Acceptable Risk Research Articles

Contamination and health risk assessment of potentially toxic elements in agricultural soil of the Al-Ahsa Oasis, Saudi Arabia using health indices and GIS

The current work aimed to assess contamination and human health risk of potentially toxic elements (PTEs) in agricultural soil of the Al-Ahsa Oasis, Saudi Arabia. For the purpose of evaluating the potential risks to human health associated with ingestion, skin contact, and inhalation, the chronic daily intake (CDI), hazard quotient (HQ), hazard index (HI), cancer risk (CR), and total lifetime cancer risk (LCR) were calculated in 30 soil samples. The spatial distribution and possible sources of HMs were investigated using GIS and multivariate analysis. The descending order of PTE averages (dw, µg/g) was Fe (11790) > Mn (176.43) > Zn (54.43) > Cr (28.67) > Ni (14.53) > V (12.33) > Cu (10.83) > Pb (5.23) > Co (2.87) > As (2.27). The average CDI for all PTEs from ingestion pathway in children indicates an increase of approximated 9 times compared to adults. The HI values varied from 1.969 × 10-4 to 2.318 × 10-2 for Adults, and from 1.835 × 10-3 to 2.158 × 10-1 for children, suggesting there is no significant non-carcinogenic risk to the people inhabiting the Al-Ahsa Oasis. The CRs and LCR for Cr, As, and Pb in children was found to be significantly greater than that of adults. LCR values for As, Pb, and Cr varied from lower than 1 × 10-6 to 1 × 10-4, indicating no significant health hazards to acceptable carcinogenic risk.

Determining possibilities for applying theoretical principles of situational risk management in the aviation safety system

Aviation safety is one of the main criteria for its sustainable development. The object of this study is safety risk management, which is the main tool of the aviation safety management system. The problem that needs to be further solved is the improvement of aviation risk management methods under war, force majeure, and crisis conditions, as well as under conditions of uncertainty, when there is a minimum of time to make a single correct decision. The theory of situational management can be chosen as the theoretical basis for creating decision-making systems. The development of special languages for describing the situation arising at the control object, as well as in its control system, makes it possible to correctly represent the models of control objects and the evolution of knowledge about them. The work solves the task of building a model of the control object, which takes into account the maximum number of its features suitable for implementation. In order to represent the management object based on the method of expert assessments, the weighting coefficients of the risk characteristics’ probabilities and the values of the weighting coefficients of the degrees of severity were calculated, a matrix of risk assessment indicators was built, and risk assessment criteria were developed. Based on the calculations, general approaches to aviation safety risk management were specified. The paper developed a «dramatic script» of an episode of aviation security risk management, which includes the stages of the episode, the content of necessary actions, the corresponding stages of aviation security risk management and the corresponding aviation security risk management. The content of the management itself consists in preventing the transition from the zone of acceptable risk to the zone of permissible and from the zone of permissible risk to the zone of unacceptable risk, as well as the implementation of measures to stimulate the transition from the zone of unacceptable to the zone of permissible risk and from the zone of permissible to the zone of acceptable risk

The Risk of Failure Assessment in Bina Marga Standard Designed Prestressed Concrete Girder Bridges under B-WIM Load Measurement

The use of precast prestressed concrete girder bridges in Indonesia has been increasing rapidly due to their high quality, reliability, and faster construction on site. The girder components are typically designed for a specific bridge span and can be prefabricated. The Directorate General of Highways of the Ministry of PUPR (Bina Marga) has released a standard design for prestressed concrete girder bridges with a typical span of up to 40 m. This design is based on the bridge loading standard SNI 1725 2016, which determines the live traffic load through consensus due to limited data on actual traffic load measurement results. However, the Ministry of PUPR has been implementing actual traffic load measurements using weigh-in-motion (WIM) technology to directly measure the load of passing vehicles. In this study, a risk assessment of the failure risk of a standard Bina Marga bridge with a 40-m span prestressed concrete girder type was conducted based on B-WIM load measurements. The results of this assessment indicate that the standard Bina Marga bridge has a failure risk of 1.48 x 10-4, which is smaller than the acceptable risk of failure according to the AASHTO LRFD Bridge Design Specification as referenced in SNI 1725 2016.

Multi-media distribution and risk assessment of per- and polyfluoroalkyl substances in the Huai River Basin, China

The widespread existence, environmental persistence, and risks of per- and polyfluoroalkyl substances (PFASs) have attracted widespread attention. Herein, the distribution and risk assessment of PFASs were investigated from the Huai River Basin. The ranges in different media were 29.83–217.96 (average of 75.82 ± 35.64 ng/L) in water, 0.17–9.55 ng/g (2.56 ± 2.83 ng/g) in sediments, and 0.21–9.76 ng/g (3.43 ± 3.07 ng/g) in biota. Perfluoropentanoic acid (PFPeA) was the most prevalent PFAS in surface water, followed by perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA), accounted for 42.62 %, 22.23 % and 17.72 % of the total concentrations of the PFASs analyzed, respectively. PFBA was dominant in sediments, accounting for 60.37 % of the total concentrations of the PFASs analyzed. Perfluorooctane sulfonate (PFOS) was the main pollutant in biota, and the highest concentration (5.09 ng/g) was found in Channa argus. Considering the measured concentrations in water, sediments and biota, the sediment-water partition coefficients (log Kd) and bioaccumulation factors (BAF) of PFASs were determined. The log Kd of the PFASs differed among those with a different carbon chain length, C7-C11 PFASs were more likely to be adsorbed onto sediments as the carbon chain length increases, and PFUnDA and PFDA showed the higher BAF value in Channa argus. PFASs in the Huai River Basin posed an acceptable ecological risk, and long-chain PFAS contamination provided green algae with a higher potential ecological risk. Compared to drinking water, aquatic products constituted a higher PFASs threat to human health, especially for children. The highest HQ was found in PFOS, with an HQmax of 0.97–4.32. Residents in the Huai River Basin should reduce their intake of Channa argus, Coilia nasus, and Carassius auratus, children aged 2 to 4 are limited to consuming no more than 6.9 g/d, 9.7 g/d, and 16.6 g/d, respectively.

Research on Flood Risk Control Methods and Reservoir Flood Control Operation Oriented towards Floodwater Utilization

Since improving floodwater utilization may increase flood risk, flood risk control methods for trade-offs between these factors have research value. This study presented a flood risk control method oriented towards floodwater utilization which considers multiple main flood risk factors. The proposed method not only achieves the boundaries of the flood limited water level (FLWL) under various acceptable risks but also dynamically controls the water level to enhance floodwater utilization. A case study conducted on the Danjiangkou reservoir yielded the following results: (1) The proposed method provides FLWL dynamic control boundaries under various acceptable risks. (2) The proposed method reveals the potential to raise the FLWL, with a possibility to raise it by 1.00 m above the present FLWL under the absence of flood risk. (3) The available flood resources in both the wet and dry seasons increase, on average, by 0.83 and 0.81 billion m3, and the flood risk remains within the acceptable range after raising the FLWL by 1.00 m, which contributes to enhancing floodwater utilization.

Risk Evaluation and Management Involved in Supply Chain Management

Supply chain management holds a pivotal role in determining the success of businesses, and its effectiveness can significantly influence an organization's performance. Nevertheless, it is vulnerable to a wide array of risks that have the potential to disrupt operations, result in financial losses, and tarnish a company's reputation. This summary offers an insight into the crucial components of evaluating and managing risks within supply chain management. In this context, risk evaluation encompasses the identification and assessment of various risk categories that could impact the supply chain. These risks may include natural disasters, geopolitical challenges, fluctuations in demand, delays in transportation, and issues related to suppliers. A comprehensive risk assessment involves both quantitative and qualitative analysis to gauge the likelihood and potential consequences of these risks on the supply chain. Effective risk management strategies are indispensable for mitigating the adverse effects of these identified risks. Risk management in supply chain management encompasses several actions, such as risk avoidance, risk transfer, risk reduction, and risk acceptance. Developing a resilient supply chain capable of adapting to unforeseen circumstances is also a critical element of risk management. Furthermore, this summary underscores the significance of technological tools and data analytics in the field of risk management. Advanced technologies like the Internet of Things (IoT), blockchain, and artificial intelligence enable real-time monitoring and predictive analytics, which can improve the visibility of risks and provide early warning signals. The success of a supply chain heavily relies on a proactive approach to risk assessment and management. By identifying potential risks, evaluating their impact, and implementing robust risk management strategies, organizations can bolster the resilience of their supply chains and ensure uninterrupted operations even in challenging environments. This abstract emphasizes the significance of understanding, evaluating, and effectively managing risks in supply chain management, as it contributes to an organization's long-term sustainability and competitive advantage.

Characteristics, source, and health risk assessment of aerosol polyaromatic hydrocarbons in the rural and urban regions of western Saudi Arabia

Abstract Air quality represents one of the most important parameters determining indoor microclimate and human comfort. Thus, the current study reports a comprehensive study on the dominant sources, organic compositions, and potential health impacts of the polyaromatic hydrocarbons (PAHs) in the atmospheric particle matters (PMs) ranging from 2.5 µm (PM2.5) to 10 µm (PM10) size in the rural and urban regions of western (Jeddah city) Saudi Arabia collected over 1 year between 2014 and 2015. The levels of PAHs in two locations namely Obhur (Urban) and Hada Alsham (Rural) were monitored over 1 year (2014 and 2015) using the gas chromatography coupled mass spectrometry. The level of ƩPAHs in Obhur (819.25 ng/m3) has a significantly high concentration of PAHs compared to Hada Alsham (Rural) (675.26 ng/m3). Indeno(1,2,3-CD)pyrene was the major contributor with an average value of 215.66 ng/m3 followed by benzo[k]fluranthene with a concentration of 150.68 ng/m3, respectively. The major contributors were indeno[1,2,3-cd]pyrene, benzo[k]fluranthene, dibenzo[a,h]anthracene, benzo[g,h]perylene, and benzo[b]fluranthene are the major contributors with contributing percentages of 26.32, 18.39, 9.07, and 8.29%, respectively. The rest of all compounds were below 4%. The highest concentrations of PAHs in Obhur (1836.99 ng/m3) and in Hada Alsham (1107.40 ng/m3) were observed in winter in January 2014. PAHs with 4–6 aromatic ring components are primarily emitted by high temperature combustion. The average values for the BaA/(BaA + Chr) and Flt/(Flt + Pyr) ratios at Obhur were found 0.58 and 0.43 and at Hada Alsham were found 0.63 and 0.38, respectively, indicating that coal/biomass burning is the major source of PAHs. Hada Alsham (rural area), the transportation system, is a significant contributor to the observed PAHs. These results reflect Saudi Arabia’s traffic load in both rural and urban areas. On road sites, the impact of petroleum combustion and vehicular emissions was also identified. The sum of the incremental lifetime cancer risk (ILCR) for all congeners for infants along the Obhur location was 2.13 × 10−6 and 1.38 × 10−6, respectively. ILCR values were less than 1.0 × 10−4, implying that PAH exposure posed an acceptable potential cancer risk in this study. Various local emission sources contributed more PAHs in many Saudi urban areas, increasing the risk of lung cancer, and the health risk. PAHs have an associated large surface area and are capable of deposition in the respiratory system with high efficiency. The total health risk assessment study also helps in alarming the toxicity at both the locations.

Characteristics, source, and health risk assessment of aerosol polyaromatic hydrocarbons in the rural and urban regions of western Saudi Arabia

Abstract Air quality represents one of the most important parameters determining indoor microclimate and human comfort. Thus, the current study reports a comprehensive study on the dominant sources, organic compositions, and potential health impacts of the polyaromatic hydrocarbons (PAHs) in the atmospheric particle matters (PMs) ranging from 2.5 µm (PM2.5) to 10 µm (PM10) size in the rural and urban regions of western (Jeddah city) Saudi Arabia collected over 1 year between 2014 and 2015. The levels of PAHs in two locations namely Obhur (Urban) and Hada Alsham (Rural) were monitored over 1 year (2014 and 2015) using the gas chromatography coupled mass spectrometry. The level of ƩPAHs in Obhur (819.25 ng/m3) has a significantly high concentration of PAHs compared to Hada Alsham (Rural) (675.26 ng/m3). Indeno(1,2,3-CD)pyrene was the major contributor with an average value of 215.66 ng/m3 followed by benzo[k]fluranthene with a concentration of 150.68 ng/m3, respectively. The major contributors were indeno[1,2,3-cd]pyrene, benzo[k]fluranthene, dibenzo[a,h]anthracene, benzo[g,h]perylene, and benzo[b]fluranthene are the major contributors with contributing percentages of 26.32, 18.39, 9.07, and 8.29%, respectively. The rest of all compounds were below 4%. The highest concentrations of PAHs in Obhur (1836.99 ng/m3) and in Hada Alsham (1107.40 ng/m3) were observed in winter in January 2014. PAHs with 4–6 aromatic ring components are primarily emitted by high temperature combustion. The average values for the BaA/(BaA + Chr) and Flt/(Flt + Pyr) ratios at Obhur were found 0.58 and 0.43 and at Hada Alsham were found 0.63 and 0.38, respectively, indicating that coal/biomass burning is the major source of PAHs. Hada Alsham (rural area), the transportation system, is a significant contributor to the observed PAHs. These results reflect Saudi Arabia’s traffic load in both rural and urban areas. On road sites, the impact of petroleum combustion and vehicular emissions was also identified. The sum of the incremental lifetime cancer risk (ILCR) for all congeners for infants along the Obhur location was 2.13 × 10−6 and 1.38 × 10−6, respectively. ILCR values were less than 1.0 × 10−4, implying that PAH exposure posed an acceptable potential cancer risk in this study. Various local emission sources contributed more PAHs in many Saudi urban areas, increasing the risk of lung cancer, and the health risk. PAHs have an associated large surface area and are capable of deposition in the respiratory system with high efficiency. The total health risk assessment study also helps in alarming the toxicity at both the locations.

Developing the Aesthetic Postoperative Complication Score (APeCS) for Detecting Major Morbidity in Facial Aesthetic Surgery.

Facial aesthetic surgery encompasses a variety of procedures with complication rates that are difficult to estimate due to a lack of published data. We sought to estimate major complication rates in patients undergoing facial aesthetic procedures and develop a risk assessment tool to stratify patients. We utilized the Tracking Operation and Outcomes for Plastic Surgeons (TOPS) database from 2003-2018. The analytic database included major facial aesthetic procedures. Univariate analysis and a backward stepwise multivariate regression model identified risk factors for major complications. Regression coefficients were utilized to create the score. Performance robustness was measured with area under receiver operating characteristic curves and sensitivity analyses. A total of 38,569 patients were identified. The major complication rate was 1.2% (460). The regression model identified risk factors including over 3 concomitant surgeries, BMI ≥25, ASA class ≥2, current or former smoker status, and age ≥45 as the variables fit for risk prediction (n = 13,004; area under curve: 0.68, standard error: 0.013, [0.62-0.67]). Each of the 5 variables counted for 1 point, except over 3 concomitant surgeries counting for 2, giving a score range from 0 to 6. Sensitivity analysis showed the cutoff point of ≥3 to best balance sensitivity and specificity, 58% and 66%, respectively. At this cutoff, 65% of cases were correctly classified as having a major complication. We developed an acceptable risk prediction score with a cutoff value of ≥3 associated with correctly classifying approximately 65% of those at risk for major morbidity when undergoing face and neck aesthetic surgery.

Relational continuity may give better clinical outcomes in patients with serious mental illness – a systematic review

BackgroundContinuity of care is considered important for results of treatment of serious mental illness (SMI). Yet, evidence of associations between relational continuity and different medical and social outcomes is sparse. Research approaches differ considerably regarding how to best assess continuity as well as which outcome to study. It has hitherto been difficult to evaluate the importance of relational continuity of care. The aim of this systematic review was to investigate treatment outcomes, including effects on resource use and costs associated with receiving higher relational continuity of care for patients with SMI.MethodsEleven databases were searched between January 2000 and February 2021 for studies investigating associations between some measure of relational continuity and health outcomes and costs. All eligible studies were assessed for study relevance and risk of bias by at least two independent reviewers. Only studies with acceptable risk of bias were included. Due to study heterogeneity the synthesis was made narratively, without meta-analysis. The certainty of the summarized result was assessed using GRADE. Study registration number in PROSPERO: CRD42020196518.ResultsWe identified 8 916 unique references and included 17 studies comprising around 300 000 patients in the review. The results were described with regard to seven outcomes. The results indicated that higher relational continuity of care for patients with serious mental illness may prevent premature deaths and suicide, may lower the number of emergency department (ED) visits and may contribute to a better quality of life compared to patients receiving lower levels of relational continuity of care. The certainty of the evidence was assessed as low or very low for all outcomes. The certainty of results for the outcomes hospitalization, costs, symptoms and functioning, and adherence to drug treatment was very low with the result that no reliable conclusions could be drawn in these areas.ConclusionsThe results of this systematic review indicate that having higher relational continuity of care may have beneficial effects for patients with severe mental illness, and no results have indicated the opposite relationship. There is a need for better studies using clear and distinctive measures of exposure for relational continuity of care.

Comparative Outcomes of Radical Cystectomy in Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-Analysis.

Muscle-invasive bladder cancerposes a significant clinical challenge that necessitates effective therapeutic interventions. Radical cystectomy is a primary treatment option, but a comprehensive understanding of its outcomes is crucial for informed clinical decision-making.This systematic review and meta-analysis aimed to investigate and summarize the outcomes associated with radical cystectomy as a primary treatment for muscle-invasive bladder cancer with a focus on survival rates, complications, and quality of life.A systematic search across databases-PubMed, Google Scholar, and others-covered studies from 2017 onwards. Included were studies reporting survival rates, complications, and quality of life post-radical cystectomy in muscle-invasive bladder cancer patients, including randomized controlled trials, cohort, and observational studies. Multidimensional analysis revealed promising findings regarding the efficacy of radical cystectomy in muscle-invasive bladder cancer. Survival outcomes, including overall survival and disease-specific mortality, have demonstrated significant improvements, particularly in recent randomized controlled trials and cohort studies. Complications associated with the surgical procedure, such as positive surgical margins and lymph node yields, were generally acceptable. Quality of life outcomes post-radical cystectomy exhibited positive trends, although variations were noted in the emotional and social domains. This review underscores radical cystectomy's role in enhancing overall survival and reducing disease-specific mortality in muscle-invasive bladder cancer. Despite reported complications, recent studies support its acceptable risk profile. Detailed examination of various factors contributes to a comprehensive understanding of the procedure. These findings emphasize the importance of individualized treatment approaches in the management of muscle-invasive bladder cancer, considering both oncological efficacy and perioperative outcomes.Radical cystectomy remains fundamental in urological oncology, with ongoing advancements refining its significance.

Adding simultaneous integrated boost to whole brain radiation therapy improved intracranial tumour control and minimize radiation-induced brain injury risk for the treatment of brain metastases

BackgroundBrain metastases (BMs) are the most frequent intracranial tumours associated with poor clinical outcomes. Radiotherapy is essential in the treatment of these tumours, although the optimal radiation strategy remains controversial. The present study aimed to assess whether whole brain radiation therapy with a simultaneous integrated boost (WBRT + SIB) provides any therapeutic benefit over WBRT alone.MethodsWe included and retrospectively analysed 82 patients who received WBRT + SIB and 83 who received WBRT alone between January 2012 and June 2021. Intracranial progression-free survival (PFS), local tumour control (LTC), overall survival (OS), and toxicity were compared between the groups.ResultsCompared to WBRT alone, WBRT + SIB improved intracranial LTC and PFS, especially in the lung cancer subgroup. Patients with high graded prognostic assessment score or well-controlled extracranial disease receiving WBRT + SIB had improved intracranial PFS and LTC. Moreover, WBRT + SIB also improved the long-term intracranial tumour control of small cell lung cancer patients. When evaluating toxicity, we found that WBRT + SIB might slightly increase the risk of radiation-induced brain injury, and that the risk increased with increasing dosage. However, low-dose WBRT + SIB had a tolerable radiation-induced brain injury risk, which was lower than that in the high-dose group, while it was comparable to that in the WBRT group.ConclusionsWBRT + SIB can be an efficient therapeutic option for patients with BMs, and is associated with improved intracranial LTC and PFS. Furthermore, low-dose WBRT + SIB (biologically effective dose [BED] ≤ 56 Gy) was recommended, based on the acceptable risk of radiation-induced brain injury and satisfactory tumour control.Trial registrationRetrospectively registered.

Chemical pollution in Arctic cities: public health risk assessment and solutions

The research presents characteristics of non-carcinogenic and carcinogenic inhalation and aquatic chemical risk caused by chemical pollutants of atmospheric air and drinking water exposure to the health of the population of the Arctic city of Salekhard. It has been established that carcinogenic risks with inhalation exposure to chromium, soot and formaldehyde as well as with oral exposure to cadmium, beryllium, lead and hexavalent chromium correspond to the upper limit of the acceptable risk and are subject to constant monitoring. The risk of oral exposure to arsenic needs to be minimized through the development and implementation of additional health measures. The calculated indices of non-carcinogenic risk for inhalation and oral exposure, not exceeding 1.0, that shows a low probability of adverse effects from critical organs / systems.

Attitudes of healthcare professionals and drug regulators about progression-free survival as endpoint in the advanced cancer setting

PurposeTo describe the attitudes of healthcare professionals and drug regulators about progression-free survival (PFS) as efficacy endpoint in clinical trials with patients with advanced cancer and to explore to what extent these attitudes influence the willingness to trade between PFS and toxicity. MethodsCross-sectional survey with regulators from the European Medicines Agency (EMA), and healthcare professionals (HCP) from the “Stichting Hemato-Oncologie voor Volwassenen Nederland” (HOVON) collaborative group and the European Organisation for Research and Treatment of Cancer (EORTC). Attitudes towards PFS were elicited using 5-point Likert items. The respondents’ willingness to trade between PFS and grade 3 or 4 (G34) toxicity was assessed using the threshold technique and quantified in terms of their maximum acceptable risk (MAR). ResultsResponses were collected from 287 HCPs and 64 regulators with mainly clinical expertise. Attitudes towards PFS were often spread out in both groups and related to beliefs about PFS being a likely surrogate for clinical benefit, being an intrinsic benefit to be distinguished from OS, or on the importance given to OS. Being a regulator or holding stronger beliefs about PFS being a likely surrogate or an intrinsic benefit were associated with a higher MAR. Presence of a supportive trend in OS was stated as important but was not associated with MAR. There was agreement on the need to address bias in the adjudication of PFS and the need for improving communication to patients about meaning, strengths, and limitations of improvements in PFS. ConclusionAttitudes towards PFS were spread out and were associated with individual differences in the willingness to trade between toxicity and PFS. There was agreement on the need to address bias in the adjudication of PFS and improving communication to patients.

Characterisation of polycyclic aromatic hydrocarbons associated with indoor PM0.1 and PM2.5 in Hanoi and implications for health risks

Polycyclic aromatic hydrocarbons (PAHs) associated with indoor PM pose a high risk to human health because of their toxicity. A total of 160 daily samples of indoor PM2.5 and PM0.1 were collected in Hanoi and analysed for 15 PAHs. In general, the concentrations of carcinogenic PAHs (car-PAHs) accounted for 21% ± 2%, 19.1% ± 2%, and 26% ± 3% of the concentrations of 15 PAHs in PM2.5, PM0.1-2.5, and PM0.1, respectively. Higher percentages of car-PAHs were found in smaller fractions (PM0.1), which can be easily deposited deep in the pulmonary regions of the human respiratory tract. The concentrations of 15 PAHs were higher in winter than in summer. The most abundant PAH species were naphthalene and phenanthrene, accounting for 11%–21% and 19%–23%, respectively. The PAH content in PM0.1 was almost twice as high as those in PM2.5 and PM0.1-2.5. Principal component analysis found that vehicle emissions and the combustion of biomass and coal were the main outdoor sources of PAHs, whereas indoor sources included cooking activities, the combustion of incense, scented candles, and domestic uses in houses. According to the results, 60%–90% of the PM0.1-bound BaP(eq) was deposited in the alveoli region, whereas 63%–75% of the PM2.5-bound BaP(eq) was deposited in head airways (HA), implying that most of the particles deposited in the HA region were PM0.1-2.5. The contributions of dibenz[a,h]anthracene and benzo[a]pyrene were dominant and contributed from 36% to 51% and 31%–50%, respectively, to the carcinogenic potential, whereas benzo[a]pyrene contributed from 30% to 49% to the mutagenic potential for both size fractions. The incremental lifetime cancer risk, simulated by Monte Carlo simulation, was within the limits set by the US EPA, indicating an acceptable risk for the occupants. These results provide an additional scientific basis for protecting human health from exposure to indoor PAHs.

Assessing the ecological impacts of polycyclic aromatic hydrocarbons petroleum pollutants using a network toxicity model

Polycyclic aromatic hydrocarbons (PAHs) are significant petroleum pollutants that have long-term impacts on human health and ecosystems. However, assessing their toxicity presents challenges due to factors such as cost, time, and the need for comprehensive multi-component analysis methods. In this study, we utilized network toxicity models, enrichment analysis, and molecular docking to analyze the toxicity mechanisms of PAHs at different levels: compounds, target genes, pathways, and species. Additionally, we used the maximum acceptable concentration (MAC) value and risk quotient (RQ) as an indicator for the potential ecological risk assessment of PAHs. The results showed that higher molecular weight PAHs had increased lipophilicity and higher toxicity. Benzo[a]pyrene and Fluoranthene were identified as core compounds, which increased the risk of cancer by affecting core target genes such as CCND1 in the human body, thereby influencing signal transduction and the immune system. In terms of biological species, PAHs had a greater toxic impact on aquatic organisms compared to terrestrial organisms. High molecular weight PAHs had lower effective concentrations on biological species, and the ecological risk was higher in the Yellow River Delta region. This research highlights the potential application of network toxicity models in understanding the toxicity mechanisms and species toxicity of PAHs and provides valuable insights for monitoring, prevention, and ecological risk assessment of these pollutants.

Occurrence of Pesticides in Polished Rice Samples From Tanjung Karang and Sekinchan and the Health Risk among Consumers

Introduction: One of the key staple foods in many different countries, including Malaysia, is rice (Oryzae sativa L.). Pesticides are used to reduce weed growth and safeguard crops from insect attacks in order to boost paddy output. Objective: This research quantifies the concentration of pymetrozine, chlorantraniliprole, and difenoconazole, along with any potential health risks to consumers. Methods: Samples of polished rice from three rice milling factories in Tanjung Karang and Sekinchan were extracted using the QuEChERS (Quick Easy Cheap Effective Rugged Safe) technique. The amount of pesticide residue in polished rice was then measured using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). A health risk assessment was conducted utilizing the Hazard Quotient (HQ) and Lifetime Cancer Risk (LCR) to estimate the non-carcinogenic and carcinogenic health risks. Results: The mean concentration of pesticides in polished rice ranged from less than the detection limit (difenoconazole) to 1.122 µg/kg (pymetrozine). No rice samples above the Maximum Residue Limit (MRL) specified in the Food Act 1983 as implemented by Malaysia’s Food Regulations 1985. Pymetrozine, chlorantraniliprole, and difenoconazole in rice had respective MRLs of 50 µg/kg, 2000 µg/kg, and 100 µg/kg. For all age groups, no significant non-carcinogenic health risk was associated with consuming polished rice from the study area, where the HQ and Hazard Index (HI) were less than one. When LCR values were less than 10-6, carcinogenic health risks of consuming polished rice from the study area were at a clearly acceptable risk level. Conclusion: As no sample exceeded the MRL, the findings indicated that all rice samples collected from Tanjung Karang and Sekinchan were safe for consumption.

More trust or more risk? User acceptance of artificial intelligence virtual assistant

AbstractArtificial intelligence (AI) virtual assistants are rapidly growing, permeating people's daily lives and work. However, some trust and risk issues prevent the acceptance and use of AI virtual assistants by users. Thus, understanding the roles of trust and perceived risk in user acceptance of AI virtual assistants is crucial. This study develops a comprehensive research model based on unified theory of acceptance and use of technology (UTAUT) to explain user acceptance of AI virtual assistants. This model extends UTAUT by adding users' perception of trust and risk. The research model and hypotheses are validated through structural equation modeling with a sample of 926 AI virtual assistant users. Results show that gender is significantly related to behavioral intention to use, education is positively related to trust and behavioral intention to use, and usage experience is positively related to attitude toward using. UTAUT variables, including performance expectancy, effort expectancy, social influence, and facilitating conditions, are positively related to behavioral intention to use AI virtual assistant. Trust and perceived risk respectively have positive and negative effects on attitude toward using and behavioral intention to use AI virtual assistants. Trust and perceived risk play equally important roles in explaining user acceptance of AI virtual assistants. Theoretical and practical implications of the current AI virtual assistant acceptance model and directions for future research are discussed.

Perception of Food Safety Associated with Entomophagy among Higher-Education Students: Exploring Insects as a Novel Food Source.

Edible insects can diversify diets, improve livelihoods, contribute to food and nutrition security, and have a smaller ecological impact. The European Union has categorized insects as novel food, and recently, in 2021 and 2022, two species, Tenebrio molitor and Acheta domesticus, were authorized for commercialization. The acceptance and perception of food risk derived from insect consumption vary depending on factors impacting insect consumption acceptability, including neophobic tendencies, gender differences, familiarity, and gastronomic perceptions. The aim of this work was to evaluate the perception and acceptance of edible insects by exploring these factors. This study was carried out on higher-education students from universities in Valencia (Spain). The students recognized insects' high nutritional value, particularly protein content, and had varying levels of knowledge about specific nutritional components. In terms of labeling and marketing, removing health and sustainability benefits from packaging can improve consumer responses. Most respondents prefer clear labeling of insect derivatives, quality certification seals, and complete information about insect content. Students consider marketing and knowledge to be significant influencers of insect consumption. In summary, this text highlights the multifaceted nature of insect consumption acceptability. These insights offer valuable perspectives on insect consumption dynamics.

Health Risk Assessment of Heavy Metals in Soil of Lalu Wetland Based on Monte Carlo Simulation and ACPS-MLR

Lalu wetland is the world’s largest plateau urban wetland. It was designated as a national-level nature reserve in China in 2004 and is often called “the lung of Lhasa”. It serves as a vital recreational area for urban residents. Concerns have arisen about the potential harm to human health due to heavy metals (HMs) in the wetland soil. This study assessed the ecological risk of HMs in Lalu wetland soil by using the potential ecological risk index and geo-accumulation index techniques. The findings showed that the Lalu wetland’s overall risk level is low risk. with Cd being the primary pollutant. Through the absolute principal component scores–multiple linear regression (APCS-MLR) model and Pearson correlation analysis, three sources of HMs were identified, including traffic sources, soil parent material sources, and geothermal sources, contributing 51.13%, 32.35%, and 16.52%, respectively. The results of the probabilistic health risk assessment based on Monte Carlo simulation indicate that non-carcinogenic risks are absent for both adults and children. However, acceptable carcinogenic risks are present. For adults, the main exposure mode is through dermal contact, while children are primarily exposed through ingestion. Children manifest a heightened vulnerability to these risks compared to adults, with As being the primary contributing element. The source-oriented health risk assessment (HRA) highlights geothermal sources as the primary contributors to health risks. The research results provide insights into the current status of HMs in Lalu wetland soil, offering a scientific basis for restricting and managing contamination by HMs in wetlands.