Acceptable Risk Research Articles

A Framework for Upgrading Contaminated Urban Land and Soil by Nature-Based Solutions: Demonstration with a Swedish Case

To move towards a circular economy and to meet the upcoming EU soil health legislation, both contaminated land and contaminated soil should be acknowledged as fragile and valuable resources to be restored and recycled to provide essential ecosystem services to humans. Underused, often contaminated land can be returned to beneficial use as urban greenspace (UGS) with the help of gentle remediation options (GROs). GROs are plant-, fungi-, bacteria-, and soil amendments-based risk management mechanisms that can also simultaneously improve soil functions and the provision of ecosystem services. This study (i) presents a framework including tools and methods for exploring opportunities for transforming brownfields to UGS using GROs to deal with soil contamination, (ii) demonstrates its application for a case study site in Gothenburg, Sweden, and (iii) presents stakeholders’ views on the suggested framework. This framework can support the transition of brownfields to UGS while recycling both land and soil and increasing the market value of the site and its surroundings. Stakeholders found the suggested framework useful but identified some challenges for its practical implementation, mainly associated with financial aspects and the existing practice and level of knowledge. Stakeholders also identified the need for additional practical tools to (a) make predictions about the time required for GROs to reach acceptable risk levels, (b) monetize non-market benefits such as ecosystem services for communicating benefits to decision-makers, and (c) provide support for plant and soil amendment selection for various GROs and contaminants.

Aortic arch replacement in patients with previous repair of acute aortic dissection: a systematic review and meta-analysis.

Despite the popularity of the frozen elephant technique procedure in recent years, evidence is scarce regarding its utilisation for aortic arch replacement following previous acute aortic dissection repair. In this systematic review and meta-analysis, we aimed to analyse clinical outcomes of aortic arch replacement in patients with previous repair of acute aortic dissection. A systematic literature search on PubMed, MEDLINE via Ovid, Embase, Scopus, and Web of Science until March 2024 was performed for studies on open aortic arch replacement with or without frozen elephant technique procedure in adult patients after previous acute aortic dissection repair. Early and late postoperative mortality were primary, while postoperative complications were outcomes of interest. Additionally, a meta-analysis was performed to pool the early and late postoperative mortality. A total of 574 studies were identified, of which 9 studies including a total of 677 patients met the eligibility criteria. In-hospital or 30-day postoperative mortality and stroke were 0-17.5% and 0-7.7%, respectively. Duration of follow-up across all studies varied from 1.1 to 5.1 years. All-cause late mortality rate ranges from 5.9-30.5%. Aortic reintervention rate was 4.8-38.7%. The pooled early and late mortality rate were 8.7% ([95% CI: 5.7-13%], I2=52%) and 24.9% ([95% CI: 19.5-31.1%], I2=54%), respectively. Current evidence suggest that relatively younger patients with chronic post-dissection aneurysm or residual aortic dissection after acute aortic dissection repair can undergo an aortic arch replacement by a dedicated aortic team with acceptable mortality risk. However, postoperative neurological deficit remains an issue.

Insights on environmental behavior and dietary risk of spirotetramat and its metabolites in Goji berry and soil: “Third Pole” medicine and food homologous crop

Goji berry is an important cash crop in Qinghai Plateau, in this study, the potential residual risk and dietary risks of spirotetramat and its four metabolites are assessed in Goji berry. The results showed that the mean recoveries were 80.02~102.39% and the relative standard deviations (RSDs) were 1.45~9.09%. According to the experimental results, the degradation of spirotetramat in fresh Goji berry and soil were best fitted to the first-order kinetics model, and the half-lives were 7.7 d and 7.3 d, respectively. The terminal residues of spirotetramat in fresh Goji berry, dried Goji berry and soil were 0.0394~0.2105mg/kg, 0.0013~0.0795mg/kg and 0.0165~0.8694mg/kg, respectively. The chronic dietary intake risk (RQc) was 12.25% and the acute dietary intake risk (RQa) was 0.002~0.020%, which were well below the 100% threshold and represent an acceptable dietary risk range. This means that spirotetramat and its four metabolites are safe.

Failed radial head arthroplasty treated by removal of the implant.

In patients with a failed radial head arthroplasty (RHA), simple removal of the implant is an option. However, there is little information in the literature about the outcome of this procedure. The aim of this study was to review the mid-term clinical and radiological results, and the rate of complications and removal of the implant, in patients whose initial RHA was undertaken acutely for trauma involving the elbow. A total of 11 patients in whom removal of a RHA without reimplantation was undertaken as a revision procedure were reviewed at a mean follow-up of 8.4 years (6 to 11). The range of motion (ROM) and stability of the elbow were recorded. Pain was assessed using a visual analogue scale (VAS). The functional outcome was assessed using the Mayo Elbow Performance Score (MEPS), the Oxford Elbow Score (OES), and the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH). Radiological examination included the assessment of heterotopic ossification (HO), implant loosening, capitellar erosion, overlengthening, and osteoarthritis. Complications and the rate of further surgery were also recorded. The indications for removal of the implant were stiffness in five patients, aseptic loosening in five, and pain attributed to the RHA in three. The mean time interval between RHA for trauma to removal was ten months (7 to 21). Preoperatively, three patients had overlengthening of the implant, three had capitellar erosion, six had HO, and four had radiological evidence of loosening. At the final follow-up, the mean the flexion-extension arc improved significantly by 38.2° (95% CI 20 to 59; p = 0.002) and the mean arc of prono-supination improved significantly by 20° (95% CI 0 to 72.5; p = 0.035). The mean pain VAS score improved significantly by 3.5 (95% CI 2 to 5.5; p = 0.004). The mean MEPS improved significantly by 27.5 (95% CI 17.5 to 42.5; p = 0.002). The mean OES improved significantly by 9 (95% CI 2.5 to 14; p = 0.012), and the mean DASH score improved significantly by 23.5 (95% CI 7.5 to 31.6; p = 0.012). Ten patients (91%) had HO and osteoarthritis. Two patients underwent further surgery due to stiffness and pain, respectively. Simple removal of the implant at revision surgery following a failed RHA introduced following trauma provides satisfactory mid-term results with an acceptable risk of complications. Osteoarthritis, instability, and radioulnar impingement were not problems in this series.

Transcatheter closure of atrial septal defect (ASD) in adult and paediatric population without transoesophageal echocardiography/general anaesthesia

Abstract Background Transcatheter device closure is the preferred therapeutic option for ostium secundum atrial septal defect(OS-ASD). Standard practice is to perform it under transoesophageal echocardiography(TEE) guidance. However, TEE is performed under general anaesthesia (GA) and leads to increases in cost, procedural duration, ICU stay, total hospital stays, risk of oesophageal injury and complications of GA. Transthoracic echocardiography(TTE) is an excellent alternative and prior studies have shown it to be a safe alternative in paediatric population. In current study we analysed safety and efficacy of TTE-guided device closure of OS-ASD in all comer population irrespective of age, weight, defect size. Methods The study enrolled all patients who underwent device closure of OS-ASD between March 2017 and December 2023. All procedures were performed under LA for adults and conscious sedation for children. The device was placed under fluoroscopy guidance and position were confirmed on TTE. Procedural success, device, defect size ratio, procedural time, fluoroscopy time, complications, intensive care unit/hospital stay duration were analysed and compared with our own experience of 125 patients with TEE-guided closures before switching to complete TTE-guided procedure(before 2017). Results 340 patients underwent TTE-guided device closure of ASD. Procedure success was 97.4% with acceptable risk of major complications. Three(0.8%) had embolization into pulmonary artery, successfully operated surgically. Two had tamponade requiring drainage. In 9 patients, device could not be deployed despite multiple attempts and approaches. All of these had defect size of > 34mm and deficient IVC rim along with shorter (other than aortic) rim. Findings were compared with our own previous experience of TOE guided closure (practised before 2017). Compared to TOE group, TTE group had significantly lower total procedural duration (75±4 vs. 28 ±1 min; p < 0.01), intensive care unit stay (24±10 vs. 10.5±1 h; p < 0.01), and hospital (48±12 vs. 25.5±4h; p < 0.01) stay duration. Fluoroscopic time was similar in both. There was no mortality in either group. Major complications were comparable, TTE-guided group had less post-procedure complications of vomiting and headache. Additional findings of less pre-procedure fasting duration and early commencement of post procedure oral intake were noted in TTE group. Conclusion TTE-guided device closure of OS-ASD is a safe and feasible in all-comer population in experienced hands. It can definitely negate the use of TEE except in very poor echo window. The added advantages include utilization of physiological variations in PV/LV pressure during cough, Valsalva manoeuvres in awake patients. It definitely reduces the procedural duration, cost of procedure and dependence on GA and trained transoesophageal echocardiographer.

Determination of PAH Contamination in Breast Milk Samples from Hungarian Volunteering Mothers, Using HPLC–FLD

(1) The evidence is mounting that polycyclic aromatic hydrocarbons (PAHs) are a class of hazardous organic compounds with established carcinogenic and toxic properties. Humans may be exposed to PAHs through several different routes, including diet, inhalation, and dermal contact. There is also a possibility that they could transfer into breast milk following maternal exposure, which could potentially endanger breastfeeding infants. (2) The objective of this study was to ascertain the concentration of polycyclic aromatic hydrocarbons (PAHs) in breast milk samples from 50 Hungarian mothers, employing high-performance liquid chromatography with fluorescence detection (HPLC–FLD). An Incremental Life Risk Calculation (IRCL) model estimated the carcinogenic risk to infants. (3) Total PAH concentrations ranged from 0 to 78 ng/mL, with fluorene (5.3 ng/mL), phenanthrene (3.2 ng/mL), and pyrene (2.5 ng/mL) being the most abundant. PAHs were detected in 48 of the 50 samples, with phenanthrene present in 92% of samples. Dibenzo (a,h)anthracene was not detected. (4) According to the model measurements, most of the samples were within acceptable risk levels; however, 2 samples out of 50 posed a higher risk. Statistical analysis of questionnaires completed by the mothers indicated that factors such as diet, residence, and education may influence PAH levels in breast milk.

Probabilistic health risk assessment of primary aromatic amines in polyamide cooking utensils in China by Monte Carlo simulation

The migration of primary aromatic amines (PAAs) from food contact materials raises significant public health concerns. In this study, the migration levels of 26 PAAs were analyzed in 242 nylon cooking utensils using ultra-performance liquid chromatography-tandem mass spectrometry. A total of 18 PAAs were detected, of which 14 were quantified, with 4,4′-diaminodiphenylmethane (4,4′-MDA) and aniline being the most prevalent ones. The compliance rates for nylon kitchenware were similar under both legislation of European Commission (76.9%) and Chinese legislation (77.9%). Probabilistic non-carcinogenic and carcinogenic risk assessment were conducted using Monte Carlo simulation, with read-across approach applied to fill the gap of toxicity data. The hazard quotients for 18 PAAs were calculated, revealing that 17 PAAs (excluding 4,4′-MDA) had acceptable hazard quotients (<1). Lifetime cancer risks for 17 PAAs were determined, with 15 PAAs (excluding benzidine and 4,4′-MDA) showing acceptable cancer risks (<10−4). The study suggests that the non-carcinogenic and carcinogenic health risks posed by PAAs migrating from FCMs can be effectively mitigated by promptly identifying non-compliant products and reducing exposure to high-risk PAAs such as 4,4′-MDA and benzidine. Enhancing the understanding of PAA hazard characterization and implementing measures to minimize health risks associated with PAA migration from FCMs is hence recommended.

Quantifying the noncarcinogenic and carcinogenic risks resulting from the inhalation of PM2.5-bound metals: A multicity analysis and implications for public health

Toxic metals in PM2.5 represent a growing public health concern because of their potential health effects. Ambient PM2.5 samples were collected from five provinces around Bangkok from December 2020 to December 2021. The concentrations of PM2.5 and metals (arsenic, cadmium, chromium, cobalt, nickel, lead, and vanadium) were analyzed. The noncarcinogenic and carcinogenic risks were evaluated via Monte Carlo simulations in four age groups (0 to <6, 6 to <12, 12 to <18, 18–70 years), with a dataset comprising 2282 heavy metal assays within the particulate matter. Significantly higher PM2.5 concentrations were detected in provinces with higher factory densities, as well as higher concentrations during haze periods than during non-haze periods. The HI values for all age groups and provinces were lower than 1, indicating acceptable noncarcinogenic risks. The carcinogenic risks from PM2.5-bound metals varied between 7.08×10−7 and 4.29×10−6, indicating increased cancer risks, for preschool children and adults. Cancer risk was highest in industrial areas, followed by areas with dense traffic, and lowest in agricultural areas. The results indicated that Thailand's current air quality regulations, which primarily provide only lead limits, are insufficient considering the high carcinogenic potential of other metals. The Monte Carlo simulation results confirmed that lowering Thailand’s 24-h PM2.5 standard from 37.5 to either 25 or 15 µg m−3, as specified in the 2021 World Health Organization guidelines, would decrease cancer risk by 9.63–43.18 %.

Adverse drug reactions in older people following hospitalisation: a qualitative exploration of general practitioners' perspectives.

Older people have greater comorbidity and medication burden. Adverse drug reactions occur in up to 30% of older people within one month of hospital discharge. General practitioners are key stakeholders in transitions of care from hospital to the community. The study aimed to explore general practitioner perspectives of adverse drug reactions in older people after hospitalisation, investigating the medication-related issues encountered and possible approaches to reduce the risk. An invitation to participate in the study was sent to general practitioners in Southern Tasmania, Australia. A semi-structured interview occurred in person at their practice or online. The questions covered experiences with managing medication in older people after hospital discharge, challenges and risks involving adverse drug reactions and suggestions to prevent adverse drug reactions. The interviews were transcribed and analysed through thematic analysis. Twelve general practitioners were interviewed, revealing four themes describing challenges, including (i) complex patients and acceptance of risk, (ii) patient confusion and decline in hospital, (iii) time taken to manage older patients and (iv) communication challenges. Three themes describing recommendations were identified, including (i) clear communication on discharge, (ii) patient involvement and (iii) roles for pharmacists. Prevention of adverse drug reactions after hospital discharge may require clear and timely communication to general practitioners, patients and families to be educated and empowered to help manage their own health and risk, and pharmacists to support both patients and general practitioners in managing the risks.

Fire Safety Assessment of a Typical Sports Hall Building Based on Fire Dynamics and Crowd Movement Models

Fire risk analysis is one of the essential components of building design to ensure the safety of occupants and properties in case of fires. Currently, the Ministry of Public Works and Housing Regulation No. 20/PRT/M/2009 provides guidelines for conducting a fire risk analysis, however, without a clear consideration of fire dynamics in the estimation of the fire risk level. In this work, we investigate the fire safety aspects of a typical sports hall buildings by a fire dynamics deterministic model (Fire Dynamics Simulator (FDS) of the National Institute of Science and Technology, USA) and crowd movement model for occupant evacuation (Pathfinder of Thunderhead Engineering). Systematic investigations were made on the effects of the fire growth category and smoke extraction system on the Available Safe Egress Time (ASET). The results of ASET were then compared to the Required Safe Egress Time (RSET) which is obtained from the evacuation model. Our results suggest that ASET decreases exponentially with fire growth rate, especially from slow to medium growth rate. The fire growth rate significantly affects the acceptable fire risk of ASET longer than RSET. Occupant capacity, fire management systems, and smoke extraction systems play important roles in reducing fire risk. However, as the fire growth rate increases, the effects of smoke extraction in maintaining safe conditions diminish. This study provides recommendations to reduce risks to the occupants in case of fire, contributing to the considerations of the design and management of a typical sports hall building.

Considerations regarding the use of mission command at the tactical level

Mission Command is a specific component of the command and control system of military structures at all levels of leadership. Implementing the concept allows the commanders to encourage their subordinates to make quick and effective decisions. It also allows them to show their initiative and freedom of decision within the limits of the intention of the superior commander. In this article, a doctrinal-comparative introspection will be carried out to facilitate the identification of some advantages and disadvantages of using the Mission Command concept in the process of planning, leading, and evaluating operations at the tactical level. The research is based on the assumption that adapting the act of command and control to the particularities of the operation aims to maximize the effect of the action. Taking into account the aforementioned and not limiting ourselves to the principles of leadership, we can assert that this concept, which uses principles of military art and operational art, will become a tool at the disposal of future generations of military leaders to facilitate leading of forces with efficiency and effectiveness based on doctrinal foundations, within the limits of acceptable risks.

Haploidentical hematopoietic stem cell transplantation for hematologic malignancies: a novel conditioning regimen with anti-T lymphocyte immunoglobulin instead of anti-thymocyte globulin for in vivo T cell depletion.

We evaluated the safety and efficacy of a novel protocol for haploidentical stem cell transplantation (haplo-SCT) in 312 patients with hematologic malignancies. The protocol evolved from the Beijing platform replacing ATG with ATLG; adding Fludarabine and removing cytarabine and Simustine. GVHD prophylaxis combined Basiliximab and low-dose cyclophosphamide post-transplant; overall, the conditioning duration was shortened. Median times to neutrophil and platelet recovery were both 11 days. Graft rejection occurred in 0.96% of patients. Cumulative incidences of grades II-IV and III-IV acute GVHD by day 200 were 35.3% and 8.9%, respectively. Probabilities of total and extensive chronic GVHD at 2 years were 40.7% and 14.7%. CMV viremia was observed in 35.6% of patients, with a 1.9% 100-day CMV pneumonia incidence and no CMV-related mortality. Cumulative incidences of non-relapse mortality at 100 days, 1 year, and 2 years were 2.9, 4.4, and 6.6%. The 4-year OS, RFS, and GRFS rates were 78.9, 70.7, and 47.3%. Older recipient age was associated with higher NRM, while positive pre-transplant MRD predicted worse OS, RFS, and higher relapse incidence. Our novel protocol for haplo-SCT is associated with low infection rates and acceptable risks of graft failure, severe GVHD, and mortality, representing a safe and effective haploidentical transplantation strategy.

Exploring college students' risk perception and acceptance intention of facial recognition technology in China

In response to China’s ‘smart campus’ trend, facial recognition technology (FRT) in higher education has evolved from identification to emotion recognition, raising various risks and controversies. Understanding college students’ perceptions is key to addressing these concerns and facilitating AI integration. This study extends the Unified Theory of Acceptance and Use of Technology (UTAUT) model to gauge students’ attitudes towards FRT, introducing three new constructs: ‘personal innovativeness,’ ‘trust in the system,’ and ‘perceived risks.’ Results show that students’ personal innovativeness and trust in the system positively relate to their acceptance intention. Trust in FRT is hindered by perceived privacy, psychological, and performance risks, while perceived social risks are insignificant. Higher education shows less resistance to FRT due to normalized campus surveillance. Compared to Western societies, Chinese students’ Confucian cultural stance of ‘harmony but not uniformity’ reduces concerns about racial or religious discrimination from FRT. These findings are crucial for assessing FRT’s necessity and legality in higher education and devising risk mitigation strategies.

Adaptive stereotactic radiosurgery for cerebral metastases of non-small cell lung cancer: a retrospective study

INTRODUCTION: Non-small cell lung cancer (NSCLC) is a common cause of brain metastases (BM). Adaptive stereotactic radiosurgery (ASRS) may be a useful option in the treatment of patients with large unresectable brain metastases (BM), but to date there are only a limited number of studies evaluating the effectiveness of this method.OBJECTIVE: To analyze the effectiveness of ASRS in patients with large BM NSCLC not subject to surgical resection.MATERIAL AND METHODS: We retrospectively analyzed data from 37 patients suffering from NSCLC with 45 large (&gt;2 cm in diameter, volume &gt;4 cm3) unresectable BM treated with the Gamma Knife Perfexion model using two- and three-fraction ASRS. Of these, 14 foci (31.1%) were metastases of squamous cell lung cancer, 31 (68.9%) were metastases of adenocarcinoma. The median volume of lesions treated with ASRS was 9.8 (range 4.6–30.6 cm3). The dynamics of volume changes between fractions and the cumulative incidence of local relapses (CILR) were studied, and ROC analysis was performed for the tumor volume parameter. Intracranial progression-free survival (iPFS) and overall survival (OS) were assessed. Statistics: To establish statistical significance of differences for related variables, the Wilcoxon test for pairwise comparisons and the Friedman test for three or more groups were used. The Kaplan-Meier method was used to calculate local control, PFS, and OS rates. The log-rank test was used to compare survival data in two groups.RESULTS: The median follow-up period was 19.4 months. With two-fraction ASRS, the median volume of metastasis decreased by 28.6% by the second session, with three-fraction — by 40.0% by the third session. The 1-year and 2-year CILR rates were 8.6±6.1%, respectively; 26.1±12.3%. In ROC analysis, the area under the curve (AUC) for tumor volume was 0.80 (95% CI 0.6– 1.0) with an optimal cutoff of 18.5 cm3. The differences in CILR between the groups with metastasis volume &lt;18.5 cm3 and ≥18.5 cm3 were statistically significant (p&lt;0.001). Median iPFS was 8.3 (95% CI 5.9–10.7) months, 1-year iPFS was 33.5±8.1%;2-year — 7.8±5.2%. Median OS was 13.2 (95% CI 9.0–17.4) months; 1-year OS — 52.9±8.7%, 2-year — 22.4±8.8%.DISCUSSION: Using two- and three-fraction ASRS, we delivered doses to large BM sufficient for a high level of local control with an acceptable risk of neurotoxicity: 1-year local control was 91.4%; 2-year — 73.9%; the incidence of radionecrosis is 8.5%. A statistically significant effect of lesion volume ≥18.5 cm3 on the risk of local recurrence was found. The iPFS and OS indicators after ASRS can be considered satisfactory for this group of patients.CONCLUSION: ASRS is an effective and perhaps optimal strategy for the treatment of large unresectable BM in patients with NSCLC, but comparison with other modern radiotherapy modalities such as stereotactic hypofractionated radiotherapy and WBRT with simultaneous integrated boost is needed.

Managing Induced Seismicity Risks From Enhanced Geothermal Systems: A Good Practice Guideline

AbstractGeothermal energy is a green source of power that could play an important role in climate‐conscious energy portfolios; enhanced geothermal systems (EGS) have the potential to scale up exploitation of thermal resources. During hydraulic fracturing, fluids injected under high‐pressure cause the rock mass to fail, stimulating fractures that improve fluid connectivity. However, this increase of pore fluid pressure can also reactivate pre‐existing fault systems, potentially inducing earthquakes of significant size. Induced earthquakes are a significant concern for EGS operations. In some cases, ground shaking nuisance, building damages, or injuries have spurred the early termination of projects (e.g., Basel, Pohang). On the other hand, EGS operations at Soultz‐sous‐Forêts (France), Helsinki (Finland), Blue Mountain (Nevada, USA), and Utah FORGE (USA) have adequately managed induced earthquake risks. The success of an EGS operation depends on economical reservoir enhancements, while maintaining acceptable seismic risk levels. This requires state‐of‐the‐art seismic risk management. This article reviews domains of seismology, earthquake engineering, risk management, and communication. We then synthesize “good practice” recommendations for evaluating, mitigating, and communicating the risk of induced seismicity. We advocate for a modular approach. Recommendations are provided for key technical aspects including (a) a seismic risk management framework, (b) seismic risk pre‐screening, (c) comprehensive seismic hazard and risk evaluation, (d) traffic light protocol designs, (e) seismic monitoring implementation, and (f) step‐by‐step communication plans. Our recommendations adhere to regulatory best practices, to ensure their general applicability. Our guidelines provide a template for effective earthquake risk management and future research directions.

Content and Health Risks of Microplastics and Phthalate Esters in Bottled Water

To study the content and health risks of microplastics （MPs） and phthalate esters （PAEs） in bottled water, a quantitative analysis of MPs was conducted by using Rose Bengal staining and stereomicroscopy. Seven PAEs were quantified by using gas chromatography-triple quadrupole tandem mass spectrometry （GC-MS/MS）. The daily intake of MPs was estimated and the carcinogenic and non-carcinogenic risks of PAEs were evaluated through a health risk assessment model. The results showed that the abundance of MPs in 21 bottled waters ranged from 48 n·L-1 to 216 n·L-1 （with the median abundance of 88 n·L-1）. The majority （72.1%） of MPs were fibrous in shape, and fragments accounted for only 27.9%. The average proportion of small-sized （10-50 μm） MPs was 33.9%, and that of large-sized MPs （&gt;500 μm） was 4.3%. Most MPs were blue. The ∑(PAEs) in bottled water was 1.15-2.47 μg·L-1 （average 1.62 μg·L-1）. PAEs detected with high frequencies （100%） included dimethyl phthalate （DMP）, diethyl phthalate （DEP）, diisobutyl phthalate （DIBP）, di-n-butyl phthalate （DBP）, and di（2-ethylhexyl） phthalate （DEHP）, while the detection frequencies of butylbenzyl phthalate （BBP） and di-n-octyl phthalate （DNOP） were relatively low. The concentrations of DBP, DEHP, and DEP were all below the standard limits for drinking water in China. The ∑(PAEs) in the migration experiments was 0.61-2.04 μg·L-1 （average 1.33 μg·L-1）. The migration amounts of DBP and DEHP were also within the allowable range under the condition of 60℃ for 10 days. Seven PAEs were detected in both the bottles and caps, and the average content of DEHP in bottles was the highest, while DBP had the highest content in caps. The estimated intake of MPs （EDI） by drinking bottled water in different age groups of humans was 2.87 n·（kg·d）-1 for adults, 3.87 n·（kg·d）-1 for children, and 5.85 n·（kg·d）-1 for infants. The carcinogenic risks of DEHP in 21 bottled water samples and the migration test were less than the maximum acceptable risk level （1×10-6）, and the non-carcinogenic risk indices （HIs） of PAEs were all less than 1, indicating no non-carcinogenic risk to humans； however, the risk value of infants and children was higher than that of adults and should not be ignored.

Petroleum hydrocarbons in arctic urban lake sediments (Murmansk, Russia)

The level of pollution of lake sediments located in the city of Murmansk (Russia) with petroleum hydrocarbons was studied. The most urban lakes can be classified as slightly polluted, representing the maximum acceptable risk for human health and ecosystems; Lake Yuzhnoe – as moderately polluted with a negative impact on the aquatic environment, and Lake Ledovoe located near the highway, gas station, and car service, – as dangerously polluted, posing a threat to human health and requiring remediation. The background content of organic compounds identified as petroleum hydrocarbons in the sediments of Murmansk lakes ranges from 76 to 307 mg TPH/kg. High background concentrations of hydrocarbons can be associated with a large amount of organic matter in the sediments of lakes. The standards for the content of hydrocarbons in sediments, developed for other regions, give an ambiguous assessment of their content in the sediments of lakes in Murmansk. It is not entirely correct to use the background content of hydrocarbons in the sediments of lakes in other regions, which differ in particle size distribution, content of organic matter, and chemical composition, to assess the degree of pollution. Additional research is needed to determine the content of hydrocarbons in the sediments of background lakes in the Murmansk region and to develop standards for the content of hydrocarbons in the bottom sediments of Arctic cities.

Probabilistic risk analysis of local verification of Load Model 1 in Eurocode for Soil-Steel Composite bridges in Sweden

Bridges must be designed to ensure safety for all users. At the same time, the design should be performed with an appropriate risk level. In Sweden, Soil-Steel Composite bridges (SSCB) are the most common bridge type. For SSCB, local verification of Load Model 1 in Eurocode is most often governing the design. The objective of this study was to investigate whether local verification of LM1 load case could be modified without decreasing the agreed risk level in Eurocode. Weight in motion measurements from real traffic were extrapolated with Rice formula. Monte Carlo simulations were used to simulate the 1000-year return period event to obtain the acceptable risk level as prescribed in Eurocode. The results show that the local verification of LM1 is conservative, considering the acceptable risk level in Eurocode. With a modified implementation of local verification, this paper shows that a potential saving of up to 14% in terms of economic cost and CO2-equivalents is possible. A modified implementation of local verification of LM1 in Eurocode for SSCB is proposed, which could reduce the climate impact by up to 14% associated to the construction of new SSCB in Sweden.

Risk Propensity and Acceptance of Gene-edited and Genetically Modified Food among US Consumers: A Comparison between Plants and Animal Products

Abstract Utilizing online survey data of US consumers, this study examines the extent to which consumers' acceptance of genetically modified (GM) and gene-edited (GE) food is driven by their risk attitudes. Our results indicate that individuals with high-risk propensity are more likely to accept both GM and GE food than individuals with low- and medium-risk propensity. Our results also find differences in consumers' attitudes toward plants and animal products in the context of both GM and GE. Intriguingly, these attitudinal differences can be explained by consumers' risk propensities. Specifically, both low- and medium-risk propensity consumers differentiate between plants and animal products; the latter is less acceptable than the former, indicating a tendency to have more concerns about the application of biotechnology to animals than plants. However, individuals with high-risk propensity do not differentiate between GM and GE plants and animal products. Our results suggest that policymakers, the food industry, and researchers need to consider these attitudinal differences while studying consumer attitudes toward GM and GE food. Failing to capture these attitudinal differences in studies focusing on consumer behavior toward GM and GE food may result in either overestimating or underestimating consumer response.

A-202 Quality control design survey reveals 399 ways to do it wrong

Abstract Background The effectiveness of statistical quality control processes to detect unacceptable patient risk depends on the choices that laboratory professionals make for the design of quality control charts and acceptable patient risk. Recommended best practice consists of putting a meaningful recent mean and SD on the QC chart, selecting rules based on the method’s margin for error to unacceptable risk or Sigma value, and basing acceptable risk on clinical need. Methods A survey was circulated through LinkedIn and Labvine. Forty respondents who included their credentials were included in the final analysis. Respondents were asked to select the one most correct answer four questions regarding the parameters that govern the effectiveness of quality control processes. 1. The best source of the mean on the QC chart? (Four choices) 2. Best source of the SD on the QC chart? (Five choices) 3. Best way to select QC rules for each QC sample? (Six choices) 4. If an analytical process “fails,” we should stop reporting before [errors are reported.] (Five choices) A total of 400 potential patterns of QC selections were chosen. (4 * 5 * 5 * 4). Results When asked acceptable error rate if an analytical process “fails,” responses were More than 5% errors are reported - 11%. Any errors are reported - 66% It varies with clinical use of the test - 16% It varies with capabilities of our method - 8% While most respondents chose at least one of the recommended answers for QC chart design and rules, only three chose the best choice for all parameters. Conclusions Despite decades of recommendations of best practice for quality control, typical practice throughout the laboratory community in general does not reflect this. It is time to consider a new approach to teaching, validating and certifying competency in medical laboratory quality control.