterization against the standard of manual preparation. The accurate identification of fossils, including those of early hominins, that were not visible on the surface of individual blocks, is shown to be possible. The discovery of unexpected fossils is reduced, thus lowering the potential that fossils could be damaged through accidental encounter during routine preparation, or even entirely missed. This study should significantly change the way fossil discovery, recovery and preparation is done in the South African context and has potential for application in other palaeontological situations. Medical CT imaging is shown to be reliable, readily available, cost effective and accurate in finding fossils within matrix conglomerates. Improvements in CT equipment and in CT image quality are such that medical CT is now a viable imaging modality for this palaeontological application.

Accounting for meaning: On §22 of David Foster Wallace's The Pale King

Abstract The Pale King (2011) is David Foster Wallace's iconic portrait and parody of a modern workplace that is also, not accidentally, an accounting institution – namely, the United States Internal Revenue Service. Many reviewers summarize its topic as boredom – of work in general, and tax accounting in particular. However, its longest section is a nearly one hundred-page, first-person narrative of how one Chris Fogle found his “calling” in accounting, including an accidental encounter with a professor who deemed it to be nothing less than “heroic.” Examined through the lens of ethical criticism, §22 of The Pale King is an important text for examining moral questions about what makes work meaningful and whether we have obligations to perform it ourselves and provide it to others. Through the lens of literary critical theory, it can also be read as a commentary on the meaningfulness (or meaninglessness) of accounting and what its methods imply about what has meaning and value in work and life.

Accidental Encounter: Why John Quincy Adams Translated German Culture for Americans

This article explores the significance of a chance encounter with a foreign culture during the early American republic. It examines the diaries, letters, essays, poems, reviews, and translations produced by John Quincy Adams during his four-year diplomatic appointment in Berlin (1797–1801). His transmission of German works and perspectives to America coincided with a growing American resistance to the legacy of English and French cultural influence. His contribution, while inspired by a curiosity about German culture, was primarily intended to provide Americans with a fresh way of viewing the United States. Adams’s accidental encounter with German society, ideas, and culture highlights key cultural concerns in the early republic and alerts us to the productive unpredictability of cultural transfer.

Improvization and strategic risk-taking in informal learning with digital media literacy

The city provides a rich array of learning opportunities for young children. However, in many urban schools, often it can be logistically difficult to get young children out of the building. But when elementary children are encouraged to view the city as a classroom and use digital media to explore and represent their neighborhoods, they can be inspired by the unpredictable events of daily life to ask naïve, critical and sometimes troubling questions. This paper presents a case study of a teacher in an informal media literacy learning environment who worked with a group of 9-year olds in Philadelphia. It documents the experience of a novice teacher who, flummoxed by an accidental encounter between her students and a homeless person, transformed an uncomfortable experience into a teachable moment. Children's questions about homelessness became the organizing frame for learning experience, as the instructor helped children make sense of the information on the Internet, analyze popular culture films and news media, and conduct interviews with community leaders and advocates for the homeless. The inquiry process resulted in a collaboratively produced multimedia project, created by children. The case study has implications for pre- and in-service teacher education for digital and media literacy. This paper suggests that improvization and strategic risk-taking must be conceptualized as a set of socio-emotional and experiential competencies that teachers need when using digital media in an urban community as a tool for learning.

Beaten into action: A perspective on blood sports

Beaten into action: A perspective on blood sports

My Encounter with Canned Briefs

Briefing cases is an integral part of the learning process in the first year of law school. Despite the near-universal advice of law professors and law school guides to “brief the cases yourself,” students may be tempted to rely on commercial “canned” briefs instead.This author’s accidental encounter with canned briefs while preparing for a Contracts class reinforced his opinion that his law school bookstore was right to ban canned briefs. No only do they impair the learning process, they are unreliable and can cause misunderstandings. They also have the potential to embarrass students who rely on them when reciting in class. Students who want to maximize their success should shun canned briefs.