The study aimed to perform a cross-sectional comparative assessment of the content and quality of information available on the treatment of depression over websites in English and Hindi language. We screened the first 50 links obtained on searching for depression treatment on Google, and selected 72 (44 in English; 28 in Hindi) websites. They were evaluated for coverage of different aspects of depression, quality of treatments mentioned, esthetics, and interactivity. A significantly lesser number of Hindi websites discussed the minimum duration of treatment needed for a depressive episode (36% vs. 79%), possible side effects of treatment (18% vs. 77%), discussed suicidality in depression explicitly (25% vs. 57%), or recommended consultation with a mental health professional (11% vs. 43%). English websites more commonly mentioned psychotherapy (86% vs. 64%), electroconvulsive therapy (64% vs. 21%), and social support measures (59% vs. 32%) for depression treatment. Whereas, Hindi websites more commonly mentioned Ayurvedic/herbal medicines (46% vs. 16%), and yoga (29% vs. 4%) for treatment. Lastly, the esthetics score for English websites was significantly higher than for Hindi websites. A significantly greater number of Hindi websites were owned by commercial entities. This is the first study to systematically compare online information on depression treatment in English and Hindi language websites, and identify areas for further improvement in the overall quality of online information in Hindi. There is a need for the creation of credible and accessible online resources in regional languages like Hindi for the promotion of depression literacy among the general public by government and non-profit professional organizations.